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GENTLE-PACE - A multicenter, randomized, double-blinded research study comparinG the Efficacy and safety of cardioNeuroablaTion vs. permanent pacing in patients with an implantabLE PACEmaker for symptomatic bradycardia. GENTLE-PACE--一项多中心、随机、双盲研究,比较了植入 PACE 起搏器治疗症状性心动过缓患者的心脏神经起搏与永久起搏的有效性和安全性。
Cardiology journal Pub Date : 2024-01-01 Epub Date: 2024-11-25 DOI: 10.5603/cj.100718
Przemysław Skoczyński, Bruno Hrymniak, Bartosz Skonieczny, Bartosz Biel, Krystian Josiak, Bartosz Krakowiak, Kuba Ptaszkowski, Krzysztof S Gołba, Jacek Bednarek, Jarosław Kosior, Edyta Stodółkiewicz-Nowarska, Anna Skotny, Patrycja Aktanorowicz, Agnieszka Andrejków, Anna Ratajska, Magdalena Zając, Waldemar Banasiak, Adrian Doroszko, Dorota Zyśko, Sebastian Stec, José Carlos Pachón-Mateos, Dariusz Jagielski
{"title":"GENTLE-PACE - A multicenter, randomized, double-blinded research study comparinG the Efficacy and safety of cardioNeuroablaTion vs. permanent pacing in patients with an implantabLE PACEmaker for symptomatic bradycardia.","authors":"Przemysław Skoczyński, Bruno Hrymniak, Bartosz Skonieczny, Bartosz Biel, Krystian Josiak, Bartosz Krakowiak, Kuba Ptaszkowski, Krzysztof S Gołba, Jacek Bednarek, Jarosław Kosior, Edyta Stodółkiewicz-Nowarska, Anna Skotny, Patrycja Aktanorowicz, Agnieszka Andrejków, Anna Ratajska, Magdalena Zając, Waldemar Banasiak, Adrian Doroszko, Dorota Zyśko, Sebastian Stec, José Carlos Pachón-Mateos, Dariusz Jagielski","doi":"10.5603/cj.100718","DOIUrl":"10.5603/cj.100718","url":null,"abstract":"","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"909-916"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of multimodality imaging in infective endocarditis diagnosis. 多模态成像在感染性心内膜炎诊断中的应用。
Cardiology journal Pub Date : 2024-01-01 DOI: 10.5603/cj.100016
Michał Wrzosek, Karina Zatorska, Anna Konopka, Małgorzata Pastuszek-Tyc, Paweł Litwiński, Piotr Trochimiuk, Tomasz Hryniewiecki, Ilona Michałowska
{"title":"The use of multimodality imaging in infective endocarditis diagnosis.","authors":"Michał Wrzosek, Karina Zatorska, Anna Konopka, Małgorzata Pastuszek-Tyc, Paweł Litwiński, Piotr Trochimiuk, Tomasz Hryniewiecki, Ilona Michałowska","doi":"10.5603/cj.100016","DOIUrl":"10.5603/cj.100016","url":null,"abstract":"","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":"31 4","pages":"645-646"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of etripamil nasal spray for acute conversion of supraventricular tachycardia: a network meta-analysis. 依曲帕米鼻喷雾剂对室上性心动过速急性转归的疗效:网络荟萃分析。
Cardiology journal Pub Date : 2024-01-01 Epub Date: 2024-08-12 DOI: 10.5603/cj.100869
Adam Macech, Nicola Luigi Bragazzi, Francesco Chirico, Basar Cander, Michal Pruc, Zubaid Rafique, William Frank Peacock, Arash Ziapour, Lukasz Szarpak, Anna Salak, Milosz J Jaguszewski
{"title":"Efficacy of etripamil nasal spray for acute conversion of supraventricular tachycardia: a network meta-analysis.","authors":"Adam Macech, Nicola Luigi Bragazzi, Francesco Chirico, Basar Cander, Michal Pruc, Zubaid Rafique, William Frank Peacock, Arash Ziapour, Lukasz Szarpak, Anna Salak, Milosz J Jaguszewski","doi":"10.5603/cj.100869","DOIUrl":"10.5603/cj.100869","url":null,"abstract":"","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"640-642"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Right ventricle to pulmonary artery coupling as a predictor of perioperative outcome in patients with secondary mitral valve insufficiency. 右心室-肺动脉耦合作为继发性二尖瓣关闭不全患者围手术期预后的预测指标。
Cardiology journal Pub Date : 2024-01-01 Epub Date: 2023-09-29 DOI: 10.5603/cj.92559
