DEN open最新文献

{"title":"Best Reviewers Award for 2024","authors":"","doi":"10.1002/deo2.70101","DOIUrl":"https://doi.org/10.1002/deo2.70101","url":null,"abstract":"<p>Total number of reviews (for 2024: 1.5 or above).</p><p>Total score of review quality.</p><p>Review period: from 1 January 2024 to 31 December 2024\u0000\u0000 </p><p>\u0000 </p><p>\u0000 </p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxaliplatin-induced portal hypertension manifesting as portosystemic shunt: A case report and review of sinusoidal obstruction syndrome in gastric cancer","authors":"Toshimitsu Ichimaru,&nbsp;Takamitsu Sakamoto,&nbsp;Teruyoshi Amagai","doi":"10.1002/deo2.70109","DOIUrl":"https://doi.org/10.1002/deo2.70109","url":null,"abstract":"<p>A 77-year-old woman with stage IVB gastric adenocarcinoma (cT4N2M1) received 10 cycles of S-1, oxaliplatin, and nivolumab combination chemotherapy. Imaging and biopsy confirmed a complete response. However, thrombocytopenia, mild splenomegaly, and elevated liver enzymes developed following oxaliplatin administration. After the tenth cycle, a contrast-enhanced computed tomography scan revealed a portosystemic shunt. Oxaliplatin was discontinued, but the shunt persisted after 1 year. Balloon-occluded retrograde transvenous obliteration was successfully performed, resulting in the resolution of the shunt. This case highlights the potential for oxaliplatin-induced portal hypertension requiring close monitoring.</p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot study of a novel lumen-apposing metal stent for endoscopic ultrasound-guided procedures in porcine models","authors":"Benedetto Mangiavillano,&nbsp;Gianluca Franchellucci,&nbsp;Francesco Auriemma,&nbsp;Daryl Ramai,&nbsp;Alberto Larghi,&nbsp;Danilo Paduano,&nbsp;Diletta De Deo,&nbsp;Federica Calabrese,&nbsp;Carmine Gentile,&nbsp;Matteo Fiacca,&nbsp;Antonio Facciorusso,&nbsp;Alessandro Repici","doi":"10.1002/deo2.70084","DOIUrl":"https://doi.org/10.1002/deo2.70084","url":null,"abstract":"<p>Lumen-apposing metal stents have expanded the therapeutic potential of interventional endoscopic ultrasound (EUS). The Hot-Spaxus (Taewoong Medical Co., Ltd.), the second most commonly utilized lumen-apposing metal stent, requires two operators for its release which has been considered a limitation compared to other lumen-apposing metal stents. We aimed to test the feasibility and the technical success of a newly available version of the Hot-Spaxus stent equipped with an innovative handle delivery system for EUS-guided interventional procedures. We conducted a pilot study using porcine models. The novel Hot-Spaxus 2 was tested by performing four EUS-guided procedures including four EUS-guided gallbladder drainage and 12 EUS-guided gastrojejunostomy) procedures. Technical success was reported in 100% of cases. The mean procedure time for EUS-guided gatrojejunostomyJ and EUS-guided gallbladder drainage was 23.85 min (standard deviation 3.41) and 16.15 min (standard deviation 2.72), respectively. The distal and proximal flanges were safely released by the endosonographer without any complications. No adverse events were reported. In conclusion, the novel Hot-Spaxus 2 stent may represent an improvement compared to the prior Spaxus model. Unlike its predecessor, this newly designed stent eliminates the need for two endoscopists and can be deployed by a single operator. Further human studies are necessary to validate its clinical effectiveness.