Clinical EEG and neuroscience最新文献_第6页

Prefrontal and Occipital Network Excitability Differences in Dementia with Lewy Bodies and Alzheimer's Disease. 路易体痴呆和阿尔茨海默病的前额叶和枕叶网络兴奋性差异。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-05-21 DOI: 10.1177/15500594261452759

Noa Bregman, Noa Zifman, Hilla Fogel, Eden Abulher, Inbal Maidan, Tamara Shiner

{"title":"Prefrontal and Occipital Network Excitability Differences in Dementia with Lewy Bodies and Alzheimer's Disease.","authors":"Noa Bregman, Noa Zifman, Hilla Fogel, Eden Abulher, Inbal Maidan, Tamara Shiner","doi":"10.1177/15500594261452759","DOIUrl":"https://doi.org/10.1177/15500594261452759","url":null,"abstract":"BackgroundThere is a great need in distinguishing Dementia with Lewy Body (DLB) from Alzheimer's disease (AD) and elucidating its pathophysiology. Transcranial magnetic stimulation (TMS) evoked potentials (TEPs) offer a non-invasive measure of neurophysiological alterations associated with underlying disease pathology.MethodsA total of 39 participants were included: 12 DLB, 10 AD, and 17 age-matched healthy controls (HC). TEPs were measured in the dorsolateral prefrontal cortex (DLPFC), primary motor cortex (M1), and primary visual cortex (V1).ResultsGlobal mean field potential (GMFP) TEP (130-250 ms) showed a significant interaction of group and stimulation site (p = .0101, ηp2 = 0.175) with a significant group effect (p = .0071, ηp2 = 0.234), attributed to higher GMFP in DLB compared to AD and HC in response to V1 stimulation (p = .001, p = .001, respectively). TEP amplitude corresponding to P60 displayed a significant group*stimulation site interaction (p = .0037, ηp2 = 0.202) arising from differences in DLPFC stimulation, between DLB compared to AD (p = .0013) and HC (p = .0032). DLPFC N45 presented a significant stimulation site effect not associated to a specific group in addition to DLPFC N45 amplitude being correlated to the UPDRS-III score (r = 0.9, p = .0002). A relative higher left over right DLPFC P30 amplitude was correlated with poorer MoCA scores in AD (r = -0.84, p = .002), as indicated by others before.ConclusionsDLPFC may be a target for both diagnosis and assessment of severity of motor symptoms in DLB and cognitive impairment in AD. These results propose a promising method to non-invasively distinguish DLB from AD and monitor disease, based on DLPFC and V1 network characteristics.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594261452759"},"PeriodicalIF":1.7,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thalamocortical Auditory Processing Across the Lifespan: A Study with Speech-Evoked Cortical Potentials. 终生的丘脑皮质听觉加工：言语诱发皮层电位的研究。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-05-01 Epub Date: 2025-09-05 DOI: 10.1177/15500594251374772

Pamela Papile Lunardelo, Marisa Tomoe Hebihara Fukuda, Bianca Tonsic Carmona, Laura Caetano Meneghelli, Patrícia Aparecida Zuanetti, Ângela Cristina Pontes-Fernandes, Sthella Zanchetta

