Clinical EEG and neuroscience最新文献

qEEG Neuromarkers of Complex Childhood Trauma in Adolescents. 青少年复杂童年创伤的qEEG神经标志物。

Clinical EEG and neuroscience Pub Date : 2025-01-17 DOI: 10.1177/15500594241309456

Gabriela Mariana Marcu, Raluca D Szekely-Copîndean, Andrei Dumbravă, Ainat Rogel, Ana-Maria Zăgrean

{"title":"qEEG Neuromarkers of Complex Childhood Trauma in Adolescents.","authors":"Gabriela Mariana Marcu, Raluca D Szekely-Copîndean, Andrei Dumbravă, Ainat Rogel, Ana-Maria Zăgrean","doi":"10.1177/15500594241309456","DOIUrl":"https://doi.org/10.1177/15500594241309456","url":null,"abstract":"Introduction. Complex childhood trauma (CCT) involves prolonged exposure to severe interpersonal stressors, leading to deficits in executive functioning and self-regulation during adolescence, a critical period for neurodevelopment. While qEEG parameters, particularly alpha oscillations, have been proposed as potential biomarkers for trauma, empirical documentation in developmental samples is limited. Aim. This preregistered study investigated whether adolescents with CCT exhibit qEEG patterns similar to those reported for PTSD, such as reduced posterior alpha power, increased individual alpha peak frequency (iAPF), right-lateralized alpha frequencies, and lower total EEG power (RMS) compared to controls. Materials and Methods. EEG data from 26 trauma-exposed adolescents and 28 controls, sourced from an open database, underwent similar preprocessing. qEEG features, including alpha power, iAPF, alpha asymmetry, and RMS, were extracted from eyes-open and eyes-closed conditions and analyzed using mixed ANOVAs. Results. Significant group differences were found in total EEG power, with trauma-exposed adolescents showing lower RMS than controls. No significant differences were found in posterior absolute alpha power, iAPF, or alpha asymmetry. However, we observed that posterior relative alpha power was higher in the trauma group, though the difference was not statistically significant but showing a small to medium effect size. Additionally, a negative correlation between CPTSD severity and EEG power in the EO condition was observed, suggesting trauma-related cortical hypoactivation. Conclusion. Reduced total EEG power and modified alpha dynamics may serve as candidate neuromarkers of CCT. These findings underscore the need for further research to validate qEEG biomarkers for understanding and diagnosing trauma-related disorders in developmental populations.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241309456"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The P200 ERP Response in Mild Cognitive Impairment and the Aging Population. 轻度认知障碍与老年人群的P200 ERP反应。

Clinical EEG and neuroscience Pub Date : 2025-01-10 DOI: 10.1177/15500594241310533

David Oakley, David Joffe, Francis Palermo, Marta Spada, Sanjay Yathiraj

{"title":"The P200 ERP Response in Mild Cognitive Impairment and the Aging Population.","authors":"David Oakley, David Joffe, Francis Palermo, Marta Spada, Sanjay Yathiraj","doi":"10.1177/15500594241310533","DOIUrl":"https://doi.org/10.1177/15500594241310533","url":null,"abstract":"Evoked potential metrics extracted from an EEG exam can provide novel sources of information regarding brain function. While the P300 occurring around 300 ms post-stimulus has been extensively investigated in relation to mild cognitive impairment (MCI), with decreased amplitude and increased latency, the P200 response has not, particularly in an oddball-stimulus paradigm. This study compares the auditory P200 amplitudes between MCI (28 patients aged 74(8)) and non-MCI, (35 aged 72(4)). Data were collected in routine clinical evaluations where EEG with audio oddball ERPs were measured as part of a health screening exam from 2 clinics serving MCI patients and one clinic serving a non-MCI population as part of a wellness/preventative care program. We also investigated the disease course for 3 patients as case studies. The results revealed the P200 amplitudes to be significantly increased in the MCI compared to the non-MCI groups, alongside the expected reduction in P300, Trail Making, and reaction time. Moreover, the ratio of P200-to-P300 was also increased in the MCI groups even in cases where the P300 was strong. This trend continued for patients who were tracked from early-to-later stages in the case studies. While the pathophysiology of the P200 response in a 2-tone auditory oddball protocol is not well understood, this measure may help indicate signs of early MCI, particularly in cases where the P300 is still strong.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241310533"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monitoring the Response of Treatment in Major Depressive Disorder with EEG: Could it be an Indicator of Returning to Health in Responders. 脑电图监测重度抑郁症治疗反应：能否作为应答者恢复健康的指标？