</p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric inverted polyp successfully resected by underwater endoscopic mucosal resection","authors":"Yuki Nakamura,&nbsp;Takahiro Nomi,&nbsp;Sho Yasui,&nbsp;Jun-ichi Okano,&nbsp;Ichiro Yamadori,&nbsp;Hidetaka Yamamoto,&nbsp;Yuichiro Sasaki,&nbsp;Hajime Isomoto","doi":"10.1002/deo2.70103","DOIUrl":"https://doi.org/10.1002/deo2.70103","url":null,"abstract":"<p>A 47-year-old man, who underwent an annual esophagogastroduodenoscopy as part of his routine check-up, was found to have a small subepithelial lesion on the posterior wall of the gastric body in 2013. The lesion gradually increased in size during follow-up. In 2024, 11 years after the initial detection, the lesion had grown to over 10 mm in diameter and exhibited central erythematous depression. Endoscopic ultrasonography was performed, revealing that the lesion originated from the second layer with uniformly low internal echogenicity. A biopsy suggested the possibility of a benign stromal tumor, but a definitive diagnosis was not achieved. To obtain a complete biopsy, en bloc resection was performed using underwater endoscopic mucosal resection. Histopathological examination confirmed the diagnosis of a gastric inverted polyp. Since gastric inverted polyps with central depression or erosion have the potential for malignancy, endoscopic resection is recommended.</p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The anti-migration effect of partially covered self-expandable metal stents for unresectable malignant distal biliary obstruction: A multicenter comparative study","authors":"Shinya Kohashi,&nbsp;Arata Sakai,&nbsp;Keisuke Furumatsu,&nbsp;Takeshi Ezaki,&nbsp;Takao Iemoto,&nbsp;Takeshi Tanaka,&nbsp;Masahiro Tsujimae,&nbsp;Takashi Kobayashi,&nbsp;Atsuhiro Masuda,&nbsp;Yuzo Kodama","doi":"10.1002/deo2.70100","DOIUrl":"10.1002/deo2.70100","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Covered self-expandable metal stents are commonly used for unresectable malignant distal biliary obstruction. Partially covered self-expandable metal stents have uncovered sections at both ends; however, their anti-migration effect remains unclear. The objective of this study was to evaluate that effect by comparing such stents with fully covered self-expandable metal stents for patients with unresectable malignant distal biliary obstruction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a multicenter, retrospective comparative study of partially covered stents with fully covered stents for unresectable malignant distal biliary obstruction. Stent migration, recurrent biliary obstruction, and the time to recurrent biliary obstruction were compared between them.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-nine patients with partially covered stents were included and compared with 42 patients with fully covered stents. The partially covered group had a significantly lower stent migration rate (3% vs. 36%; <i>p </i>&lt; 0.001). The recurrent biliary obstruction rate was significantly lower in the partially covered group (21% vs. 43%; <i>p </i>= 0.036). The non-recurrent biliary obstruction rate at 6 months was 90% and 68% in the partially and fully covered groups, respectively. The time to recurrent biliary obstruction was significantly longer in the partially covered group (Gray's test, <i>p </i>= 0.016). Only partially covered stent placement was significantly associated with a lower risk of stent migration (subdistribution hazard ratio = 0.077; 95% confidence interval = 0.01–0.60; <i>p </i>= 0.014) in