Bruna Parapinski Santos, Júlio Augusto Naylor Lisbôa, José Antônio Bessegatto, Carlos Henrique Montemor, Lais Resende Paulino, Amauri Alcindo Alfieri, J Scott Weese, Marcio Carvalho Costa
{"title":"Impact of virginiamycin on the ruminal microbiota of feedlot cattle.","authors":"Bruna Parapinski Santos, Júlio Augusto Naylor Lisbôa, José Antônio Bessegatto, Carlos Henrique Montemor, Lais Resende Paulino, Amauri Alcindo Alfieri, J Scott Weese, Marcio Carvalho Costa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Growth-promoting antibiotics have been used in cattle, but concern about antimicrobial overuse has prompted a re-evaluation of this practice. To evaluate changes in the ruminal microbiota of feedlot cattle by virginiamycin, a total of 76 crossbreed beef cattle from 2 batches of cattle at different sampling periods (B1 and B2) were divided into 2 groups: one receiving virginiamycin in their diet (ATB) and the other receiving the same diet without any growth promoter (CON). The use of virginiamycin was associated with significant changes in the diversity and composition of the ruminal microbiota of cattle in B1, but not in cattle in B2. Several bacterial taxa were significantly more abundant in samples from CON, <i>e.g</i>., an unclassified genus of the TM7 phylum, whereas others were associated with the use of virginiamycin, <i>e.g., Holdemania</i> and <i>Selenomonas</i> spp. In conclusion, virginiamycin can affect bacterial diversity and composition in the rumen of feedlot cattle, but its effect is inconsistent in different seasons of the year.</p>","PeriodicalId":93919,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":"88 4","pages":"114-122"},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11418755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diana A Mendonça, Flávia Tavares, Cristiano C Pessoa da Veiga, Fabiana Knackfuss, Bruno Alberigi
{"title":"Clinical respiratory and radiographic abnormalities in dogs with spontaneous hypercortisolism.","authors":"Diana A Mendonça, Flávia Tavares, Cristiano C Pessoa da Veiga, Fabiana Knackfuss, Bruno Alberigi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The objective of this study was to characterize respiratory clinical signs, other than panting and respiratory distress, as well as thoracic radiographic abnormalities, in dogs with hypercortisolism. Although there have been case reports and studies evaluating the results of pulmonary scintigraphy, no studies have yet reviewed respiratory clinical signs and radiograph results in dogs with hypercortisolism. This study addresses this gap. A case series was evaluated and the dogs' clinical histories were obtained, including clinical signs and physical examination. Digital thoracic radiographs were analyzed to consider such parameters as the diameter of the main bronchi, lung patterns, and the size of the pulmonary trunk. The most common respiratory symptoms were snoring (61.9%), coughing (57.1%), and fatigue (52.4%). Physical examination revealed a high frequency of changes on lung auscultation (95.2%). The body condition score (BCS) was high in 95% of dogs and a significant correlation was observed between the presence of cyanosis and changes in lung auscultation, both of which present similar risk factors. Furthermore, body weight showed a moderate correlation with respiratory rate (RR = 0.571). Radiographic changes were evident in 47.5% of dogs, with the bronchial pattern being the most common (70%). Based on these results, it was observed that respiratory and radiographic abnormalities are frequent in dogs with spontaneous hypercortisolism and a high body condition score was relevant for exacerbating clinical respiratory signs, such as cyanosis and tachypnea.</p>","PeriodicalId":93919,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":"88 4","pages":"101-113"},"PeriodicalIF":0.