Environmental toxicology and pharmacology最新文献

When biomarkers disagree: temporal trends, magnitude, and predictability of physiological responses in White Stork (Ciconia ciconia) nestlings. 当生物标志物不一致：白鹳（Ciconia Ciconia）雏鸟生理反应的时间趋势、幅度和可预测性。

IF 4.2

Environmental toxicology and pharmacology Pub Date : 2026-10-19 DOI: 10.1016/j.etap.2026.105206

Ana Marija Caha, Alma Mikuška, Mirna Velki, Hani Amir Aouissi, Mostefa Ababsa, Dora Bjedov

{"title":"When biomarkers disagree: temporal trends, magnitude, and predictability of physiological responses in White Stork (Ciconia ciconia) nestlings.","authors":"Ana Marija Caha, Alma Mikuška, Mirna Velki, Hani Amir Aouissi, Mostefa Ababsa, Dora Bjedov","doi":"10.1016/j.etap.2026.105206","DOIUrl":"https://doi.org/10.1016/j.etap.2026.105206","url":null,"abstract":"Wildlife is exposed to fluctuating environmental stressors, yet biomarker-based assessments are typically derived from single-year research. This study evaluated temporal dynamics of blood responses (cholinesterase [ChE], carboxylesterase [CES], glutathione S-transferase [GST], glutathione reductase [GR], reactive oxygen species [ROS], reduced glutathione [GSH]) in White Stork (Ciconia ciconia) nestlings from eastern Croatia over a six-year period (2020-2025): (I) interannual variation and temporal trends, (II) magnitude of change, and (III) temporal predictability. Interannual variation was observed across all biomarkers, with linear trends indicating increasing plasma ChE activity, but decreasing trends in detoxification and antioxidant biomarkers. Standardised slopes revealed that ROS increased, whereas antioxidant and detoxification enzymes decreased. ChE activity displayed non-concordant patterns between blood fractions. Temporal cross-validation demonstrated differences in predictability. Detoxification enzymes showed low prediction error, whereas antioxidant biomarkers exhibited high prediction error. The results indicate that multi-year and multi-biomarker monitoring frameworks may improve the interpretation of long-term environmental impacts on wildlife.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"105206"},"PeriodicalIF":4.2,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In primary human lymphocytes, the triazole fungicide cyproconazole impairs regulatory B cell interleukin-10 expression and induces T cell senescence. 在人原代淋巴细胞中，三唑类杀菌剂环康唑可损害B细胞白介素-10的表达，诱导T细胞衰老。

IF 4.2

Environmental toxicology and pharmacology Pub Date : 2026-10-17 DOI: 10.1016/j.etap.2026.105203

Asma Mnassri, Imen Ayed-Boussema, Le-Hoa Mai, Thi-Van-Ha Nguyen, Sophie Brouard, Karima Rjiba, Salwa Abid-Essefi

{"title":"In primary human lymphocytes, the triazole fungicide cyproconazole impairs regulatory B cell interleukin-10 expression and induces T cell senescence.","authors":"Asma Mnassri, Imen Ayed-Boussema, Le-Hoa Mai, Thi-Van-Ha Nguyen, Sophie Brouard, Karima Rjiba, Salwa Abid-Essefi","doi":"10.1016/j.etap.2026.105203","DOIUrl":"10.1016/j.etap.2026.105203","url":null,"abstract":"Triazole fungicides are applied worldwide, yet their effects on human lymphocytes remain poorly characterised. We examined whether cyproconazole impairs regulatory B cell function and induces T cell senescence. Purified B and T lymphocytes were exposed to cyproconazole (30-200 µM, 48-72 h). B cells were more susceptible to apoptosis than T cells, their regulatory output collapsing disproportionately to cell loss: IL-10 in viable CD19⁺ cells fell by 87% at 30 µM, granzyme B declining only at higher concentrations. Cyproconazole drove T cells out of the cell cycle into G0 at 48 h, before any viability loss, and towards a CD27⁻CD28⁻CD57⁺ senescent phenotype, increased 5.6-fold in CD8⁺ cells. Reduced PD-1 identified senescence rather than exhaustion, and TNF-α and IFN-γ rose up to 3.9-fold within the senescent compartment (p < 0.05). Cyproconazole thus dismantles two layers of human immune regulation, at concentrations comparable to plasma levels during triazole therapy.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"105203"},"PeriodicalIF":4.2,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic co-exposure to benzo[a]pyrene and BDE-47 induces malignant transformation of human mammary epithelial cells via dysregulation of the miR-491-5p/VPS28 axis. 慢性共暴露于苯并[a]芘和BDE-47通过miR-491-5p/VPS28轴的失调诱导人乳腺上皮细胞的恶性转化。

