Clinical EEG and neuroscience最新文献_第3页

Characterization of Vertex Sharp Waves: Sleep Stage Distribution Pattern and Implications for Scoring. 顶点尖波的特征：睡眠阶段分布模式及其对评分的影响。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-09-01 Epub Date: 2026-02-06 DOI: 10.1177/15500594261420478

Gulcin Benbir Senel, Merve Hazal Ser, Gokcen Hatipoglu, Derya Karadeniz, Lourdes M DelRosso

{"title":"Characterization of Vertex Sharp Waves: Sleep Stage Distribution Pattern and Implications for Scoring.","authors":"Gulcin Benbir Senel, Merve Hazal Ser, Gokcen Hatipoglu, Derya Karadeniz, Lourdes M DelRosso","doi":"10.1177/15500594261420478","DOIUrl":"10.1177/15500594261420478","url":null,"abstract":"Study ObjectivesVertex sharp waves(VSW) are sharply contoured waves with a duration of less than 500 mille-seconds and maximal over the central regions of the brain, that have been identified to appear during N1. Here we postulate that VSW are sleep stage-specific and can also identify a sleep stage shift to NREM sleep from REM sleep.MethodsWe retrospectively analyzed PSG data of 20 out of 74 consecutive patients who were studied with 18-channel EEG within the last year. Vertex sharp waves were visually and manually scored and analyzed by sleep stage.ResultsTwenty patients(12 men, 60.0%) were analyzed. The median age was 37 years(95% CI 31.3-46.2 years) with a mean of 38.7 ± 14.4 years. Seventeen patients(85%) had VSW in both N1 and N2 sleep stage, only 6 patients(30%) had VSW in N3 sleep, and 10 patients(50%) in REM sleep. Regression analysis showed that the occurrence of VSW in N2 sleep(r2 = 0.747,F = 44.366;p < 0.001) and REM sleep(r2 = 0.473,F = 7.174; p = 0.028) was positively correlated with the presence of VSW in N1 sleep stage. The positive correlation during REM sleep was only spared for the VSW appearing following an arousal reaction(r2 = 0.432, F = 5.329;p = 0.05).ConclusionsOur results suggest that vertex sharp waves are state-dependent activities of NREM sleep, predominantly seen in N1 sleep stage, and also in N2 sleep. As they emerge in REM sleep, following an arousal reaction or not, it may be regarded as a sleep stage shift from REM to NREM sleep stage. These findings may help clarify scoring rules for REM sleep and arousal.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"442-448"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated Paroxysmal Right Upward Eye Deviation as the Sole Semiology of Childhood Occipital Epilepsy: An Electroclinical Case Report. 孤立性阵发性右眼上斜是儿童枕癫痫的唯一符号学：一个电临床病例报告。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-09-01 Epub Date: 2026-06-21 DOI: 10.1177/15500594261462223

Gunce Basarir, Rıdvan Avcı

{"title":"Isolated Paroxysmal Right Upward Eye Deviation as the Sole Semiology of Childhood Occipital Epilepsy: An Electroclinical Case Report.","authors":"Gunce Basarir, Rıdvan Avcı","doi":"10.1177/15500594261462223","DOIUrl":"10.1177/15500594261462223","url":null,"abstract":"BackgroundIsolated paroxysmal eye deviation in children is often considered a benign nonepileptic phenomenon. When epileptic in origin, gaze deviation is usually accompanied by visual symptoms, autonomic features, impaired awareness, or additional motor manifestations.CaseWe report a 6-year-old boy with frequent daily episodes of brief right upward eye deviation without impaired awareness, visual symptoms, head version, or other ictal features. Neurological and ophthalmological examinations, routine laboratory investigations, and brain magnetic resonance imaging were unremarkable. Video-electroencephalography demonstrated repetitive spike-wave discharges over the left occipital region, supporting an epileptic origin.ResultsCarbamazepine treatment markedly reduced episode frequency, and the spells resolved completely after dose adjustment during follow-up. Next-generation sequencing analysis of calcium channelopathy-related genes revealed no pathogenic variants.ConclusionsThis case highlights that isolated paroxysmal right upward eye deviation, even in the absence of other ictal features, may represent a focal preserved consciousness seizure rather than a benign ocular phenomenon. Early electroencephalographic evaluation is essential in children with frequent or atypical paroxysmal eye movements to avoid misdiagnosis and delayed treatment.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"438-441"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148297901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Right Temporal Delta Power in Quantitative Electroencephalogram as Predictor of Early Response to Clozapine in Treatment-Resistant Schizophrenia. 定量脑电图右颞波功率作为治疗难治性精神分裂症患者氯氮平早期反应的预测因子。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-09-01 Epub Date: 2025-10-22 DOI: 10.1177/15500594251389251

