European journal of microbiology & immunology最新文献_第3页

Toxoplasma gondii seroprevalence and risk factors of cats in the Budapest area. 布达佩斯地区猫的弓形虫血清流行率和风险因素。

European journal of microbiology & immunology Pub Date : 2024-11-04 Print Date: 2024-12-18 DOI: 10.1556/1886.2024.00079

Miklós Pál Dunay, Dorottya Zólyomi, Eszter Gulyás, Ildiko Rita Dunay

引用次数: 0

Replicative co-infections with human immunodeficiency virus 1 and 2 as well as hepatitis B and C virus in Ghanaian individuals. 加纳人中人类免疫缺陷病毒 1 和 2 以及乙型肝炎和丙型肝炎病毒的复制性合并感染。

European journal of microbiology & immunology Pub Date : 2024-10-30 Print Date: 2024-12-18 DOI: 10.1556/1886.2024.00103

Lynn Glyschewski, Andreas Hahn, Holger Rohde, Marc Lütgehetmann, Torsten Feldt, Fred Stephen Sarfo, Richard Odame Phillips, Albert Dompreh, Shadrack Osei Asibey, Richard Boateng, Felix Weinreich, Hagen Frickmann, Kirsten Alexandra Eberhardt

{"title":"Replicative co-infections with human immunodeficiency virus 1 and 2 as well as hepatitis B and C virus in Ghanaian individuals.","authors":"Lynn Glyschewski, Andreas Hahn, Holger Rohde, Marc Lütgehetmann, Torsten Feldt, Fred Stephen Sarfo, Richard Odame Phillips, Albert Dompreh, Shadrack Osei Asibey, Richard Boateng, Felix Weinreich, Hagen Frickmann, Kirsten Alexandra Eberhardt","doi":"10.1556/1886.2024.00103","DOIUrl":"10.1556/1886.2024.00103","url":null,"abstract":"Background: The study assessed replicative human immunodeficiency virus-(HIV-) infection and replicative co-infections as well as molecular determinants of reduced susceptibility towards anti-retroviral therapy in a Ghanaian population of known HIV patients and a control group.Methods: Real-time PCRs for HIV-1, HIV-2, hepatitis B virus (HBV) and hepatitis C virus (HCV) were run with serum samples from known Ghanaian HIV-patients (n = 975) and control individuals (n = 105). For 108 individuals, HIV-sequence analysis was performed.Results: Prevalence of replicative HIV-1 infection was 59.8% (583/975) in the known HIV-positive population and 2.9% (3/105) in the controls. Prevalences of replicative HBV-infection were comparable with 3.4% (33/975) in the HIV-positive individuals and 3.8% (4/105) in the controls. HIV-2 and HCV sequences were not recorded. Almost perfect concordance between two compared HIV-1-PCR assays was indicated by Fleiss' Kappa >0.8. Sanger sequencing indicated CRF_02AG, G and A3 as the quantitatively dominating HIV-1 subtypes, a minority of 3.4% CXCR4 tropism and high detection rates of mutations mediating reduced susceptibility towards nucleoside reverse transcriptase inhibitors (71.9%, 64/89), non-nucleoside reverse transcriptase inhibitors (95.5%, 85/89), protease inhibitors (95.9%, 93/97) and integrase inhibitors (22.4%, 22/98).Conclusions: The assessment did not suggest HIV-triggered increased replication of HBV and HCV in the investigated Ghanaian population.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"346-360"},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial and temporal dynamics of the prevalence of resistance genes and gastrointestinal pathogens in stool samples of German deployment returnees. 德国部署回国人员粪便样本中抗药性基因和胃肠道病原体流行的时空动态。

European journal of microbiology & immunology Pub Date : 2024-10-29 Print Date: 2024-12-18 DOI: 10.1556/1886.2024.00093

Vanessa Navabi, Dorothea Franziska Wiemer, Matthias Halfter, Ulrich Müseler, Susann Dupke, Anja Petrov-Salzwedel, Ulrich Schotte, Hagen Frickmann

