Environmental toxicology and pharmacology最新文献

Chronic carbendazim exposure disrupts behavioral responses and redox-regulatory mechanisms in non-target detritivore Nauphoeta cinerea nymphs.

Environmental toxicology and pharmacology Pub Date : 2024-12-17 DOI: 10.1016/j.etap.2024.104618

Adeboye A Olaseni, Gbemisola T Oyedele, Cynthia N Ikeji, Christiana K Jimoh, Babajide O Ajayi, Joao B T Rocha, Isaac A Adedara, Ebenezer O Farombi

{"title":"Chronic carbendazim exposure disrupts behavioral responses and redox-regulatory mechanisms in non-target detritivore Nauphoeta cinerea nymphs.","authors":"Adeboye A Olaseni, Gbemisola T Oyedele, Cynthia N Ikeji, Christiana K Jimoh, Babajide O Ajayi, Joao B T Rocha, Isaac A Adedara, Ebenezer O Farombi","doi":"10.1016/j.etap.2024.104618","DOIUrl":"10.1016/j.etap.2024.104618","url":null,"abstract":"Carbendazim is widely applied in agriculture to control various fungal diseases during pre-harvest and post-harvest processes owing to its efficacy and cost-effectiveness. However, environmental and food contamination by carbendazim has become a global health issue. Indeed, the declining biodiversity of beneficial insects owing to agricultural intensification is currently of keen concern to the scientific community. The toxicological responses of Nauphoeta cinerea nymphs, a non-target insect, to ecologically realistic concentrations of carbendazim at 0, 0.25, 2.5, 5.0 and 25 μg/L for 50 uninterrupted days were assessed. Neurobehavioral data generated by video-tracking software revealed that chronic nymphal exposure to carbendazim significantly diminished the path efficiency, body rotation, maximum speed, turn angle and distance traveled but increased the immobility time, total time of freezing and episodes of freezing in insects. The deterioration in the locomotor and exploratory abilities of carbendazim-exposed insects was substantiated by high heat map intensity and reduced track plots. Further, chronic carbendazim exposure diminished acetylcholinesterase activity in head of the insects. Chronic carbendazim exposure significantly decreased antioxidant defense mechanisms but increased nitric oxide, hydrogen peroxide and lipid peroxidation levels in fat body, midgut and head of exposed insects. Activities of acid and alkaline phosphatases which play important roles in detoxification and metabolic processes were also markedly decreased in carbendazim-exposed insects when compared with control. Altogether, carbendazim represents an ecological threat to non-target insects through induction of oxido-inflammatory injury, providing valuable insights into the behavioral dysfunction and toxicological mechanisms of carbendazim in beneficial insects.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104618"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TOXICITY ASSESSMENT OF EFFLUENT FROM A POTATO-PROCESSING INDUSTRY IN Cyprinus carpio.

Environmental toxicology and pharmacology Pub Date : 2024-12-17 DOI: 10.1016/j.etap.2024.104616

Carine Baggiotto, Marciano Friedrich, Vania Lucia Loro, Tiele Medianeira Rizzetti, Renato Zanella, Jossiele Wesz Leitemperger, Bárbara Estevao Clasen, Rosana de Cassia De Souza Schneider, Francisco Rossarolla Forgiarini

