Endokrynologia Polska最新文献

{"title":"Thymic well-differentiated neuroendocrine tumor with isolated bone marrow metastases: an unusual metastatic pattern.","authors":"Katarzyna Jóźwik-Plebanek, Marek Saracyn, Weronika Mądra, Maciej Kołodziej, Adam Durma, Bartłomiej Grala, Katarzyna Gniadek-Olejniczak, Rafał Stec, Grzegorz Kamiński","doi":"10.5603/ep.105376","DOIUrl":"https://doi.org/10.5603/ep.105376","url":null,"abstract":"<p><p>Not required for Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long non-coding RNA MIR22HG impedes the progression of anaplastic thyroid carcinoma via targeting miR-141-3p/PTEN/AKT axis.","authors":"Junyu Cao, Peng Jiang, Songliang Jiang, Yuhan Zhao, Xin Jiang, Chuancheng Zhou, Jing Li, Kunxian Yang","doi":"10.5603/ep.104958","DOIUrl":"https://doi.org/10.5603/ep.104958","url":null,"abstract":"<p><strong>Introduction: </strong>Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal malignancies. The MiR-22 host gene (MIR22HG) has been identified as a novel long non-coding RNA (lncRNA) in a few types of cancer. Nevertheless, little is known about the potential role of MIR22HG in ATC. In this study, we aimed to investigate the biological functions and underlying molecular mechanisms of MIR22HG in ATC.</p><p><strong>Material and methods: </strong>The expression of MIR22HG in tissues and cells of ATC were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The cell viabilities and invasive abilities were evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay, wound healing assay, and Matrigel invasion assay. The mechanism of MIR22HG interacting with microRNA-141-3p (miR-141-3p) was measured by RNA immunoprecipitation (RIP) assay, RNA pull-down assay, and dual-luciferase reporter assay.</p><p><strong>Results: </strong>MIR22HG was downregulated in ATC tissues and cells. More importantly, decreased expression of MIR22HG was found to be correlated with poor prognosis of ATC patients. Functional analysis showed that overexpression of MIR22HG attenuated the proliferation and metastasis of ATC both in vitro and in vivo. Mechanistically, MIR22HG positively modulated phosphatase and tensin homolog deleted on chromosome ten (PTEN) expression via sponging miR-141-3p, thus inhibiting downstream protein kinase B (AKT) signaling cascade.</p><p><strong>Conclusions: </strong>MIR22HG serves as a tumor suppressor in ATC and impedes the progression of ATC through regulation of miR-141-3p/PTEN/AKT axis. Our findings illustrate the critical role of the MIR22HG/miR-141-3p/PTEN/AKT axis in the progression of ATC, which offers new insights for the therapeutic strategies of ATC.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lublin Comorbidity of Adiposity Study (LUCAS 1.0 BMI) - quantifying the success of a region-wide overweight and obesity treatment program: a retrospective real‑world data analysis.","authors":"Monika Lenart-Lipińska, Jakub Gołacki, Jakub Wronecki, Beata Matyjaszek-Matuszek","doi":"10.5603/ep.102917","DOIUrl":"https://doi.org/10.5603/ep.102917","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity has emerged as a global health epidemic, which carries significant implications for both individual health and healthcare systems worldwide. Numerous reports have shown the health advantages associated with a 5-10% reduction of one's initial body weight, but it remains unclear whether the data from clinical trials translate to real-world clinical practice. In our retrospective analysis, we evaluated the effectiveness of a multifactorial obesity treatment, including pharmacotherapy, in Polish conditions. The objective was to assess the efficacy of this multimodal treatment in achieving a 5-10% weight reduction over 3-6 months.</p><p><strong>Material and methods: </strong>The patient cohort included 1114 adults: 243 (22%) men and 871 (78%) women, aged 16-80 years, diagnosed with obesity and overweight in a team-based obesity treatment program with one-day-stay admissions. Each patient underwent a tailored multifactorial obesity treatment regimen, which incorporated dietary adjustments, physical activity, psychological support, and pharmacotherapy.</p><p><strong>Results: </strong>Weight reduction was observed in 868 (78%) patients. Of these, 635 (57%) achieved a 5% weight reduction, and 379 (34%) achieved a 10% reduction. No significant gender differences were found in weight reduction. Unlike clinical trials, weight reduction was similar between those receiving only behavioral treatment and those also on medication. The profile of a good responder in real-world conditions included high adherence to recommendations and follow-up visits, and absence of type 2 diabetes.