{"title":"Spatial and temporal dynamics of the prevalence of resistance genes and gastrointestinal pathogens in stool samples of German deployment returnees.","authors":"Vanessa Navabi, Dorothea Franziska Wiemer, Matthias Halfter, Ulrich Müseler, Susann Dupke, Anja Petrov-Salzwedel, Ulrich Schotte, Hagen Frickmann","doi":"10.1556/1886.2024.00093","DOIUrl":"10.1556/1886.2024.00093","url":null,"abstract":"Background: The exploratory study assessed trends in the abundance of CTX-M-type extended spectrum beta-lactamase (ESBL) and vancomycin-resistance genes vanA and vanB in the stool samples of German soldiers and police officers returning from predominantly tropical deployments next to the common diarrheagenic Escherichia (E.) coli pathovars enteropathogenic Escherichia coli (EPEC), enterotoxigenic E. coli (ETEC) and enteroaggregative E. coli (EAEC)) as well as rarely imported Vibrio spp. between 2006 and 2024.Methods: Surveillance was performed applying real-time polymerase chain reaction and results were stratified by World Health Organization region of deployment as well as by deployment period. For the latter, the study interval was divided into three pre-COVID-19-pandemic periods, the COVID-19-pandemic period and the post-COVID-19-pandemic period. Averaged prevalences were used as references.Results: In stool samples of 1817 deployed German soldiers and 117 police officers, averaged prevalences were 47.9% and 24.8% for the ESBL-type beta-lactamase blaCTX-M, 30.2% and 14.5% for vanB, 9.0% and 17.9% for EPEC, 3.4% and 12.8% for ETEC, 4.0% and 3.4% for EAEC as well as 2.0% and 3.4% for Vibrio spp., respectively. While resistance genes peaked during early deployments, maximum prevalences for enteropathogens were seen later.Conclusions: The assessment suggested time- and region-dependence of the assessed parameters.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"309-332"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A recent update on the antibacterial effects of distinct bioactive molecules derived from the Cannabis plant. 从大麻植物中提取的独特生物活性分子抗菌效果的最新进展。

European journal of microbiology & immunology Pub Date : 2024-10-29 Print Date: 2024-12-18 DOI: 10.1556/1886.2024.00098

Mathis Werner, Stefan Bereswill, Markus M Heimesaat

{"title":"A recent update on the antibacterial effects of distinct bioactive molecules derived from the Cannabis plant.","authors":"Mathis Werner, Stefan Bereswill, Markus M Heimesaat","doi":"10.1556/1886.2024.00098","DOIUrl":"10.1556/1886.2024.00098","url":null,"abstract":"The number of human infections with multidrug-resistant (MDR) bacteria is increasing worldwide and constitutes a serious threat to human health. Given the lack of novel antibiotic compounds worsening this dilemma, alternative antibiotic-independent treatment and prevention strategies of infectious diseases applying natural compounds appear highly appreciable. Given the long-known health-beneficial and disease-alleviating properties of Cannabis, we performed a literature search summarizing current knowledge regarding the antibacterial effects of extracts from different parts of the Cannabis sativa plant and of defined Cannabis-derived molecules and their potential mode of action. The included studies revealed that various extracts and essential oils of C. sativa as well as major cannabinoids exerted potent activities against a broad spectrum of Gram-positive bacteria and against some Gram-negative bacterial species including MDR strains. Particularly the disruption of the bacterial cytoplasmic membrane by some cannabinoids resulted in potent antibacterial effects against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus. Furthermore, defined cannabinoids inhibited the formation of and eradicated existing bacterial biofilms. In conclusion, given their antibacterial properties distinct Cannabis-derived molecules expand the repertoire of antibiotics-independent treatment options in the combat of bacterial infectious diseases which should be further addressed in future studies including clinical trials.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"333-339"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11836653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allergens causing contact dermatitis of the feet: Investigation and analysis of allergic reaction causes. 导致足部接触性皮炎的过敏原：过敏反应原因调查与分析。

European journal of microbiology & immunology Pub Date : 2024-08-29 Print Date: 2024-09-11 DOI: 10.1556/1886.2024.00076