Jolanta Rzucidło-Resil, Karolina Golińska-Grzybała, Barbara Szlósarczyk, Paweł Rostoff, Andrzej Gackowski, Grzegorz Gajos, Bogusław Kapelak, Jarosław Stoliński
{"title":"Right ventricle to pulmonary artery coupling as a predictor of perioperative outcome in patients with secondary mitral valve insufficiency.","authors":"Jolanta Rzucidło-Resil, Karolina Golińska-Grzybała, Barbara Szlósarczyk, Paweł Rostoff, Andrzej Gackowski, Grzegorz Gajos, Bogusław Kapelak, Jarosław Stoliński","doi":"10.5603/cj.92559","DOIUrl":"10.5603/cj.92559","url":null,"abstract":"<p><strong>Background: </strong>The aim of the study was to assess some parameters of right ventricle (RV) function as predictors of short-term mortality in patients with severe secondary mitral regurgitation (SMR) after mitral valve surgery.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 112 consecutive patients with severe SMR who had undergone mitral valve repair or replacement with or without concomitant coronary artery bypass surgery. We assessed RV to pulmonary artery coupling by calculating the ratio of tricuspid annular plane systolic excursion (TAPSE) to non-invasively estimated RV systolic pressure (RVSP). The study endpoint was 30 days post-procedural mortality.</p><p><strong>Results: </strong>Overall, the 30-day mortality was 6%. TAPSE/RVSP ratio < 0.42 mm/mmHg was a significant predictor of mortality and remained so after adjusting for age and sex. The Kaplan-Meier survival analysis showed that patients with RVSP > 55 mmHg and those with TAPSE/RVSP ratio < 0.42 mm/mmHg had a lower survival probability.</p><p><strong>Conclusions: </strong>TAPSE/RVSP < 0.42 mm/mmHg is a strong predictor of short-term mortality in patients with SMR when considered for valve surgery.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"731-739"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41108074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Initial results of investigator initiated international database on catheter directed therapy of acute pulmonary embolism. 由研究者发起的导管指导治疗急性肺栓塞国际数据库的初步结果。
Cardiology journal Pub Date : 2024-01-01 Epub Date: 2023-09-29 DOI: 10.5603/cj.95949
Mateusz T Jermakow, Slobodan Obradovic, Pablo Salinas, Marek Roik, Boris Dzudovic, Igor Sekulic, Fernando Macaya, Jose Paredes-Vazquez, Maite Velázquez Martín, Nicolás Manuel Maneiro Melón, Djordje Nedeljkov, Jovan Matijasevic, Andrzej Łabyk, Marcin Krakowian, Jakub Stępniewski, Aleksander Araszkiewicz, Piotr Pruszczyk
{"title":"Initial results of investigator initiated international database on catheter directed therapy of acute pulmonary embolism.","authors":"Mateusz T Jermakow, Slobodan Obradovic, Pablo Salinas, Marek Roik, Boris Dzudovic, Igor Sekulic, Fernando Macaya, Jose Paredes-Vazquez, Maite Velázquez Martín, Nicolás Manuel Maneiro Melón, Djordje Nedeljkov, Jovan Matijasevic, Andrzej Łabyk, Marcin Krakowian, Jakub Stępniewski, Aleksander Araszkiewicz, Piotr Pruszczyk","doi":"10.5603/cj.95949","DOIUrl":"10.5603/cj.95949","url":null,"abstract":"<p><strong>Background: </strong>Catheter directed therapies (CDT) are widely used in the treatment of acute pulmonary embolism (PE). A multicenter registry was organized to evaluate their application in real life and to determine efficacy and safety of these procedures. Local experience of participating centers in percutaneous techniques for PE treatment was assessed.</p><p><strong>Methods: </strong>An internet-based registry was designed to collect clinical, echocardiographic and laboratory data of consecutive PE patients treated with CDT in participating centers between 2017 and 2022.