DEN open最新文献

{"title":"Guidewire-assisted successful closure of mis-punctured transverse colon during endoscopic ultrasound-guided cyst drainage","authors":"Naoki Fujita,&nbsp;Hideki Kamada,&nbsp;Ryota Nakabayashi,&nbsp;Takuma Yamashita,&nbsp;Shima Mimura,&nbsp;Hiroki Yamana,&nbsp;Kiyoyuki Kobayashi,&nbsp;Minoru Oshima,&nbsp;Keiichi Okano,&nbsp;Hideki Kobara","doi":"10.1002/deo2.70112","DOIUrl":"https://doi.org/10.1002/deo2.70112","url":null,"abstract":"<p>Endoscopic ultrasound-guided cyst drainage (EUS-CD) was performed for walled-off pancreatic necrosis. Computed tomography performed the next day showed that the tip of the external drainage tube was located in the transverse colon, confirming an accidental EUS-CD-associated complication of mis-puncture. A colonoscopy was performed to confirm the puncture site, which was identified as a defect measuring 2 mm in diameter. The external drainage tube was removed immediately via a guidewire. We intentionally retained the guidewire as a landmark for the puncture site in the colon. The defect was approximated using an endoclip under full vision, with the guidewire covered with surrounding mucosa. After removing the guidewire smoothly, complete closure was achieved with additional endoclips. Four days later, EUS-CD was successfully repeated, resulting in the resolution of the walled-off pancreatic necrosis. This is the first known case in which an accidental puncture of the transverse colon occurred during EUS-CD for walled-off pancreatic necrosis, and guidewire-guided clip closure of the colon contributed to troubleshooting.</p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful conservative management of delayed perforation following endoscopic submucosal dissection of the esophagus: A case report","authors":"Sachiyo Onishi,&nbsp;Jun Takada,&nbsp;Kiichi Otani,&nbsp;Naoya Masuda,&nbsp;Hiroki Taniguchi,&nbsp;Kentaro Kojima,&nbsp;Masaya Kubota,&nbsp;Takashi Ibuka,&nbsp;Takuji Iwashita,&nbsp;Masahito Shimizu","doi":"10.1002/deo2.70115","DOIUrl":"https://doi.org/10.1002/deo2.70115","url":null,"abstract":"<p>Delayed perforation after esophageal endoscopic submucosal dissection is a rare complication that may result in severe outcomes. Here, we report a case of delayed perforation that was successfully managed with conservative treatment. A 72-year-old male with hypertensive renal failure and on maintenance hemodialysis underwent endoscopic submucosal dissection for a 2/3 circumferential superficial esophageal cancer in the middle thoracic esophagus, involving resection of 4/5 of the esophageal circumference. Locoregional steroid injections were administered after resection to prevent stenosis. No perforation occurred during the procedure; however, delayed perforation was identified on postoperative day 3. Endoscopy revealed necrosis and brittleness in a large area of the post-endoscopic submucosal dissection ulcer. The patient developed fever and mediastinal emphysema, and endoscopic attempts to close the perforation were unsuccessful. Conservative management—including fasting, antibiotics, and subsequent drainage—was initiated. The patient's condition improved with drainage tube placement, enteral nutrition, and antibiotic administration. A follow-up computed tomography scan on postoperative day 56 confirmed the resolution of mediastinal emphysema, and endoscopy revealed that the perforation healed with scarring. This case highlights that surgery may be avoided if appropriate treatment is initiated as early as possible, including drainage to prevent exposure to gastric and intestinal fluids, early initiation of enteral nutrition, rehabilitation to maintain strength, and blood transfusions as supportive care.