Marvin Krawutschke, Martin Teufel, Kira Schmidt, Saskia Pasche, Theresa Schweig, Anna Bialek, Axel Kowalski, Mitra Tewes, Martin Schuler, Dirk Schadendorf, Norbert Scherbaum, Eva-Maria Skoda, Madeleine Fink, Bernhard W Müller
{"title":"Neurofeedback Reduces P300 Amplitudes to Intensely Emotive Pictures in Depressed Cancer Patients.","authors":"Marvin Krawutschke, Martin Teufel, Kira Schmidt, Saskia Pasche, Theresa Schweig, Anna Bialek, Axel Kowalski, Mitra Tewes, Martin Schuler, Dirk Schadendorf, Norbert Scherbaum, Eva-Maria Skoda, Madeleine Fink, Bernhard W Müller","doi":"10.1177/15500594241287961","DOIUrl":"https://doi.org/10.1177/15500594241287961","url":null,"abstract":"<p><p><i>Objective.</i> Electroencephalographic neurofeedback (EEG NF) or its effects on event-related potentials (ERPs) in quantitative EEG have not yet been systematically studied in cancer patients. The aim of this study was to investigate the emotional arousal and valence effects on the event-related P300 in a visual oddball paradigm by an individualized EEG alpha and theta/beta NF intervention in cancer patients and survivors (<i>N </i>= 18, age between 31 and 73 years). <i>Methods</i>. ERPs to low and high arousal target stimuli with either emotional positive or negative content and depressive state were obtained in cancer patients before and after a five-week NF intervention in a waitlist paradigm, following the consensus on the reporting and experimental design of clinical and cognitive-behavioral NF studies (CRED-nf checklist). <i>Results</i>. Overall, P300 amplitudes decreased significantly (<i>p </i>< .05) from pre to post therapy. Effects concerning high arousal stimuli with negative and positive valences were on the border to significance. Moreover, patients achieved significant relief of depressive symptoms (<i>p </i>< .05). Especially younger participants (<55 yrs.) benefited. <i>Conclusions</i>. P300 observations could reflect a therapeutic effect on brain activity level. EEG NF alleviates depressive symptoms in cancer patients. <i>Significance</i>. Based on these findings, further studies are needed to investigate the effects on event-related potentials by NF therapy.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241287961"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142483189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EEG Oscillatory Activity and Resting-State Networks Associated with Neurocognitive Function in Mild Traumatic Brain Injury.","authors":"Masaya Ueda, Keita Ueno, Takuma Yuri, Yasunori Aoki, Masahiro Hata, Takao Inoue, Ryouhei Ishii, Yasuo Naito","doi":"10.1177/15500594241290858","DOIUrl":"https://doi.org/10.1177/15500594241290858","url":null,"abstract":"<p><p>This study aimed to investigate the characteristics of resting-state electroencephalography (EEG) activity and brain networks in patients with mild traumatic brain injury (mTBI) and their association with neurocognitive function (NCF). We analyzed 26 patients with subacute mTBI and 21 healthy controls. The subacute mTBI group (9 females, 17 males) had a mean age of 29.9 ± 9.9 years, and the healthy controls (11 females, 10 males) had a mean age of 29.7 ± 11.5 years. Current source density, lagged phase synchronization, and resting-state network activity were analyzed using exact low-resolution electromagnetic tomography (eLORETA) with 60 s resting-state EEG data. In addition, a correlation analysis was performed between these EEG parameters and NCF in patients with mTBI. We used the statistical nonparametric mapping method in eLORETA to correct for multiple comparisons. There were no significant differences in EEG parameters between the patients with mTBI and healthy controls. However, in patients with mTBI, correlation analysis revealed negative correlations between theta activity in the anterior cingulate cortex and verbal short-term memory and between activity in the memory perception network and verbal memory. Our findings suggest that resting-state EEG may be clinically useful in investigating the mechanism of NCF decline in patients with mTBI.