</p><p><strong>Results: </strong>Under analysis were 145 consecutive patients with acute PE, aged 61 ± 15 years, treated with CDT in 7 centers: 50 (34.5%) patients with high-risk PE (HRPE), and 95 (65.5%) patients with intermediate-high risk PE (IHRPE). 100 (69%) patients were treated with dedicated devices, in 45 (31%) subjects a pigtail catheter was used. Total PE or CDT related in-hospital mortality in HRPE reached 14% (7 patients), while in IHRPE 3.2% (3 patients) (p = 0.032). 50% of PE or CDT related deaths occurred in patients treated with a pigtail catheter. All-cause mortality in 145 patients was 9.7%, and it was higher in HRPE than in IHRPE (18% vs. 5.3%, p = 0.019). The use of pigtail catheters compared to dedicated systems was associated with higher mortality (20% vs. 5%, p = 0.01).</p><p><strong>Conclusions: </strong>Catheter directed therapies is a real option of treating PE. It was used as primary therapy also in patients without contraindication for thrombolysis suggesting that clinical practice does not always follow current PE guidelines. Patients treated with dedicated CDT systems had a higher survival rate than subjects treated with pigtail catheters.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"390-397"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic value of soluble urokinase-type plasminogen activator receptor in patients with acute coronary syndrome: A systematic review and meta-analysis. 可溶性尿激酶型纤溶酶原激活物受体对急性冠状动脉综合征患者的诊断价值:系统综述和荟萃分析。
Cardiology journal Pub Date : 2024-01-01 Epub Date: 2023-09-29 DOI: 10.5603/cj.96228
Michal Pruc, Iwona Jannasz, Damian Swieczkowski, Grzegorz Procyk, Aleksandra Gasecka, Zubaid Rafique, Francesco Chirico, Nicola Luigi Bragazzi, Milosz J Jaguszewski, Jaroslaw Wysocki, Lukasz Szarpak
{"title":"Diagnostic value of soluble urokinase-type plasminogen activator receptor in patients with acute coronary syndrome: A systematic review and meta-analysis.","authors":"Michal Pruc, Iwona Jannasz, Damian Swieczkowski, Grzegorz Procyk, Aleksandra Gasecka, Zubaid Rafique, Francesco Chirico, Nicola Luigi Bragazzi, Milosz J Jaguszewski, Jaroslaw Wysocki, Lukasz Szarpak","doi":"10.5603/cj.96228","DOIUrl":"10.5603/cj.96228","url":null,"abstract":"<p><strong>Background: </strong>In contemporary clinical practice, there is an increasing need for new clinically relevant biomarkers potentially optimizing management strategies in patients with suspected acute coronary syndrome (ACS). This study aimed to determine the diagnostic utility of soluble urokinase-type plasminogen activator receptor (suPAR) levels in individuals with suspected ACS.</p><p><strong>Methods: </strong>A literature search was performed in Web of Science, PubMed, Scopus, and the Cochrane Central Register of Controlled Trials databases, for studies comparing suPAR levels among patients with and without ACS groups. The methodological quality of the included papers was assessed using the Newcastle-Ottawa Scale (NOS). A fixed-effects model was used if I² < 50%; otherwise, the random-effects model was performed.</p><p><strong>Results: </strong>Five studies with 3417 participants were included in the meta-analysis. Pooled analysis showed that mean suPAR levels in the ACS group were statistically significantly higher than in the control group (3.56 ± 1.38 vs. 2.78 ± 0.54 ng/mL, respectively; mean difference: 1.04; 95% confidence interval: 0.64-1.44; I² = 99%; p < 0.001).</p><p><strong>Conclusions: </strong>In the context of acute coronary syndrome, suPAR is a potential biomarker for the early identification of medical conditions in individuals who are being treated in emergency rooms.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"564-572"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are we at dawn of the drug-coated balloons era? Current evidence, future directions, and tasks of the newly established working group of the Association of Cardiovascular Interventions. 药物涂层球囊时代来临了吗?当前证据、未来方向以及心血管介入协会新成立工作组的任务。
