Clinical EEG and neuroscience最新文献_第2页

Brain Oscillations in Bipolar Disorder: Insights from Quantitative EEG Studies. 双相情感障碍的脑振荡：定量脑电图研究的见解。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2025-07-29 DOI: 10.1177/15500594251360059

Amir Reza Bahadori, Erfan Naghavi, Pantea Allami, Saba Dahaghin, Afshan Davari, Sahar Ansari, Sara Ranji, Mehrdad Sheikhvatan, Sajad Shafiee, Abbas Tafakhori

{"title":"Brain Oscillations in Bipolar Disorder: Insights from Quantitative EEG Studies.","authors":"Amir Reza Bahadori, Erfan Naghavi, Pantea Allami, Saba Dahaghin, Afshan Davari, Sahar Ansari, Sara Ranji, Mehrdad Sheikhvatan, Sajad Shafiee, Abbas Tafakhori","doi":"10.1177/15500594251360059","DOIUrl":"https://doi.org/10.1177/15500594251360059","url":null,"abstract":"IntroductionQuantitative electroencephalography (QEEG) is a neurophysiological tool that analyzes brain oscillations across frequency bands, providing insights into psychiatric conditions like bipolar disorder (BD). This disorder, marked by mood fluctuations, poses diagnostic and treatment challenges, highlighting the need for reliable biomarkers.ObjectiveThis systematic review aims to evaluate QEEG changes in BD patients, investigate its diagnostic and therapeutic potential, and differentiate BD from major depressive disorder (MDD) and schizophrenia.MethodsFollowing PRISMA 2020 guidelines, a comprehensive search of PubMed, Scopus, Web of Science, and Embase was conducted till 30th of October 2024 without timeline restrictions. Studies involving BD patients assessed using QEEG were included. Key outcomes focused on frequency band alterations, treatment responses, and diagnostic differentiation.ResultsThe review included 20 studies with 475 BD patients. Increased gamma and beta activity were consistently observed in BD. However, the directionality of alpha and theta band changes varied, with differences observed depending on brain region and mood state. Delta band alterations were more prominent in BD I. Treatment responses showed reduced power in gamma, theta, and alpha bands. QEEG also distinguished BD from MDD and schizophrenia based on frequency band characteristics.ConclusionQEEG demonstrates significant promise as a diagnostic and therapeutic tool for BD. Despite methodological variability, its integration with machine learning could enhance diagnostic precision and guide personalized treatments. Further research is needed to standardize methodologies and validate findings.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594251360059"},"PeriodicalIF":1.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lance-Adams Syndrome: Current Understanding and Management. 兰斯-亚当斯综合症：当前的理解和管理。

Clinical EEG and neuroscience Pub Date : 2025-07-10 DOI: 10.1177/15500594251358581

Aleksandar Sič

{"title":"Lance-Adams Syndrome: Current Understanding and Management.","authors":"Aleksandar Sič","doi":"10.1177/15500594251358581","DOIUrl":"https://doi.org/10.1177/15500594251358581","url":null,"abstract":"BackgroundLance-Adams Syndrome (LAS) is a rare neurological complication of hypoxic brain injury, characterized by action- and stimulus-sensitive myoclonus in patients who have regained consciousness. Although often misinterpreted as a sign of poor prognosis, LAS can lead to significant long-term disability but also shows potential for functional recovery with appropriate management.MethodologyA narrative review was conducted using a predefined search strategy across PubMed and ScienceDirect databases to identify peer-reviewed studies on LAS published between January 2000 and April 2025. A total of 47 studies were included in the final synthesis, comprising 34 case reports, 7 narrative or scoping reviews, 2 systematic reviews and 4 original clinical studies.ResultsThe pathophysiology of LAS remains multifactorial, involving cortical hyperexcitability, subcortical disinhibition, and neurotransmitter imbalances. Electroencephalographic and imaging studies provide important diagnostic clues. Management remains largely symptomatic, based on empirical evidence. Clonazepam and valproate remain first-line therapies, while agents such as perampanel, sodium oxybate, cannabidiol, and intrathecal baclofen have been trialed in refractory cases. Multidisciplinary rehabilitation plays a crucial role in long-term outcomes.ConclusionGreater awareness and earlier recognition of LAS can improve diagnostic accuracy and therapeutic outcomes. Despite its rarity, clinicians should remain alert to LAS as a potentially reversible disorder when appropriately diagnosed and managed. Standardized treatment guidelines remain a future priority.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"15500594251358581"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrode Artifact, Breach Rhythm, or Focal Seizures: Navigating an Electrographic Quandary. 电极伪影，突破节奏，或局灶性癫痫：导航电图困境。

Clinical EEG and neuroscience Pub Date : 2025-07-10 DOI: 10.1177/15500594251358594