Maria Zofia Lisiecka

{"title":"Allergens causing contact dermatitis of the feet: Investigation and analysis of allergic reaction causes.","authors":"Maria Zofia Lisiecka","doi":"10.1556/1886.2024.00076","DOIUrl":"10.1556/1886.2024.00076","url":null,"abstract":"Introduction: Allergic contact dermatitis of the feet is a significant problem that affects the quality of life and requires attention from the medical community due to the number of studied and still unidentified allergens. The purpose of this review article is to summarize the available scientific data regarding the most common allergens that cause ACD of the feet.Methods: Nickel sulphate, neomycin sulphate, thiuram mix and colophony occupy a significant place in the prevalence of allergies. The prevalence of sensitization to rubber and leather products can vary depending on the ethno-demographic characteristics of the country, as well as the specifics of a person's professional activity, such as the use of protective waterproof shoes, increased humidity of the microclimate, and atopy in anamnesis.Results: Patch testing has been shown to be an important method for identifying allergens, however, not all footwear components are tested during patch testing with standard allergen series, requiring the use of patches made from patient shoe samples.Conclusions: Expanding the scope of patch testing to include other possible allergens is important for the accurate diagnosis of ACD of the feet and a more detailed study of those allergens that were previously considered rare.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"219-227"},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antifungal potential, mechanism of action, and toxicity of 1,4-naphthoquinone derivatives. 1,4-萘醌衍生物的抗真菌潜力、作用机制和毒性。

European journal of microbiology & immunology Pub Date : 2024-08-23 Print Date: 2024-09-11 DOI: 10.1556/1886.2024.00072

Juan Diego Ribeiro de Almeida, Raissa Sayumy Kataki Fonseca, Naira Sulany Oliveira de Sousa, Ana Cláudia Alves Cortez, Emerson Silva Lima, Juliana Gomes de Souza Oliveira, Érica Simplício de Souza, Hagen Frickmann, João Vicente Braga de Souza

{"title":"Antifungal potential, mechanism of action, and toxicity of 1,4-naphthoquinone derivatives.","authors":"Juan Diego Ribeiro de Almeida, Raissa Sayumy Kataki Fonseca, Naira Sulany Oliveira de Sousa, Ana Cláudia Alves Cortez, Emerson Silva Lima, Juliana Gomes de Souza Oliveira, Érica Simplício de Souza, Hagen Frickmann, João Vicente Braga de Souza","doi":"10.1556/1886.2024.00072","DOIUrl":"10.1556/1886.2024.00072","url":null,"abstract":"Background: The rising prevalence of fungal infections and challenges such as adverse effects and resistance against existing antifungal agents have driven the exploration of new antifungal substances.Methods: We specifically investigated naphthoquinones, known for their broad biological activities and promising antifungal capabilities. It specifically examined the effects of a particular naphthoquinone on the cellular components of Candida albicans ATCC 60193. The study also assessed cytotoxicity in MRC-5 cells, Artemia salina, and the seeds of tomatoes and arugula.Results: Among four tested naphthoquinones, 2,3-DBNQ (2,3-dibromonaphthalene-1,4-dione) was identified as highly effective, showing potent antifungal activity at concentrations between 1.56 and 6.25 μg mL-1. However, its cytotoxicity in MRC-5 cells (IC50 = 15.44 µM), complete mortality in A. salina at 50 μg mL-1, and significant seed germination inhibition suggest limitations for its clinical use.Conclusions: The findings indicate that primary antifungal mechanism of 2,3-DBNQ might involve disrupting fungal membrane permeability, which leads to increased nucleotide leakage. This insight underscores the need for further research to enhance the selectivity and safety of naphthoquinones for potential therapeutic applications.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"289-295"},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of RND efflux pump expression and AdeRS mutations in tigecycline-resistant Acinetobacter baumannii from Thai clinical isolates. 泰国临床分离物中耐替加环素鲍曼不动杆菌的 RND 外排泵表达与 AdeRS 突变的相关性。

European journal of microbiology & immunology Pub Date : 2024-08-23 Print Date: 2024-09-11 DOI: 10.1556/1886.2024.00070

Siriphan Boonsilp, Anchalee Homkaew, Thanwa Wongsuk, Konrawee Thananon, Worrapoj Oonanant

