Environmental toxicology and pharmacology最新文献_第2页

Evaluating the impact of neonicotinoids on aquatic non-target species: A comprehensive review.

Environmental toxicology and pharmacology Pub Date : 2024-12-06 DOI: 10.1016/j.etap.2024.104606

Ahamadul Hoque Mandal, Auroshree Sadhu, Surajit Ghosh, Nimai Chandra Saha, Camilla Mossotto, Paolo Pastorino, Shubhajit Saha, Caterina Faggio

{"title":"Evaluating the impact of neonicotinoids on aquatic non-target species: A comprehensive review.","authors":"Ahamadul Hoque Mandal, Auroshree Sadhu, Surajit Ghosh, Nimai Chandra Saha, Camilla Mossotto, Paolo Pastorino, Shubhajit Saha, Caterina Faggio","doi":"10.1016/j.etap.2024.104606","DOIUrl":"10.1016/j.etap.2024.104606","url":null,"abstract":"Neonicotinoid insecticides (NNIs) are the fastest-growing class in agricultural protection. They target nicotinic acetylcholine receptors (nAChR) in pests, stimulating the nervous system at low doses and causing paralysis and death at higher concentrations. NNIs are used in crop protection, seed treatment, forestry, agriculture, and flea control in domestic cattle. Effective at lower concentrations and offering long-term control, NNIs are favoured for their systemic activity. However, due to their water solubility, mobility, and moderate persistence, NNIs easily contaminate adjacent aquatic environments via runoff, leaching, or spray drift. While less toxic to vertebrates, their widespread use poses threats to aquatic and terrestrial organisms, causing neurotoxicity, nephrotoxicity, cytotoxicity, genotoxicity, immunotoxicity, hepatotoxicity, endocrine disruption, and reproductive malformations. This review synthesizes research to address knowledge gaps on the environmental impact of NNIs and proposes policies to mitigate their harmful effects on aquatic non-target species.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104606"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative toxicities of commonly used agricultural insecticides to four honey bee species (Hymenoptera: Apidae) in Vietnam.

Environmental toxicology and pharmacology Pub Date : 2024-12-06 DOI: 10.1016/j.etap.2024.104605

Thai H Pham, Ngoc T Phan, Duy D Trinh, Ha N Duong, Phuong T Tran, Khanh D Nguyen, Gadi V P Reddy, Chuleui Jung, Neelendra K Joshi

{"title":"Comparative toxicities of commonly used agricultural insecticides to four honey bee species (Hymenoptera: Apidae) in Vietnam.","authors":"Thai H Pham, Ngoc T Phan, Duy D Trinh, Ha N Duong, Phuong T Tran, Khanh D Nguyen, Gadi V P Reddy, Chuleui Jung, Neelendra K Joshi","doi":"10.1016/j.etap.2024.104605","DOIUrl":"10.1016/j.etap.2024.104605","url":null,"abstract":"Beekeeping for honey production is a vital economic activity in Vietnam, significantly contributing to the nation's agricultural exports and poverty alleviation. However, the widespread use of pesticides, compounded by insufficient regulations, poses serious challenges to the industry and threatens bee health. This study examined the oral toxicities of five commonly used agricultural insecticides including bifenthrin, imidacloprid, thiacloprid, thiamethoxam, and chlorantraniliprole, on four honey bee species prevalent in Vietnam: the Asian honey bee (Apis cerana), the European honey bee (A. mellifera), the giant honey bee (A. dorsata), and the red dwarf honey bee (A. florea). Our results indicated significant variability in toxicity among the pesticides and honey bee species, with the managed species A. cerana showing the highest tolerance across all tested insecticides. In contrast, the wild species A. dorsata and A. florea were significantly more sensitive. These findings highlight the need to develop a pesticide risk assessment and improve pesticide regulations that consider the impacts on a broader range of honey bee species beyond A. mellifera.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104605"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular pathway disturbances elicited by realistic dexamethasone concentrations in gills of mussel Mytilus galloprovincialis as assessed by a multi-biomarker approach.