{"title":"TOXICITY ASSESSMENT OF EFFLUENT FROM A POTATO-PROCESSING INDUSTRY IN Cyprinus carpio.","authors":"Carine Baggiotto, Marciano Friedrich, Vania Lucia Loro, Tiele Medianeira Rizzetti, Renato Zanella, Jossiele Wesz Leitemperger, Bárbara Estevao Clasen, Rosana de Cassia De Souza Schneider, Francisco Rossarolla Forgiarini","doi":"10.1016/j.etap.2024.104616","DOIUrl":"https://doi.org/10.1016/j.etap.2024.104616","url":null,"abstract":"Potato (Solanum tuberosum) cultivation faces the challenge of excessive pesticide use. During processing, the disposal of large volumes of contaminated water into water bodies can result in severe environmental damage, such as fish deaths. This study aimed to evaluate the toxicological effects of chemical compounds present in the effluent from a potato-processing industry using the test organism Cyprinus carpio. The liver, gills, muscles, and brain were analyzed for biochemical parameters such as catalase (CAT), superoxide dismutase (SOD), acetylcholinesterase (AChE), and lipid peroxidation (TBARS). The highest quantities of pesticides found in the effluent were atrazine, azoxystrobin, fipronil, flutolanil, imidacloprid, tebuconazole, and thiamethoxam. Fish were exposed to the effluent for 7, 14, and 28 days in the laboratory. The CAT enzyme increased activity in the gills at 7 (p-value=0.000) and 14 days (p-value=0.003). Lipid peroxidation showed an increase in the gills at seven days (p-value=0.0281) and in the liver at 7 (p-value=0.000) and 14 days (p-value=0.000). There was also a significant increase (p-value=0.000) in AChE activity in the muscle at all periods. This result highlights the environmental risk and toxicity of potato effluent containing pesticide residues, which can cause biochemical damage to C. carpio and other living organisms.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104616"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASSESSING AZITHROMYCIN'S ECOLOGICAL TOLL: UNVEILING MULTIFACETED IMPACTS ON POECILIA RETICULATA THROUGH BIOMARKER ANALYSIS.

Environmental toxicology and pharmacology Pub Date : 2024-12-17 DOI: 10.1016/j.etap.2024.104617

G P Marinsek, M A Tagliamento, I C C S Oliveira, A Capaldo, P L Gusso-Choueri, C C Ribeiro, C C Feitosa, D M S Abessa, M A Oliveira, R B Mari

引用次数: 0

Polycyclic aromatic hydrocarbons in human granulosa cells: first in vivo presence and positive correlation with body mass index and in vitro ovarian cell steroidogenesis regulation. 人类颗粒细胞中的多环芳烃：首次在体内存在，并与体重指数和体外卵巢细胞类固醇生成调节呈正相关。

Environmental toxicology and pharmacology Pub Date : 2024-12-16 DOI: 10.1016/j.etap.2024.104611

Patrycja Kurowska, Lucille Berthet, Christelle Ramé, Małgorzata Węgiel, Anna Maślanka, Fabrice Guérif, Pascal Froment, Agnieszka Rak, Joelle Dupont

{"title":"Polycyclic aromatic hydrocarbons in human granulosa cells: first in vivo presence and positive correlation with body mass index and in vitro ovarian cell steroidogenesis regulation.","authors":"Patrycja Kurowska, Lucille Berthet, Christelle Ramé, Małgorzata Węgiel, Anna Maślanka, Fabrice Guérif, Pascal Froment, Agnieszka Rak, Joelle Dupont","doi":"10.1016/j.etap.2024.104611","DOIUrl":"10.1016/j.etap.2024.104611","url":null,"abstract":"Polycyclic Aromatic Hydrocarbons (PAHs) exposure leads to disorders reported in female infertility patients. Our hypothesis is that PAHs accumulate in granulosa cells (Gc) according to body mass index (BMI) and directly affects its functions. All 16 high-priority PAHs were in human FF, Gc and blood plasma with the highest concentration in Gc (GC-MS/MS). Their highest concentration was in obese Gc, except for acenaphthene and acenaphthylene, and positively correlated with BMI. In FF, we noted only positive correlation between naphthalene and BMI, whereas in blood plasma positive correlation between naphthalene, acenaphthene, pyrene and BMI. Phenanthrene and naphthalene but not fluoranthene inhibited totally steroidogenesis (ELISA), CYP19A1 mRNA expression (real-time PCR) and increased oxidative stress index and catalase expression in Gc independently on BMI. While all studied PAHs decreased Gc proliferation (BrdU assay) and viability (Cell Count kit-8 assay). Thus, Gc PAHs concentrations are positively correlated with BMI and alter ovarian functions.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104611"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixture of neonicotinoid and fungicide affects foraging activity of honeybees. 新烟碱和杀真菌剂的混合物影响蜜蜂的觅食活动。

Environmental toxicology and pharmacology Pub Date : 2024-12-13 DOI: 10.1016/j.etap.2024.104613