{"title":"Thalamocortical Auditory Processing Across the Lifespan: A Study with Speech-Evoked Cortical Potentials.","authors":"Pamela Papile Lunardelo, Marisa Tomoe Hebihara Fukuda, Bianca Tonsic Carmona, Laura Caetano Meneghelli, Patrícia Aparecida Zuanetti, Ângela Cristina Pontes-Fernandes, Sthella Zanchetta","doi":"10.1177/15500594251374772","DOIUrl":"10.1177/15500594251374772","url":null,"abstract":"ObjectiveThis cross-sectional study aimed to identify electrophysiological markers distinguishing stages of development, stability, and early aging in cortical auditory processing to elucidate neurophysiological changes in healthy auditory aging.MethodsWe evaluated 149 healthy participants (both sexes; aged 7-59 years) recruited from the general community via electronic media, posters, radio, and regional television, divided into six age groups (7-11, 12-17, 18-29, 30-39, 40-49, and 50-59 years). Eligibility criteria included normal hearing, no neurological disorders, and normal otoscopy. Cortical auditory evoked potentials (CAEPs) were recorded using the syllable /da/ (binaural stimulation, 70 dB HL) with eye-movement control.ResultsSignificant differences in P1 latency were observed between children (7-11 years) and older participants (12-59 years). N1 latency differed between children and adults (30-59 years), while N1 amplitude varied between adolescents (12-19 years) and adults aged 40-49 years. P1-N1 latency differed between adolescents and adults aged 40-59 years. Age correlated moderately negatively with P1/N1 latencies and weakly positively with N1 amplitude.ConclusionMaturational changes in P1/N1 latencies were evident, but no decline occurred during adulthood or pre-senescence, suggesting stable auditory processing until at least age 59.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"241-249"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring Brain Activity with EEG Source Localization in Rituximab-Treated Anti-NMDAR Encephalitis: A Case Study. 用脑电图源定位监测利妥昔单抗治疗的抗nmdar脑炎的脑活动：一个案例研究。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-05-01 Epub Date: 2025-10-29 DOI: 10.1177/15500594251387165

Ge Dang, Bo Hu, Gang Li, Jing Han, Lin Zhu, Yi Guo

{"title":"Monitoring Brain Activity with EEG Source Localization in Rituximab-Treated Anti-NMDAR Encephalitis: A Case Study.","authors":"Ge Dang, Bo Hu, Gang Li, Jing Han, Lin Zhu, Yi Guo","doi":"10.1177/15500594251387165","DOIUrl":"10.1177/15500594251387165","url":null,"abstract":"Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a severe autoimmune encephalitis that often demonstrates a favorable response to immunotherapy, including rituximab. While disease outcomes have been widely documented, longitudinal characterization of brain activity changes following treatment remains limited. Electroencephalography (EEG) source localization provides a non-invasive approach for assessing regional brain dynamics. We report a case of a 17-year-old male patient with anti-NMDAR encephalitis who underwent serial EEG recordings before and after rituximab administration, with source power spectral density analysis performed. Symptom improvement following rituximab corresponded with reductions in cortical and subcortical delta power alongside increases in cortical alpha power, while transient symptom exacerbation was associated with elevated delta and diminished alpha activity in the cortex. Cerebellar activity alterations were not observed alongside symptom variations. Moreover, pre-treatment EEG revealed extensive delta band activity in the right hemisphere, with right-sided hypermetabolism observed on 18F-FDG PET/CT. These findings underscore the potential of source-localized EEG as a promising tool for region-specific monitoring of brain activity in NMDAR encephalitis, warranting rigorous validation in larger patient cohorts.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"259-264"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reappraisal of Palinopsia as a Disregarded Symptom in Epilepsy: A Case Report and Systematic Review of the Related EEG Findings. 重新评估Palinopsia作为癫痫的一种被忽视的症状：一个病例报告和相关脑电图结果的系统回顾。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-05-01 Epub Date: 2025-09-02 DOI: 10.1177/15500594251371782