Mohammad Samara, Naeem Mahfooz, Ajaz Sheikh

引用次数: 0

Pre-implantation Scalp EEG Can Predict VNS Efficacy in Children. 植入前头皮脑电图可预测儿童VNS疗效。

Clinical EEG and neuroscience Pub Date : 2025-07-01 Epub Date: 2024-12-24 DOI: 10.1177/15500594241308594

Tereza Jurková, Jan Chládek, Irena Doležalová, Štefania Aulická, Jan Chrastina, Tomáš Zeman, Ondřej Horák, Eva Koriťáková, Milan Brázdil

{"title":"Pre-implantation Scalp EEG Can Predict VNS Efficacy in Children.","authors":"Tereza Jurková, Jan Chládek, Irena Doležalová, Štefania Aulická, Jan Chrastina, Tomáš Zeman, Ondřej Horák, Eva Koriťáková, Milan Brázdil","doi":"10.1177/15500594241308594","DOIUrl":"10.1177/15500594241308594","url":null,"abstract":"Introduction. Vagal nerve stimulation (VNS) is a therapeutical option for the treatment of drug-resistant epileptic patients. The response to VNS varies from patient to patient and is difficult to predict. The proposed study is based on our previous work, identifying relative mean power in pre-implantation EEG as a reliable marker for VNS efficacy prediction in adult patients. Our study has two main tasks. Firstly, to confirm the utility of relative mean power as a feature correlating with VNS efficacy in children. The second is to validate the applicability of our prediction classifier, Pre-X-Stim, in the pediatric population. Material and Methods. We identified a group of children with drug-resistant epilepsy. We included only children in whom EEG contained photic stimulation (Task 1) or was recorded based on the defined acquisition protocol used for development Pre-X-Stim (Task 2). Relative mean powers were calculated. VNS responders and non-responders were compared based on relative mean powers' values. In the next step, we evaluate the utility of our classifier, Pre-X-Stim, in the children population. Results: We identified 57 children treated with VNS - 17 patients were recruited for the Task 1 and 7 patients for the Task 2. When focusing on relative mean powers in EEG spectra, we observed statistically significant differences in theta range. The Pre-X-Stim algorithm was able to predict VNS efficacy correctly in 6 out of 7 patients (the accuracy 83.3%, the sensitivity 75%, the specificity 100%). Conclusions. Based on our results, it seems that children and adults share a similar pattern of EEG relative mean power changes. These changes can be used for pre-implantation prediction of VNS efficacy.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"380-387"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterizing PTSD Using Electrophysiology: Towards A Precision Medicine Approach. 使用电生理学表征创伤后应激障碍：走向精确医学方法。

Clinical EEG and neuroscience Pub Date : 2025-07-01 Epub Date: 2025-01-07 DOI: 10.1177/15500594241309680

Natasha Kovacevic, Amir Meghdadi, Chris Berka

{"title":"Characterizing PTSD Using Electrophysiology: Towards A Precision Medicine Approach.","authors":"Natasha Kovacevic, Amir Meghdadi, Chris Berka","doi":"10.1177/15500594241309680","DOIUrl":"10.1177/15500594241309680","url":null,"abstract":"Objective. Resting-state EEG measures have shown potential in distinguishing individuals with PTSD from healthy controls. ERP components such as N2, P3, and late positive potential have been consistently linked to cognitive abnormalities in PTSD, especially in tasks involving emotional or trauma-related stimuli. However, meta-analyses have reported inconsistent findings. The understanding of biomarkers that can classify the varied symptoms of PTSD remains limited. This study aimed to develop a concise set of electrophysiological biomarkers, using neutral cognitive tasks, that could be applied across psychiatric conditions, and to identify biomarkers associated with the anxiety and depression dimensions of PTSD. Approach. Continuous simultaneous recordings of EEG and electrocardiogram (ECG) were obtained in veterans with PTSD (n = 29) and healthy controls (n = 62) during computerized tasks. EEG, ERP, and heart rate measures were evaluated in terms of their ability to discriminate between the groups or correlate with psychological measures. Results. The PTSD cohort exhibited faster alpha oscillations, reduced alpha power, and a flatter power spectrum. Furthermore, stronger reduction in alpha power was associated with higher trait anxiety, while a flatter slope was related to more severe depression symptoms in individuals with PTSD. In ERP tasks of visual memory and sustained attention, the PTSD cohort demonstrated delayed and exaggerated early components, along with attenuated LPP amplitudes. The three tasks revealed distinct and complementary EEG signatures PTSD. Significance. Multimodal individualized biomarkers based on EEG, cognitive ERPs, and ECG show promise as objective tools for assessing mood and anxiety disturbances within the PTSD spectrum.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"305-315"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal EEG Characteristics of Anti-GAD65 Antibody Related Autoimmune Epilepsy. 抗gad65抗体相关自身免疫性癫痫的纵向脑电图特征