the multivariable analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The anti-migration effect of partially covered self-expandable metal stents was associated with a reduced recurrence of biliary obstruction and prolonged time to such obstruction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the resection depth between endoscopic mucosal resection and underwater endoscopic mucosal resection for superficial non-ampullary duodenal epithelial tumors: A retrospective study","authors":"Toshiki Horii,&nbsp;Yohei Harada,&nbsp;Gen Kitahara,&nbsp;Takuya Wada,&nbsp;Akinori Watanabe,&nbsp;Kenji Ishido,&nbsp;Hisatomo Ikehara,&nbsp;Chika Kusano","doi":"10.1002/deo2.70091","DOIUrl":"https://doi.org/10.1002/deo2.70091","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>There is concern that underwater endoscopic mucosal resection (UWEMR) uses buoyancy to elevate the lesion for snare resection, resulting in a shallower resection depth than that in endoscopic mucosal resection (EMR). We aimed to compare conventional EMR and UWEMR in terms of resection depth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively reviewed cases in which EMR or UWEMR was performed for superficial non-ampullary duodenal epithelial tumors of ≤20 mm between April 2018 and February 2024. The endpoints were histological complete resection rate, en bloc resection rate, presence of muscularis mucosa and submucosa in the resection specimen, and submucosal index calculated from the resection specimen.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>EMR was performed on 19 lesions and UWEMR was performed on 52 lesions. Histological complete and en bloc resection rates were not significantly different between EMR and UWEMR (57.9% and 63.5%, respectively, <i>p</i> = 0.78; 78.9% and 90.4%, respectively, <i>p</i> = 0.24). No significant differences were observed between EMR and UWEMR in the muscularis mucosa of the resected specimens (78.9% and 92.3%, respectively, <i>p</i> = 0.20). The presence of submucosa in resected specimens was encountered less often in EMR cases than in UWEMR cases (57.9% versus [vs.] 84.6%, <i>p</i> = 0.03). There were significant differences in the submucosal index in the resected specimens between EMR and UWEMR cases (median 0.15 [interquartile range 0–0.39] vs. 0.33 [0.17–0.57], <i>p</i> = 0.04).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>UWEMR potentially includes the submucosa within the specimen.</p>\u0000 </section>\u0000 </div>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injured submucosal arteries following cold snare polypectomy are significantly fewer versus those after endoscopic mucosal resection for 10–19-mm nonpedunculated colorectal polyps","authors":"Shingo Kurasawa,&nbsp;Ichitaro Horiuchi,&nbsp;Masashi Kajiyama,&nbsp;Hiroe Kitahara,&nbsp;Tsuyoshi Terashima,&nbsp;Akira Horiuchi","doi":"10.1002/deo2.70099","DOIUrl":"https://doi.org/10.1002/deo2.70099","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We compared the frequency of post-polypectomy bleeding or injured submucosal arteries between cold snare polypectomy (CSP) and endoscopic mucosal resection (EMR) for nonpedunculated colorectal polyps.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a prospective, randomized, single-center study. Patients who underwent CSP or EMR for 10–19-mm nonpedunculated polyps were enrolled in CSP and EMR groups, and we compared the patient and polyp characteristics, the number of clips used, clinical outcomes, adverse events, and pathological features of the resected polyps between these groups. The primary outcome was the presence of injured arteries in the submucosal layer of the resected polyps examined histologically. The secondary outcomes were immediate bleeding and delayed bleeding.