Dean F Salisbury, Fran López Caballero, Brian A Coffman
{"title":"Development of Biomarkers Potentially Sensitive to Early Psychosis Using Mismatch Negativity (MMN) to Complex Pattern Deviations.","authors":"Dean F Salisbury, Fran López Caballero, Brian A Coffman","doi":"10.1177/15500594241254896","DOIUrl":"10.1177/15500594241254896","url":null,"abstract":"<p><p>Infrequent stimulus deviations from repetitive sequences elicit mismatch negativity (MMN) even passively, making MMN practical for clinical applications. Auditory MMN is typically elicited by a change in one (or more) physical stimulus parameters (eg, pitch, duration). This lower-order simple MMN (sMMN) is impaired in long-term schizophrenia. However, sMMN contains activity from release from stimulus adaptation, clouding its face validity as purely deviance-related. More importantly, it is unreliably reduced in samples of first-episode psychosis, limiting its utility as a biomarker. Complex pattern-deviant MMN (cMMN) tasks, which elicit early and late responses, are based on higher-order abstractions and better isolate deviance detection. Their abstract nature may increase the sensitivity to processing deficits in early psychosis. However, both the early and late cMMNs are small, limiting separation between healthy and psychotic samples. In 29 healthy individuals, we tested a new dual-rule cMMN paradigm to assess additivity of deviance. Sounds alternated lateralization between left and right, and low and high pitches, creating a left-low, right-high alternating pattern. Deviants were a repeated left-low, violating lateralization and pitch patterns. Early and late cMMNs on the dual-rule task were significantly larger than those on the one-rule extra tone cMMN task (<i>P</i> < .05). Further, the dual-rule early cMMN was not significantly smaller than pitch or duration sMMNs (<i>P</i> > .48, .28, respectively). These results demonstrate additivity for cMMN pattern-violating rules. This increase in cMMN amplitude should increase group difference effect size, making it a prime candidate for a biomarker of disease presence at first psychotic episode, and perhaps even prior to the emergence of psychosis.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"83-90"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tereza Jurková, Jan Chládek, Irena Doležalová, Štefania Aulická, Jan Chrastina, Tomáš Zeman, Ondřej Horák, Eva Koriťáková, Milan Brázdil
{"title":"Pre-implantation Scalp EEG Can Predict VNS Efficacy in Children.","authors":"Tereza Jurková, Jan Chládek, Irena Doležalová, Štefania Aulická, Jan Chrastina, Tomáš Zeman, Ondřej Horák, Eva Koriťáková, Milan Brázdil","doi":"10.1177/15500594241308594","DOIUrl":"https://doi.org/10.1177/15500594241308594","url":null,"abstract":"<p><p><i>Introduction.</i> Vagal nerve stimulation (VNS) is a therapeutical option for the treatment of drug-resistant epileptic patients. The response to VNS varies from patient to patient and is difficult to predict. The proposed study is based on our previous work, identifying relative mean power in pre-implantation EEG as a reliable marker for VNS efficacy prediction in adult patients. Our study has two main tasks. Firstly, to confirm the utility of relative mean power as a feature correlating with VNS efficacy in children. The second is to validate the applicability of our prediction classifier, Pre-X-Stim, in the pediatric population. <i>Material and Methods.</i> We identified a group of children with drug-resistant epilepsy. We included only children in whom EEG contained photic stimulation (Task 1) or was recorded based on the defined acquisition protocol used for development Pre-X-Stim (Task 2). Relative mean powers were calculated. VNS responders and non-responders were compared based on relative mean powers' values. In the next step, we evaluate the utility of our classifier, Pre-X-Stim, in the children population. <i>Results:</i> We identified 57 children treated with VNS - 17 patients were recruited for the Task 1 and 7 patients for the Task 2. When focusing on relative mean powers in EEG spectra, we observed statistically significant differences in theta range. The Pre-X-Stim algorithm was able to predict VNS efficacy correctly in 6 out of 7 patients (the accuracy 83.3%, the sensitivity 75%, the specificity 100%). <i>Conclusions.</i> Based on our results, it seems that children and adults share a similar pattern of EEG relative mean power changes. These changes can be used for pre-implantation prediction of VNS efficacy.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241308594"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saghar Vosough, Gian Candrian, Johannes Kasper, Hossam Abdel Rehim, Dominique Eich, Andreas Müller, Lutz Jäncke