</p><p><strong>Conclusions: </strong>Our study demonstrates that obesity can be effectively managed through individualized multimodal treatment. Nonetheless, this process demands sustained effort and necessitates individualized therapy overseen by a multidisciplinary therapeutic team.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surprising diagnosis of Paget's disease of bone during malignancy diagnosis.","authors":"Katarzyna Wandzilak, Marcin Renke, Łukasz Obołończyk","doi":"10.5603/ep.102636","DOIUrl":"https://doi.org/10.5603/ep.102636","url":null,"abstract":"<p><p>Not required for Clinical Vignette.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations between skeletal muscle mass to visceral fat area ratio (SVR) with bone mineral density (BMD) and 10-year probability of fracture risk in Chinese patients with type 2 diabetes mellitus (T2DM): a cross-sectional study.","authors":"Yuning Guo, Renxuan Li, Na Xu, Yan Wang, Wentong Jiang, Jianxia Wei, Xiaolian Zhou, Yanwei Liang, Lei Zhu, Yanman Zhou, Jin Xu","doi":"10.5603/ep.102613","DOIUrl":"https://doi.org/10.5603/ep.102613","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with type 2 diabetes mellitus (T2DM) have a higher risk of fracture, higher visceral fat, and lower muscle mass. The combined effect of skeletal muscle mass and visceral fat area [skeletal muscle mass to visceral fat area ratio (SVR)] on bone mineral density (BMD) and fracture risk in T2DM patients is still unknown.</p><p><strong>Materials and methods: </strong>A cross-sectional study was performed on 422 patients. The associations between SVR with BMD and the 10-year probability of fractures [included major osteoporotic fracture (MOF), and hip fracture (HF)] were analyzed using R studio 4.2.3. Generalized additive models (GAMs) were used to identify the associations between SVR and BMD and fracture risk.</p><p><strong>Results: </strong>There was a lower SVR in patients with osteoporosis/osteopenia than in controls. SVR was an independent determinant for BMD and MOF and HF, and SVR was positively associated with BMD and negatively associated with 10-year fracture risk in non-elderly men or elderly women with T2DM. SVR had an approximately positive linear association with BMD in elderly males and females, and it had an N-shaped curve association with BMD in non-elderly males. In addition, the associations between SVR and MOF/HF were negative linear in females and elderly men, and non-linear in non-elderly men.</p><p><strong>Conclusion: </strong>Our study provided a novel viewpoint on the relationship between SVR and BMD/fracture risk. Relatively high SVR is a protective factor for bone in T2DM patients, but the osteoprotective effect of SVR was mediated by age and gender, and it persisted only in non-elderly men and elderly women with T2DM.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 2","pages":"202-211"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-thyroid axis: investigating the causality between the gut microbiota and autoimmune thyroid disease based on a Mendelian randomization study.","authors":"Ting Zheng, Xin Li, Hongyu Xiang","doi":"10.5603/ep.102030","DOIUrl":"https://doi.org/10.5603/ep.102030","url":null,"abstract":"<p><strong>Introduction: </strong>Current studies have identified a close connection between the gut microbiota (GM) and autoimmune thyroid disease (AITD), indicating that the dysregulation of the GM could play a crucial bridging role in AITD. However, the causality between them has not been definitively defined.</p><p><strong>Material and methods: </strong>We utilized the summary statistics of GM from the largest available meta-analysis of genome-wide association studies conducted by the MiBioGen consortium. The data on AITD were derived from the Genome-Wide Association Study (GWAS) database. We investigated the causality between GM and AITD through various analytical methods in a bidirectional Mendelian randomization (MR) analysis. This encompassed methods like inverse variance weighted, MR-Egger, weighted median, weighted mode, and simple mode.