Shreya Batra, Priti Arun, Prinka Arora, Simranjit Kaur

{"title":"Right Temporal Delta Power in Quantitative Electroencephalogram as Predictor of Early Response to Clozapine in Treatment-Resistant Schizophrenia.","authors":"Shreya Batra, Priti Arun, Prinka Arora, Simranjit Kaur","doi":"10.1177/15500594251389251","DOIUrl":"10.1177/15500594251389251","url":null,"abstract":"BackgroundSchizophrenia affects millions globally, with up to 30% showing resistance to standard antipsychotics. Clozapine is effective for treatment resistant schizophrenia (TRS), but its use is often delayed. This study explores Quantitative electroencephalogram (QEEG) as a tool to predict clozapine response in Indian TRS patients, aiming to support early, personalized treatment.AimThis study aims to predict treatment response to clozapine in TRS patients using quantitative electroencephalogram (QEEG) by assessing and comparing baseline and 6 weeks QEEG patterns and their changes in responders versus non-responders.Methods39 clozapine-naïve TRS patients were recruited at tertiary care hospital in North India and assessed using BPRS, GASS-C and EEG at baseline, 3 weeks and 6 weeks. EEG data were processed and analyzed for frequency band power to compare responders (≥20% BPRS improvement) and non-responders.ResultsOf the 39 patients included, 36 completed the study, with 67% classified as responders and 33% as non-responders. Responders showed significantly higher right temporal delta power at 3 and 6 weeks, with ROC analysis at 6 weeks yielding an Area under curve of 0.757 (P = .014). Statistically significant increases in delta and theta power were observed in responders.ConclusionsIncreased right temporal delta power was seen in responders, but changes were insufficient to reliably predict outcomes.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"404-412"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145350531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissociation Between Neural Functional Connectivity and Brain Volume Loss with Age: Insights from Resting-State Magnetoencephalography. 神经功能连通性与脑容量随年龄减少之间的分离：静息状态脑磁图的见解。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-09-01 Epub Date: 2026-01-21 DOI: 10.1177/15500594251410820

Yuga Takeda, Jun-Ichi Uemura, Satsuki Yamauchi, Katsuyuki Iwatsuki, Sota Saeki, Shotaro Okajima, Tomokazu Abe, Shingo Shimoda, Hitoshi Hirata, Minoru Hoshiyama

{"title":"Dissociation Between Neural Functional Connectivity and Brain Volume Loss with Age: Insights from Resting-State Magnetoencephalography.","authors":"Yuga Takeda, Jun-Ichi Uemura, Satsuki Yamauchi, Katsuyuki Iwatsuki, Sota Saeki, Shotaro Okajima, Tomokazu Abe, Shingo Shimoda, Hitoshi Hirata, Minoru Hoshiyama","doi":"10.1177/15500594251410820","DOIUrl":"10.1177/15500594251410820","url":null,"abstract":"To investigate the relationship between age-related brain volume loss and neural functional connectivity (FC), whole brain volume and mean FC were calculated in 75 healthy participants aged 20 to 86 years (39 women, 36 men; mean age: 59.31 years). Resting-state MEG with eyes closed and MRI were conducted. Correlations between age and whole brain volume, mean neural connectivity expressed as amplitude envelope correlation (AEC) in the alpha frequency band across 66 functional parcellations, and the standard deviation (SD) of AEC were analyzed. In seven brain regions showing significant age-related volume loss, mean AEC and SD of AEC with other regions were assessed. Whole brain volume decreased with age (r = -0.322, p = .00480), particularly in participants older than 75 years (p < .05, ANOVA). AEC values also declined with age (r = -0.359, p = .00153), with significant differences observed between generational subgroups under 45 and over 75 years (p < .05). The SD of AEC decreased across the brain with age (r = -0.326, p = .0043). However, seven brain regions with significant age-related volume loss did not consistently show significant differences in AEC or its SD between generational subgroups, in contrast to consistent volume differences observed. Overall, brain volume and neural FC declined with age, accompanied by reduced variability in FC across the brain. Nevertheless, regions exhibiting significant volume loss were not always associated with functional decline in FC or its variability, suggesting the brain may compensate for global decline through localized functional adaptations.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"426-437"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual Evoked Potentials as a Biomarker for Visual Hallucination Pathway Integrity in Late-Stage Alzheimer's Disease. 视觉诱发电位作为晚期阿尔茨海默病视幻觉通路完整性的生物标志物。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-09-01 Epub Date: 2025-12-02 DOI: 10.1177/15500594251403219