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241290858"},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142483188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simultaneous Infantile Spasms and Focal Seizures: A Rarely Reported Combined Seizure Phenomenon on Video Electroencephalogram (VEEG).","authors":"Katherine Horman, Sonal Bhatia","doi":"10.1177/15500594241289637","DOIUrl":"https://doi.org/10.1177/15500594241289637","url":null,"abstract":"<p><p>Focal seizures (FS) have previously been described before or after infantile spasm (IS) clusters, but FS occurring simultaneously with an IS cluster has been rarely reported in the EEG literature. We present three cases where focal seizures (FS) occurred concurrently during an infantile spasm (IS) cluster on VEEG. On VEEG, onset of IS cluster preceded FS in all three patients; however, patient three was diagnosed with FS prior to the onset of IS. FS duration ranged from 10-90 s and was electrographic-only in two out of the three patients. Unfortunately, the first two patients are now deceased, and for patient two no etiology was ever identified. Currently, patient three is free of spasms as well as seizures but has global developmental delay; no definite etiology has been identified for their presentation. Concurrent FS with IS suggests that the seizure types may be generated in different brain areas with one seizure type potentially triggering the other and is generally reflective of multifocal or diffuse cerebral disease with a poor prognosis as was seen in at least two of our patients. Our three cases of IS where FS occurred concurrently contribute to the limited existing data describing this phenomenon on VEEG.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241289637"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142483190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electrophysiological and Cognitive Changes in Hard Coal Miners Associated with Working Underground.","authors":"Samet Çelik, Ebru Yıldırım, Bahar Güntekin","doi":"10.1177/15500594241237912","DOIUrl":"10.1177/15500594241237912","url":null,"abstract":"<p><p>Miners working underground face some risk factors that affect the nervous system-such as high noise, dark environment, chronic stress, and exposure to toxic gases. However, it is not known whether these risk factors affect the cognition of miners. In this study, the cognitive changes of miners were examined through event-related oscillations via electroencephalogram (EEG). Twenty underground miners and control groups, equal to each other in age, education level, and working duration, participated in this study. Neuropsychological tests were applied to all participants to examine their cognitive characteristics. Then, 20-channel EEG was recorded for electrophysiological changes during visual oddball paradigm. Event-related power spectrum and phase locking were analyzed in delta (0.5-3.5), theta (4-7), and alpha (8-13 Hz) frequency bands. It was determined that the delta responses that emerged during the target stimulus differed between the two groups in terms of phase locking (p < 0.05). Considering event-related alpha responses, a statistical difference was found regarding power spectrum and phase locking (p < 0.05). Moreover, the alpha power spectrum in the miners was found to be negatively statistically correlated with working duration (p < 0.05). This study determined that the event-related electrophysiological responses of the miners were negatively affected depending on the working conditions. In addition, neuropsychological assessment determined miners had deficiencies in learning and memory skills and many other cognitive functions such as attention, behavioral inhibition, and visual perception.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"561-571"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140133626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Portable Headband Electroencephalogram in the Detection of Absence Epilepsy.","authors":"Douglas R Nordli, Kaila Fives, Fernando Galan","doi":"10.1177/15500594241229153","DOIUrl":"10.1177/15500594241229153","url":null,"abstract":"<p><p>The accuracy of headband electroencephalogram (EEG) was compared to traditional EEG in pediatric patients with absence epilepsy. This study enrolled 10 patients with previously diagnosed absence epilepsy and examined the concordance of headband EEG and traditional EEG in the follow-up EEG of treated absence epilepsy. The study found a concordant result in 80% of cases providing a signal that absence epilepsy is an effective target for headband EEG. The study showcases a need for further research in headband EEG technology and continued improvements in technology.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"581-585"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuba Guney, Mert Demirel, Ulufer Celebi, Kudret Aytemir, F Irsel Tezer, Cem Coteli, Hikmet Yorgun, Serap Saygi