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11418753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"<i>Varroa destructor</i> and deformed wing virus interaction increases incidence of winter mortality in honey bee colonies.","authors":"Gabrielle Claing, Pascal Dubreuil, Martine Bernier, Julie Ferland, Yvan L'Homme, Edisleidy Rodriguez, Julie Arsenault","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Winter mortality of honey bee colonies represents a major source of economic loss for the beekeeping industry. The objectives of this prospective study were to estimate the incidence risk of winter colony mortality in southwestern Quebec, Canada and to evaluate and quantify the impact of the associated risk factors. A total of 242 colonies from 31 apiaries was selected for sampling in August 2017. The presence of <i>Varroa destructor, Vairimorpha (Nosema)</i> spp., <i>Melissococcus plutonius</i>, deformed wing virus (DWV), and viruses of the acute-Kashmir-Israeli complex (AKI complex) was investigated in each colony. Management practices of the various colonies were obtained from a questionnaire. The incidence risk of colony mortality during the winter of 2017-2018 was estimated to be 26.5% [95% confidence interval (CI): 15.4 to 40.3]. In logistic regression modeling of winter mortality in colonies, an interaction was discovered between <i>V. destructor</i> and DWV; the detection of ≥ 1 <i>V. destructor</i> mites per 100 bees was associated with higher odds of mortality (3.46, 95% CI: 1.35 to 8.90) compared to colonies with < 1 mite per 100 bees, but only in DWV-positive colonies. There were more colony losses in apiaries from beekeepers owning 1 to 5 colonies than in apiaries from beekeepers owning over 100 colonies, which suggests that beekeeper experience and/or type of management are important contributors to winter colony mortality. Assuming a causal relationship, the results of this study suggest that up to 9% of all colony mortalities in the population could have been prevented by reducing the level of <i>V. destructor</i> to < 1 mite per 100 bees in all colonies.</p>","PeriodicalId":93919,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":"88 3","pages":"69-76"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeff Wilson, Teresa Cereno, Mike Petrik, Negin Esfandiari, Derek Davy, Aaya Mahdi, Jeff Aramini, William Joseph Gilliam, Treasure Hunt, Jocelyn Rivers
{"title":"It's time to apply outbreak response best practices to avian influenza: A national call to action.","authors":"Jeff Wilson, Teresa Cereno, Mike Petrik, Negin Esfandiari, Derek Davy, Aaya Mahdi, Jeff Aramini, William Joseph Gilliam, Treasure Hunt, Jocelyn Rivers","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cases of high pathogenicity avian influenza (HPAI) in Canada are upon us again and with reports of infection in US dairy cattle and a dairy farmer in the United States, concern has been raised. Although panic isn't helpful, this heightened level of concern is appropriate, given that reports of human infections with the H5N1 virus often indicate high mortality rates. These can range from 14 to 50%. The current devastating impact of the virus on the poultry industry, as well as its propensity to mutate are also reasons for concern. At the same time, HPAI provides an opportunity for the poultry and livestock industries to align and organize coherently for the management of all zoonotic diseases and other industry issues. To manage HPAI more effectively, it is essential to align all stakeholders under Outbreak Response Best Practices using a formal Quality Management System (QMS). The objective of this article is to describe this approach with examples drawn from management of the Walkerton waterborne disease crisis. We urge the veterinary profession to rise to the challenge of HPAI and use it as a context in which to align more coherently with national stakeholders for the prevention and management of all priority issues within the areas of Agri-food and Public Health.</p>","PeriodicalId":93919,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":"88 3","pages":"94-98"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Characteristics of gallbladder microbiome in healthy dogs and cats, dogs with gallbladder mucocele, and cats with suspected cholangitis/cholangiohepatitis.","authors":"Nathita Phumthanakorn, Seenam Potivanakul, Siripassorn Kitjarak, Thanadol Lopnapun, Nutchawara Moonkaew, Thawanchay Changtrakul, Wichunee Chotimol, Jeerawat Soonthornsit","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this study was to investigate and characterize the microbiome in bile samples obtained from dogs with gallbladder mucocele (6), cats with suspected cholangitis/cholangiohepatitis (4), as well as from healthy dogs (6) and cats (4). Our goal was to compare the microbiome patterns with clinical findings and bacterial culture