Jingyuan Lin

{"title":"Visual Evoked Potentials as a Biomarker for Visual Hallucination Pathway Integrity in Late-Stage Alzheimer's Disease.","authors":"Jingyuan Lin","doi":"10.1177/15500594251403219","DOIUrl":"10.1177/15500594251403219","url":null,"abstract":"ObjectiveAlzheimer's disease (AD) often presents visual hallucinations (VH) in late stages. Visual evoked potentials (VEPs) are noninvasive electrophysiological measures that reflect the functional integrity of the visual conduction pathway. This study uses visual evoked potentials (VEP) to assess visual pathway dysfunction and evaluates VEP as a biomarker for disease progression.MethodsA retrospective study of 112 AD patients (2016-2024) was conducted, categorizing individuals into VH and non-VH groups based on the presence of visual hallucinations. VEP testing assessed P100 latency and amplitude. Baseline characteristics and VEP parameters were compared between groups, and correlations with disease duration were analyzed.ResultsNo significant differences were observed between the two groups in terms of age, sex, years of education, homocysteine (HCY) levels, or Mini-Mental State Examination (MMSE) scores (p > 0.05). However, disease duration was significantly longer in the VH group than in the non-VH group (p = 0.00). VEP findings revealed a significantly prolonged P100 latency (p = 0.01) and reduced P100 amplitude (p = 0.00) in the VH group. Correlation analysis indicated a positive correlation between P100 latency and disease duration (r = 0.21, p = 0.03) and a negative correlation between P100 amplitude and disease duration (r = -0.34, p = 0.00), suggesting progressive impairment of the visual conduction pathway over the course of the disease.ConclusionAD patients with visual hallucinations exhibit more severe impairments in the integrity of the visual conduction pathway than those without hallucinations, as evidenced by prolonged P100 latency and decreased amplitude. These changes are closely associated with disease duration.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"458-463"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

P300 Predicts the Effect of a Brief Intervention on Alcohol Consumption in Habitual Drinkers. P300预测短期干预对习惯性饮酒者酒精消费的影响。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-09-01 Epub Date: 2026-02-16 DOI: 10.1177/15500594261420477

Risa Yamada, Andrew Stickley, Tomiki Sumiyoshi

{"title":"P300 Predicts the Effect of a Brief Intervention on Alcohol Consumption in Habitual Drinkers.","authors":"Risa Yamada, Andrew Stickley, Tomiki Sumiyoshi","doi":"10.1177/15500594261420477","DOIUrl":"10.1177/15500594261420477","url":null,"abstract":"BackgroundThis study investigated whether P300, a component of event-related potentials (ERPs), and cognitive performance related to frontal lobe function can predict responsiveness to a brief cognitive behavioral intervention in individuals who consume alcohol on ≥3 days per week.MethodsParticipants were 35 habitual drinkers (drinking alcohol on ≥3 days per week). At baseline, they completed self-report questionnaires assessing alcohol consumption, neuropsychological tests reflecting frontal lobe function (eg, the Trail Making Test, Stroop Test, Digit Symbol Substitution Test, verbal fluency tests), and P300 assessment during a visual oddball task with alcohol-related images. All participants then received ∼30 min of structured counseling on drinking behavior, followed by a second brief intervention at 3 months. Alcohol intake was reported at both time points, and total daily alcohol consumption (in standard drinks) was calculated. Participants were categorized as successful reducers if their daily alcohol intake at three months was lower than at baseline (n = 27), and as unsuccessful if intake was unchanged or increased (n = 8). Baseline ERP and neuropsychological measures were compared between groups.ResultsParticipants who reduced their drinking had significantly lower P300 amplitudes at P3 and Fz at baseline compared with those who did not. No significant between-group differences were found in neuropsychological performance.ConclusionsLower P300 amplitudes may serve as a neurophysiological marker for predicting responsiveness to brief psychosocial interventions for alcohol reduction in individuals with high-risk drinking, potentially providing greater sensitivity than traditional neuropsychological tests.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"383-393"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146204210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Envelope of Alpha Activity in Depression and Anxiety: A Novel Analysis of the Second-Order Derivatives of Alpha Envelope of EEG. 抑郁和焦虑的α活动包络：脑电图α包络二阶导数的新分析。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-09-01 Epub Date: 2025-11-13 DOI: 10.1177/15500594251387497