{"title":"Ictal Asystole During Focal Seizures Due to Left Occipital Glioneuronal Tumor: A Report of Case Treated With Cardiac Neuromodulation.","authors":"Tuba Guney, Mert Demirel, Ulufer Celebi, Kudret Aytemir, F Irsel Tezer, Cem Coteli, Hikmet Yorgun, Serap Saygi","doi":"10.1177/15500594241234831","DOIUrl":"10.1177/15500594241234831","url":null,"abstract":"<p><p>Ictal asystole (IA) is a rare but potentially life-threatening complication of focal epilepsy. The sudden onset of loss of consciousness and drop attacks in a patient with chronic epilepsy should suggest the possibility of this complication. Once the diagnosis is established, rapid management should be considered, especially in high-risk cases. The approach does not differ between temporal and extratemporal lobe epilepsies. Strategies can be aimed at preventing the emergence of cortical epileptic activity from the beginning (surgery, antiseizure therapy), neutralizing negative chronotropic effects on the heart (cardiac neuromodulation), or restarting the heart rhythm with a pacemaker. Pacemaker implantation is not a completely complication-free treatment, and living with a device that requires care and follow-up throughout life makes alternative treatment methods more valid for young patients with many years to live or cases that could benefit from surgery. In this article, we present a patient with a left occipital glioneuronal tumor and drug-resistant occipital lobe epilepsy. IA was documented by long-term video EEG monitoring (VEM). During about 2 years of follow-up after a cardiac neuromodulation procedure, there were no drop attacks or asystole with seizures, confirmed by long-term VEM.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"586-590"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alireza Faridi, Farhad Taremian, Robert W Thatcher
{"title":"Effectiveness of Low-Resolution Brain Electromagnetic Tomography Z Score Neurofeedback Comparison with Cognitive Rehabilitation in Depression and Anxiety in Opioid Use Disorder.","authors":"Alireza Faridi, Farhad Taremian, Robert W Thatcher","doi":"10.1177/15500594241229194","DOIUrl":"10.1177/15500594241229194","url":null,"abstract":"<p><p><b>Background:</b> Previous studies have shown that conventional neurofeedback (NFB) and cognitive rehabilitation can improve psychological outcomes in people with opioid use disorders (OUDs). However, the effectiveness of Low-Resolution Brain Electromagnetic Tomography (LORETA) Z-score neurofeedback (LZNFB) and attention bias modification training (ABMT) on depression and anxiety of these people has not been investigated yet. The present study aims to compare the effect of these two methods on depression and anxiety of men with OUD under methadone maintenance therapy (MMT). <b>Methods:</b> In this randomized controlled clinical trial with a pre-test, post-test, and follow-up design, 30 men with OUD under MMT were randomly assigned into three groups of LZNFB, ABMT, and control (MMT alone). The LZNFB group underwent LZNFB at 20 sessions. The ABMT using the dot-probe task was provided individually to the second group for 2 weeks at 15 sessions. The Beck Anxiety Inventory and the Beck Depression Inventory were completed by the participants before, immediately after, and 1-month after interventions. The collected data were analyzed in SPSS v.22 software. <b>Results:</b> Both intervention groups showed a significant reduction in anxiety and depression at the post-test phase (p < 0.05), where LZNFB group showed more decrease in anxiety and depression than the ABMT group. This decrease continued in the follow-up period. <b>Conclusion:</b> Both LZNFB and ABMT with the dot-robe task are effective in reducing depression and anxiety of men with OUD under MMT. However, LZNFB is more effective. These findings add to the growing body of literature supporting the effectiveness of NFB and cognitive rehabilitation therapy in treating addiction-related comorbidities.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"553-560"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139914263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hyperventilation Induced Seizures in Focal Epilepsy: Two Cases and a Review of Literature.","authors":"Anna Milan, Majed Alzahrany, Ajay Gupta","doi":"10.1177/15500594231222982","DOIUrl":"10.1177/15500594231222982","url":null,"abstract":"<p><p>We report two cases of temporo-perisylvian epilepsy with habitual seizures consistently inducible by hyperventilation (HV). One case was non-lesional, while the other was a lesional temporo-perisylvian epilepsy. Both underwent surgical resection and were seizure-free or nearly seizure-free thereafter. We discuss the pathophysiological changes evoked by HV in healthy brains, and those with generalized and focal epilepsy. We provide a comprehensive and critical review of the literature on the role of HV in focal epilepsy. We suggest HV should be considered an activation method for patients with focal epilepsy during epilepsy monitoring unit admissions and may help in the localization of the epileptogenic network/zone.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"576-580"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139081174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiheon Kim, Seungchan Park, Hansol Kim, Daeyoung Roh, Do Hoon Kim