</p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visibility evaluation of gastric epithelial neoplasm of fundic gland mucosa lineage using texture and color enhancement imaging","authors":"Hisanori Utsunomiya,&nbsp;Hiroya Ueyama,&nbsp;Tsutomu Takeda,&nbsp;Shunsuke Nakamura,&nbsp;Yasuko Uemura,&nbsp;Tomoyo Iwano,&nbsp;Momoko Yamamoto,&nbsp;Ryota Uchida,&nbsp;Daiki Abe,&nbsp;Shotaro Oki,&nbsp;Nobuyuki Suzuki,&nbsp;Atsushi Ikeda,&nbsp;Yoichi Akazawa,&nbsp;Kumiko Ueda,&nbsp;Mariko Hojo,&nbsp;Shuko Nojiri,&nbsp;Takashi Yao,&nbsp;Akihito Nagahara","doi":"10.1002/deo2.70110","DOIUrl":"https://doi.org/10.1002/deo2.70110","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Recently, the incidence of Helicobacter pylori-uninfected gastric cancers, such as gastric epithelial neoplasm of fundic-gland mucosa lineage (GEN-FGML), has increased with the widespread use of eradication therapy. Because the detection and endoscopic diagnosis of GEN-FGML are difficult, an effective observation method in screening endoscopy is required. We investigated whether texture and color enhancement imaging (TXI) improved the visibility of GEN-FGML compared with white light imaging (WLI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this single-center prospective clinical study, 50 GEN-FGML lesions (35 patients) treated at our hospital between October 2020 and June 2023 were analyzed. The endoscopic images of GEN-FGML obtained using WLI, TXI mode 1 (TXI-1), TXI mode 2 (TXI-2), and narrow-band imaging were compared by 10 endoscopists. We analyzed the visibility score and inter-rater reliability (intraclass correlation coefficient and conducted an objective evaluation based on <i>L* a* b*</i> color values and the color difference (Δ<i>E*</i>) in the CIE LAB color space system.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Histologically, GEN-FGML was classified as gastric adenocarcinoma of fundic-gland type (<i>n</i> = 45) and gastric adenocarcinoma of fundic-gland mucosa type (<i>n</i> = 5). The total visibility score for all endoscopists was significantly higher for TXI than for WLI (<i>p</i> &lt; 0.01); and for TXI-1 than for TXI-2 (<i>p</i> &lt; 0.01). The intraclass correlation coefficients for TXI-1 and TXI-2 were “almost perfect” and “substantial,” respectively, for all endoscopists. Δ<i>E*</i> was significantly higher for TXI than for WLI (<i>p</i> &lt; 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>TXI improved the visibility of GEN-FGML for all endoscopists compared with WLI when evaluated subjectively and objectively.</p>\u0000 </section>\u0000 </div>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of Barrett's esophageal adenocarcinoma in a young adult aged 20 years","authors":"Takayuki Ohi,&nbsp;Fumisato Sasaki,&nbsp;Nobuhisa Maeda,&nbsp;Shohei Uehara,&nbsp;Hidehito Maeda,&nbsp;Akihito Tanaka,&nbsp;Shuji Kanmura,&nbsp;Akihiro Yamasuji,&nbsp;Akio Ido","doi":"10.1002/deo2.70111","DOIUrl":"https://doi.org/10.1002/deo2.70111","url":null,"abstract":"<p>In Japan, the prevalence of Barrett's esophageal adenocarcinoma (BEA) has recently increased owing to a decrease in the number of patients with <i>Helicobacter pylori</i> infection, westernization of the diet, and an increase in obesity prevalence. However, BEA in patients in their 20s is extremely rare. Our patient was a 20-year-old Japanese woman with chief complaints of vomiting and nausea. Esophagogastroduodenoscopy was performed to investigate the cause of vomiting, and a raised lesion was found in the gastroesophageal junctional zone. In the magnified observation, the mucosal pattern of the lesion was partially invisible, and the vascular pattern was irregular; the lesion was diagnosed based on the Japan Esophageal Society classification for Barrett's esophagus -related superficial neoplasia. Endocytoscopic observations revealed a highly irregular glandular structure. Computed tomography showed no distant metastasis. Based on these results, we diagnosed BEA as short-segment Barrett's esophagus and performed an endoscopic submucosal dissection. The pathological diagnosis was pT1a-DMM. It was a well-differentiated adenocarcinoma and was treated with curative resection.</p><p>BEA is extremely rare in young adults in their 20s. Nonetheless, appropriate surveillance is required for patients with multiple risk factors, including obesity and exposure to acid and bile resulting from persistent vomiting.