Shohei Mori, Aiko Hoshino, Jun-Ichi Uemura, Misako Sano, Yuko Nishiura, Izumi Morikawa, Katsuyuki Iwatsuki, Hitoshi Hirata, Minoru Hoshiyama

{"title":"Envelope of Alpha Activity in Depression and Anxiety: A Novel Analysis of the Second-Order Derivatives of Alpha Envelope of EEG.","authors":"Shohei Mori, Aiko Hoshino, Jun-Ichi Uemura, Misako Sano, Yuko Nishiura, Izumi Morikawa, Katsuyuki Iwatsuki, Hitoshi Hirata, Minoru Hoshiyama","doi":"10.1177/15500594251387497","DOIUrl":"10.1177/15500594251387497","url":null,"abstract":"This study examined the relationship between alpha activity fluctuations in resting-state electroencephalography (EEG) and the Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory (STAI) scores. A novel approach was introduced using second-order derivatives of the alpha envelope to identify potential functional biomarkers for depression and anxiety conditions. Two 30-s eyes-closed epochs of 64-channel EEG data were collected from open dataset of 113 college-aged participants with the BDI and STAI scores. Metrics including mean positive (Ap) and negative (An) second-order derivatives, the Ap-An ratio, root mean square (RMS), and peak frequency of the alpha envelope were extracted. Correlations between these EEG metrics and scores on the BDI and STAI were analyzed. BDI (Spearman's rank correlation, rs = 0.253-0.304,) and STAI (rs = 0.222-0.339) scores showed significant but weak positive correlations with the Ap-An ratio, in the left frontal regions (P < .05, FDR-corrected). No significant correlation was found between envelope amplitude and either score. The Ap-An ratio at the frontal, temporal, and central electrodes, and peak alpha frequency at the electrodes including the parietal and occipital regions, were significantly higher in participants with BDI scores above 10 compared to those with scores of 10 or below (P < .05, FDR, Mann-Whitney U test). These findings suggest that the second-order derivatives of alpha envelope may serve as functional biomarkers for psychiatric disorders, differently from the frequency and amplitude. Further research is needed to confirm whether these EEG features reflect regional neural activity, such as excitatory and inhibitory activities.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"413-425"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145514639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Anti-Seizure Medications on Interictal Epileptiform Discharges in Focal Epilepsy. 抗癫痫药物对局灶性癫痫发作间期癫痫样放电的影响。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-09-01 Epub Date: 2025-12-10 DOI: 10.1177/15500594251401765

Caralynn Li, Bassel W Abou-Khalil, Jonah Fox

{"title":"Effect of Anti-Seizure Medications on Interictal Epileptiform Discharges in Focal Epilepsy.","authors":"Caralynn Li, Bassel W Abou-Khalil, Jonah Fox","doi":"10.1177/15500594251401765","DOIUrl":"10.1177/15500594251401765","url":null,"abstract":"The purpose of this study was to assess the change in frequency and distribution of focal interictal epileptiform discharges (IEDs) as measured on scalp EEG after anti-seizure medications (ASMs) were weaned in the epilepsy monitoring unit. We retrospectively reviewed the EEG of patients with focal epilepsy on a single ASM. A two-hour EEG epoch was selected at sleep onset during the first day of admission and defined as the high-ASM epoch. This was compared to a two-hour low-ASM epoch at sleep onset after the ASM was weaned, at least 6 h before or after a seizure. IEDs were manually counted and characterized. A total of 115 patients were included. For those on levetiracetam, there was a significant increase in IED quantity when comparing the high-ASM to the low-ASM epoch (mean 40.6 to 71.4, p < 0.001). For those on sodium channel blockers, there was a non-significant trend towards a decrease in IED quantity as the ASM dose was decreased (p = 0.065). There was no statistically significant change found for other individual ASMs. For the cohort, 12 patients had IED observed only on the low-ASM epoch (which were not present on the high-ASM epoch), 6 of which were treated with levetiracetam. In summary, our findings showed weaning of levetiracetam was associated with a significant increase in IEDs whereas other ASMs were not. Some populations of IEDs were only seen after ASMs were weaned. These findings suggest that different ASMs may have unique effects on IEDs when weaned.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"464-470"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13477501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145727692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous EEG Monitoring and Clinical Outcomes in Patients Undergoing ECMO. ECMO患者连续脑电图监测与临床结果。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-09-01 Epub Date: 2025-11-14 DOI: 10.1177/15500594251390692