Clinical EEG and neuroscience Pub Date : 2025-01-08 DOI: 10.1177/15500594241310949

Mehmet Kemal Arıkan, Şakir Gıca, Reyhan İlhan, Özden Orhan, Öznur Kalaba, Mehmet Güven Günver

{"title":"Monitoring the Response of Treatment in Major Depressive Disorder with EEG: Could it be an Indicator of Returning to Health in Responders.","authors":"Mehmet Kemal Arıkan, Şakir Gıca, Reyhan İlhan, Özden Orhan, Öznur Kalaba, Mehmet Güven Günver","doi":"10.1177/15500594241310949","DOIUrl":"https://doi.org/10.1177/15500594241310949","url":null,"abstract":"Background: Quantitative electroencephalography (qEEG) data can facilitate the monitoring of treatment progress and the evaluation of therapeutic responses in patients with Major Depressive Disorder (MDD). This study aims to compare the qEEG data of MDD patients and healthy controls, both before and after treatment, to assess the effect of treatment response on neural activity. Methods: A total of 72 patients, aged 18-60, who had not used any psychopharmacological medication for at least two weeks, were included in the study. Based on a minimum 50% reduction in scores on the Hamilton Depression Rating Scale (HDRS-17) and Hamilton Anxiety Rating Scale (HARS), the patients were divided into two groups: responders (n = 51) and non-responders (n = 21). qEEG data were recorded before and after treatment. Results: Responders exhibited a significant shift in cortical activity-particularly in theta, alpha, and high-beta power-toward patterns resembling those observed in the healthy control group (improvement range: 15% to 67%). In contrast, non-responders showed minimal changes in cortical activity (improvement range: 38% to 46%). These findings suggest that while qEEG spectral data reflect marked neural changes in responders, no significant alterations occur in non-responders. Conclusion: The use of qEEG spectral analysis to monitor MDD patients provides valuable insights into treatment efficacy. The distinct patterns of cortical activity observed across most brain regions before treatment, compared to healthy individuals, highlight the potential of qEEG to predict treatment outcomes.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241310949"},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Electroencephalography Following CAR-T Cell Therapy in Clinical Practice. CAR-T细胞治疗后脑电图在临床实践中的作用。

Clinical EEG and neuroscience Pub Date : 2025-01-08 DOI: 10.1177/15500594241312451

Alexander J Matthews, Fiona E Starkie, Lydia E Staniaszek, Nicholas M Kane

{"title":"The Role of Electroencephalography Following CAR-T Cell Therapy in Clinical Practice.","authors":"Alexander J Matthews, Fiona E Starkie, Lydia E Staniaszek, Nicholas M Kane","doi":"10.1177/15500594241312451","DOIUrl":"https://doi.org/10.1177/15500594241312451","url":null,"abstract":"Objectives:Neurotoxicity, encephalopathy, and seizures can occur following chimeric antigen receptor (CAR)-T cell therapy. Our aim was to assess what value electroencephalography (EEG) offers for people undergoing CAR-T treatment in clinical practice, including possible diagnostic, management, and prognostic roles. Methods: All patients developing CAR-T related neurotoxicity referred for EEG were eligible for inclusion. Reasons for EEG referral and qualitative EEG findings were analysed and reported. The relationship between objective quantitative EEG (QEEG) encephalopathy grade and clinical neurotoxicity (immune effector cell-associated neurotoxicity syndrome; ICANS) grade was determined. The prognostic ability of QEEG grade was assessed for survival and functional status. Results: Twenty-eight patients with 53 EEG recordings were included. Common reasons given on EEG referrals were possible seizure diagnosis (n = 38), reduced consciousness (n = 8), and superimposed cerebral infection (n = 4). Four focal seizures were detected on three (3/53; 5.7%) EEGs. There was a moderately positive correlation between QEEG grade and ICANS grade (r = + 0.41, p = .030). QEEG grade could not predict survival at 3 months (Area Under Curve; AUC = 0.673) or 6 months (AUC = 0.578), nor could it predict functional status at 1 month (r = + 0.40; p = .080), 3 months (r = + 0.19; p = .439), or time to return to baseline (r = + 0.32; p = .156). Conclusions: EEG was useful in seizure diagnosis. QEEG has a possible role as a specific biomarker of encephalopathy/neurotoxicity. EEG generated no tangible changes in patient management. QEEG was unable to prognosticate survival or functional status.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241312451"},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NRXN2 Homozygous Variant Identified in a Family with Global Developmental Delay, Severe Intellectual Disability, EEG Abnormalities and Speech Delay: A new Syndrome? NRXN2纯合变异在一个整体发育迟缓、严重智力残疾、脑电图异常和语言迟缓的家庭中被发现：一种新的综合征？