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-three patients with 60 eligible polyps were enrolled. The numbers of polyps/patients were 30/26 in the CSP group and 30/27 in the EMR group. The patient and polyp characteristics were similar between the groups. The total number of hemostatic clips used for hemostasis or prophylactic clipping was significantly greater in the EMR group compared to the CSP group (78 vs. 10, <i>p</i> &lt; 0.001). The frequency of immediate bleeding after CSP was similar to that after EMR [6.7% (2/30) vs. 13% (4/30), <i>p</i> = 0.39]. Delayed bleeding did not occur in either group. The presence of injured submucosal arteries after CSP was significantly less frequent than that after EMR: 10% (3/30) versus 67% (20/30), <i>p</i> &lt; 0.001.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In the resection of 10–19-mm nonpedunculated colorectal polyps, CSP may decrease post-polypectomy bleeding without prophylactic clipping compared to EMR as it results in fewer injured submucosal arteries. www.clinicaltrials.gov (NCT05930041).</p>\u0000 </section>\u0000 </div>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic mucosal resection with an over-the-scope clip for colorectal tumors (with video)","authors":"Takahiro Muramatsu,&nbsp;Tomoaki Tashima,&nbsp;Tomonori Kawasaki,&nbsp;Tsubasa Ishikawa,&nbsp;Kodai Esaki,&nbsp;Kei Sugimoto,&nbsp;Masami Sano,&nbsp;Shotaro Ishizaka,&nbsp;Yumi Mashimo,&nbsp;Takao Itoi,&nbsp;Shomei Ryozawa","doi":"10.1002/deo2.70076","DOIUrl":"https://doi.org/10.1002/deo2.70076","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection may result in complications or may be unsuitable for tumors that are difficult to treat endoscopically. We investigated the usefulness of a newly developed endoscopic resection technique—EMR with an over-the-scope clip (EMR-O)—for difficult-to-treat lesions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>We retrospectively examined patients who underwent EMR-O for colorectal tumors between September 2017 and January 2024. Patient and lesion characteristics, technical success rates, en bloc resection rates, R0 resection rates, procedure time, histopathology, and the clinical course were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>EMR-O was performed for 18 patients. Indications for EMR-O included residual or recurrent lesions (seven patients; 38.9%), diverticulum lesions (five patients; 27.8%), appendiceal orifice lesions (three patients; 16.7%), T1 cancers (two patients; 11.1%), and subepithelial tumors (one patient; 5.5%). The median lesion size was 11 mm. The rates of technical success, en bloc resection, and R0 resection were 100%, 86.7%, and 86.7%. The median procedure time was 10 min. The only adverse event was diverticulitis (one patient; 5.5%). Intraoperative and delayed perforation and bleeding were not observed. The pathological resection depths were full-thickness for three patients (16.7%), muscularis resection for four patients (22.2%), and deep submucosal resection for 11 patients (61.1%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although EMR-O is limited by the target lesion size, it shortens the procedure time, prevents perforation, and avoids the need for surgery. EMR-O may be a minimally invasive treatment option for small lesions that are difficult to treat endoscopically.