</p><p><strong>Results: </strong>Our findings revealed a protective effect of genus Methanobrevibacter [odds ratio (OR) = 0.791, p = 0.044], order Rhodospirillales(OR = 0.775, p = 0.019) on Graves' disease (GD). However, the family Clostridiales vadin BB60 group (OR = 1.222, p = 0.038), genus Anaerofilum (OR = 1.243, p = 0.038), genus Barnesiella (OR = 1.405, p = 0.021), genus Intestinibacter (OR = 1.777, p = 0.000), and order NB1n (OR = 1.270, p = 0.003) were identified as risk factors for GD. In addition, family Alcaligenaceae (OR = 0.691, p= 0.004), family Rhodospirillaceae (OR = 0.813, p = 0.013), genus Butyrivibrio (OR = 0.877, p = 0.019), genus Prevotella 7 (OR = 0.835, p = 0.026), genus Ruminococcaceae UCG011 (OR = 0.883, p = 0.032), genus Ruminococcaceae UCG013 (OR = 0.797, p = 0.048), and order Lactobacillales (OR = 0.759, p = 0.009) had a protective effect on Hashimoto's thyroiditis (HT). Genus Intestinimonas (OR = 1.247, p = 0.010) was a risk factor for HT. Based on the findings from the reverse MR analysis, AITD did not exert a significant causal influence on the GM. There waere no observed remarkable instrumental variables of heterogeneity or horizontal pleiotropy.</p><p><strong>Conclusion: </strong>Our study offered evidence of causal relationship between certain GM and AITD using two-sample MR analysis. This may provide novel perspectives on diagnosis and latent therapeutic targets for AITD.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 2","pages":"153-164"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in imaging examination of bone density and bone quality.","authors":"Junyan Li, BiYan She, MingLi He, Chuyue Yuan, Na Li","doi":"10.5603/ep.100805","DOIUrl":"10.5603/ep.100805","url":null,"abstract":"<p><p>Bone mineral density is the primary basis for the diagnosis of osteoporosis. Bone mineral density measurement methods include dual-energy X-ray (DXA) and quantitative computed tomography (QCT). Based on traditional bone density detection equipment, the newly developed imaging detection technology can further detect the microstructures and geometric features of bones, providing important reference for exploring the pathophysiological changes, sensitive clinical diagnosis, and disease monitoring of osteoporosis.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 1","pages":"29-39"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to use properly the POL-RISK algorithm developed for 10-year prediction of osteoporotic fractures in daily practice.","authors":"Wojciech Pluskiewicz, Piotr Adamczyk, Bogna Drozdzowska","doi":"10.5603/ep.103617","DOIUrl":"10.5603/ep.103617","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis is one of the most common diseases in elderly subjects. Accurate assessment of fracture risk is essential in the management of osteoporotic patients. The aim of the study was to present the optimal manner of using a method designed for fracture risk prediction, e.g. POL-RISK, in daily practice.</p><p><strong>Material and methods: </strong>Methods for fracture prediction were presented, especially those which allow easy and quick online assessment. In addition to true medical aspect, e.g. the ability to accurately detect high fracture risk patients who need therapy, the economic aspects were also presented. Due to the enormous number of osteoporotic patients the therapy should be indicated mainly in patients with high fracture risk. The optimal threshold of fracture risk for the initiation of reimbursed therapy should be established as a compromise of prior established medical threshold and economic aspects. The expected endpoint is the reduction of new fractures noted in longitudinal observation.</p><p><strong>Conclusion: </strong>Implementation of the described scenario should enable the development of the optimal model of care in osteoporotic subjects. Broad use of fracture risk thresholds to initiate reimbursed therapy, encompassing both true medical and economic aspects, should result in the reduction of osteoporotic fractures and decrease overall osteoporosis-related costs to the healthcare system.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 1","pages":"82-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of preoperative risk factors for complications after distal pancreatectomy for neuroendocrine tumors.","authors":"Bartosz Molasy, Patryk Zemła, Sławomir Mrowiec, Katarzyna Kuśnierz","doi":"10.5603/ep.102243","DOIUrl":"https://doi.org/10.5603/ep.102243","url":null,"abstract":"<p><strong>Introduction: </strong>Resection of pancreatic neuroendocrine tumors is associated with a high risk of clinically relevant postoperative complications. This study aimed to evaluate and analyze the relationship between selected preoperative risk factors and the occurrence of clinically relevant early postoperative complications, including pancreatic fistulas, after distal pancreatic resections for neuroendocrine tumors.