Clinical EEG and neuroscience Pub Date : 2025-01-02 DOI: 10.1177/15500594241309948

Derya Karaer, Ayşe Aysima Özçelik, Kadri Karaer

{"title":"NRXN2 Homozygous Variant Identified in a Family with Global Developmental Delay, Severe Intellectual Disability, EEG Abnormalities and Speech Delay: A new Syndrome?","authors":"Derya Karaer, Ayşe Aysima Özçelik, Kadri Karaer","doi":"10.1177/15500594241309948","DOIUrl":"https://doi.org/10.1177/15500594241309948","url":null,"abstract":"Background. This study aims to characterize the clinical phenotype of a family with two siblings exhibiting neurological manifestations, utilizing whole exome sequencing (WES) to identify potential pathogenic variants within the NRXN2 gene. Methods. A consanguineous family with two affected siblings displaying developmental delay, severe intellectual disability, epilepsy, and speech delay was examined. WES was performed on DNA samples from affected and unaffected family members, followed by a comprehensive bioinformatics analysis. In-silico tools were employed for variant interpretation and structural modeling of the NRXN2 protein. Clinical and genetic data were integrated to elucidate the potential impact of the identified variant. Results. WES revealed a novel homozygous missense variant (c.1475T>G, p.Leu492Arg) in the NRXN2 gene in both affected siblings. This variant was absent in healthy family members and public databases. In-silico analysis predicted a detrimental effect on protein function. Parental segregation confirmed heterozygous carrier status. The variant was classified as 'Likely Pathogenic' based on ACMG/AMP criteria. Conclusion. This study identifies a novel homozygous missense variant in NRXN2 associated with global developmental delay, severe intellectual disability, speech delay and epilepsy. The findings underscore the critical role of NRXN2 in neurodevelopment and highlight the potential implications of genetic variations within this gene in neurodevelopmental disorders. Further research and functional validation are warranted to deepen our understanding of NRXN2-related disorders and explore potential therapeutic interventions.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241309948"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contextualised Processing of Stimuli Modulates Auditory Mismatch Responses in the Rat. 刺激的情境化处理调节大鼠的听觉错配反应

Clinical EEG and neuroscience Pub Date : 2025-01-01 Epub Date: 2024-11-20 DOI: 10.1177/15500594241300726

Jaishree Jalewa, Juanita Todd, Patricia T Michie, Deborah M Hodgson, Lauren Harms