Ozgun Yetkin, Hande Yuceer Korkmaz, Betul Baykan

{"title":"Reappraisal of Palinopsia as a Disregarded Symptom in Epilepsy: A Case Report and Systematic Review of the Related EEG Findings.","authors":"Ozgun Yetkin, Hande Yuceer Korkmaz, Betul Baykan","doi":"10.1177/15500594251371782","DOIUrl":"10.1177/15500594251371782","url":null,"abstract":"ObjectiveTo present a case of epileptic palinopsia successfully treated with lamotrigine and systematically review EEG findings, clinical features, and treatment outcomes of epileptic palinopsia.MethodsWe report a 58-year-old male with right occipital hemorrhage who developed seizures characterized by palinoptic phenomena four years post-injury. A systematic review of available cases was conducted using PRISMA guidelines and multiple databases (PubMed, Scopus, Embase, and Web of Science) through December 2024.ResultsThe patient's seizures included visual perseveration followed by bilateral tonic-clonic activity and achieved a >50% reduction in palinoptic phenomena with lamotrigine treatment over 20 months. Interictal EEG showed sharp and slow wave activity in the right temporal region, while MRI revealed right occipital encephalomalacia. The systematic review identified 40 cases from 34 articles (mean age 50.56 ± 16.10 years, 65.0% male). Interictal EEG abnormalities were present in 70.0% of cases, predominantly spikes/sharp waves (60.7%) localized to the right temporal and occipital regions. Ictal EEG recordings were available in 22.5% of cases. Both interictal (71.4%) and ictal (71.4%) findings demonstrated right-hemisphere predominance, particularly in the occipital region (30% of all cases, with 58.3% being right-sided). Structural abnormalities were identified in 26 cases, with tumors (42.3%) being the most common etiology. Anti-seizure drugs were prescribed in 57.5% of cases.ConclusionOur study highlights palinopsia as an overlooked seizure symptom with potential right hemispheric lateralization. Recognizing its EEG and neuroimaging patterns is essential for early diagnosis and treatment. Clinicians should maintain a high suspicion for epileptic palinopsia in patients with structural brain lesions involving temporo-occipital regions.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"271-284"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Effects of Z-Score Neurofeedback Training in PTSD: A Preliminary Investigation. Z-Score神经反馈训练对PTSD治疗效果的初步研究。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-05-01 Epub Date: 2025-10-09 DOI: 10.1177/15500594251382655

Sungjin Im

{"title":"Exploring the Effects of Z-Score Neurofeedback Training in PTSD: A Preliminary Investigation.","authors":"Sungjin Im","doi":"10.1177/15500594251382655","DOIUrl":"10.1177/15500594251382655","url":null,"abstract":"Neurofeedback, a form of biofeedback using electroencephalography, enables individuals to self-regulate brain activity through operant conditioning. This technique shows promise as a non-invasive intervention for neuropsychiatric disorders like post-traumatic stress disorder (PTSD) and may improve cognitive functions such as attention and working memory. However, limited research, particularly using Z-Score neurofeedback, exists on its effects on PTSD-related symptoms, cognitive function, and identifying treatment-specific EEG markers. In this study, twenty-one individuals diagnosed with PTSD (17 females; mean age = 26.02 [SD = 9.51]) received a diagnostic interview using the MINI Neuropsychiatric Interview and completed self-report measures on PTSD, depression, and insomnia symptoms. Participants completed 5-min eyes-open and eyes-closed EEG recordings and received 10 20-min Z-scoring neurofeedback sessions. Results indicated significant reductions in PTSD and insomnia symptoms, with the most pronounced effects observed in intrusion, negative alterations in cognition and mood, and arousal/reactivity symptoms. Additionally, executive attention improved post-treatment. Alterations in cognition and mood were negatively correlated with alpha power globally and positively correlated with beta power in the parietal region. Beta power at T3 significantly decreased following neurofeedback training. These findings provide further support for neurofeedback as a viable intervention for PTSD, with implications for both symptom reduction and cognitive enhancement. Future studies are needed to investigate individual differences in treatment response and assess long-term outcomes to improve the clinical applicability of this approach.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"230-240"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal Study of P3a Potential in First-Episode Schizophrenia. 首发精神分裂症患者P3a电位的纵向研究。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-05-01 Epub Date: 2025-09-12 DOI: 10.1177/15500594251376389