</p><p><strong>Material and methods: </strong>The analysis included 78 patients who underwent surgery for neuroendocrine tumors of the body or tail of the pancreas. A retrospective analysis was carried out regarding age, sex, comorbidities, preoperative C-reactive protein (CRP) levels, American Society of Anesthesiologists (ASA) score, tumor size, and Wirsung's duct diameter as measured on preoperative computed tomography (CT) scans of the abdomen. The severity of postoperative complications was assessed using the Clavien-Dindo classification, while the International Study Group on Pancreatic Fistula (ISGPF) classification was utilized to evaluate pancreatic fistulas.</p><p><strong>Results: </strong>Pancreatic fistula was the most common complication and occurred in 42 cases (55.3%). A significant relationship was found between the ASA score and complication severity according to the Clavien-Dindo classification (p = 0.01). Multivariate analyses indicated associations between the occurrence of pancreatic fistula and male sex (OR = 0.17, p = 0.06), age (OR = 0.86, p < 0.01), preoperative CRP level (OR = 1.05, p = 0.01), and ASA score (OR = 125.97, p < 0.01). No significant correlation was identified between tumor size or Wirsung's duct diameter and the occurrence of clinically relevant postoperative complications or pancreatic fistulas (p > 0.05).</p><p><strong>Conclusion: </strong>The ASA score correlates with the severity of postoperative complications as assessed by the Clavien-Dindo classification. The risk factors for developing B and/or C pancreatic fistulas include age, male sex, elevated preoperative CRP levels, and higher ASA scores.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 2","pages":"182-190"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Framework guidelines for the process of caring for the health of adolescent transgender (T) and non-binary (NB) people experiencing gender dysphoria - the position statement of the expert panel.","authors":"Aneta Gawlik-Starzyk, Marta Dora, Dorota Baran, Łukasz Szostakiewicz, Małgorzata Trofimiuk-Müldner, Łukasz Müldner-Nieckowski, Agnieszka Bielska-Brodziak, Milena Adamczewska-Stachura, Aleksandra Antosz, Katarzyna Bajszczak, Ewa Barg, Barbara Barteczka-Eckert, Aleksandra Chodecka, Lena Cichoń, Ewa Dobiała, Agnieszka Drosdzol-Cop, Izabela Fornalik, Justyna Holka-Pokorska, Grzegorz Iniewicz, Tomasz Jakubowski, Małgorzata Janas-Kozik, Karina Kapczuk, Julia Kata, Tomasz Koszutski, Grzegorz Kudela, Joanna Ławicka, Anna Mazurczak, Magdalena Mijas, Magdalena Nowacka, Beata Pastwa-Wojciechowska, Katarzyna Pilarczyk-Parchanowicz, Paulina Pilch, Maciej Pilecki, Dominik Rachoń, Barbara Remberk, Violetta Skrzypulec-Plinta, Jagoda Sikora, Sylwia Stankiewicz, Maria Szarras-Czapnik, Marta Szymańska-Pytlińska, Mieczysław Walczak, Krzysztof Wilczyński, Beata Wróbel, Bartosz Grabski","doi":"10.5603/ep.104289","DOIUrl":"10.5603/ep.104289","url":null,"abstract":"<p><p>This article presents framework guidelines for the care of adolescent transgender (T) and non-binary (NB) individuals experiencing gender dysphoria (GD) and/or gender incongruence (GI). Developed by a multidisciplinary expert panel, these guidelines aim to address the complex medical, psychological, and social needs of this diverse population. The document emphasises the importance of individualised, affirmative care that respects the autonomy, identity, and rights of adolescents. It outlines best practices for psychiatric, psychological, and sexological assessment; criteria and protocols for gender-affirming hormonal interventions (GAHI) and puberty suppression; and ethical considerations for medical decision-making. The guidelines advocate for comprehensive support systems, including family involvement and multidisciplinary team collaboration, while addressing co-occurring mental health conditions and neurodiversity. The article also highlights global perspectives on gender-affirming care, comparing practices and policies across countries to provide a contextualised approach that aligns with international standards while addressing local legal and healthcare frameworks. The proposed care model is designed to enhance the mental and physical well-being of adolescents, reduce stigma, and improve their overall quality of life. This work serves as a vital resource for healthcare professionals, policymakers, and advocates seeking to advance equitable, effective, and compassionate care for gender-diverse youths.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"76 1","pages":"1-28"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}