Cardiology journal Pub Date : 2024-01-01 DOI: 10.5603/cj.98927
Sylwia Iwańczyk, Kamil Bujak, Rafał Wolny, Adam Janas, Miłosz Dziarmaga, Maksymilian P Opolski, Rafał Januszek, Adrian Włodarczak, Piotr Desperak, Piotr Niezgoda, Michał Kryjak, Mariusz Tomaniak, Zenon Huczek, Michał Hawranek, Bernardo Cortese, Wojciech Wańha
{"title":"Are we at dawn of the drug-coated balloons era? Current evidence, future directions, and tasks of the newly established working group of the Association of Cardiovascular Interventions.","authors":"Sylwia Iwańczyk, Kamil Bujak, Rafał Wolny, Adam Janas, Miłosz Dziarmaga, Maksymilian P Opolski, Rafał Januszek, Adrian Włodarczak, Piotr Desperak, Piotr Niezgoda, Michał Kryjak, Mariusz Tomaniak, Zenon Huczek, Michał Hawranek, Bernardo Cortese, Wojciech Wańha","doi":"10.5603/cj.98927","DOIUrl":"10.5603/cj.98927","url":null,"abstract":"","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":"31 4","pages":"507-511"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of life in heart failure: New data, new drugs and devices. 心力衰竭患者的生活质量:新数据、新药物和设备。
Cardiology journal Pub Date : 2024-01-01 Epub Date: 2023-10-12 DOI: 10.5603/cj.92243
Katarzyna Major, Aleksandra Bodys-Pełka, Marcin Grabowski, Małgorzata Lelonek
{"title":"Quality of life in heart failure: New data, new drugs and devices.","authors":"Katarzyna Major, Aleksandra Bodys-Pełka, Marcin Grabowski, Małgorzata Lelonek","doi":"10.5603/cj.92243","DOIUrl":"10.5603/cj.92243","url":null,"abstract":"<p><p>Quality of life (QoL) is a therapeutic goal in heart failure. There are many EBM therapies for improving QoL. In this study, data is presented on new pharmacotherapies and devices that impact QoL in the heart failure population.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"156-167"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41223564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statins and the risk of pancreatic cancer: A systematic review and meta-analysis of 2,797,186 patients. 他汀类药物与胰腺癌风险:一项对2,797,186例患者的系统回顾和荟萃分析。
Cardiology journal Pub Date : 2024-01-01 Epub Date: 2022-04-04 DOI: 10.5603/CJ.a2022.0014
Eryka Karbowska, Damian Swieczkowski, Aleksandra Gasecka, Michal Pruc, Kamil Safiejko, Jerzy R Ladny, Tomasz Kopiec, Milosz J Jaguszewski, Krzysztof J Filipiak, Zubaid Rafique, Lukasz Szarpak
{"title":"Statins and the risk of pancreatic cancer: A systematic review and meta-analysis of 2,797,186 patients.","authors":"Eryka Karbowska, Damian Swieczkowski, Aleksandra Gasecka, Michal Pruc, Kamil Safiejko, Jerzy R Ladny, Tomasz Kopiec, Milosz J Jaguszewski, Krzysztof J Filipiak, Zubaid Rafique, Lukasz Szarpak","doi":"10.5603/CJ.a2022.0014","DOIUrl":"10.5603/CJ.a2022.0014","url":null,"abstract":"<p><strong>Background: </strong>Statin use in many studies is related to the improvement of a patients' condition including reducing the risk of various malignancies. Herein, is a systematic review and meta-analysis to examine the evidence on the association between statin therapy and the risk of the occurrence of pancreatic cancer, mainly in terms of decreased risk of developing pancreatic cancer among patients using statin therapy in the long-term perspective.</p><p><strong>Methods: </strong>PubMed, Web of Science, Scopus and Cochrane Central Register of Controlled Trials (CENTRAL) were searched from database inception to December 1st, 2021. Random effect models were used to estimate summary odds ratios (OR) and the corresponding 95% confidence intervals (CI).