{"title":"Treatment of Hepatocellular Carcinoma Using Endoscopic Ultrasound-guided Radiofrequency Ablation: A Case Series","authors":"Yogesh Harwani, Shreya Butala, Varun Shukla, Anand Patel, Surbhi Dogra Jani","doi":"10.1002/deo2.70171","DOIUrl":null,"url":null,"abstract":"<p>Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is an emerging technique for treating pancreatic and neuroendocrine tumors in patients who are not candidates for surgery. However, there is limited evidence of EUS-RFA in hepatic cancers. The present case series describes five elderly patients with compensated cirrhotic hepatocellular carcinomas (HCCs) treated locally using EUS-RFA. Alpha-fetoprotein levels were reduced in patients after 1 month of the procedure. Computed tomography analysis also reported a reduction in HCCs in patients postoperatively. Repeat computed tomography triple-phase abdomen also showed complete radiological response to treatment in lesions <3 cm. None of the patients reported any procedural adverse event. EUS-RFA offers safe ablation of <3 cm HCC lesions.</p>","PeriodicalId":93973,"journal":{"name":"DEN open","volume":"6 1","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/deo2.70171","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"DEN open","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/deo2.70171","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is an emerging technique for treating pancreatic and neuroendocrine tumors in patients who are not candidates for surgery. However, there is limited evidence of EUS-RFA in hepatic cancers. The present case series describes five elderly patients with compensated cirrhotic hepatocellular carcinomas (HCCs) treated locally using EUS-RFA. Alpha-fetoprotein levels were reduced in patients after 1 month of the procedure. Computed tomography analysis also reported a reduction in HCCs in patients postoperatively. Repeat computed tomography triple-phase abdomen also showed complete radiological response to treatment in lesions <3 cm. None of the patients reported any procedural adverse event. EUS-RFA offers safe ablation of <3 cm HCC lesions.
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