IF 4.2

Environmental toxicology and pharmacology Pub Date : 2026-10-17 DOI: 10.1016/j.etap.2026.105201

Yongjun Tang, Chenlu Ma, Zhenning Feng, Nian Jiang, Xiaolong Chen, Yingxu He, Francis L Martin, Hui Liu, Weiyi Pang

{"title":"Chronic co-exposure to benzo[a]pyrene and BDE-47 induces malignant transformation of human mammary epithelial cells via dysregulation of the miR-491-5p/VPS28 axis.","authors":"Yongjun Tang, Chenlu Ma, Zhenning Feng, Nian Jiang, Xiaolong Chen, Yingxu He, Francis L Martin, Hui Liu, Weiyi Pang","doi":"10.1016/j.etap.2026.105201","DOIUrl":"10.1016/j.etap.2026.105201","url":null,"abstract":"Benzo[a]pyrene (B[a]P) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) are widespread environmental pollutants associated with breast carcinogenesis, yet their combined effects remain unclear. In this study, a chronic low-dose exposure model was established using human mammary epithelial MCF-10A cells to investigate co-exposure-induced malignant transformation and underlying mechanisms. Both single and combined exposures promoted proliferation, clonogenicity, epithelial-mesenchymal transition, and tumorigenicity. Notably, co-exposure produced weaker proliferative effects than single exposures, suggesting a potential antagonistic interaction. Mechanistically, miR-491-5p was downregulated, whereas VPS28 expression was upregulated during transformation. Functional assays demonstrated that miR-491-5p suppressed, while VPS28 enhanced, proliferation under single-exposure conditions, but not under co-exposure. Molecular docking suggested potential interactions between VPS28 and both compounds. Overall, co-exposure induces malignant transformation accompanied by miR-491-5p/VPS28 dysregulation; the functional contribution of this axis under co-exposure warrants further investigation.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"105201"},"PeriodicalIF":4.2,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Individual and mixed urinary trace metal exposures and their associations with prostate cancer in Tanzania: A case-control study using BKMR. 坦桑尼亚个体和混合尿微量金属暴露及其与前列腺癌的关系：一项使用BKMR的病例对照研究

IF 4.2

Environmental toxicology and pharmacology Pub Date : 2026-10-17 DOI: 10.1016/j.etap.2026.105204

Emmanuel Njale, John Andrew Marco Mahugija, Dativa Joseph Shilla

{"title":"Individual and mixed urinary trace metal exposures and their associations with prostate cancer in Tanzania: A case-control study using BKMR.","authors":"Emmanuel Njale, John Andrew Marco Mahugija, Dativa Joseph Shilla","doi":"10.1016/j.etap.2026.105204","DOIUrl":"10.1016/j.etap.2026.105204","url":null,"abstract":"Trace metals are essential for normal physiology, but their imbalance may contribute to cancer. In Tanzania, evidence linking trace metal exposure to prostate cancer remains inconsistent, particularly for combined exposures. This study investigated associations between urinary trace metals and prostate cancer using logistic regression and Bayesian Kernel Machine Regression (BKMR). A total of 180 participants, comprising 100 prostate cancer patients and 80 controls, were enrolled. Urine samples were digested using nitric acid and hydrogen peroxide, and trace metals were determined by inductively coupled plasma atomic emission spectrometry. Cancer patients had significantly higher concentrations of Co, Se, Cu, and Mn, whereas Zn, Cr, and Fe were higher among controls. Logistic regression showed that Cu was significantly associated with prostate cancer while Se demonstrated an inverse association with prostate cancer. BKMR indicated no significant association between metal mixture and prostate cancer. Overall, Cu may increase risk, while Se was inversely associated with prostate cancer. Prospective studies are needed to validate findings and clarify combined metal effects.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"105204"},"PeriodicalIF":4.2,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary KIM-1 Transcript Detectability in Workers Chronically Exposed to Arsenic and Antimony in an Industrial Area of Central Chile: A Cross-Sectional Pilot Study. 智利中部工业区长期暴露于砷和锑的工人的尿KIM-1转录物可检测性：一项横断面试点研究。