Environmental toxicology and pharmacology Pub Date : 2024-12-01 DOI: 10.1016/j.etap.2024.104598

Giuseppe De Marco, Antonio Cristaldi, Maria Concetta Eliso, Gea Oliveri Conti, Mariachiara Galati, Barbara Billè, Mery Terranova, Vincenzo Parrino, Tiziana Cappello, Margherita Ferrante, Maria Maisano

{"title":"Cellular pathway disturbances elicited by realistic dexamethasone concentrations in gills of mussel Mytilus galloprovincialis as assessed by a multi-biomarker approach.","authors":"Giuseppe De Marco, Antonio Cristaldi, Maria Concetta Eliso, Gea Oliveri Conti, Mariachiara Galati, Barbara Billè, Mery Terranova, Vincenzo Parrino, Tiziana Cappello, Margherita Ferrante, Maria Maisano","doi":"10.1016/j.etap.2024.104598","DOIUrl":"10.1016/j.etap.2024.104598","url":null,"abstract":"The growing usage of glucocorticoids for a variety of diseases raises concerns since these drugs, including the anti-inflammatory dexamethasone (DEX), are frequently found in the environment. The impact of DEX was evaluated on mussels Mytilus galloprovincialis (Lamarck, 1819) by exposure to environmental concentrations (C1: 4 ng/L; C2: 40 ng/L; C3: 400 ng/L; C4: 2000 ng/L), and sampling at 3 (T3), 6 (T6), and 12 (T12) days. A multi-biomarker approach was applied on gills, involved in gas exchange, feed filtering, and osmoregulation. A dose- and time-dependent uptake of DEX was recorded, besides haemocyte infiltration, increased neutral and acid mucopolysaccharides, and a general pro-oxidant effect witnessed by lipid peroxidation and altered antioxidant system. Metabolomics revealed rise in protein turnover and energy demand by fluctuations in free amino acids (alanine, glycine) and energy-related metabolites (succinate, ATP/ADP). It is necessary to reduce DEX dosage from the environment by recovery strategies and effective eco-pharmacovigilance programs.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104598"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing H₂O₂-induced susceptibility in Galleria mellonella larvae: A robust model for exploring oxidative stress and biomarkers.

Environmental toxicology and pharmacology Pub Date : 2024-11-26 DOI: 10.1016/j.etap.2024.104596

L M M Mattos, R N Silva, L G Santos, L Giovanini, V S Cruz, N M B Barreto, D Perrone, A L S Santos, M D Pereira

{"title":"Harnessing H2O2-induced susceptibility in Galleria mellonella larvae: A robust model for exploring oxidative stress and biomarkers.","authors":"L M M Mattos, R N Silva, L G Santos, L Giovanini, V S Cruz, N M B Barreto, D Perrone, A L S Santos, M D Pereira","doi":"10.1016/j.etap.2024.104596","DOIUrl":"10.1016/j.etap.2024.104596","url":null,"abstract":"Oxidative stress plays a crucial role in various pathological conditions. This study introduces an enhanced model using hydrogen peroxide (H2O2)-induced stress in Galleria mellonella larvae, offering a cost-effective and ethically sound alternative for oxidative stress research. The model bridges in vitro and in vivo studies to identify biomarkers like lipid peroxidation, protein carbonylation, hemocyte count, and antioxidant enzyme activities. Our results show that while G. mellonella larvae tolerated high doses of H2O2, increased susceptibility occurred with prolonged toxicosis and higher concentrations. Acute H2O2 exposure (5.0 M/1st day) led to elevated lipid and protein oxidation and decreased superoxide dismutase activity and hemocyte count, while catalase activity and total antioxidant capacity increased. Despite these defenses, the larvae's antioxidant capacity was insufficient under severe oxidative stress, reducing survival. This study highlights G. mellonella larvae as a promising model for examining reactive oxygen species (ROS)-induced oxidative stress.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104596"},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathology and changes in the expression of metallothioneins, heat shock proteins and inducible nitric oxide synthase in Prochilodus costatus from a neotropical river contaminated by heavy metals. 受重金属污染的新热带河流中鲈鱼的组织病理学以及金属硫蛋白、热休克蛋白和诱导型一氧化氮合酶的表达变化。