{"title":"Correlation of RND efflux pump expression and AdeRS mutations in tigecycline-resistant Acinetobacter baumannii from Thai clinical isolates.","authors":"Siriphan Boonsilp, Anchalee Homkaew, Thanwa Wongsuk, Konrawee Thananon, Worrapoj Oonanant","doi":"10.1556/1886.2024.00070","DOIUrl":"10.1556/1886.2024.00070","url":null,"abstract":"Tigecycline-resistant Acinetobacter baumannii (TRAB) is increasing in Thailand, complicating antibiotic treatment due to limited antibiotic options. The specific resistance mechanism behind tigecycline resistance is still unclear, necessitating further investigation. We investigated the presence of OXA-type carbapenemases, the antimicrobial susceptibility profile, the inhibitory effect of carbonyl cyanide m-chlorophenylhydrazone (CCCP) on tigecycline susceptibility, the expression levels of RND-type efflux pumps and amino acid substitutions within a two-component regulatory system on 30 Thai clinical isolates. Our investigation revealed that most of (73.3%) TRAB isolates expressed at least one member of the Ade efflux pumps. The adeB was most frequently expressed (63.3%), followed by adeR (50%), adeS (43.3%), adeJ (30%) and adeG (10%). Overexpression of the AdeABC was associated with increased tigecycline minimum inhibitory concentrations (MICs) and amino acid substitutions within the AdeRS. Notably, isolates harbouring simultaneous mutations in these genes exhibited an increase in the transcription level of the adeB. Our findings highlight the significant role of the AdeABC system in tigecycline resistance among Thai clinical TRAB isolates. This is supported by point mutations within the AdeRS and upregulated expression of the adeB. These results provide valuable insights for understanding resistance mechanisms and developing novel therapeutic strategies.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"280-288"},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating dengue virus serotypes, demographics, and epidemiology in the 2023 dengue outbreak in Chittagong, Bangladesh. 2023 年孟加拉国吉大港登革热疫情中的登革热病毒血清型、人口统计学和流行病学。

European journal of microbiology & immunology Pub Date : 2024-08-22 Print Date: 2024-09-11 DOI: 10.1556/1886.2024.00069

Md Abdur Rob, Mohabbat Hossain, M A Sattar, Istiaq Uddin Ahmed, Abul Faisal Md Nuruddin Chowdhury, H M Hamidullah Mehedi, Noor Mohammed, Mohammed Maruf Ul Quader, Md Zakir Hossain, Mustafizur Rahman, Kallyan Chakma, Susmita Barua, Silvia Naznin Etu, Uschash Sikder, Afroza Akter Tanni, Adnan Mannan

{"title":"Circulating dengue virus serotypes, demographics, and epidemiology in the 2023 dengue outbreak in Chittagong, Bangladesh.","authors":"Md Abdur Rob, Mohabbat Hossain, M A Sattar, Istiaq Uddin Ahmed, Abul Faisal Md Nuruddin Chowdhury, H M Hamidullah Mehedi, Noor Mohammed, Mohammed Maruf Ul Quader, Md Zakir Hossain, Mustafizur Rahman, Kallyan Chakma, Susmita Barua, Silvia Naznin Etu, Uschash Sikder, Afroza Akter Tanni, Adnan Mannan","doi":"10.1556/1886.2024.00069","DOIUrl":"10.1556/1886.2024.00069","url":null,"abstract":"Dengue is a serious epidemic for Bangladesh affecting thousands of lives. This study aimed to identify and determine the prevalence of the circulating variants of dengue virus (DENV) and their association with demographics and clinical manifestations among the dengue-infected patients. A total of 711 participants with NS1 antigen positivity were enrolled, followed by viral RNA extraction from the collected blood samples and a multiplex real-time reverse transcription-polymerase chain reaction (RT-PCR) assay to determine the dengue virus serotypes. Of 711 dengue-infected patients, 503 (70.7%) were male. Among different age groups, most of the patients were 21-30 years old (n = 255, 35.9%). The DENV2 (n = 483, 67.9%) serotype was more prevalent than the DENV3 (n = 144, 20.3%) and DENV1 (n = 84, 11.8%). The duration of fever was highest in the DENV-1 patients (4.79 ± 1.84 days) in contrast to DENV-3 (4.48 ± 1.68 days) and DENV-2 (4.33 ± 1.45 days) (P = 0.039). Importantly, five highly populated areas were identified as dengue hotspots in Chittagong metropolitan city. Our results provide crucial insights into the patterns of dengue virus transmission and severity among southern Bangladeshi population, thereby aiding in the development of targeted public health interventions and management strategies to combat future outbreaks.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"272-279"},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological and immunological characterization of primary cultured chicken caecal epithelial cells. 原代培养鸡盲肠上皮细胞的形态学和免疫学特征。