{"title":"Facial Affect Recognition and Executive Function Abnormalities in ADHD Subjects: An ERP Study.","authors":"Saghar Vosough, Gian Candrian, Johannes Kasper, Hossam Abdel Rehim, Dominique Eich, Andreas Müller, Lutz Jäncke","doi":"10.1177/15500594241304492","DOIUrl":"https://doi.org/10.1177/15500594241304492","url":null,"abstract":"<p><p>Attention-deficit/hyperactivity disorder (ADHD) affects approximately 12% of children worldwide. With a 50% chance of persistence into adulthood and associations with impairments in various domains, including social and emotional ones, early diagnosis is crucial. The exact neural substrates of ADHD are still unclear. This study aimed to reassess the behavioral and neural metrics of executive functions and neural substrates of facial affect recognition. A total of 117 ADHD patients and 183 healthy controls were evaluated by two Go/NoGo tasks: the classic visual continuous performance test and the emotional continuous performance test, which requires facial affect encoding. Group differences between ADHD subjects and healthy controls were assessed using analysis of covariance (ANCOVA), with age and sex included as covariates. Dependent variables comprised behavioral (number of omission and commission errors, reaction time, and reaction time variability) and neurophysiological measures (event-related potentials [ERPs]). As the main result, we identified significant differences between ADHD patients and healthy controls in all behavioral metrics, one neural marker of action inhibition (P3d) and the facial processing marker (N170). The differences were moderate-to-large when expressed as effect size measures in behavioral variables and small-to-moderate for neurophysiological variables. The small-to-moderate effect sizes obtained from the neurophysiological measures suggest that ERPs are insufficient as sole markers for effectively screening emotion and face processing abnormalities in ADHD.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241304492"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sonia Sistiaga, Alice Bodart, Henrique Sequeira, Salvatore Campanella
{"title":"Emotion Regulation Assessment: A New Perspective Using Simultaneous Electroencephalographic and Electrodermal Recordings.","authors":"Sonia Sistiaga, Alice Bodart, Henrique Sequeira, Salvatore Campanella","doi":"10.1177/15500594241302553","DOIUrl":"https://doi.org/10.1177/15500594241302553","url":null,"abstract":"<p><p>Recognized as a transdiagnostic factor, emotion regulation (ER) is increasingly embedded into conceptualizations of psychopathology development and maintenance, emerging as a core component of treatment methodologies. Therefore, the incorporation of ER into various facets of affective sciences, including theoretical frameworks, experimental paradigms, assessment methods, and intervention strategies, raises new challenges, particularly regarding the measurement of ER. In the evaluation and understanding of complex, multifaceted processes like ER, the combination of different assessment methods encompassing diverse units of analysis across multiple domains encompassing cerebral, physiological, and behavioral measures can prove particularly interesting. Among these approaches, the concurrent recording of electroencephalographic (EEG) and electrodermal activity (EDA) emerges as a promising strategy, enabling a more holistic exploration of the ER process at both central and peripheral levels. This brief paper aims to explore current literature concerning the utilization of EEG and EDA in the investigation of ER and to bring arguments supporting their simultaneous recording in order to gain a better understanding of ER processes.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241302553"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Osama Ejaz, Muhammad Abul Hasan, Mishal Ashraf, Saad Ahmed Qazi
{"title":"Brain Insights and Resolution of Youth Depression through Neurotechnology.","authors":"Osama Ejaz, Muhammad Abul Hasan, Mishal Ashraf, Saad Ahmed Qazi","doi":"10.1177/15500594241304512","DOIUrl":"https://doi.org/10.1177/15500594241304512","url":null,"abstract":"<p><p>As per United Nations, the youth constitute 16% of total population globally whereas World Health Organization reported that one in every seven young individual suffers from depression. Among various tested therapeutic solutions for depression management, the efficacy of transcranial Direct Current Stimulation (tDCS) is still unexplored specifically in young participants. Therefore, this study aims to investigate the cross hemispheric tDCS intervention with a smaller number of sessions in youth population by means of neurological, neuropsychological, and behavioural measures. A total of 50 young participants were recruited comprising of 25 healthy and 25 depressed individuals. The participants of depressed group were randomly assigned to active tDCS and sham tDCS sub groups and completed 150 min of training over 5 consecutive days. The active tDCS group received stimulation of 2 mA over dorsolateral prefrontal cortex. Unlike healthy individuals, depressed participants demonstrated reduced difference of brain activity between eyes opened and closed resting conditions which gets restored following the intervention in active group. Additionally, the tDCS intervention effectively modified the previously reduced alpha asymmetry observed in depressed participants compared to healthy individuals. These neurological outcomes may also be supported with enhanced neuropsychological score of depression <i>(t = 5.47, P < .01)</i> in active group. The attention score <i>(t = 5.14, P < .01)</i> and reaction time <i>(t = 2.22, P = .02)</i> evaluated through behavioural measure of Stroop task were also significantly improved in active group post tDCS intervention. The reported outcomes of the study highlighted the ability of tDCS for prompt and efficient youth depression management.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241304512"},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Murat Aşık, Reyhan İlhan, Mehmet Güven Günver, Özden Orhan, Muhammed Taha Esmeray, Öznur Kalaba, Mehmet Kemal Arıkan