Kinshuk Sahaya, Micaela T Chatman, Sandra Castro-Pearson, Ashley E Stenzel, Catherine A St Hill, Maximilian Mulder

{"title":"Continuous EEG Monitoring and Clinical Outcomes in Patients Undergoing ECMO.","authors":"Kinshuk Sahaya, Micaela T Chatman, Sandra Castro-Pearson, Ashley E Stenzel, Catherine A St Hill, Maximilian Mulder","doi":"10.1177/15500594251390692","DOIUrl":"10.1177/15500594251390692","url":null,"abstract":"BackgroundNeurological complications during Extracorporeal membrane oxygenation (ECMO) can result in long-term cognitive deficits. This exploratory study aimed to determine the association between continuous EEG (cEEG) findings and neurological outcome in adult patients undergoing ECMO,MethodsThis retrospective cohort study analyzed EEG characteristics, and clinical outcomes in adult ECMO patients at a tertiary care center. We included all adult ECMO patients from January 1, 2015, to July 31, 2019 including patients in whom cEEG was initiated ASAP with ECMO orders. EEG data were evaluated for association with clinical outcome. Clinical outcomes were assessed using the Glasgow Outcome Scale (GOS), modified Rankin Scale (mRS), and Cerebral Performance Category (CPC) scale at discharge and 6 months.ResultsAmong 329 ECMO encounters, 214 (65%) included cEEG monitoring. Low EEG voltage was associated with poor outcome (CPC, 52.4% vs 64% p = 0.001). EEG reactivity was associated with outcome at 6 months (CPC, 54.8% reactive and good outcome vs 67% unreactive and poor outcomes p = 0.005). The presence of predominant background frequency, normal voltage, was associated with good outcome while higher Mayo EEG grade with poor outcomes. In the limited subset of patients with Sequential Organ Failure Assessment (SOFA) Score, no significant differences were noted between patients with different Mayo EEG grades, EEG reactivity, or background changes. Higher SOFA scores were associated with poor outcomes.ConclusionscEEG monitoring may provide prognostic information for adult ECMO patients. It remains unclear if the EEG findings are solely reflective of underlying severity of illness or not.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"449-457"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Electroencephalogram in Persons with Alcohol Dependence Syndrome: A Pre- and Post-Treatment Findings. 酒精依赖综合征患者的定量脑电图：治疗前后的结果。

IF 1.7

Clinical EEG and neuroscience Pub Date : 2026-09-01 Epub Date: 2026-01-27 DOI: 10.1177/15500594261417529

Srishti Sharma, Ajeet Sidana, Shivangi Mehta, Simranjit Kaur

{"title":"Quantitative Electroencephalogram in Persons with Alcohol Dependence Syndrome: A Pre- and Post-Treatment Findings.","authors":"Srishti Sharma, Ajeet Sidana, Shivangi Mehta, Simranjit Kaur","doi":"10.1177/15500594261417529","DOIUrl":"10.1177/15500594261417529","url":null,"abstract":"BackgroundAssessment and treatment monitoring in alcohol dependence syndrome often rely on subjective measures, particularly in resource-limited settings. Quantitative electroencephalogram (qEEG) provides an objective alternative, though its role in alcohol use and abstinence remains underexplored in the Indian context.AimTo study changes in the quantitative electroencephalogram in persons with alcohol dependence syndrome undergoing treatment.MethodsPatients diagnosed with alcohol dependence syndrome as per ICD-11 were recruited. At baseline, the Severity of Alcohol Dependence Questionnaire (SADQ) (mean 22.60 ± 4.81) and Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-Ar) (mean 10.98 ± 2.45) were administered to assess the severity of dependence and withdrawal symptoms. qEEG was recorded at baseline, following detoxification and at 12 weeks. Detoxification was done using benzodiazepines via a symptom-triggered regimen. Baclofen was offered post-detoxification with regular follow-ups. EEG signals were analysed for changes across standard frequency bands in various scalp regions and in terms of absolute powers.ResultsSixty patients completed the 12-week follow-up. The sample consisted of all males, with a mean age of 40.85 ± 8.30 years. Alpha and gamma powers showed increasing trends, while beta, theta, and delta powers declined across most scalp regions. Absolute power trends were similar, with a statistically significant reduction noted in the delta wave (p-value=.024). No significant correlation was found between severity of dependence and wave powers, except for gamma in the fronto-parietal region (p-value=.01) and beta in the central region (p-value=.021).ConclusionqEEG changes with detoxification and abstinence may serve as an objective indicator for assessing treatment efficacy and abstinence status in alcohol dependence.","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":" ","pages":"394-403"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0