European journal of microbiology & immunology Pub Date : 2024-06-21 Print Date: 2024-09-11 DOI: 10.1556/1886.2024.00053

Thomas Willer, Annette Kaiser, Adrian Smith, Silke Rautenschlein

{"title":"Morphological and immunological characterization of primary cultured chicken caecal epithelial cells.","authors":"Thomas Willer, Annette Kaiser, Adrian Smith, Silke Rautenschlein","doi":"10.1556/1886.2024.00053","DOIUrl":"10.1556/1886.2024.00053","url":null,"abstract":"Cell cultures are models in biological and medical research to understand physiological and pathological processes. Cell lines are not always available depending on cell type and required species. In addition, the immortalization process often affects cell biology. Primary cells generally maintain a greater degree of similarity in short-term culture to the cells in tissue. Goal of this study was to verify the suitability of chicken primary epithelial caecal cells (PECCs) for in vitro investigations of host‒pathogen interactions. Epithelial nature of PECCs was confirmed by detection of tight and adherens junctions and cobblestone-like cell morphology. Sialic acids distribution was similar to that in caecal cyrosections. To understand the capacity of PECCs to respond to microbial challenges, the Toll-like receptors (TLRs) repertoire was determined. Exposure of PECCs to polyinosinic-polycytidylic acid (poly(I:C)) or lipopolysaccharide (LPS) led to upregulation of type I and III interferon (IFN) as well as interleukin (IL-) 1β, IL-6 and IL-8 mRNA expression. Overall, the PECCs showed properties of polarized epithelial cells. The presence of TLRs, their differential expression, as well as pattern recognition receptor dependent immune responses enable PECCs to act as suitable in vitro model for host‒pathogen interaction studies, which are difficult to conduct under in vivo conditions.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"261-271"},"PeriodicalIF":0.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141437944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of oral benzoic acid application during acute murine campylobacteriosis. 急性鼠弯曲杆菌病期间口服苯甲酸的治疗效果

European journal of microbiology & immunology Pub Date : 2024-05-27 Print Date: 2024-09-11 DOI: 10.1556/1886.2024.00059

Ke Du, Soraya Mousavi, Minnja S Foote, Stefan Bereswill, Markus M Heimesaat

{"title":"Therapeutic effects of oral benzoic acid application during acute murine campylobacteriosis.","authors":"Ke Du, Soraya Mousavi, Minnja S Foote, Stefan Bereswill, Markus M Heimesaat","doi":"10.1556/1886.2024.00059","DOIUrl":"10.1556/1886.2024.00059","url":null,"abstract":"Serious risks to human health are posed by acute campylobacteriosis, an enteritis syndrome caused by oral infection with the food-borne bacterial enteropathogen Campylobacter jejuni. Since the risk for developing post-infectious autoimmune complications is intertwined with the severity of enteritis, the search of disease-mitigating compounds is highly demanded. Given that benzoic acid is an organic acid with well-studied health-promoting including anti-inflammatory effects we tested in our present study whether the compound might be a therapeutic option to alleviate acute murine campylobacteriosis. Therefore, microbiota-depleted IL-10-/- mice were perorally infected with C. jejuni and received benzoic acid through the drinking water from day 2 until day 6 post-infection. The results revealed that benzoic acid treatment did not affect C. jejuni colonization in the gastrointestinal tract, but alleviated clinical signs of acute campylobacteriosis, particularly diarrheal and wasting symptoms. In addition, benzoic acid mitigated apoptotic cell responses in the colonic epithelia and led to reduced pro-inflammatory immune reactions in intestinal, extra-intestinal, and systemic compartments tested on day 6 post-infection. Hence, our preclinical placebo-controlled intervention trial revealed that benzoic acid constitutes a promising therapeutic option for treating acute campylobacteriosis in an antibiotic-independent fashion and in consequence, also for reducing the risk of post-infectious autoimmune diseases.","PeriodicalId":93998,"journal":{"name":"European journal of microbiology & immunology","volume":" ","pages":"243-260"},"PeriodicalIF":0.0,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11393648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141159224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0