</p>\u0000 </section>\u0000 </div>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tribute to Our Reviewers 2024","authors":"","doi":"10.1002/deo2.70098","DOIUrl":"https://doi.org/10.1002/deo2.70098","url":null,"abstract":"&lt;p&gt;The Editorial Board of &lt;i&gt;DEN Open&lt;/i&gt; takes this opportunity to acknowledge with particular gratitude the following reviewers who have provided their valuable time and expertise in the evaluation of manuscripts submitted to &lt;i&gt;DEN Open&lt;/i&gt; during the period of 1 January 2024 to 31 December 2024.&lt;/p&gt;&lt;p&gt;Takao Itoi&lt;/p&gt;&lt;p&gt;Editor-in-Chief&lt;/p&gt;&lt;p&gt;&lt;i&gt;DEN Open&lt;/i&gt;&lt;/p&gt;&lt;p&gt;Nobutsugu Abe&lt;/p&gt;&lt;p&gt;Kyoichi Adachi&lt;/p&gt;&lt;p&gt;Yoichi Akazawa&lt;/p&gt;&lt;p&gt;Teppei Akimoto&lt;/p&gt;&lt;p&gt;Shintaro Akiyama&lt;/p&gt;&lt;p&gt;Ikuo Aoyama&lt;/p&gt;&lt;p&gt;Taiki Aoyama&lt;/p&gt;&lt;p&gt;Reiko Ashida&lt;/p&gt;&lt;p&gt;Shinya Ashizuka&lt;/p&gt;&lt;p&gt;Maki Ayaki&lt;/p&gt;&lt;p&gt;Rafael Castro&lt;/p&gt;&lt;p&gt;Shannon Chan&lt;/p&gt;&lt;p&gt;Li-Chun Chang&lt;/p&gt;&lt;p&gt;Hideyuki Chiba&lt;/p&gt;&lt;p&gt;Eduardo De Moura&lt;/p&gt;&lt;p&gt;Akira Dobashi&lt;/p&gt;&lt;p&gt;Osamu Dohi&lt;/p&gt;&lt;p&gt;Shinpei Doi&lt;/p&gt;&lt;p&gt;Alanna Ebigbo&lt;/p&gt;&lt;p&gt;Mitsuru Esaki&lt;/p&gt;&lt;p&gt;Yuki Fujii&lt;/p&gt;&lt;p&gt;Nao Fujimori&lt;/p&gt;&lt;p&gt;Ai Fujimoto&lt;/p&gt;&lt;p&gt;Toshio Fujisawa&lt;/p&gt;&lt;p&gt;Akashi Fujita&lt;/p&gt;&lt;p&gt;Yuji Fujita&lt;/p&gt;&lt;p&gt;Mitsuharu Fukasawa&lt;/p&gt;&lt;p&gt;Nobuhiko Fukuba&lt;/p&gt;&lt;p&gt;Shuichi Fukuda&lt;/p&gt;&lt;p&gt;Hayato Fukui&lt;/p&gt;&lt;p&gt;Shusei Fukunaga&lt;/p&gt;&lt;p&gt;Yoshihiro Furuichi&lt;/p&gt;&lt;p&gt;Kenichi Goda&lt;/p&gt;&lt;p&gt;Osamu Goto&lt;/p&gt;&lt;p&gt;Ryunosuke Hakuta&lt;/p&gt;&lt;p&gt;Natalie Halvorsen&lt;/p&gt;&lt;p&gt;Kenta Hamada&lt;/p&gt;&lt;p&gt;Yasuhiko Hamada&lt;/p&gt;&lt;p&gt;Kazuo Hara&lt;/p&gt;&lt;p&gt;Ryo Harada&lt;/p&gt;&lt;p&gt;Minami Hashimoto&lt;/p&gt;&lt;p&gt;Shinichi Hashimoto&lt;/p&gt;&lt;p&gt;Hisashi Hidaka&lt;/p&gt;&lt;p&gt;Kazutoshi Higuchi&lt;/p&gt;&lt;p&gt;Takuma Higurashi&lt;/p&gt;&lt;p&gt;Takuto Hikichi&lt;/p&gt;&lt;p&gt;Makoto Hinokuchi&lt;/p&gt;&lt;p&gt;Hiroto Hiraga&lt;/p&gt;&lt;p&gt;Kingo Hirasawa&lt;/p&gt;&lt;p&gt;Takashi Hirose&lt;/p&gt;&lt;p&gt;Takashi Hisabe&lt;/p&gt;&lt;p&gt;Yusuke Horiuchi&lt;/p&gt;&lt;p&gt;Kinichi Hotta&lt;/p&gt;&lt;p&gt;Ryoji Ichijima&lt;/p&gt;&lt;p&gt;Katsuro Ichimasa&lt;/p&gt;&lt;p&gt;Eikichi Ihara&lt;/p&gt;&lt;p&gt;Toshiro Iizuka&lt;/p&gt;&lt;p&gt;Yuichiro Ikebuchi&lt;/p&gt;&lt;p&gt;Eriko Ikeda&lt;/p&gt;&lt;p&gt;Hisatomo Ikehara&lt;/p&gt;&lt;p&gt;Atsushi Imagawa&lt;/p&gt;&lt;p&gt;Hajime Imai&lt;/p&gt;&lt;p&gt;Ken Inoue&lt;/p&gt;&lt;p&gt;Tadahisa Inoue&lt;/p&gt;&lt;p&gt;Fumiaki Ishibashi&lt;/p&gt;&lt;p&gt;Yusuke Ishida&lt;/p&gt;&lt;p&gt;Kazunaga Ishigaki&lt;/p&gt;&lt;p&gt;Ryu Ishihara&lt;/p&gt;&lt;p&gt;Naoki Ishii&lt;/p&gt;&lt;p&gt;Hirotoshi Ishiwatari&lt;/p&gt;&lt;p&gt;Ken Ito&lt;/p&gt;&lt;p&gt;Masanori Ito&lt;/p&gt;&lt;p&gt;Nobuhito Ito&lt;/p&gt;&lt;p&gt;Masahiro Itonaga&lt;/p&gt;&lt;p&gt;Hiroyoshi Iwagami&lt;/p&gt;&lt;p&gt;Naoto Iwai&lt;/p&gt;&lt;p&gt;Masaya Iwamuro&lt;/p&gt;&lt;p&gt;Takuji Iwashita&lt;/p&gt;&lt;p&gt;Keisuke Iwata&lt;/p&gt;&lt;p&gt;Taro Iwatsubo&lt;/p&gt;&lt;p&gt;Ryuhei Jinushi&lt;/p&gt;&lt;p&gt;Tomohiro Kadota&lt;/p&gt;&lt;p&gt;Hideki Kamada&lt;/p&gt;&lt;p&gt;Ken Kamata&lt;/p&gt;&lt;p&gt;Takashi