</p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unusual case of polyp with multiple appears honeycomb-like depressions","authors":"Makoto Koda,&nbsp;Ikuro Koba,&nbsp;Taku Morita,&nbsp;Kazuhide Shimamatsu,&nbsp;Araki Toshihiro,&nbsp;Takumi Kawaguchi,&nbsp;Takuji Torimura","doi":"10.1002/deo2.70106","DOIUrl":"https://doi.org/10.1002/deo2.70106","url":null,"abstract":"<p>The patient is a 63-year-old woman. She underwent lower gastrointestinal endoscopy at her local doctor, and a serrated lesion with a honeycomb-like depression in the surface mucosa of the ascending colon measuring 35 mm in size was observed. The lesion was thought to be a sessile serrated lesion (SSL), but since there was a lot of mucus and it was difficult to observe the inside of the depression, SSL with dysplasia was also mentioned as a possible diagnosis. The patient was referred to our department and underwent endoscopic submucosal dissection of the colon. The pathological results showed no dysplasia component, and the diagnosis of SSL with inverted growth was made. Inverted SSL has been reported in the past, but a lesion with a honeycomb-like depression has never been reported before, making this an interesting lesion. We report here the mechanism of the depression and the morphology of the depression, together with a review of the literature.</p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Best Reviewers Award for 2024","authors":"","doi":"10.1002/deo2.70101","DOIUrl":"https://doi.org/10.1002/deo2.70101","url":null,"abstract":"<p>Total number of reviews (for 2024: 1.5 or above).</p><p>Total score of review quality.</p><p>Review period: from 1 January 2024 to 31 December 2024\u0000\u0000 </p><p>\u0000 </p><p>\u0000 </p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxaliplatin-induced portal hypertension manifesting as portosystemic shunt: A case report and review of sinusoidal obstruction syndrome in gastric cancer","authors":"Toshimitsu Ichimaru,&nbsp;Takamitsu Sakamoto,&nbsp;Teruyoshi Amagai","doi":"10.1002/deo2.70109","DOIUrl":"https://doi.org/10.1002/deo2.70109","url":null,"abstract":"<p>A 77-year-old woman with stage IVB gastric adenocarcinoma (cT4N2M1) received 10 cycles of S-1, oxaliplatin, and nivolumab combination chemotherapy. Imaging and biopsy confirmed a complete response. However, thrombocytopenia, mild splenomegaly, and elevated liver enzymes developed following oxaliplatin administration. After the tenth cycle, a contrast-enhanced computed tomography scan revealed a portosystemic shunt. Oxaliplatin was discontinued, but the shunt persisted after 1 year. Balloon-occluded retrograde transvenous obliteration was successfully performed, resulting in the resolution of the shunt. This case highlights the potential for oxaliplatin-induced portal hypertension requiring close monitoring.</p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot study of a novel lumen-apposing metal stent for endoscopic ultrasound-guided procedures in porcine models","authors":"Benedetto Mangiavillano,&nbsp;Gianluca Franchellucci,&nbsp;Francesco Auriemma,&nbsp;Daryl Ramai,&nbsp;Alberto Larghi,&nbsp;Danilo Paduano,&nbsp;Diletta De Deo,&nbsp;Federica Calabrese,&nbsp;Carmine Gentile,&nbsp;Matteo Fiacca,&nbsp;Antonio Facciorusso,&nbsp;Alessandro Repici","doi":"10.1002/deo2.70084","DOIUrl":"https://doi.org/10.1002/deo2.70084","url":null,"abstract":"<p>Lumen-apposing metal stents have expanded the therapeutic potential of interventional endoscopic ultrasound (EUS). The Hot-Spaxus (Taewoong Medical Co., Ltd.), the second most commonly utilized lumen-apposing metal stent, requires two operators for its release which has been considered a limitation compared to other lumen-apposing metal stents. We aimed to test the feasibility and the technical success of a newly available version of the Hot-Spaxus stent equipped with an innovative handle delivery system for EUS-guided interventional procedures. We conducted a pilot study using porcine models. The novel Hot-Spaxus 2 was tested by performing four EUS-guided procedures including four EUS-guided gallbladder drainage and 12 EUS-guided gastrojejunostomy) procedures. Technical success was reported in 100% of cases. The mean procedure time for EUS-guided gatrojejunostomyJ and EUS-guided gallbladder drainage was 23.85 min (standard deviation 3.41) and 16.15 min (standard deviation 2.72), respectively. The distal and proximal flanges were safely released by the endosonographer without any complications. No adverse events were reported. In conclusion, the novel Hot-Spaxus 2 stent may represent an improvement compared to the prior Spaxus model. Unlike its predecessor, this newly designed stent eliminates the need for two endoscopists and can be deployed by a single operator. Further human studies are necessary to validate its clinical effectiveness.