Endokrynologia Polska最新文献

{"title":"Association between the C-reactive protein-triglyceride-glucose index and risks of all-cause and cardiovascular mortality in USA adults: a prospective cohort study.","authors":"Li Li, Lisha Guo, Chunxia Li, Xia Jing, Qinghua Han","doi":"10.5603/ep.111545","DOIUrl":"10.5603/ep.111545","url":null,"abstract":"<p><strong>Introduction: </strong>The C-reactive protein-triglyceride-glucose index (CTI) is an emerging composite biomarker reflecting insulin resistanceand systemic inflammation. Research regarding the relationship between CTI and risks of all-cause and cardiovascular mortality remainslimited and inconsistent.</p><p><strong>Material and methods: </strong>Data from 9,264 USA adults aged ≥ 20 years were obtained from the National Health and Nutrition Examination Survey (1999-2010). Mortality status was determined through linkage to the National Death Index through 31 December 2019. Hazardratios (HRs) for all-cause and cardiovascular mortality were estimated using weighted Kaplan-Meier methods, restricted cubic spline(RCS) models, and multivariable Cox proportional hazards regression models. Prespecified subgroup analyses and sensitivity analyseswere conducted to assess the robustness of the findings.</p><p><strong>Results: </strong>Over a median follow-up of 12.8 years, 2,644 deaths occurred, including 2,009 attributable to all causes and 635 to cardiovascular causes. After adjustment for potential confounders, each one-unit increment in CTI was associated with a 26% higher risk of all-causemortality [HR, 1.26; 95% confidence interval (CI), 1.15-1.38; p < 0.001) and a 25% higher risk of cardiovascular mortality (HR, 1.25; 95% CI,1.03-1.51; p = 0.021). Participants in the highest CTI quartile demonstrated a 33% higher risk of all-cause mortality compared with thosein the lowest quartile (HR, 1.33; 95% CI, 1.07-1.64; p = 0.010). RCS analyses indicated a nonlinear association between CTI and all-causemortality (p for nonlinearity = 0.018), with an inflection point at a CTI value of 9.25, whereas a linear association was observed for cardiovascular mortality (p for nonlinearity = 0.072). No statistically significant interactions were identified across prespecified subgroups. The results remained consistent after exclusion of early deaths (≤ 2 years) and after exclusion of participants with neoplasms.</p><p><strong>Conclusions: </strong>Higher CTI levels were independently associated with increased risks of all-cause and cardiovascular mortality among USA adults. These findings suggest that CTI may serve as a clinically relevant biomarker for early identification of individuals at elevated mortality risk, with potential implications for risk stratification, targeted prevention strategies, and healthcare resource allocation.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"327-339"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early serum estradiol decline as a predictive biomarker of spontaneous abortion without fetal chromosomal abnormalities.","authors":"Yu-Han Shen, Sui Peng, Jiayi Li, Lei Shi, Yi-Xiao He, Ting Zhu, Ming-Jie Shen","doi":"10.5603/ep.106766","DOIUrl":"10.5603/ep.106766","url":null,"abstract":"<p><strong>Introduction: </strong>Identifying reliable biomarkers to predict spontaneous abortion (SA), particularly in pregnancies without fetal chromosomal abnormalities, remains a critical objective in obstetric care. This retrospective cohort study assessed the predictive utility of serum β-human chorionic gonadotropin (β-hCG), estradiol, and progesterone concentrations in patients experiencing SA with confirmed chromosomally normal chorionic villi.</p><p><strong>Material and methods: </strong>A retrospective analysis was conducted on clinical and laboratory data from 76 patients who experienced SA between 5 and 10 weeks of gestation and received care at the Department of Obstetrics and Gynecology of our hospital between 2019 and 2024. All patients underwent uterine evacuation, and chorionic villus specimens were assessed for chromosomal abnormalities using next-generation sequencing (NGS). Based on NGS findings, two groups were defined: patients without fetal chromosomal abnormalities [n = 36; defined as no structural variants > 0.1 megabase pairs (Mb)] and patients with fetal chromosomal abnormalities (n = 40; variants > 1 Mb). An additional control group (n = 100) with uncomplicated, ongoing pregnancies was included for comparison. Serum concentrations of βhCG, estradiol, and progesterone were measured and compared across groups in the pregnant women.</p><p><strong>Results: </strong>Peak serum β-hCG concentrations were significantly lower in the SA group without chromosomal abnormalities compared to both the chromosomally abnormal SA group and the control group. Similarly, peak progesterone and estradiol concentrations were lowest in the SA group without chromosomal abnormalities (p < 0.05). Among the three biomarkers, estradiol demonstrated the highest discriminatory capacity. A significantly higher rate of early serum estradiol decline was observed in the SA group without chromosomal abnormalities compared to the group with abnormalities (p = 0.027). In contrast, no significant differences were found in the rate of progesterone decline across the groups. The median estradiol concentration at the time of initial decline was also significantly lower in the SA group without chromosomal abnormalities than in the other two groups.