{"title":"Contextualised Processing of Stimuli Modulates Auditory Mismatch Responses in the Rat.","authors":"Jaishree Jalewa, Juanita Todd, Patricia T Michie, Deborah M Hodgson, Lauren Harms","doi":"10.1177/15500594241300726","DOIUrl":"10.1177/15500594241300726","url":null,"abstract":"Mismatch negativity (MMN), an auditory prediction error signal, is an enhanced response to unexpected (deviant) stimuli compared to expected (standard) stimuli. There is strong interest in MMN due to reliable findings of reduced MMN in schizophrenia. To interpret reduced MMN in schizophrenia, an enhanced understanding of the factors that influence MMN amplitude could lead to a better understanding of neural mechanisms underpinning the reduction. While several laboratories have observed mismatch responses (MMRs) in rodents, this study assesses how MMR is altered in more complex auditory sequences in rats. Prediction-errors are elicited in relation to \"predictive\" internal models of regularities. These internal models are updated dynamically when a regularity changes, but human MMN exhibits order effects when two regularities alternate; while deviants in both regularities elicit MMN (ie, the model updates) there is a slower build-up in MMN amplitude over time in the second encountered regularity type. We investigate whether order effects occur in rat MMRs. MMRs were studied to rare ascending and descending frequency deviations in awake, freely moving Wistar rats using wireless telemetry in both separate sequences (one regularity at a time) and in alternating sequences where regularities changed back and forth. The rat MMR did not show order effects, however, substantial MMRs occurred in response to both ascending and descending deviants in the alternating context but to the ascending deviant only when the same regularities were presented separately. The longer-term sequence structure altered prediction-error signalling in rat auditory system revealing a long term context sensitivity in internal models.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"35-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal Temporal Window of Integration in Auditory Sensory Memory in Schizophrenia. 精神分裂症患者听觉感官记忆的异常时空整合窗口

Clinical EEG and neuroscience Pub Date : 2025-01-01 Epub Date: 2024-07-21 DOI: 10.1177/15500594241263378

Ren Asai, Hirooki Yabe, Tomiharu Hiruma, Takashi Matsuoka, Haruko Asai, Etsuko Hara, Yuhei Mori, Ken Suzutani, Hiroshi Hoshino, Tetsuya Shiga, Itaru Miura, Koichi Hirata, Sunao Kaneko

{"title":"Abnormal Temporal Window of Integration in Auditory Sensory Memory in Schizophrenia.","authors":"Ren Asai, Hirooki Yabe, Tomiharu Hiruma, Takashi Matsuoka, Haruko Asai, Etsuko Hara, Yuhei Mori, Ken Suzutani, Hiroshi Hoshino, Tetsuya Shiga, Itaru Miura, Koichi Hirata, Sunao Kaneko","doi":"10.1177/15500594241263378","DOIUrl":"10.1177/15500594241263378","url":null,"abstract":"Mismatch negativity (MMN) is automatically elicited by incoming sound deviation compared to the neural representation of preceding homogenous sounds stored in the brain's auditory sensory memory. This study aimed to assess time-functional deviation sensitivity in auditory sensory memory associated with a temporal window of integration (TWI) of 160-170 msec in patients with schizophrenia. To this end, we measured the magnetic counterpart of the MMN (MMNm) in 20 patients with schizophrenia on medication and 20 healthy age-matched adults as a control group responding to an omitted tone segment incorporated into a complex sound of 176 ms duration corresponding to the TWI duration. Overall, the magnitude of the MMNm was smaller in the patients with schizophrenia than in the healthy control group. The peak latency of the MMNm was prolonged in the latter omitted segments for both groups, but to a greater extent in patients with schizophrenia. These results indicate that deviation detection is impaired in the later part of the TWI, corresponding to the duration of auditory sensory memory in patients with schizophrenia. Thus, the specific impairment of MMN in response to duration deviants (duration MMN), as previously reported, might result from a damaged mechanism in the later part of the TWI of sensory memory, suggesting that a decline in sensory memory causes distorted perception or disturbances in cognitive function in patients with schizophrenia.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"100-105"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From the Laboratory to the Real-World: The Role of Mismatch Negativity in Psychosis. 从实验室到现实世界：错配负性在精神病中的作用》。

Clinical EEG and neuroscience Pub Date : 2025-01-01 Epub Date: 2024-11-06 DOI: 10.1177/15500594241294188

Mariko Tada, Sho Yagishita, Takanori Uka, Ryoichi Nishimura, Taiki Kishigami, Kenji Kirihara, Daisuke Koshiyama, Kaori Usui, Mao Fujioka, Tsuyoshi Araki, Kiyoto Kasai

