Endokrynologia Polska最新文献

{"title":"Eradicating hyperandrogenism? Hormonal changes following Helicobacter pylori eradication in women with polycystic ovary syndrome: an observational case series.","authors":"Joanna Wutke-Ostręga, Mateusz Szul, Dagmara Pluta","doi":"10.5603/ep.110428","DOIUrl":"https://doi.org/10.5603/ep.110428","url":null,"abstract":"<p><strong>Introduction: </strong>Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder in which hyperandrogenism represents a centralpathophysiological feature. Increasing attention has been directed toward chronic inflammatory factors that may modulate androgenexcess. Helicobacter pylori (H. pylori) infection is a prevalent chronic bacterial infection associated with systemic low-grade inflammation.However, its potential relationship with androgen-related hormonal parameters in PCOS remains poorly explored.</p><p><strong>Material and methods: </strong>This observational mini case series included seven women with PCOS diagnosed according to the Rotterdam criteriaand confirmed active H. pylori infection. Hormonal parameters including total testosterone, androstenedione, dehydroepiandrosteronesulfate (DHEAS), sex hormone-binding globulin (SHBG), anti-Müllerian hormone (AMH), and free androgen index (FAI) were assessedduring active infection and after confirmed eradication. No hormonal contraception, antiandrogens, metformin, incretin-based therapies,or inositol supplements were used during the study period.</p><p><strong>Results: </strong>Following successful H. pylori eradication, consistent changes in androgen-related parameters were observed. Median DHEAS,androstenedione, and total testosterone concentrations decreased, while SHBG levels increased. Consequently, the free androgen indexdecreased in all patients. AMH levels showed a downward trend after eradication. Due to the descriptive nature of the study, no inferentialstatistical analyses were performed.</p><p><strong>Conclusions: </strong>In this observational case series, H. pylori eradication was associated with coherent changes in androgen-related hormonal parameters and reduced androgen bioavailability in women with PCOS. Although causality cannot be established, these findings suggestthat chronic infection-related inflammation may influence the androgenic milieu in PCOS.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"77 2","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147792825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of incretin levels in patients with prolactinoma.","authors":"Gökçe Altunay Vurğun, Nusret Yılmaz, Sebahat Özdem, Ramazan Sarı","doi":"10.5603/ep.109775","DOIUrl":"10.5603/ep.109775","url":null,"abstract":"<p><strong>Introduction: </strong>Prolactin has been shown to play an important role in the regulation of glucose metabolism. The present study aimed toevaluate incretin hormones in patients with prolactinoma.</p><p><strong>Material and methods: </strong>The study included 13 patients with prolactinoma without a history of diabetes and in 13 healthy volunteers.All participants underwent a 75-g oral glucose tolerance test (OGTT). Serum glucose, insulin, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) were measured at 0, 30, 60, 90, and 120 minutes.</p><p><strong>Results: </strong>Serum glucose and insulin levels at baseline and during the OGTT were similar in both groups (p > 0.05). GLP-1 levels, including baseline values, area under the curve (AUC), and all time points during OGTT, were also comparable between the groups (p > 0.05).In contrast, baseline GIP (p = 0.024), AUC (p = 0.011), and GIP levels at 30, 90, and 120 minutes were significantly lower in patients withprolactinoma (p = 0.006, p = 0.015, and p = 0.035, respectively).</p><p><strong>Conclusions: </strong>These findings suggest that incretins may play a role in the mechanisms underlying glucose metabolism disorders in patientswith hyperprolactinemia due to prolactinoma. Larger studies are needed to confirm this potential association.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"112-119"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When lymphadenopathy is not what it seems - coexistence of mantle cell lymphoma and pancreatic neuroendocrine tumor.","authors":"Weronika Wasyluk, Anna Wilczek, Marek Niewiedzioł, Aneta Szudy-Szczyrek, Magdalena Kozioł, Agnieszka Zwolak","doi":"10.5603/ep.109328","DOIUrl":"10.5603/ep.109328","url":null,"abstract":"","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"120-121"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-4260 serves as a prognostic biomarker and suppresses thyroid cancer progression.","authors":"Hongyan Xuan, Defu Zhang, Qinghua Zhang, Zhao Liu, Zhiyong Li, Xiancun Hou, Changli Ouyang, Xiangwen Li","doi":"10.5603/ep.107982","DOIUrl":"10.5603/ep.107982","url":null,"abstract":"<p><strong>Introduction: </strong>MicroRNAs (miRNAs) play critical roles in tumorigenesis and malignant transformation. Studies indicate aberrant expressionof miR-4260 in various cancers. However, its specific function and underlying molecular mechanisms in thyroid cancer (TC) remainpoorly understood.