Clinical Implications of Various Electroencephalographic Patterns in Post-Stroke Seizures. The Utility of Routine Electroencephalogram.

Erum Shariff, Saima Nazish, Azra Zafar, Rizwana Shahid, Norah A AlKhaldi, Modhi Saad A Alkhaldi, Danah AlJaafari, Nehad M Soltan, Mohammed AlShurem, Aishah Ibrahim Albakr, Feras AlSulaiman, Majed Alabdali
{"title":"Clinical Implications of Various Electroencephalographic Patterns in Post-Stroke Seizures. The Utility of Routine Electroencephalogram.","authors":"Erum Shariff, Saima Nazish, Azra Zafar, Rizwana Shahid, Norah A AlKhaldi, Modhi Saad A Alkhaldi, Danah AlJaafari, Nehad M Soltan, Mohammed AlShurem, Aishah Ibrahim Albakr, Feras AlSulaiman, Majed Alabdali","doi":"10.1177/15500594241229825","DOIUrl":null,"url":null,"abstract":"<p><p><b>Objective:</b> Post-stroke seizures (PSS) are one of the major stroke-related complications. Early therapeutic interventions are critical therefore using electroencephalography (EEG) as a predictive tool for future recurrence may be helpful. We aimed to assess frequencies of different EEG patterns in patients with PSS and their association with seizure recurrence and functional outcomes. <b>Methods:</b> All patients admitted with PSS were included and underwent interictal EEG recording during their admission and monitored for seizure recurrence for 24 months. <b>Results:</b> PSS was reported in 106 patients. Generalized slow wave activity (GSWA) was the most frequent EEG pattern observed (n  =  62, 58.5%), followed by Focal sharp wave discharges (FSWDs) (n  =  57, 55.8%), focal slow wave activity (FSWA) (n  =  56, 52.8%), periodic discharges (PDs) (n  =  13, 12.3%), and ictal epileptiform abnormalities (n  =  6, 5.7%). FSWA and ictal EAs were positively associated with seizure recurrence (<i>p</i> < .001 and <i>p</i>  =  .015 respectively) and it remained significant even after adjusting for age, sex, stroke severity, stroke subtype, or use of anti-seizure medications (ASMs). Other positive associations were status epilepticus (SE) (<i>p</i>  =  .015), and use of older ASM (<i>p</i> < .001). FSWA and GSWA in EEG were positively associated with severe functional disability (<i>p</i>  =  .055, <i>p</i>  =  .015 respectively). Other associations were; Diabetes Mellitus (<i>p</i>  =  .034), Chronic Kidney Disease (<i>p</i>  =  .002), use of older ASMs (<i>p</i>  =  .037), presence of late PSS (<i>p</i>  =  .021), and those with Ischemic stroke (<i>p</i>  =  .010). <b>Conclusions:</b> Recognition and documentation of PSS-related EEG characteristics are important, as certain EEG patterns may help to identify the patients who are at risk of developing recurrence or worse functional outcomes.</p>","PeriodicalId":93940,"journal":{"name":"Clinical EEG and neuroscience","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical EEG and neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/15500594241229825","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: Post-stroke seizures (PSS) are one of the major stroke-related complications. Early therapeutic interventions are critical therefore using electroencephalography (EEG) as a predictive tool for future recurrence may be helpful. We aimed to assess frequencies of different EEG patterns in patients with PSS and their association with seizure recurrence and functional outcomes. Methods: All patients admitted with PSS were included and underwent interictal EEG recording during their admission and monitored for seizure recurrence for 24 months. Results: PSS was reported in 106 patients. Generalized slow wave activity (GSWA) was the most frequent EEG pattern observed (n  =  62, 58.5%), followed by Focal sharp wave discharges (FSWDs) (n  =  57, 55.8%), focal slow wave activity (FSWA) (n  =  56, 52.8%), periodic discharges (PDs) (n  =  13, 12.3%), and ictal epileptiform abnormalities (n  =  6, 5.7%). FSWA and ictal EAs were positively associated with seizure recurrence (p < .001 and p  =  .015 respectively) and it remained significant even after adjusting for age, sex, stroke severity, stroke subtype, or use of anti-seizure medications (ASMs). Other positive associations were status epilepticus (SE) (p  =  .015), and use of older ASM (p < .001). FSWA and GSWA in EEG were positively associated with severe functional disability (p  =  .055, p  =  .015 respectively). Other associations were; Diabetes Mellitus (p  =  .034), Chronic Kidney Disease (p  =  .002), use of older ASMs (p  =  .037), presence of late PSS (p  =  .021), and those with Ischemic stroke (p  =  .010). Conclusions: Recognition and documentation of PSS-related EEG characteristics are important, as certain EEG patterns may help to identify the patients who are at risk of developing recurrence or worse functional outcomes.

卒中后癫痫发作中各种脑电图模式的临床意义。常规脑电图的实用性。
目的:中风后癫痫发作(PSS)是与中风有关的主要并发症之一。早期治疗干预至关重要,因此使用脑电图(EEG)作为未来复发的预测工具可能会有所帮助。我们旨在评估 PSS 患者不同脑电图模式的频率及其与癫痫复发和功能预后的关系。研究方法纳入所有入院的 PSS 患者,在入院期间进行发作间期脑电图记录,并在 24 个月内监测癫痫复发情况。结果有 106 名患者报告了 PSS。全身慢波活动(GSWA)是最常见的脑电图模式(n = 62,58.5%),其次是局灶性锐波放电(FSWDs)(n = 57,55.8%)、局灶性慢波活动(FSWA)(n = 56,52.8%)、周期性放电(PDs)(n = 13,12.3%)和发作性癫痫样异常(n = 6,5.7%)。FSWA和发作期痫样异常与癫痫复发呈正相关(p p = .015),即使调整年龄、性别、卒中严重程度、卒中亚型或抗癫痫药物(ASMs)的使用后,仍有显著性。其他正相关的因素包括癫痫状态(SE)(p = .015)和使用较老的抗癫痫药物(分别为 p p = .055 和 p = .015)。其他相关因素包括:糖尿病(p = .034)、慢性肾病(p = .002)、使用较老的 ASM(p = .037)、晚期 PSS(p = .021)和缺血性中风(p = .010)。结论:识别和记录与 PSS 相关的脑电图特征非常重要,因为某些脑电图模式可能有助于识别有复发风险或功能预后较差的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信