{"title":"Home-based, Remotely Supervised, 6-Week tDCS in Patients With Both MCI and Depression: A Randomized Double-Blind Placebo-Controlled Trial.","authors":"Jiheon Kim, Seungchan Park, Hansol Kim, Daeyoung Roh, Do Hoon Kim","doi":"10.1177/15500594231215847","DOIUrl":"10.1177/15500594231215847","url":null,"abstract":"<p><p>As depressive symptom is considered a prodrome, a risk factor for progression from mild cognitive impairment (MCI) to dementia, improving depressive symptoms should be considered a clinical priority in patients with MCI undergoing transcranial direct current stimulation (tDCS) intervention. We aimed to comprehensively evaluate the efficacy of the home-based and remotely monitored tDCS in patients with both MCI and depression, by integrating cognitive, psychological, and electrophysiological indicators. In a 6-week, randomized, double blind, and sham-controlled study, 37 community-dwelling patients were randomly assigned to either an active or a sham stimulation group, and received 30 home-based sessions of 2 mA tDCS for 30 min with the anode located over the left and cathode over the right dorsolateral prefrontal cortex. We measured depressive symptoms, neurocognitive function, and resting-state electroencephalography. In terms of effects of both depressive symptoms and cognitive functions, active tDCS was not significantly different from sham tDCS. However, compared to sham stimulation, active tDCS decreased and increased the activation of delta and beta frequencies, respectively. Moreover, the increase in beta activity was correlated with the cognitive enhancement only in the active group. It was not possible to reach a definitive conclusion regarding the efficacy of tDCS on depression and cognition in patients with both MCI and depression. Nevertheless, the relationship between the changes of electrophysiology and cognitive performance suggests potential neuroplasticity enhancement implicated in cognitive processes by tDCS.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"531-542"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138813399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shams Farhad, Sinem Zeynep Metin, Çağlar Uyulan, Sahar Taghi Zadeh Makouei, Barış Metin, Türker Tekin Ergüzel, Nevzat Tarhan
{"title":"Application of Hybrid DeepLearning Architectures for Identification of Individuals with Obsessive Compulsive Disorder Based on EEG Data.","authors":"Shams Farhad, Sinem Zeynep Metin, Çağlar Uyulan, Sahar Taghi Zadeh Makouei, Barış Metin, Türker Tekin Ergüzel, Nevzat Tarhan","doi":"10.1177/15500594231222980","DOIUrl":"10.1177/15500594231222980","url":null,"abstract":"<p><p><b>Objective:</b> Obsessive-compulsive disorder (OCD) is a highly common psychiatric disorder. The symptoms of this condition overlap and co-occur with those of other psychiatric illnesses, making diagnosis difficult. The availability of biomarkers could be useful for aiding in diagnosis, although prior neuroimaging studies were unable to provide such biomarkers. <b>Method:</b> In this study, patients with OCD were classified from healthy controls using 2 different hybrid deep learning models: one-dimensional convolutional neural networks (1DCNN) together with long-short term memory (LSTM) and gradient recurrent units (GRU), respectively. <b>Results:</b> Both models exhibited exceptional classification accuracies in cross-validation and external validation phases. The mean classification accuracies in the cross-validation stage were 90.88% and 85.91% for the 1DCNN-LSTM and 1DCNN-GRU models, respectively. The inferior frontal, temporal, and occipital electrodes were predominant in providing discriminative features. <b>Conclusion:</b> Our findings underscore the potential of hybrid deep learning architectures utilizing EEG data to effectively differentiate patients with OCD from healthy controls. This promising approach holds implications for advancing clinical decision-making by offering valuable insights into diagnostic markers for OCD.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"543-552"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139405656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}