IF 4.2

Environmental toxicology and pharmacology Pub Date : 2026-10-17 DOI: 10.1016/j.etap.2026.105200

Nicole Roldán, Javier Tognarelli, Martín Castro, Rodrigo Miranda, Javiera Gutiérrez, Valeria Riveros, Catalina Ruiz, Marcelo Verdugo, Alexis A Gonzalez, Waldo Quiroz, Carolina Cantillana, Juan Pablo Gigoux, Leonel Muñoz

{"title":"Urinary KIM-1 Transcript Detectability in Workers Chronically Exposed to Arsenic and Antimony in an Industrial Area of Central Chile: A Cross-Sectional Pilot Study.","authors":"Nicole Roldán, Javier Tognarelli, Martín Castro, Rodrigo Miranda, Javiera Gutiérrez, Valeria Riveros, Catalina Ruiz, Marcelo Verdugo, Alexis A Gonzalez, Waldo Quiroz, Carolina Cantillana, Juan Pablo Gigoux, Leonel Muñoz","doi":"10.1016/j.etap.2026.105200","DOIUrl":"https://doi.org/10.1016/j.etap.2026.105200","url":null,"abstract":"Background: Chronic arsenic (As) and antimony (Sb) exposure causes renal toxicity in experimental models, but early molecular indicators of tubular stress in humans remain uncharacterised.Methods: We assessed 12 male workers from Puchuncaví, Chile. Urinary and blood As and Sb were quantified by hydride-generation atomic fluorescence spectrometry (HG-AFS). Urinary KIM-1, NGAL, CTGF and PAI-1 transcripts were assessed by RT-qPCR, with 18S rRNA confirming amplifiability; detection required Ct < 35 with a single melting peak.Results: Ten samples passed quality control. KIM-1 was detected in 5 of 10 participants (50%); NGAL, CTGF and PAI-1 were detected sporadically. Serum creatinine and blood urea nitrogen remained within reference ranges. Detection was not associated with urinary or blood metalloid concentrations (Mann-Whitney U, p ≥ 0.11).Conclusion: Urinary KIM-1 transcripts are detectable in workers chronically exposed to As and Sb despite normal conventional renal function. Establishing biomarker performance requires larger studies with unexposed reference populations.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"105200"},"PeriodicalIF":4.2,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The comprehensive transcriptomic profiling of RNA classes for biomonitoring and mechanistic studies. 用于生物监测和机制研究的RNA类的综合转录组学分析。

IF 4.2

Environmental toxicology and pharmacology Pub Date : 2026-10-15 DOI: 10.1016/j.etap.2026.105199

Andrea Rossnerova, Zuzana Simova, Aidan C Manning, Denise McGrath, Sergio Barberan-Soler, Pavlina Klusackova, Daniela Pelclova, Pavel Rossner, Michal Sima

{"title":"The comprehensive transcriptomic profiling of RNA classes for biomonitoring and mechanistic studies.","authors":"Andrea Rossnerova, Zuzana Simova, Aidan C Manning, Denise McGrath, Sergio Barberan-Soler, Pavlina Klusackova, Daniela Pelclova, Pavel Rossner, Michal Sima","doi":"10.1016/j.etap.2026.105199","DOIUrl":"10.1016/j.etap.2026.105199","url":null,"abstract":"The effects of various chemical compounds exposure on genetic material, including the risks of disease, are frequently evaluated by analyses of biomarkers. Among them, RNA markers play an important role in understanding the changes of transcriptomic processes. In this research we tested a new methodological approach of RNA libraries preparation in combination with sequencing to analyze the full transcriptome, including fragmented RNAs. Samples collected from firefighters at three time points were analyzed. A wide range of RNA types [non-coding RNAs (rRNA, tRNA, miRNA, snRNA, snoRNA, lncRNA, piRNA) and protein coding mRNAs] were detected simultaneously which allowed us to track the dynamics of their expression. The application of this comprehensive RNA profiling in a future biomonitoring study is promising: (i) for identification of the novel biomarkers of specific exposures; and (ii) to study the complex mechanisms of transcription including protective modifications, and/or harmful deregulations increasing the risk of diseases, e.g. cancer.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"105199"},"PeriodicalIF":4.2,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of a method for fluorescently labeling polyethylene and polypropylene nanoplastic particles for biological impact assessment research. 用于生物影响评价研究的聚乙烯和聚丙烯纳米塑料粒子荧光标记方法的研究。