Clinical EEG and neuroscience Pub Date : 2025-07-01 Epub Date: 2025-05-14 DOI: 10.1177/15500594251341060

Tian Wang, Cameron Mohammadi, Robert K Shin, Tricia Y Ting

引用次数: 0

Facial Affect Recognition and Executive Function Abnormalities in ADHD Subjects: An ERP Study. ADHD受试者的面部情绪识别和执行功能异常：一项ERP研究。

Clinical EEG and neuroscience Pub Date : 2025-07-01 Epub Date: 2024-12-19 DOI: 10.1177/15500594241304492

Saghar Vosough, Gian Candrian, Johannes Kasper, Hossam Abdel Rehim, Dominique Eich, Andreas Müller, Lutz Jäncke

{"title":"Facial Affect Recognition and Executive Function Abnormalities in ADHD Subjects: An ERP Study.","authors":"Saghar Vosough, Gian Candrian, Johannes Kasper, Hossam Abdel Rehim, Dominique Eich, Andreas Müller, Lutz Jäncke","doi":"10.1177/15500594241304492","DOIUrl":"10.1177/15500594241304492","url":null,"abstract":"Attention-deficit/hyperactivity disorder (ADHD) affects approximately 12% of children worldwide. With a 50% chance of persistence into adulthood and associations with impairments in various domains, including social and emotional ones, early diagnosis is crucial. The exact neural substrates of ADHD are still unclear. This study aimed to reassess the behavioral and neural metrics of executive functions and neural substrates of facial affect recognition. A total of 117 ADHD patients and 183 healthy controls were evaluated by two Go/NoGo tasks: the classic visual continuous performance test and the emotional continuous performance test, which requires facial affect encoding. Group differences between ADHD subjects and healthy controls were assessed using analysis of covariance (ANCOVA), with age and sex included as covariates. Dependent variables comprised behavioral (number of omission and commission errors, reaction time, and reaction time variability) and neurophysiological measures (event-related potentials [ERPs]). As the main result, we identified significant differences between ADHD patients and healthy controls in all behavioral metrics, one neural marker of action inhibition (P3d) and the facial processing marker (N170). The differences were moderate-to-large when expressed as effect size measures in behavioral variables and small-to-moderate for neurophysiological variables. The small-to-moderate effect sizes obtained from the neurophysiological measures suggest that ERPs are insufficient as sole markers for effectively screening emotion and face processing abnormalities in ADHD.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"327-341"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detectability in Scalp EEGs of Epileptic Spikes Emitted from Brain Electrical Sources of Different Sizes and Locations: A Simulation Study Using Realistic Head Models of Elderly Adults. 不同大小和位置的脑电源发出的癫痫尖峰在头皮脑电图中的可探测性：使用老年人真实头部模型的模拟研究。

Clinical EEG and neuroscience Pub Date : 2025-07-01 Epub Date: 2025-02-27 DOI: 10.1177/15500594251323625

Makoto Takenaka, Mark E Pflieger, Tomokatsu Hori, Yudai Iwama, Jumpei Matsumoto, Tsuyoshi Setogawa, Atsushi Shirasawa, Hiroshi Nishimaru, Hisao Nishijo

{"title":"Detectability in Scalp EEGs of Epileptic Spikes Emitted from Brain Electrical Sources of Different Sizes and Locations: A Simulation Study Using Realistic Head Models of Elderly Adults.","authors":"Makoto Takenaka, Mark E Pflieger, Tomokatsu Hori, Yudai Iwama, Jumpei Matsumoto, Tsuyoshi Setogawa, Atsushi Shirasawa, Hiroshi Nishimaru, Hisao Nishijo","doi":"10.1177/15500594251323625","DOIUrl":"10.1177/15500594251323625","url":null,"abstract":"Background. Epilepsy is prevalent in the elderly, whose brain morphologies and skull electrical characteristics differ from those of younger adults. Here, using a multivariate definition of signal-to-noise ratio (SNR), we explored the detectability of epileptic spikes in scalp EEG measurements in elderly by forward simulations of hypersynchronous spikes generated at 78 cortical regions of interest (ROIs) in the presence of background noise. Methods. Simulated electric potentials were measured at 18, 35, and 70 standard 10-20 electrode positions using three reference methods: infinity reference (INF), common average reference (CAR), and average mastoid reference (M1M2). MRIs of six elderly subjects were used to construct finite element method (FEM) models with age-adjusted skull conductivities. Results. SNRs of epileptic spikes increased with increasing sizes of the brain electrical source areas, although medial and deep brain regions such as the hippocampus showed lower SNRs, consistent with clinical findings. The SNRs were greater in the 70-channel dataset than in the 18-channel and 35-channel datasets, especially for ROIs located closer to the head surface. In addition, the SNRs were lower for the CAR and M1M2 references than for the ideal INF reference. Moreover, we found comparable results in the standard FEM heads with age-adjusted skull conductivities. Conclusions. The results provide insights for evaluating scalp EEG data in elderly patients with suspected epilepsy, and suggest that age-adjusted skull conductivity is an important factor for forward models in elderly adults, and that the standard FEM head with age-adjusted skull conductivity can be used when MRIs are not available.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"358-371"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain Insights and Resolution of Youth Depression through Neurotechnology. 通过神经技术观察和解决青少年抑郁症。