</p><p><strong>Conclusion: </strong>Early decline in serum estradiol levels may serve as a superior biomarker for predicting SA not associated with fetal chromosomal abnormalities. In contrast, serum β-hCG and progesterone concentrations exhibited limited predictive value in this context. These findings support consideration of serum estradiol monitoring to facilitate timely clinical intervention in pregnancies at increased risk for non-chromosomal miscarriage.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated secondary adrenal failure accompanied by primary hypothyroidism after treatment with nivolumab and ipilimumab for kidney cancer.","authors":"Ewa Bieniek, Ewa Kalinka, Marta Mikulak, Igor Symonowicz, Krzysztof Cezary Lewandowski","doi":"10.5603/ep.109308","DOIUrl":"10.5603/ep.109308","url":null,"abstract":"","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"266-267"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147978083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioactive iodine (¹³¹I) therapy in a patient with unresectable papillary thyroid cancer: when palliative treatment becomes neoadjuvant.","authors":"Iwona Pałyga, Klaudia Nowak, Patrycja Krawczyk, Aldona Kowalska","doi":"10.5603/ep.112336","DOIUrl":"10.5603/ep.112336","url":null,"abstract":"","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"262-263"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior pituitary tumors: clinicopathological features and patient outcomes from a referral pituitary center.","authors":"Jacek Kunicki, Barbara Buchalska, Jakub Skiba, Wiesława Grajkowska, Maria Maksymowicz","doi":"10.5603/ep.109542","DOIUrl":"10.5603/ep.109542","url":null,"abstract":"<p><strong>Introduction: </strong>Posterior pituitary tumors (PPTs) are rare pathologies universally identified by positive immunoreactivity for thyroidtranscription factor-1 (TTF-1). They include four subtypes: pituicytoma (PC), granular cell tumor (GCT), spindle cell oncocytoma (SCO),and sellar ependymoma (SE). Because these tumors are rare, data regarding the optimal treatment strategy and prognosis are lacking. The aim of our study was to describe a large single-center cohort of patients with PPTs.</p><p><strong>Material and methods: </strong>We retrospectively analyzed data from 15 patients diagnosed with PPTs among 2108 patients who underwent pituitary surgery at our institution between 2009 and 2024, examining their clinical presentations, imaging studies, surgical techniques, and recovery trajectories. The mean age was 50.5 years (range, 18-74 years). The mean follow-up time was 6.4 years (range, 0-15 years).</p><p><strong>Results: </strong>We describe eight cases of PC, four of SCO, and three of GCT. The most common symptoms were visual impairment (46.7%) and headache (40.0%). Thirteen patients (86.7%) underwent endoscopic transsphenoidal surgery, ten of whom achieved gross total resection (GTR).</p><p><strong>Conclusions: </strong>The endoscopic transsphenoidal approach has proven to be a safe and highly effective method for achieving GTR in patients with PPTs. Spindle cell oncocytoma, with a higher level of vascularization than PC and GCT, poses a greater risk of surgical complicationsand may result in non-GTR.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"147-155"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare false-positive uptake: orbital conjunctival cyst mimicking metastasis on post-therapeutic radioiodine scan in thyroid cancer.","authors":"Ruiguo Zhang, Hui Wang, Wei Zheng, Peng Wang, Qiang Jia","doi":"10.5603/ep.108455","DOIUrl":"10.5603/ep.108455","url":null,"abstract":"<p><p></p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"85-86"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of cytopathologist-performed rapid on-site evaluation on the diagnostic adequacy of thyroid fine-needle aspiration.","authors":"Lala Soltanova, Serdar Sahin, Emre Durcan, Efekan Yılmaz, Serhat Uysal, Ilkin Muradov, Banu Betül Kocaman, Mustafa Sait Gonen, Irem Onur","doi":"10.5603/ep.111055","DOIUrl":"10.5603/ep.111055","url":null,"abstract":"<p><strong>Introduction: </strong>Rapid on-site evaluation (ROSE) is thought to increase the adequacy of thyroid fine-needle aspiration (FNA) biopsiesand reduce overall cost.</p><p><strong>Material and methods: </strong>We conducted a retrospective review of thyroid FNA cases from patients who presented to the endocrinology outpatient clinic of a tertiary center between May 2018 and March 2023. A cytopathologist performing ROSE in an FNA room in the endocrinologyclinic was available during the period June 2019-March 2023. Between May 2018 and June 2019, ROSE was not available.</p><p><strong>Results: </strong>Of 1614 FNAs, 1212 were performed with ROSE by a cytopathologist and 402 without ROSE. The number of nondiagnostic FNA cases was 297 (24.6%) with ROSE and 140 (34.8%) without ROSE. In Group A (with ROSE), a total of 94 of 1212 nodules underwent repeatbiopsy, corresponding to a rate of 7.75%. In Group B (without ROSE), 59 of 402 nodules required repeat biopsy, yielding a rate of 14.7%.