Antonia Schuhmann, Ricarda Scheiner

引用次数: 0

Effects on lethal concentration 50 % hematological parameters and plasma components of Starry flounder, Platichthys stellatus exposed to hexavalent chromium. 星鲽暴露于六价铬对致死浓度 50%血液学参数和血浆成分的影响

Environmental toxicology and pharmacology Pub Date : 2024-12-11 DOI: 10.1016/j.etap.2024.104610

Yun-A Ryu, Cheol Young Choi, Ju-Chan Kang, Jun-Hwan Kim

{"title":"Effects on lethal concentration 50 % hematological parameters and plasma components of Starry flounder, Platichthys stellatus exposed to hexavalent chromium.","authors":"Yun-A Ryu, Cheol Young Choi, Ju-Chan Kang, Jun-Hwan Kim","doi":"10.1016/j.etap.2024.104610","DOIUrl":"10.1016/j.etap.2024.104610","url":null,"abstract":"Starry flounders (Platichthys stellatus, mean weight 105 ± 14 g, mean total length 20.2 ± 0.7 cm) were exposed to hexavalent chromium concentrations of 0, 5, 10, 20, 40, and 80 mg Cr6 +/L for 96 hours. The half-lethal concentration (LC50) of P. stellatus induced by acute exposure to waterborne hexavalent chromium for 96 hours was found to be 58.84 mg Cr6+/L. In hematological parameters, red blood cell counts (RBCs), hemoglobin and hematocrit were significantly increased (P < 0.05). Major plasma components also changed significantly due to exposure to waterborne hexavalent chromium. Calcium in plasma inorganic components significantly increased, and glucose and cholesterol in plasma organic components also showed significant increases (P < 0.05). Plasma enzyme components such as AST, ALT and ALP were significantly increased (P < 0.05) at high levels of waterborne hexavalent chromium exposure. The results of this study suggest that acute exposure to waterborne hexavalent chromium in P. stellatus affects survival rates, hematological properties and plasma components.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104610"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Optical Coherence Tomography (OCT) to Evaluate the Adverse Effects of 2,4-D Dimethylammonium on Morphological Changes in Riceland Prawn (Macrobrachium lanchesteri).

Environmental toxicology and pharmacology Pub Date : 2024-12-10 DOI: 10.1016/j.etap.2024.104608

Chutima Thanomsit, Sugunya Kumla, Jadsada Saetiew, Jiraporn Saenjae, Phochit Nanthanawat, Jakkaphun Nanuam, Panomsak Meemon

{"title":"Application of Optical Coherence Tomography (OCT) to Evaluate the Adverse Effects of 2,4-D Dimethylammonium on Morphological Changes in Riceland Prawn (Macrobrachium lanchesteri).","authors":"Chutima Thanomsit, Sugunya Kumla, Jadsada Saetiew, Jiraporn Saenjae, Phochit Nanthanawat, Jakkaphun Nanuam, Panomsak Meemon","doi":"10.1016/j.etap.2024.104608","DOIUrl":"https://doi.org/10.1016/j.etap.2024.104608","url":null,"abstract":"2,4-D dimethylammonium, a widely used herbicide, accumulates in aquatic animals, posing risks to both their populations and human consumers. This study evaluated the effects of 2,4-D on Riceland prawn (Macrobrachium lanchesteri) using Optical Coherence Tomography (OCT) to assess morphological changes. The activity of acetylcholinesterase (AChE), catalase (CAT), and glutathione S-transferase (GST) was also measured. Toxicity increased with both concentration and exposure duration. OCT revealed swelling in the gill region, tissue abnormalities, and muscle damage in the abdominal somite, telson, and uropod, along with tissue separation and degradation. Histological analysis confirmed muscle degeneration, hemocyte infiltration, and swelling. AChE expression was undetectable at 400 and 450µL/L after 96hours, with a molecular weight of 71kDa. CAT and GST activities decreased at higher herbicide concentrations, further demonstrating the harmful effects of 2,4-D on prawn health.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104608"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive tetracycline, ciprofloxacin and sulfamethoxazole toxicity evaluation to earthworm Dendrobaena veneta through life-cycle, behavioral and biochemical parameters.