Müge Devrim-Üçok, Betül Kıvanç-İnanöz, Yasemin Keskin-Ergen, Alp Üçok

{"title":"Longitudinal Study of P3a Potential in First-Episode Schizophrenia.","authors":"Müge Devrim-Üçok, Betül Kıvanç-İnanöz, Yasemin Keskin-Ergen, Alp Üçok","doi":"10.1177/15500594251376389","DOIUrl":"10.1177/15500594251376389","url":null,"abstract":"P3a is an event-related potential that reflects the involuntary orienting of attention to salient stimuli. Abnormalities in P3a have been described in schizophrenia, but it is not known when they arise over the course of illness and whether they are progressive. Previous longitudinal studies of P3a have been inconclusive because of the heterogeneity in the diagnosis of psychotic patients, lack of follow-up data on controls, and relatively short follow-up periods. P3a, elicited by novel sounds, was assessed in 21 patients with first-episode schizophrenia and 36 healthy controls at baseline and reassessed in 14 patients and 23 controls after an average follow-up of six years. The longitudinal evaluation showed that the P3a amplitude was reduced in patients compared to controls at baseline but did not differ between groups at follow-up. Although P3a was reduced over the six-year interval in both groups, the reduction was greater in controls compared to patients. Longitudinal findings suggest that the P3a amplitude deficit is present at the onset of schizophrenia. Normalization of P3a amplitudes in patients at follow-up may reflect the premature aging effect on P3a at the onset of illness, a floor effect in P3a amplitudes of both groups at follow-up, or the reversal of the P3a deficit in patients over time. Interestingly, at baseline, the P3a amplitude in patients without follow-up data did not differ from controls and was greater than in patients with follow-up data. Baseline findings indicate a heterogeneity within the first-episode schizophrenia group.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"220-229"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epileptic Networks Underlying Ictal Swearing: Evidence from a Stereoelectroencephalography Case Report. 癫痫网络潜在的咒骂：来自立体脑电图病例报告的证据。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-05-01 Epub Date: 2025-12-30 DOI: 10.1177/15500594251410726

Xinyi Liang, Yanfeng Xie, Li Jiang, Wei Dan

引用次数: 0

Investigating the Effect of Cognitive Rehabilitation on Cognitive Impairment Associated With Antiseizure Medications in Patients With Epilepsy. 研究认知康复对癫痫患者抗癫痫药物相关认知功能障碍的影响。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-05-01 Epub Date: 2025-10-08 DOI: 10.1177/15500594251376071

Akçay Övünç Karadaş, Javid Shafiyev, Ömer Karadaş, Çağla Karadaş, Uğur Burak Şimşek, Betül Özenç, Özlem Aksoy Özmenek

{"title":"Investigating the Effect of Cognitive Rehabilitation on Cognitive Impairment Associated With Antiseizure Medications in Patients With Epilepsy.","authors":"Akçay Övünç Karadaş, Javid Shafiyev, Ömer Karadaş, Çağla Karadaş, Uğur Burak Şimşek, Betül Özenç, Özlem Aksoy Özmenek","doi":"10.1177/15500594251376071","DOIUrl":"10.1177/15500594251376071","url":null,"abstract":"ObjectiveMost existing studies on cognitive rehabilitation in epilepsy focus on patients undergoing epilepsy surgery or classify interventions based on epilepsy type. This study aimed to determine whether antiseizure medications (ASMs) cause cognitive dysfunction in epilepsy patients by using neuropsychological assessments and auditory event-related potentials (ERPs), and whether cognitive rehabilitation can reduce this potential impact.Materials and MethodsThe study included patients scheduled to begin ASM monotherapy. All participants first underwent a face-to-face Montreal Cognitive Assessment (MoCA). Auditory ERPs including P300 and N200 latencies, and N2 to P3 peak-to-peak amplitudes were recorded in the electrophysiology laboratory. Patients were randomly divided into two groups: Group A (no cognitive rehabilitation) and Group B (received cognitive rehabilitation). After two months, both MoCA and auditory ERP measurements were repeated, and the results were statistically analyzed.ResultsIn Group A, patients using carbamazepine (CBZ), zonisamide (ZNS), or valproic acid (VPA) showed a statistically significant decline in MoCA scores and auditory ERP results (P < .05), suggesting a protective role of rehabilitation. For topiramate (TPM), cognitive decline was weakly significant even with rehabilitation (P = .031).","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"285-292"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deficits in Emotional Face Processing Indexed by N170 Modulation in Chronic and in First Hospitalized Schizophrenia. 慢性和首次住院精神分裂症患者N170调节诱发的情绪面孔加工缺陷

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-05-01 Epub Date: 2025-09-29 DOI: 10.1177/15500594251383030