</p><p><strong>Conclusions: </strong>Although cytopathologist assistance during thyroid FNA increases costs, it lowers insufficiency rates by reducing the need for repeat procedures and expedites the time to definitive diagnosis.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"298-302"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and fetal outcomes in pregnancies with abnormal trimester-specific thyroid-stimulating hormone levels receiving early levothyroxine therapy: a prospective cohort study.","authors":"Şeyma Sarışen, Zuhal Köksal, Rıfat Bozkuş, Ayşe S Küçkkayıkçı","doi":"10.5603/ep.113036","DOIUrl":"10.5603/ep.113036","url":null,"abstract":"<p><strong>Introduction: </strong>The effect of maternal subclinical and overt hypothyroidism on pregnancy outcomes remains controversial. Prospectivedata on outcomes in women with trimester-specific thyroid-stimulating hormone (TSH) abnormality who received early empiric levothyroxine(LT4) therapy are limited.</p><p><strong>Material and methods: </strong>In this prospective cohort study, 295 pregnant women whose TSH level at the first antenatal visit was outsidethe 2017 American Thyroid Association (ATA) trimester-specific reference ranges (cases) and 283 euthyroid pregnant women (controls)were enrolled at a tertiary internal medicine outpatient clinic. All cases received LT4 regardless of thyroid peroxidase (TPO) antibodystatus. Multivariable logistic regression adjusted for age, body mass index (BMI), gravidity, and anti-TPO positivity was performed.</p><p><strong>Results: </strong>Groups were comparable for age, BMI, gravidity, and parity (all p > 0.05). Overall composite complication rates were similar (49.8% vs. 45.6%, p = 0.348). However, oligohydramnios (7.1% vs. 2.8%, p = 0.030) and miscarriage (2.4% vs. 0.0%, p = 0.015) were significantlymore frequent in cases, with no miscarriage events occurring in the euthyroid control group. In adjusted analysis, case-group membershipwas an independent risk factor for oligohydramnios (aOR = 3.41; 95% CI: 1.42-8.19; p = 0.006). Within the case group, anti-TPOpositivity was an independent predictor of polyhydramnios (aOR = 3.93; 95% CI: 1.03-15.01; p = 0.046), and anti-TPO-positive womenrequired higher LT4 doses and delivered earlier (both p ≤ 0.001).</p><p><strong>Conclusions: </strong>Early LT4 therapy in trimester-specific TSH abnormality preserves overall pregnancy outcomes; however, residual risks of oligohydramnios and miscarriage warrant close monitoring. Anti-TPO positivity identifies a distinct phenotype with a higher treatmentrequirement and a propensity for polyhydramnios.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"303-309"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between visceral fat area and ectopic fat deposition in young and middle-aged adults with overweight or obesity.","authors":"Chaowenwei Lei, Enling Ye, Mengli Sun, Min Xiang, Zhenzhen Lin, Mengmeng Peng, De'en Shi, Hai Lin, Ruidian Li, Lechu Yu, Qiu Chen, Wenting Chen, Liangmiao Chen, Hong Yang","doi":"10.5603/ep.111420","DOIUrl":"10.5603/ep.111420","url":null,"abstract":"<p><strong>Introduction: </strong>Ectopic fat deposition in the liver and pancreas is common in people with overweight or obesity and shares metabolic riskfactors. The relationship between intrapancreatic fat deposition (IPFD) and hepatic fat deposition, and the mediating role of visceral fat,remain unclear. This study investigated their association and the influence of visceral adipose tissue in young and middle-aged adultswith overweight or obesity.</p><p><strong>Material and methods: </strong>This cross-sectional study included 197 adults (aged 18-50 years) with overweight or obesity. Hepatic and pancreatic fat contents were quantified using non-contrast computed tomography, while visceral and subcutaneous adipose tissue areas weremeasured via dual bioelectrical impedance analysis. Pearson correlation and multivariable linear regression analyses were performed,with adjustment for age, sex, and body mass index (BMI).</p><p><strong>Results: </strong>Among participants, 131 (66.5%) had abdominal obesity. The association between pancreatic and hepatic fat was significantly modified by abdominal obesity (p = 0.041). Subgroup analysis showed a positive correlation only in those without abdominal obesity.</p><p><strong>Conclusions: </strong>Abdominal obesity significantly modified the association between IPFD and hepatic fat (p for interaction = 0.041). A positive correlation was observed only in participants without abdominal obesity, while no significant association was found in those withabdominal obesity. Abdominal obesity, reflecting visceral fat accumulation, weakened the pancreas-liver fat association. This suggestsa potential modulatory role of visceral fat in ectopic fat interrelationships, although causality cannot be inferred due to the cross-sectionaldesign.</p>","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"353-359"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel pathogenic MEN1 variant in a three-member family with multiple endocrine neoplasia type 1.","authors":"Magdalena Kochman, Aldona Janoska, Witold Chudziński, Wojciech Zgliczyński, Krystian Jażdżewski","doi":"10.5603/ep.111828","DOIUrl":"10.5603/ep.111828","url":null,"abstract":"","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":" ","pages":"392-393"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}