{"title":"Multimodal Neuroimaging in the Prediction of Deep TMS Response in OCD.","authors":"Murat Aşık, Reyhan İlhan, Mehmet Güven Günver, Özden Orhan, Muhammed Taha Esmeray, Öznur Kalaba, Mehmet Kemal Arıkan","doi":"10.1177/15500594241298977","DOIUrl":"https://doi.org/10.1177/15500594241298977","url":null,"abstract":"<p><p><b>Backgrounds:</b> .Brain morphological biomarkers could contribute to understanding the treatment response in patients with obsessive-compulsive disorder (OCD). Multimodal neuroimaging addresses this issue by providing more comprehensive information regarding neural processes and structures. <b>Objectives.</b> The present study aims to investigate whether patients responsive to deep Transcranial Magnetic Stimulation (TMS) differ from non-responsive individuals in terms of electrophysiology and brain morphology. Secondly, to test whether multimodal neuroimaging is superior to unimodal neuroimaging in predicting response to deep TMS. <b>Methods.</b> Thirty-two OCD patients who underwent thirty sessions of deep TMS treatment were included in the study. Based on a minimum 50% reduction in Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores after treatment, patients were grouped as responders (n = 25) and non-responders (n = 7). The baseline resting state qEEG and magnetic resonance imaging (MRI) records of patients were recorded. Independent sample t-test is used to compare the groups. Then, three logistic regression model were calculated for only QEEG markers, only MRI markers, and both QEEG/MRI markers. The predictive values of the three models were compared. <b>Results.</b> OCD patients who responded to deep TMS treatment had increased Alpha-2 power in the left temporal area and increased volume in the left temporal pole, entorhinal area, and parahippocampal gyrus compared to non-responders. The logistic regression model showed better prediction performance when both QEEG and MRI markers were included. <b>Conclusions.</b> This study addresses the gap in the literature regarding new functional and structural neuroimaging markers and highlights the superiority of multimodal neuroimaging to unimodal neuroimaging techniques in predicting treatment response.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241298977"},"PeriodicalIF":0.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early Impairment of Face Perception in Post-Stroke Depression: An ERP Study.","authors":"Pingshu Zhang, Lingyun Cao, Jianxin Yuan, Changming Wang, Ya Ou, Jing Wang, Liqin Duan, Hongchun Qian, Qirong Ling, Xiaodong Yuan","doi":"10.1177/15500594241289473","DOIUrl":"https://doi.org/10.1177/15500594241289473","url":null,"abstract":"<p><p><b>Objective:</b> Face recognition is an important cognitive function of the human brain. Post stroke depression (PSD) is a common mental complication after stroke, which has a serious impact on individual physical function recovery and quality of life. This study aims to explore the face perception characteristics of PSD through electrophysiological indicators N170 and VPP, and provide an objective basis for the early evaluation of facial cognitive dysfunction in PSD. <b>Methods:</b> 58 patients in the cerebral small vessel disease (CSVD) with depressive symptoms (PSD) and 188 patients in the pure CSVD (NPSD). At the same time, 30 healthy subjects were selected as the healthy controls (HC). The differences of N170 and VPP components between the three groups were compared under the stimulation of inverted faces and upright faces. <b>Results:</b> PSD patients exhibited significantly longer peak latency and lower amplitude of N170 and VPP under both inverted and upright face stimulation compared to HC and NPSD. These results suggest that PSD patients have defects in early face recognition, there are abnormalities in the early perception and structural encoding of face information, and both the \"overall mechanism\" and \"feature mechanism\" of face recognition are damaged. <b>Conclusions:</b> These findings provide neuroelectrophysiological evidence for impaired emotionless face recognition in PSD patients.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241289473"},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natalia Jaworska, Sara de la Salle, Bronwen Schryver, Meagan Birmingham, Jennifer L Phillips, Pierre Blier, Verner Knott