IF 4.2

Environmental toxicology and pharmacology Pub Date : 2026-10-13 DOI: 10.1016/j.etap.2026.105197

Yudai Ikuno, Kosuke Tanaka, Go Suzuki, Osamu Udagawa

{"title":"Investigation of a method for fluorescently labeling polyethylene and polypropylene nanoplastic particles for biological impact assessment research.","authors":"Yudai Ikuno, Kosuke Tanaka, Go Suzuki, Osamu Udagawa","doi":"10.1016/j.etap.2026.105197","DOIUrl":"10.1016/j.etap.2026.105197","url":null,"abstract":"Micro- and nanoplastics, which raise concerns due to their potential impact on living organisms, exist in diverse forms and undergo surface chemical degradation through ultraviolet (UV) irradiation and other environmental factors. To provide a more realistic evaluation of their biological effects, we prepared nanoparticles of polyethylene (PE) and polypropylene (PP)-two of the most abundant plastics in the environment-and simulated their degradation by exposing them to UV light. Furthermore, to enable assessment of biological effects, we investigated fluorescent labeling using a tetrahydrofuran-based (THF) swelling-and-incorporation method. By employing the highly hydrophobic dye BODIPY and refining the staining procedure to include THF evaporation, we successfully achieved stable fluorescent labeling of both undegraded and UV-degraded PE and PP particles. Notably, the fluorescence remained intact even after washing with organic solvents capable of dissolving the dye. This robust staining technique thus provides a valuable platform for investigating the biological effects of plastic nanoparticles.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"105197"},"PeriodicalIF":4.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149185941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracellular fate of micro- and nanoplastics in human placenta: Organelle-specific toxicity and mechanistic convergence. 微塑料和纳米塑料在人胎盘中的细胞内命运：细胞器特异性毒性和机制趋同。

IF 4.2

Environmental toxicology and pharmacology Pub Date : 2026-09-01 Epub Date: 2026-08-10 DOI: 10.1016/j.etap.2026.105129

Dipita Bhakta-Guha, Gunjan Guha

{"title":"Intracellular fate of micro- and nanoplastics in human placenta: Organelle-specific toxicity and mechanistic convergence.","authors":"Dipita Bhakta-Guha, Gunjan Guha","doi":"10.1016/j.etap.2026.105129","DOIUrl":"10.1016/j.etap.2026.105129","url":null,"abstract":"Detection of micro- and nanoplastics (MNPs) in human placental tissue, fetal cord blood, and neonatal meconium marks a paradigm shift in prenatal exposure research. Yet the field lacks a mechanistic framework integrating the intracellular stress responses MNPs provoke subcellularly. This narrative review proposes an organelle-resolved model of MNP-induced cellular toxicity wherein internalized MNPs traffic through the endosomal-lysosomal system, initiating lysosomal overload and autophagic flux blockade, mitochondrial cristae disorganization consistent with ΔΨm collapse, and endoplasmic reticulum cisternal dilation with pro-apoptotic UPR switching. These converge into a unified framework - the chronic 'Plasticenta' cell danger response (cPCDR) - wherein MNP persistence is hypothesized to generate a perpetually re-triggered, incompletely resolved danger state. The Pi-GAC-glutaminolysis axis is proposed as a secondary metabolic convergence downstream of ΔΨm collapse. Contextualized within the DoHaD framework, the fetoplacental unit is positioned as a critical transgenerational MNP biosensor. Priority directions include scRNA-seq-based cPCDR validation, trophoblast organoid models, and prospective placental biobanking.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"105129"},"PeriodicalIF":4.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148708972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium Dodecylbenzenesulfonate-induced oxidative stress and tissue damage in Tubifex tubifex: A comprehensive toxicological study. 十二烷基苯磺酸钠诱导的氧化应激和组织损伤：一项全面的毒理学研究。