Clinical EEG and neuroscience Pub Date : 2025-07-01 Epub Date: 2024-12-05 DOI: 10.1177/15500594241304512

Osama Ejaz, Muhammad Abul Hasan, Mishal Ashraf, Saad Ahmed Qazi

{"title":"Brain Insights and Resolution of Youth Depression through Neurotechnology.","authors":"Osama Ejaz, Muhammad Abul Hasan, Mishal Ashraf, Saad Ahmed Qazi","doi":"10.1177/15500594241304512","DOIUrl":"10.1177/15500594241304512","url":null,"abstract":"As per United Nations, the youth constitute 16% of total population globally whereas World Health Organization reported that one in every seven young individual suffers from depression. Among various tested therapeutic solutions for depression management, the efficacy of transcranial Direct Current Stimulation (tDCS) is still unexplored specifically in young participants. Therefore, this study aims to investigate the cross hemispheric tDCS intervention with a smaller number of sessions in youth population by means of neurological, neuropsychological, and behavioural measures. A total of 50 young participants were recruited comprising of 25 healthy and 25 depressed individuals. The participants of depressed group were randomly assigned to active tDCS and sham tDCS sub groups and completed 150 min of training over 5 consecutive days. The active tDCS group received stimulation of 2 mA over dorsolateral prefrontal cortex. Unlike healthy individuals, depressed participants demonstrated reduced difference of brain activity between eyes opened and closed resting conditions which gets restored following the intervention in active group. Additionally, the tDCS intervention effectively modified the previously reduced alpha asymmetry observed in depressed participants compared to healthy individuals. These neurological outcomes may also be supported with enhanced neuropsychological score of depression (t = 5.47, P < .01) in active group. The attention score (t = 5.14, P < .01) and reaction time (t = 2.22, P = .02) evaluated through behavioural measure of Stroop task were also significantly improved in active group post tDCS intervention. The reported outcomes of the study highlighted the ability of tDCS for prompt and efficient youth depression management.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"342-351"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perinatal Hypoxic-hypoglycemic Injury and Epilepsy: A Comprehensive Analysis of Clinical and Laboratory Data in Adults. 围产期缺氧-低血糖损伤与癫痫：成人临床和实验室数据的综合分析。

Clinical EEG and neuroscience Pub Date : 2025-07-01 Epub Date: 2024-12-26 DOI: 10.1177/15500594241308592

Ozge Berna Gultekin Zaim, Rahsan Gocmen, Nese Dericioglu

{"title":"Perinatal Hypoxic-hypoglycemic Injury and Epilepsy: A Comprehensive Analysis of Clinical and Laboratory Data in Adults.","authors":"Ozge Berna Gultekin Zaim, Rahsan Gocmen, Nese Dericioglu","doi":"10.1177/15500594241308592","DOIUrl":"10.1177/15500594241308592","url":null,"abstract":"Objective. Perinatal hypoxia and/or hypoglycemia (PHH) is a serious condition leading to many neonatal deaths worldwide. It causes motor and cognitive deficits, visual disturbances, and seizures in survivors. There is limited information on the clinical course of seizures, EEG and MRI findings in adults. Methods. Adult patients with epilepsy due to PHH were included. Data on patients' demographic and clinical features, age at seizure onset, type and frequency of seizures, antiseizure medications and EEG features were extracted from electronic health records. Seizure outcome was classified as \"seizure-free for at least one year at last follow up\" versus \"continuing seizures\". Clinical and laboratory variables that could be associated with seizure outcome were investigated statistically in a subset of patients. Results. Forty-one patients (median age: 32 years) were included. Bilateral cerebral lesions, predominantly affecting the posterior regions, were present in 88% of the cases. Almost 80% experienced focal to bilateral tonic-clonic seizures. Approximately 60% of patients were on polytherapy. Half of the patients were seizure free at last follow-up. Seizure frequency decreased over time in 75% of the cohort. EEG demonstrated background slowing in 44% of patients, with epileptic discharges detected in 27%. The only variable correlated with seizure freedom was older age at seizure onset (P = .034). Conclusion. Almost half of the patients may reach seizure freedom. Seizure frequency decreases in 75% over time. Cranial MRI or EEG findings are not correlated with seizure outcomes. The only variable associated with seizure freedom at last follow up is older age at seizure onset.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"372-379"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0