results in diseases of the gallbladder and to identify a potential microbial biomarker of diseased groups. The microbial taxa composition revealed that Proteobacteria were the most dominant phylum in healthy and diseased individuals in all groups. Individuals from six families including <i>Burkholderiaceae</i>, <i>Phyllobacteriaceae</i>, <i>Bradyrhizobiaceae</i>, <i>Sphingomonadaceae</i>, <i>Moraxellaceae</i>, and <i>Caulobacteraceae</i>, constituted the core microbiome in the gallbladder of healthy dogs. A combination of LEfSe analysis and Taxa2ASV decomposer revealed that <i>Pseudomonaceae</i> and <i>Ruminococcaceae</i> exclusively occurred in the mucocele group. In conclusion, this study determined the core microbiome in the gallbladder of healthy dogs and the possible biomarkers (<i>Pseudomonaceae</i> and <i>Ruminococcaceae</i>) of gallbladder mucocele in dogs.</p>","PeriodicalId":93919,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":"88 3","pages":"77-86"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrés Giraldo, Thomas G Koch, Pavneesh Madan, Sarah Lepage, Gabrielle Monteith, Amir H Alizadeh, Andy Tran, Narman Mortagy, Judith B Koenig
{"title":"Effect of extracorporeal shockwave therapy on the immunomodulatory and anti-inflammatory properties of cultured equine umbilical cord blood mesenchymal stromal cells.","authors":"Andrés Giraldo, Thomas G Koch, Pavneesh Madan, Sarah Lepage, Gabrielle Monteith, Amir H Alizadeh, Andy Tran, Narman Mortagy, Judith B Koenig","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There is a knowledge gap regarding the effect of extracorporeal shockwave treatment (ESWT) on the stress response and immunomodulatory and anti-inflammatory properties of equine umbilical cord blood mesenchymal stromal cells (CB-MSCs). The objective of this study was to investigate the presence of cellular oxidative stress, inflammatory response, and production of growth factors in CB-MSCs after treatment with ESWT. We hypothesized that CB-MSCs treated with ESWT will experience higher levels of cellular stress and increased production of anti-inflammatory cytokines and growth factors compared to untreated CB-MSCs.</p>","PeriodicalId":93919,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":"88 3","pages":"87-93"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Production of a new tetravalent vaccine targeting fimbriae and enterotoxin of enterotoxigenic <i>Escherichia coli</i>.","authors":"ChongLi Xu, Yuhan She, Fengyang Fu, ChongBo Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Enterotoxigenic <i>Escherichia coli</i> (ETEC) is an important type of pathogenic bacteria that causes diarrhea in pigs. The objective of this study was to prepare a novel tetravalent vaccine to effectively prevent piglet diarrhea caused by <i>E. coli.</i> In order to realize the production of <i>K88ac-K99-ST</i><i><sub>1</sub></i><i>-LT</i><i><sub>B</sub></i> tetravalent inactivated vaccine, the biological characteristics, stability, preservation conditions, and safety of the recombinant strain BL21(DE3) (pXKKSL4) were studied, and the vaccine efficacy and minimum immune dose were measured. The results indicated that the biological characteristics, target protein expression, and immunogenicity of the 1st to 10th generations of the strain were stable. Therefore, the basic seed generation was preliminarily set as the 1st to 10th generations. The results of the efficacy tests showed that the immune protection rate could reach 90% with 1 minimum lethal dose (MLD) virulent strain attack in mice. The immunogenicity was stable, and the minimum immune dose was 0.1 mL per mouse. Our research showed that the genetically engineered vaccine developed in this way could prevent piglet diarrhea caused by enterotoxigenic <i>E. coli</i> through adhesin and enterotoxin. In order to realize industrial production of the vaccine as soon as possible, we conducted immunological tests and production process research on the constructed <i>K88ac-K99-ST</i><i><sub>1</sub></i><i>-LT</i><i><sub>B</sub></i> tetravalent inactivated vaccine. The results of this study provide scientific experimental data for the commercial production of vaccines and lay a solid foundation for their industrial production.