{"title":"From the Laboratory to the Real-World: The Role of Mismatch Negativity in Psychosis.","authors":"Mariko Tada, Sho Yagishita, Takanori Uka, Ryoichi Nishimura, Taiki Kishigami, Kenji Kirihara, Daisuke Koshiyama, Kaori Usui, Mao Fujioka, Tsuyoshi Araki, Kiyoto Kasai","doi":"10.1177/15500594241294188","DOIUrl":"10.1177/15500594241294188","url":null,"abstract":"Mismatch negativity (MMN) has gained attention as a biomarker for psychosis and a translational intermediate phenotype in animal models of psychosis, including rodents and non-human primates. MMN has been linked to global functioning (Global Assessment of Functioning [GAF] score) and prognosis (psychosis onset or remission), suggesting that MMN reflects activities beyond auditory processing alone. This review examines the 45-year history of MMN from the perspective of psychiatric researchers and discusses current advances in computational and translational research on MMN, summarizing the current understanding of the MMN generation mechanism. We then address the essential question, \"What do we observe through MMN?\" Currently, we regard the relationship between global functioning in the real world and MMN as the key to answering this question. As a preliminary investigation, we analyzed the relationship between GAF as an objective variable and MMN, diagnosis, and basic epidemiological factors (age, sex, premorbid intelligence quotient) as explanatory variables (total n = 201, healthy controls: n = 41, patients with psychiatric disorders: n = 160) without assuming diagnostic categories. The relationship between functional outcomes and MMN was confirmed without a case-control design. Finally, we propose that new neurophysiological studies should acknowledge psychophysiological responses such as emotion, intention, and autonomic responses, as well as behavioral differences among participants beyond the dichotomy between healthy controls and patients. Measurements could be conducted in various settings from the participant's perspective. We discuss the potential for research investigating psychosis based on the interaction between individuals and the environment, using MMN as an illustrative model.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"60-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Näätänen to now: Moving the Mismatch Negativity into the Next 50 Years. 从Näätänen到现在：将不匹配的消极情绪带入下一个50年。

Clinical EEG and neuroscience Pub Date : 2025-01-01 Epub Date: 2024-12-04 DOI: 10.1177/15500594241303562

Derek J Fisher, Juanita Todd

引用次数: 0

The Complex Pattern Mismatch Negativity as a Potential Indicator of Psychosis Across all Phases of Illness: A Meta-Analysis. 复杂模式错配负性作为各期精神病的潜在指标：一项元分析

Clinical EEG and neuroscience Pub Date : 2025-01-01 Epub Date: 2024-08-02 DOI: 10.1177/15500594241264870

Ashley M Francis, Sydney Slaunwhite-Hay, Kara Dempster, Natalia Jaworska, Philip G Tibbo, Derek J Fisher

{"title":"The Complex Pattern Mismatch Negativity as a Potential Indicator of Psychosis Across all Phases of Illness: A Meta-Analysis.","authors":"Ashley M Francis, Sydney Slaunwhite-Hay, Kara Dempster, Natalia Jaworska, Philip G Tibbo, Derek J Fisher","doi":"10.1177/15500594241264870","DOIUrl":"10.1177/15500594241264870","url":null,"abstract":"Over the past decade, there has been extensive research on the mismatch negativity (MMN) and its promise as a biomarker of illness in people with schizophrenia (SZ). Nevertheless, when attempting to assess the early stages of illness progression, the utility of MMN has been inconsistent. Recently, researchers have been investigating a more advanced MMN paradigm (the complex MMN [cMMN]) which is believed to index higher-order cognitive processing and has been suggested to be a more effective indicator of the early phases of SZ. The cMMN is defined as a paradigm that relies on alterations within a pre-established pattern of stimuli. In this meta-analysis, we investigated cMMN deficits in individuals with SZ, including an analysis involving those in the first 5 years of illness. Our search also included individuals with bipolar disorder who experience psychosis; however, no related papers were found and thus, no findings are reported. Our findings indicate a small/moderate effect (d = 0.47), suggesting that individuals with SZ exhibit reduced cMMN amplitudes compared to individuals without SZ. Interestingly, this effect seems to be more pronounced in individuals within the first 5 years of their illness (d = 0.58), suggesting that cMMN might be a more sensitive biomarker in the early phases of SZ compared to traditional paradigms.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"72-82"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141880007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0