</p><p><strong>Material and methods: </strong>Paired tumor and adjacent non-tumor tissues were collected from a cohort of 120 TC patients undergoing surgicalresection. Real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) quantified miR-4260 expression in clinical specimensand cell lines. The prognostic value of miR-4260 expression was evaluated using Kaplan-Meier survival analysis and multivariate Coxproportional hazards regression. The functional impact of miR-4260 on TC cell proliferation, migration, and invasion was assessed usingcell transfection, cell counting kit 8 (CCK-8) assays, and Transwell migration/invasion assays. The regulatory interaction between miR-4260and its potential target gene was validated by dual-luciferase reporter assay.</p><p><strong>Results: </strong>RT-qPCR analysis revealed significantly elevated miR-4260 expression in TC tissues compared to matched non-tumor tissues. High miR-4260 expression correlated significantly with larger tumor size (p = 0.035), deeper invasion depth (p = 0.038), advanced tumor-node-metastasis (TNM) stage (p = 0.022), and lymph node metastasis (LNM) (p = 0.025) compared to low expression. MultivariateCox analysis identified high miR-4260 expression as an independent predictor of poor prognosis [hazard ratio (HR) = 3.398, 95% confidenceinterval (CI): 1.559-7.406, p = 0.002]. Functional experiments demonstrated that inhibiting miR-4260 expression significantly attenuatedthe proliferative and invasive capacities of TC cells. Dual-luciferase assays validated ANK2 as a direct miR-4260 target. RT-qPCR quantification revealed significantly antagonistic expression patterns between ANK2 and miR-4260 in thyroid carcinoma specimens. Rescueexperiments further revealed that miR-4260 modulates the malignant phenotype of TC cells by negatively regulating ANK2, indicating their cooperative involvement in TC progression.</p><p><strong>Conclusions: </strong>miR-4260 is critically implicated in TC advancement and unfavorable patient outcomes, establishing its bifunctional value as a clinically significant prognostic indicator and viable therapeutic candidate.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"89-97"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of serum concentrations of the \"satiety hormone\" - peptide YY concentration in body weight disorders in girls with anorexia nervosa and obesity.","authors":"Katarzyna Gołąb-Jenerał, Małgorzata Blaska, Karolina Ziora-Jakutowicz, Elżbieta Świętochowska, Agnieszka Zachurzok, Katarzyna Ziora","doi":"10.5603/ep.108016","DOIUrl":"10.5603/ep.108016","url":null,"abstract":"<p><strong>Introduction: </strong>Peptide YY (PYY), a key satiety hormone, exhibits altered serum concentrations in body weight disorders, although its role remains debated. Conflicting adult studies highlight the need to clarify PYY 1-36 dynamics in pediatric populations with anorexia nervosa (AN) and obesity (OB).</p><p><strong>Material and methods: </strong>Fasting serum PYY 1-36 concentrations were analyzed in 199 girls: 58 with restrictive AN [median age 15.0 (interquartile range; IQR): 14.0-16.0 years], 52 with OB [14.3 (12.3-16.3) years], and 89 healthy controls (C) [16.5 (15.5-17.5) years]. Anthropometric and metabolic/hormonal parameters were assessed. Group differences were evaluated using the Kruskal-Wallis rank-sum test. Relationships between fasting serum peptide YY (PYY) 1-36 concentrations and demographic/clinical parameters were examined using Spearman rank correlation coefficients.</p><p><strong>Results: </strong>AN patients had significantly higher PYY 1-36 levels [77.2 (71.1-82.4) pg/mL] compared to OB [36.0 (34.3-38.5) pg/mL] and C [49.7 (46.7-51.5) pg/mL; p < 0.001]. A strong inverse correlation between PYY and body mass index (BMI) was observed across all subjects (Rho = -0.8, p < 0.001). Receiver operating characteristic (ROC)-derived cut-offs differentiated AN (> 59.04 pg/mL; sensitivity 95%, specificity 100%) and OB (< 43.18 pg/mL; sensitivity 89%, specificity 90%) from C.</p><p><strong>Conclusions: </strong>1. Our research underscores significant PYY concentration disparities among weight disorders. 2. Significant differences in PYY concentrations in girls with body weight disorders as compared to healthy girls with normal body weight may indicate a role of this peptide in the body's adaptation to maintain energy homeostasis in connection with the ongoing disease.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"72-80"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral adrenal lesions as a manifestation of prolonged glucocorticoid withdrawal in classical adrenal hyperplasia.","authors":"Anna Klasa, Agnieszka Stefańska, Anna Grochowska, Alicja Hubalewska-Dydejczyk, Małgorzata Trofimiuk-Müldner","doi":"10.5603/ep.106547","DOIUrl":"https://doi.org/10.5603/ep.106547","url":null,"abstract":"<p><p>Not required for Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"77 1","pages":"81-82"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of hypoparathyroidism (HypoPT): Position Statement of the Expert Group for Polish Society of Endocrinology - update 2026.","authors":"Waldemar Misiorowski, Beata Kos-Kudła, Alicja Hubalewska-Dydejczyk, Marek Ruchała, Wojciech Zgliczyński, Arkadiusz Zygmunt, John P Bilezikian","doi":"10.5603/ep.110591","DOIUrl":"https://doi.org/10.5603/ep.110591","url":null,"abstract":"<p><p>Hypoparathyroidism (HypoPT) remains the last \"classic\" endocrine deficiency hormone disorder not routinely treated with hormone replacement. In November 2023, European Medicines Agency (EMA), and in August 2024, Food and Drug Administration (FDA) registered a new parathyroid hormone analogue: palopegteryparatide (TransCon PTH; YORVIPATH®) for the treatment of selected cases of hypoparathyroidism. As the Polish Society of Endocrinology Expert Panel, we recommend that parathyroid hormone (PTH) replacement therapy should be considered for HypoPT patients in whom conventional therapy is insufficient or poorly tolerated. PTH replacement therapy offers a more physiologic approach to treating HypoPT than conventional therapy. Palopegteriparatide can lead to eucalcemia, more effectively than conventional treatment, lowers serum phosphate and urinary calcium, and improves renal function and quality of life.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"77 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food-dependent Cushing's syndrome in a patient with bilateral macronodular adrenal disease (BMAD) associated with germline KDM1A variant.","authors":"Dorota Leszczyńska, Julia Latocha, Alicja Szatko, Beata Woźniak, Wojciech Zgliczyński, Piotr Glinicki","doi":"10.5603/ep.107854","DOIUrl":"https://doi.org/10.5603/ep.107854","url":null,"abstract":"<p><p>Not required for Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"77 1","pages":"83-84"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Berardinelli-Seip syndrome.","authors":"Savelia Gavrailova Yordanova, Zdravka Todorova, Antoaneta Gateva, Vera Karamfilova, Margarita Archinkova, Zdravko Kamenov, Yavor Assyov","doi":"10.5603/ep.108324","DOIUrl":"https://doi.org/10.5603/ep.108324","url":null,"abstract":"<p><p>Berardinelli-Seip syndrome, also known as congenital generalized lipodystrophy (CGL), is a rare genetic disorder characterized by lipoatrophy, acromegaloid features, hyperinsulinemia, hypertriglyceridemia, and hepatic steatosis. With estimated prevalence 1 in every 10,000,000 births, CGL challenges medical specialists to seek better ways for early diagnosis of the disease. Despite its rarity, the condition is associated with severe metabolic and cardiovascular complications, leading to significant morbidity and reduced life expectancy. Advances in molecular genetics have identified mutations in AGPAT2, BSCL2, CAV1, and PTRF, which provide important insights into adipose tissue biology and systemic metabolism. Early recognition and genetic confirmation are crucial to initiate timely interventions, including lifestyle modification, insulin sensitizers, and lipid-lowering therapies including metreleptin therapy in indicated cases. Two illustrative cases are presented, reflecting our experience with the clinical variability, genetic findings, and therapeutic strategies in CGL as well as highlighting the importance of comprehensive care and emerging therapies.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"77 1","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of lncRNA HCG4 in thyroid cancer and its regulatory effect on tumor progression.","authors":"Chongwei Qian, Hong Yi, Jike Wang","doi":"10.5603/ep.109546","DOIUrl":"10.5603/ep.109546","url":null,"abstract":"<p><strong>Introduction: </strong>Papillary thyroid carcinoma (PTC) with metastasis has a poor prognosis and requires effective prognostic markers. Becauselong non-coding ribonucleic acid (lncRNA) HCG4 is abnormally expressed in thyroid cancer, this study investigated its prognostic valuefor PTC and its regulatory mechanisms.</p><p><strong>Material and methods: </strong>This study included 128 patients with PTC. The prognostic value of HCG4 was assessed using Kaplan-Meier curves.COX analysis was used to identify prognostic factors affecting PTC. HCG4 and miR-146b-5p levels in tissues and cells were assessed usingreal-time quantitative reverse transcription polymerase chain reaction (RT-qPCR). Cell proliferation was detected using a cell counting kit(CCK-8 kit). Cell invasion and migration were assessed using a Transwell assay. The binding relationship between HCG4 and miR-146b-5pwas detected using dual-luciferase reporter (DLR).</p><p><strong>Results: </strong>HCG4 levels were reduced in PTC tissues, and cells compared with normal tissues, while miR-146b-5p levels were increased. PTCpatients with low HCG4 levels demonstrated lower 5-year survival rates, and HCG4 also serves as an independent protective prognosticfactor for PTC. HCG4 negatively regulates the level of miR-146b-5p. HCG4 overexpression inhibits cell proliferation, invasion, and migrationabilities of the cells. These abilities were restored by increasing the level of miR-146b-5p. Therefore, increasing HCG4 could reducethe level of miR-146b-5p, thereby alleviating PTC development.</p><p><strong>Conclusions: </strong>HCG4 demonstrates favorable prognostic value. Overexpression of HCG4 can reduce the level of miR-146b-5p, inhibit the survival rate and invasiveness of PTC cells, and thereby potentially alleviate the progression of PTC.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"98-106"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}