Alfredo L Sklar, Rachel Kaskie, Dean F Salisbury

{"title":"Deficits in Emotional Face Processing Indexed by N170 Modulation in Chronic and in First Hospitalized Schizophrenia.","authors":"Alfredo L Sklar, Rachel Kaskie, Dean F Salisbury","doi":"10.1177/15500594251383030","DOIUrl":"10.1177/15500594251383030","url":null,"abstract":"IntroductionFacial emotion recognition is impaired in schizophrenia and contributes to profound social impairments. Healthy adults exhibit larger N170 amplitudes to emotional compared to neutral faces. Preliminary evidence suggests an inability to modulate N170 amplitude by emotional expression during chronic stages of the illness. The present investigation examined N170 modulation by emotion among patients with chronic (ChSz) and first hospitalized (FHSz) schizophrenia.MethodsEEG was recorded from 26 FHSz and 28 ChSz participants as well as 19 young (YC) and 21 older (OC) matched controls. Participants were asked to detect neutral faces among happy, angry, disgusted, fearful, and sad faces. N170 amplitudes were measured from P9/P10 electrodes. Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS).ResultsN170 amplitude modulation by facial emotion was observed across FHSz and YC (P < .001), though the typical right-hemisphere lateralization of this response observed in YC (P = .001) was absent in FHSz (P = .56). In contrast to OC (P = .009), ChSz did not exhibit N170 modulation by emotion (P = .32). Among ChSz, N170 modulation (mean N170 across emotional expressions minus N170 to neutral faces) at P9 were inversely correlated with PANSS negative scores (r = -.53).DiscussionResults suggests a progressive impairment of emotional facial expression processing as indexed by N170 modulation across illness stage. While losing the hemispheric specialization of face processing, FHSz exhibited preserved N170 amplitude modulation by facial emotion in contrast to ChSz. This deficit was also associated with negative symptoms, implicating progressive pathology of N170 generators in persistent and debilitating symptoms of the disorder.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"211-219"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Electrophysiological Characteristics and Prognosis of Childhood Occipital Visual Epilepsy in Light of Current ILAE Criteria. 儿童枕部视觉癫痫的临床、电生理特征及预后。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-05-01 Epub Date: 2025-10-01 DOI: 10.1177/15500594251376396

Miray Atacan Yaşgüçlükal, Bade Güleç, Doğukan Hazar Emre, Ayşe Deniz Elmalı, Özdem Ertürk Çetin, Ahmet Veysi Demirbilek

{"title":"Clinical and Electrophysiological Characteristics and Prognosis of Childhood Occipital Visual Epilepsy in Light of Current ILAE Criteria.","authors":"Miray Atacan Yaşgüçlükal, Bade Güleç, Doğukan Hazar Emre, Ayşe Deniz Elmalı, Özdem Ertürk Çetin, Ahmet Veysi Demirbilek","doi":"10.1177/15500594251376396","DOIUrl":"10.1177/15500594251376396","url":null,"abstract":"ObjectivesChildhood Occipital Visual Epilepsy (COVE) is a self-limited epileptic syndrome that typically begins in late childhood or adolescence characterized by brief visual seizures. The recent 2022 International League Against Epilepsy (ILAE) classification distinguishes COVE from photosensitive occipital lobe epilepsy (POLE), emphasizing the absence of photic-induced seizures in COVE. In this study, we aimed to describe the clinical and electrophysiological features of patients with COVE diagnosed according to the new ILAE criteria.MethodsThis retrospective cohort study analyzed 30 patients diagnosed with COVE at a tertiary epilepsy center between 1988 and 2023. Patients were selected based on ILAE 2022 criteria, and all cases with intermittent photic stimulation (IPS)-induced seizures were excluded.ResultsMost patients (93%) presented with elementary visual hallucinations, such as colorful lights. Orofacial seizures occurred in 7%, and 37% had nocturnal seizures. EEG abnormalities were primarily occipital and resolved in 85% of cases over time. Generalized spike-wave discharges (GSWDs) were rare (5%), and only one patient developed juvenile myoclonic epilepsy during follow-up. At final follow-up, 77% of patients achieved seizure freedom, and 47% discontinued medication.ConclusionCOVE is an epileptic syndrome associated with a favorable prognosis. By excluding photosensitivity in light of the newly proposed diagnostic criteria from the ILAE, future research should focus on a more homogenous group of COVE patients to enhance understanding of this syndrome. Accurate classification using updated ILAE criteria allows for clearer clinical delineation and more reliable outcome predictions.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"293-298"},"PeriodicalIF":1.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0