IF 4.2

Environmental toxicology and pharmacology Pub Date : 2025-09-01 Epub Date: 2025-08-05 DOI: 10.1016/j.etap.2025.104778

Debanjali Chakraborty, Surajit Ghosh, Ahamadul Hoque Mandal, Triparna Roy, Auroshree Sadhu, Dipanwita Sarkar Paria, Nimai Chandra Saha, Mentor Sopjani, Shubhajit Saha, Caterina Faggio

{"title":"Sodium Dodecylbenzenesulfonate-induced oxidative stress and tissue damage in Tubifex tubifex: A comprehensive toxicological study.","authors":"Debanjali Chakraborty, Surajit Ghosh, Ahamadul Hoque Mandal, Triparna Roy, Auroshree Sadhu, Dipanwita Sarkar Paria, Nimai Chandra Saha, Mentor Sopjani, Shubhajit Saha, Caterina Faggio","doi":"10.1016/j.etap.2025.104778","DOIUrl":"10.1016/j.etap.2025.104778","url":null,"abstract":"In this study, the acute and sublethal toxicity of SDBS was assessed using Tubifex tubifex. In an acute toxicity bioassay, the 96-hour LC₅₀ value for SDBS was determined to be 13.358 mg/L. The survival probability of the test organism under elevated SDBS concentrations was further assessed using General Unified Threshold models of Survival (GUTS), where the GUTS-Individual Tolerance (IT) model was applied over the GUTS-Stochastic Death (SD) model. T. tubifex was exposed for 14 days to concentrations equivalent to 10 % and 20 % of the 96-hour LC₅₀ value (1.33 mg/L and 2.67 mg/L). Significant alterations were observed in total protein content, antioxidant enzyme activities, and histopathological markers. Specifically, levels of proteins, superoxide dismutase (SOD), and catalase (CAT) decreased, while glutathione S-transferase (GST), glutathione peroxidase (GPx), and malondialdehyde (MDA) increased, indicating oxidative stress. These findings suggest exposure to sublethal levels of SDBS may compromise physiological integrity and antioxidative defense mechanisms in invertebrates.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104778"},"PeriodicalIF":4.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Larval exposure to thiamethoxam and pyraclostrobin impairs the morphology of the midgut and Malpighian tubules in newly emerged workers of Scaptotrigona postica (Hymenoptera: Meliponini). 噻虫嗪和嘧菌酯对新出工蜂中肠和马尔匹氏小管形态的影响。

IF 4.2

Environmental toxicology and pharmacology Pub Date : 2025-09-01 Epub Date: 2025-08-07 DOI: 10.1016/j.etap.2025.104780

Cliver Fernandes Farder-Gomes, Joyce Bovo, Jaqueline Aparecida da Silva, Pollyana Leão Gonçalves, Marco Antônio de Oliveira, Roberta Cornélio Ferreira Nocelli

{"title":"Larval exposure to thiamethoxam and pyraclostrobin impairs the morphology of the midgut and Malpighian tubules in newly emerged workers of Scaptotrigona postica (Hymenoptera: Meliponini).","authors":"Cliver Fernandes Farder-Gomes, Joyce Bovo, Jaqueline Aparecida da Silva, Pollyana Leão Gonçalves, Marco Antônio de Oliveira, Roberta Cornélio Ferreira Nocelli","doi":"10.1016/j.etap.2025.104780","DOIUrl":"10.1016/j.etap.2025.104780","url":null,"abstract":"The indiscriminate use of pesticides to control various pests, including insects and fungi, raises concerns about the potential long-term effects of these toxic substances on pollinators. In this study, we evaluated the effects of larval exposure to the insecticide thiamethoxam and the fungicide pyraclostrobin on the morphology of the midgut and Malpighian tubules in newly emerged Scaptotrigona postica workers. The results revealed that larvae exposed to insecticides, alone and in combination, developed into adult workers with an increased loss of cytoplasmic material in the midgut and Malpighian tubules, suggesting autophagic cell death. The loss of brush border integrity was more pronounced following pesticide treatment, suggesting potential impairment of nutrient digestion and absorption. Cell elimination was observed exclusively in the combination treatment group, indicating a synergistic interaction between the pesticides for this particular effect. These effects result in health impairments in adult bees, potentially compromising pollination services.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104780"},"PeriodicalIF":4.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0