Kanesaka&lt;/p&gt;&lt;p&gt;Atsushi Kanno&lt;/p&gt;&lt;p&gt;Yoshihide Kanno&lt;/p&gt;&lt;p&gt;Hiromitsu Kanzaki&lt;/p&gt;&lt;p&gt;Chikatoshi Katada&lt;/p&gt;&lt;p&gt;Motohiko Kato&lt;/p&gt;&lt;p&gt;Tsunetaka Kato&lt;/p&gt;&lt;p&gt;Noriyuki Kawami&lt;/p&gt;&lt;p&gt;Seiji Kawano&lt;/p&gt;&lt;p&gt;Noboru Kawata&lt;/p&gt;&lt;p&gt;Daisuke Kikuchi&lt;/p&gt;&lt;p&gt;Toshifumi Kin&lt;/p&gt;&lt;p&gt;Satoshi Kinoshita&lt;/p&gt;&lt;p&gt;Koh Kitagawa&lt;/p&gt;&lt;p&gt;Katsuya Kitamura&lt;/p&gt;&lt;p&gt;Yoko Kitamura&lt;/p&gt;&lt;p&gt;Masanori Kobayashi&lt;/p&gt;&lt;p&gt;Yousuke Kobayashi&lt;/p&gt;&lt;p&gt;Shinya Kodashima&lt;/p&gt;&lt;p&gt;Takehiko Koga&lt;/p&gt;&lt;p&gt;Hirofumi Kogure&lt;/p&gt;&lt;p&gt;Yoriaki Komeda&lt;/p&gt;&lt;p&gt;Yoshiyasu Kono&lt;/p&gt;&lt;p&gt;Shinsuke Koshita&lt;/p&gt;&lt;p&gt;Kensuke Kubota&lt;/p&gt;&lt;p&gt;Takahiro Kudo&lt;/p&gt;&lt;p&gt;Yu-Ting Kuo&lt;/p&gt;&lt;p&gt;Chika Kusano&lt;/p&gt;&lt;p&gt;Takamichi Kuwahara&lt;/p&gt;&lt;p&gt;Toshio Kuwai&lt;/p&gt;&lt;p&gt;Yasuharu Maeda&lt;/p&gt;&lt;p&gt;Mai Makiguchi&lt;/p&gt;&lt;p&gt;Akinori Maruta&lt;/p&gt;&lt;p&gt;Hirotsugu Maruyama&lt;/p&gt;&lt;p&gt;Atsuhiro Masuda&lt;/p&gt;&lt;p&gt;Saburo Matsubara&lt;/p&gt;&lt;p&gt;Akihisa Matsuda&lt;/p&gt;&lt;p&gt;Takahisa Matsuda&lt;/p&gt;&lt;p&gt;Hiroshi Matsumoto&lt;/p&gt;&lt;p&gt;Kazuyuki Matsumoto&lt;/p&gt;&lt;p&gt;Tomoaki Matsumura&lt;/p&gt;&lt;p&gt;Yukitoshi ","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing autoimmune gastritis: Polypoid nodule scar development after endoscopic submucosal dissection for early gastric cancer","authors":"Naoya Masuda,&nbsp;Kenji Yamazaki,&nbsp;Yasuhiko Maruyama,&nbsp;Ryoji Kushima,&nbsp;Nae Hasebe,&nbsp;Noritaka Ozawa,&nbsp;Shogo Shimizu,&nbsp;Masahito Shimizu","doi":"10.1002/deo2.70094","DOIUrl":"https://doi.org/10.1002/deo2.70094","url":null,"abstract":"<p>Endoscopic submucosal dissection (ESD), the standard treatment for early gastric cancer, typically results in homogeneous flat scars. However, in some cases, polypoid nodule scars (PNS) may develop, complicating the cancer recurrence assessment. This case report describes a 60-year-old man with a history of <i>Helicobacter pylori</i> infection who underwent two ESD procedures: first for early antral gastric cancer and then for gastric body adenoma. Subsequently, an erythematous protruding lesion developed at the antral ESD scar site. Lesion biopsy revealed regenerative and hyperplastic tissue growth, consistent with PNS. Despite <i>H. pylori</i> eradication therapy and discontinuation of potassium-competitive acid blockers and H₂-receptor antagonists, the lesion continued to enlarge. PNS growth may be caused by excessive mucosal regeneration and enhanced antral peristalsis, suggesting that hypergastrinemia, which may enhance these effects, may be an underlying cause. Further, elevated serum gastrin levels, decreased pepsinogen levels, the presence of antiparietal cell antibodies, and consistent pathological findings confirmed autoimmune gastritis (AIG).</p><p>This case highlights the diagnostic challenges of AIG, especially in cases of active or previous <i>H. pylori</i> infection because typical endoscopic features may be obscured. Persistent PNS after ESD warrants the consideration of excessive mucosal regeneration and enhanced peristalsis, with AIG as a potential cause because of its association with hypergastrinemia. To our knowledge, this is the first case report describing a potential link between AIG and PNS.</p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}