Environmental toxicology and pharmacology Pub Date : 2024-06-01 Epub Date: 2024-05-15 DOI: 10.1016/j.etap.2024.104473

Alessandro Loureiro Paschoalini, Yves Moreira Ribeiro, Breno Thuller, Camila Leandro Gomes Soares, Elizete Rizzo, Nilo Bazzoli

{"title":"Histopathology and changes in the expression of metallothioneins, heat shock proteins and inducible nitric oxide synthase in Prochilodus costatus from a neotropical river contaminated by heavy metals.","authors":"Alessandro Loureiro Paschoalini, Yves Moreira Ribeiro, Breno Thuller, Camila Leandro Gomes Soares, Elizete Rizzo, Nilo Bazzoli","doi":"10.1016/j.etap.2024.104473","DOIUrl":"10.1016/j.etap.2024.104473","url":null,"abstract":"The most recent dam rupture in Brazil released tons of mining tailings into the upper course of the Paraopeba River, affecting this river in an unprecedented way. The present study aimed to evaluate the influence of heavy metals on Prochilodus costatus, an important commercial species in Brazil, four years after the dam colapse. To this end, biomarkers of heavy metals, oxidative stress, and environmental stress were analyzed, and histological analyses of target organs were performed. The results demonstrated critical contamination of fish from the Paraopeba River. Increased expression of Metallothioneins - MTs, Heat Shock Protein - HSP70, and inducible nitric oxide synthase - iNOS, as well as greater rates of histological changes in the liver, spleen, and gonads, were observed in P. costatus. These findings demonstrate that, despite past contamination, the metals present in mining tailings have significantly increased the contamination of the Paraopeba River basin.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104473"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene expression profiles and protein-protein interaction networks in THP-1 cells exposed to metal-based nanomaterials. 暴露于金属基纳米材料的 THP-1 细胞的基因表达谱和蛋白质相互作用网络。

Environmental toxicology and pharmacology Pub Date : 2024-05-15 DOI: 10.1016/j.etap.2024.104469

Šíma Michal, Líbalová Helena, Závodná Táňa, Vrbová Kristýna, Kléma Jiří, Rössner Pavel

{"title":"Gene expression profiles and protein-protein interaction networks in THP-1 cells exposed to metal-based nanomaterials.","authors":"Šíma Michal, Líbalová Helena, Závodná Táňa, Vrbová Kristýna, Kléma Jiří, Rössner Pavel","doi":"10.1016/j.etap.2024.104469","DOIUrl":"https://doi.org/10.1016/j.etap.2024.104469","url":null,"abstract":"We analyzed gene expression in THP-1 cells exposed to metal-based nanomaterials (NMs) [TiO2 (NM-100), ZnO (NM-110), SiO2 (NM-200), Ag (NM-300 K)]. A functional enrichment analysis of the significant differentially expressed genes (DEGs) identified the key modulated biological processes and pathways. DEGs were used to construct protein-protein interaction networks. NM-110 and NM-300 K induced changes in the expression of genes involved in oxidative and genotoxic stress, immune response, alterations of cell cycle, detoxification of metal ions and regulation of redox-sensitive pathways. Both NMs shared a number of highly connected protein nodes (hubs) including CXCL8, ATF3, HMOX1, and IL1B. NM-200 induced limited transcriptional changes, mostly related to the immune response; however, several hubs (CXCL8, ATF3) were identical with NM-110 and NM-300 K. No effects of NM-100 were observed. Overall, soluble nanomaterials NM-110 and NM-300 K exerted a wide variety of toxic effects, while insoluble NM-200 induced immunotoxicity; NM-100 caused no detectable changes on the gene expression level.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104469"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlorpyrifos-induced suppression of the antioxidative defense system leads to cytotoxicity and genotoxicity in macrophages. 毒死蜱诱导的抗氧化防御系统抑制会导致巨噬细胞的细胞毒性和基因毒性。