</p><p><strong>Results: </strong>A total of 26 studies comprising 2,797,186 patients were included. Polled analysis showed that pancreatic cancer occurrence in statin vs. no-statin group varied and amounted to 0.4% vs. 0.6% (RR = 0.83; 95% CI: 0.72-0.96; I² = 84%; p = 0.01).</p><p><strong>Conclusions: </strong>In summary, the present analysis shows that overall statins use is significantly associated with a reduction in risk of pancreatic cancer. However, these results were not confirmed for the randomized controlled trial subgroup. Further prospective studies are needed to confirm the current results.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"243-250"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46352304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bivalirudin versus heparin in contemporary percutaneous coronary interventions for patients with acute coronary syndrome: a systematic review and meta-analysis. 比伐鲁定与肝素在当代急性冠脉综合征患者经皮冠状动脉介入治疗中的应用:一项系统综述和荟萃分析。
Cardiology journal Pub Date : 2024-01-01 Epub Date: 2023-11-15 DOI: 10.5603/cj.90956
Junyan Zhang, Zhongxiu Chen, Duolao Wang, Chen Li, Fangbo Luo, Yong He
{"title":"Bivalirudin versus heparin in contemporary percutaneous coronary interventions for patients with acute coronary syndrome: a systematic review and meta-analysis.","authors":"Junyan Zhang, Zhongxiu Chen, Duolao Wang, Chen Li, Fangbo Luo, Yong He","doi":"10.5603/cj.90956","DOIUrl":"10.5603/cj.90956","url":null,"abstract":"<p><strong>Background: </strong>Bivalirudin is associated with fewer major bleeding events than heparin in patients undergoing percutaneous coronary intervention (PCI), but confounding effects of concomitant glycoprotein IIb/IIIa inhibitors, routine femoral artery access, and less potent effects of clopidogrel limits meaningful comparisons. The present study is a systematic review and meta-analysis to compare bivalirudin to heparin in contemporary practice.</p><p><strong>Methods: </strong>The Cochrane Library, PubMed, EMBASE, and Ovid MEDLINE databases were searched for relevant studies, including comparisons between bivalirudin and heparin in the current medical era from inception to December 23, 2021. Studies reporting incidences of major adverse cardiac events (MACE) and net adverse clinical events (NACE) in patients undergoing PCI and meeting the inclusion criteria were retained. Data extraction was performed by three independent reviewers.</p><p><strong>Results: </strong>The meta-analysis included 8 studies. Compared to heparin, bivalirudin during PCI was associated with a lower NACE risk, lower all-cause death, and similar MACE risk, with a pooled risk ratio of 0.82 (95% confidence interval [CI] 0.69-0.97, p = 0.02), 0.83 (95% CI 0.74-0.94, p = 0.002), and 0.93 (95% CI 0.78-1.10, p = 0.38), respectively. Moreover, the reduction in NACE was mainly attributed to reduced bleeding (22% reduction in the risk of major bleeding, 95% CI 0.63-0.97, p = 0.03).</p><p><strong>Conclusions: </strong>These findings suggest that bivalirudin use during PCI reduced the risk of NACE and all-cause death but did not reduce the risk of MACE compared with heparin use in PCI. More studies specifically designed for anticoagulation strategies and a personalized anticoagulation regimen to comprehensively balance bleeding and ischemia risks are required.</p>","PeriodicalId":93923,"journal":{"name":"Cardiology journal","volume":" ","pages":"309-320"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107593124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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