</p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric inverted polyp successfully resected by underwater endoscopic mucosal resection","authors":"Yuki Nakamura,&nbsp;Takahiro Nomi,&nbsp;Sho Yasui,&nbsp;Jun-ichi Okano,&nbsp;Ichiro Yamadori,&nbsp;Hidetaka Yamamoto,&nbsp;Yuichiro Sasaki,&nbsp;Hajime Isomoto","doi":"10.1002/deo2.70103","DOIUrl":"https://doi.org/10.1002/deo2.70103","url":null,"abstract":"<p>A 47-year-old man, who underwent an annual esophagogastroduodenoscopy as part of his routine check-up, was found to have a small subepithelial lesion on the posterior wall of the gastric body in 2013. The lesion gradually increased in size during follow-up. In 2024, 11 years after the initial detection, the lesion had grown to over 10 mm in diameter and exhibited central erythematous depression. Endoscopic ultrasonography was performed, revealing that the lesion originated from the second layer with uniformly low internal echogenicity. A biopsy suggested the possibility of a benign stromal tumor, but a definitive diagnosis was not achieved. To obtain a complete biopsy, en bloc resection was performed using underwater endoscopic mucosal resection. Histopathological examination confirmed the diagnosis of a gastric inverted polyp. Since gastric inverted polyps with central depression or erosion have the potential for malignancy, endoscopic resection is recommended.</p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The anti-migration effect of partially covered self-expandable metal stents for unresectable malignant distal biliary obstruction: A multicenter comparative study","authors":"Shinya Kohashi,&nbsp;Arata Sakai,&nbsp;Keisuke Furumatsu,&nbsp;Takeshi Ezaki,&nbsp;Takao Iemoto,&nbsp;Takeshi Tanaka,&nbsp;Masahiro Tsujimae,&nbsp;Takashi Kobayashi,&nbsp;Atsuhiro Masuda,&nbsp;Yuzo Kodama","doi":"10.1002/deo2.70100","DOIUrl":"10.1002/deo2.70100","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Covered self-expandable metal stents are commonly used for unresectable malignant distal biliary obstruction. Partially covered self-expandable metal stents have uncovered sections at both ends; however, their anti-migration effect remains unclear. The objective of this study was to evaluate that effect by comparing such stents with fully covered self-expandable metal stents for patients with unresectable malignant distal biliary obstruction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a multicenter, retrospective comparative study of partially covered stents with fully covered stents for unresectable malignant distal biliary obstruction. Stent migration, recurrent biliary obstruction, and the time to recurrent biliary obstruction were compared between them.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-nine patients with partially covered stents were included and compared with 42 patients with fully covered stents. The partially covered group had a significantly lower stent migration rate (3% vs. 36%; <i>p </i>&lt; 0.001). The recurrent biliary obstruction rate was significantly lower in the partially covered group (21% vs. 43%; <i>p </i>= 0.036). The non-recurrent biliary obstruction rate at 6 months was 90% and 68% in the partially and fully covered groups, respectively. The time to recurrent biliary obstruction was significantly longer in the partially covered group (Gray's test, <i>p </i>= 0.016). Only partially covered stent placement was significantly associated with a lower risk of stent migration (subdistribution hazard ratio = 0.077; 95% confidence interval = 0.01–0.60; <i>p </i>= 0.014) in the multivariable analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The anti-migration effect of partially covered self-expandable metal stents was associated with a reduced recurrence of biliary obstruction and prolonged time to such obstruction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"5 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}