{"title":"Electrocortical Profiles in Relation to Childhood Adversity and Depression Severity: A Preliminary Report.","authors":"Natalia Jaworska, Sara de la Salle, Bronwen Schryver, Meagan Birmingham, Jennifer L Phillips, Pierre Blier, Verner Knott","doi":"10.1177/15500594241294021","DOIUrl":"https://doi.org/10.1177/15500594241294021","url":null,"abstract":"<p><p><b>Objective:</b> Assessment of electroencephalographic (EEG) activity in depression has provided insights into neural profiles of the illness. However, there is limited understanding on how symptom severity and risk factors, such as childhood adversity, influence EEG features. <b>Methods:</b> Eyes-closed EEG was acquired in N = 28 depressed individuals being treated in a tertiary psychiatric setting. Absolute alpha, beta, theta, and delta power and inter-/intra-hemispheric coherence were examined. Relations between the Montgomery-Åsberg Depression Scale (MADRS) and Adverse Childhood Experience (ACE) Questionnaire and EEG features were assessed. <b>Results:</b> Individuals in the high (MADRS≥30) versus lower (MADRS ≤ 29) symptom severity group exhibited greater overall beta power, and lower Fp<sub>1</sub>-Fp<sub>2</sub> delta and theta coherence. Those with high (≥3) versus lower (≤2) ACE scores exhibited greater T<sub>7</sub>-T<sub>8</sub> beta coherence. Lowest F<sub>3</sub>-F<sub>4</sub> beta coherence was observed in those with high ACE/high depression severity. A negative correlation existed between F<sub>8</sub>-P<sub>8</sub> alpha coherence and symptom severity. <b>Conclusions:</b> Those with higher depression severity exhibit increased beta power, possibly reflecting a hyper-vigilant state<b>.</b> Depression severity and ACE history may produce subtle alterations in frontal delta/theta and temporal/frontal beta coherence regions. <b>Significance:</b> This is the first study to examine the neural impact of depression severity and ACE-assessed childhood trauma in depressed individuals receiving treatment in a tertiary setting, accounting for the clinical reality of the prevalence of their co-occurrence.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241294021"},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Artifacts Deceive: The Electroretinogram in the Electroencephalogram of a teenager with cerebral anoxia.","authors":"Sonal Bhatia","doi":"10.1177/15500594241284679","DOIUrl":"https://doi.org/10.1177/15500594241284679","url":null,"abstract":"<p><p>Artifacts on an electroencephalogram (EEG) - whether physiologic or non-physiologic - can be common and are important to recognize to prevent errors in interpretation. One such EEG artifact is an electroretinogram (ERG) artifact which occurs during photic stimulation. Typically, of a low amplitude, its presence is usually obscured by normal EEG activity over the frontopolar channels but it can appear prominent in very suppressed or EEG recordings showing electrocerebral inactivity. Overall, rarely reported in the literature, the purpose of this case report is to highlight the presence of an ERG artifact in a teenage boy where EEG was obtained after a cerebral anoxic event. It is important that EEG readers identify this to be a non-cerebral waveform in order to provide an accurate assessment of neurologic prognosis.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594241284679"},"PeriodicalIF":0.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rukiye Ölçüoğlu, İlknur Kozanoğlu, Mehmet Mıdık, Eylem Gül Ateş
{"title":"The Impact of Neurofeedback Training on Cognitive Abilities Assessed by the Wechsler Intelligence Scale for Children-Revised in Children with Attention Deficit: A Randomized Single-Blind Sham-Controlled Study.","authors":"Rukiye Ölçüoğlu, İlknur Kozanoğlu, Mehmet Mıdık, Eylem Gül Ateş","doi":"10.1177/15500594241279997","DOIUrl":"10.1177/15500594241279997","url":null,"abstract":"<p><p><b>Aim:</b> This study aims to investigate the effects of a neurofeedback system on cognitive skills, as measured by the Wechsler Intelligence Scale for Children-Revised (WISC-R), in a cohort of 100 children aged 8 to 12 who were diagnosed with attention deficit.<b>Materials and Methods:</b> A randomized single-blind sham control group design was employed, with 50 participants assigned to the experimental group receiving neurofeedback training and 50 participants assigned to the sham group receiving simulated training. Participants were selected through random sampling from individuals seeking assistance at a specialized education center over the course of one year (May 2021-2022). Pre- and post-test WISC-R assessments were administered to both groups to evaluate participants' mental performance. The experimental group underwent a total of 60 sessions of quantitative electroencephalography-based infralow frequency neurofeedback training, with half-hour sessions conducted three days a week over a five-month period. The post-test WISC-R was administered at the end of the sixth month.<b>Results:</b> The results revealed significant differences between the pre- and post-training test scores, specifically in terms of verbal IQ, picture arrangement, performance IQ, and total IQ (p = 0.016, p = 0.001, p < 0.001, and p = 0.002, respectively), when comparing the differences between the two groups.<b>Conclusion:</b> These findings indicate a notable improvement in performance IQ, total IQ, and a reduction in attention deficits among the neurofeedback group based on the WISC-R assessments. Future studies should consider employing larger sample sizes, including appropriate control groups, and conducting long-term follow-ups to further elucidate the clinical significance of these results.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"603-612"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}