Environmental toxicology and pharmacology Pub Date : 2024-05-15 DOI: 10.1016/j.etap.2024.104468

Yin-Che Lu, Chen-Yu Chiang, Shih-Pin Chen, Yu-Wei Hsu, Wen-Ying Chen, Chun-Jung Chen, Yu-Hsiang Kuan, Sheng-Wen Wu

{"title":"Chlorpyrifos-induced suppression of the antioxidative defense system leads to cytotoxicity and genotoxicity in macrophages.","authors":"Yin-Che Lu, Chen-Yu Chiang, Shih-Pin Chen, Yu-Wei Hsu, Wen-Ying Chen, Chun-Jung Chen, Yu-Hsiang Kuan, Sheng-Wen Wu","doi":"10.1016/j.etap.2024.104468","DOIUrl":"https://doi.org/10.1016/j.etap.2024.104468","url":null,"abstract":"Chlorpyrifos, widely used for pest control, is known to have various harmful effects, although its toxic effects in macrophages and the mechanisms underlying its toxicity remain unclear. The present study investigated the toxic effects of chlorypyrifos in a macrophage cell line. Here, we found that chlorpyrifos induced cytotoxicity and genotoxicity in RAW264.7 macrophages. Moreover, chlorpyrifos induced intracellular ROS production, subsequently leading to lipid peroxidation. Chlorpyrifos reduced the activation of antioxidative enzymes including superoxide dismutase, catalase, and glutathione peroxidase. Chlorpyrifos upregulated HO-1 expression and activated the Keap1-Nrf2 pathway, as indicated by enhanced Nrf2 phosphorylation and Keap1 degradation. Chlorpyrifos exerted effects on the following in a dose-dependent manner: cytotoxicity, genotoxicity, lipid peroxidation, intracellular ROS production, antioxidative enzyme activity reduction, HO-1 expression, Nrf2 phosphorylation, and Keap1 degradation. Notably, N-acetyl-L-cysteine successfully inhibited chlorpyrifos-induced intracellular ROS generation, cytotoxicity, and genotoxicity. Thus, chlorpyrifos may induce cytotoxicity and genotoxicity by promoting intracellular ROS production and suppressing the antioxidative defense system activation in macrophages.","PeriodicalId":93992,"journal":{"name":"Environmental toxicology and pharmacology","volume":" ","pages":"104468"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-Acetyl-L-Cysteine Attenuates Titanium Dioxide Nanoparticle (TiO2 NP)-Induced Autophagy in Male Germ Cells. N-乙酰-L-半胱氨酸可减轻二氧化钛纳米粒子（TiO2 NP）诱导的雄性生殖细胞自噬作用

Environmental toxicology and pharmacology Pub Date : 2024-05-01 DOI: 10.1016/j.etap.2024.104466

B. Shin, Bang-Jin Kim, Eun-Ji Paeng, J. T. Rifkin, Sung-Hwan Moon, Seung Hee Shin, Buom-Yong Ryu

引用次数: 0

PM2.5 induces cardiac defects via AHR-SIRT1-PGC-1α mediated mitochondrial damage PM2.5 通过 AHR-SIRT1-PGC-1α 介导的线粒体损伤诱发心脏缺陷

Environmental toxicology and pharmacology Pub Date : 2024-02-01 DOI: 10.1016/j.etap.2024.104393

Jin Chen, Mingxuan Zhang, Stanley Aniagu, Yan Jiang, Tao Chen

引用次数: 0