Environmental toxicology and pharmacology Pub Date : 2024-12-10 DOI: 10.1016/j.etap.2024.104609

Jūratė Žaltauskaitė, Diana Miškelytė, Gintarė Sujetovienė, Austra Dikšaitytė, Giedrė Kacienė, Irena Januškaitienė, Renata Dagiliūtė

{"title":"Comprehensive tetracycline, ciprofloxacin and sulfamethoxazole toxicity evaluation to earthworm Dendrobaena veneta through life-cycle, behavioral and biochemical parameters.","authors":"Jūratė Žaltauskaitė, Diana Miškelytė, Gintarė Sujetovienė, Austra Dikšaitytė, Giedrė Kacienė, Irena Januškaitienė, Renata Dagiliūtė","doi":"10.1016/j.etap.2024.104609","DOIUrl":"10.1016/j.etap.2024.104609","url":null,"abstract":"Veterinary antibiotics are widely spread in the environment, however, the knowledge about their impact on soil key species is still limited. This study evaluated the short-term and long-term effects of tetracycline (TC), ciprofloxacin (CIP) and sulfamethoxazole (SMX) (1-500 mg kg) on earthworm Dendrobaena veneta by measuring multiple parameters (survival, growth, reproduction, behavior and biochemical responses). Neither antibiotic induced acute toxicity and low mortality was observed after chronic exposure. TC and CIP had a negligible effect on the earthworm's weight from the 6th week of exposure, SMX inhibited the earthworm growth when was present in the range of 50-500 mg kg-1. In parallel, SMX reduced earthworm reproduction at environmentally relevant concentrations. Antibiotics altered superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) and gluthathione-S-transferase (GST) activities and induced lipid peroxidation. Overall, earthworms showed no apparent acute response at environmentally relevant concentrations except for avoidance behavior; after long-term exposure earthworms experienced biochemical, physiological, and reproductive impairments and reduced survival at high soil contamination.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104609"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic damage in elasmobranchs: A review.

Environmental toxicology and pharmacology Pub Date : 2024-12-06 DOI: 10.1016/j.etap.2024.104607

Mateus Brandão Marques, Ricardo Luvizotto-Santos, Rachel Ann Hauser-Davis

引用次数: 0

Evaluating the impact of neonicotinoids on aquatic non-target species: A comprehensive review.

Environmental toxicology and pharmacology Pub Date : 2024-12-06 DOI: 10.1016/j.etap.2024.104606

Ahamadul Hoque Mandal, Auroshree Sadhu, Surajit Ghosh, Nimai Chandra Saha, Camilla Mossotto, Paolo Pastorino, Shubhajit Saha, Caterina Faggio

{"title":"Evaluating the impact of neonicotinoids on aquatic non-target species: A comprehensive review.","authors":"Ahamadul Hoque Mandal, Auroshree Sadhu, Surajit Ghosh, Nimai Chandra Saha, Camilla Mossotto, Paolo Pastorino, Shubhajit Saha, Caterina Faggio","doi":"10.1016/j.etap.2024.104606","DOIUrl":"10.1016/j.etap.2024.104606","url":null,"abstract":"Neonicotinoid insecticides (NNIs) are the fastest-growing class in agricultural protection. They target nicotinic acetylcholine receptors (nAChR) in pests, stimulating the nervous system at low doses and causing paralysis and death at higher concentrations. NNIs are used in crop protection, seed treatment, forestry, agriculture, and flea control in domestic cattle. Effective at lower concentrations and offering long-term control, NNIs are favoured for their systemic activity. However, due to their water solubility, mobility, and moderate persistence, NNIs easily contaminate adjacent aquatic environments via runoff, leaching, or spray drift. While less toxic to vertebrates, their widespread use poses threats to aquatic and terrestrial organisms, causing neurotoxicity, nephrotoxicity, cytotoxicity, genotoxicity, immunotoxicity, hepatotoxicity, endocrine disruption, and reproductive malformations. This review synthesizes research to address knowledge gaps on the environmental impact of NNIs and proposes policies to mitigate their harmful effects on aquatic non-target species.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104606"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0