</p>","PeriodicalId":93919,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":"88 2","pages":"38-44"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11000427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of pathogens in honey bee colonies and association with clinical signs in southwestern Quebec, Canada.","authors":"Gabrielle Claing, Pascal Dubreuil, Martine Bernier, Julie Ferland, Yvan L'Homme, Edisleidy Rodriguez, Julie Arsenault","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Honey bees can be affected by a variety of pathogens, which impacts their vital role as pollinators in agriculture. A cross-sectional study was conducted in southwestern Quebec to: i) estimate the prevalence of 11 bee pathogens; ii) assess the agreement between beekeeper suspicion of a disease and laboratory detection of the causative pathogen; and iii) explore the association between observed clinical signs and pathogen detection in a colony. A total of 242 colonies in 31 apiaries owned by 15 beekeepers was sampled in August 2017. The prevalence of <i>Varroa destructor</i> detection was estimated as 48% for colonies and 93% for apiaries. The apparent prevalence of colonies infected by <i>Nosema</i> spp. and <i>Melissococcus plutonius</i> was estimated as 40% and 21%, respectively. At least 180 colonies were tested by polymerase chain reaction (PCR) for deformed wing virus (DWV), acute-Kashmir-Israeli complex (AKI complex), and black queen cell virus (BQCV), which were detected in 33%, 9%, and 95% of colonies, respectively. <i>Acarapis woodi, Paenibacillus larvae</i>, and <i>Aethina tumida</i> were not detected. Varroasis was suspected by beekeepers in 14 of the 15 beekeeping operations in which the mite was detected. However, no correlation was found between suspected European foulbrood and detection of <i>M. plutonius</i> or between suspected nosemosis and detection of <i>Nosema</i> spp. Colony weakness was associated with <i>Nosema</i> spore counts of at least 0.5 × 10<sup>6</sup> per bee. <i>Melissococcus plutonius</i> was more frequently detected in colonies showing scattered brood.</p>","PeriodicalId":93919,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":"88 2","pages":"45-54"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11000428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Youngjun Kim, Ji-Yeong Ku, Kwang-Man Park, Jonghun Baek, Kyoung-Seong Choi, Jinho Park
{"title":"Comparison of blood profiles between housed and grazing Korean indigenous cattle (Hanwoo).","authors":"Youngjun Kim, Ji-Yeong Ku, Kwang-Man Park, Jonghun Baek, Kyoung-Seong Choi, Jinho Park","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The objective of this study was to compare the hematology profiles of Korean indigenous cattle (Hanwoo) raised in a barn (housed) or on pasture (grazing). Our findings showed significant differences in the red blood cell (RBC) profiles of these 2 groups. When compared to cattle raised in a barn, a significant decrease in hematocrit (<i>P</i> = 0.000), hemoglobin (<i>P</i> = 0.000), and red blood cells (RBCs) (<i>P</i> = 0.000) and a significant increase in mean cell volume (<i>P</i> = 0.015) and reticulocytes (<i>P</i> = 0.000) were observed in grazing cattle, which indicate regenerative anemia. Furthermore, indirect bilirubin was significantly higher in grazing cattle, which indicates intravascular hemolysis and neutropenia (<i>P</i> = 0.000), and monocytosis (<i>P</i> = 0.000) was also identified. To the best of our knowledge, this is the first study that demonstrates changes in reticulocyte count and indirect bilirubin levels secondary to regenerative intravascular hemolysis in grazing cattle.</p>","PeriodicalId":93919,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":"88 2","pages":"33-37"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11000426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabrina Ayoub, Xiu Ting Yiew, Gabrielle Monteith, Allan R Willms
{"title":"Comparison of estimations of urinary bladder volume in different scanning positions using 2D linear dimension formula and 3D bladder circumference tracing in client-owned cats.","authors":"Sabrina Ayoub, Xiu Ting Yiew, Gabrielle Monteith, Allan R Willms","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Urinary bladder volume (UBV) can be estimated using point-of-care ultrasound. The purpose of this study was to compare 2 UBV estimation methods, <i>i.e</i>., three-dimensional (3D) bladder circumference tracing and 2-dimensional (2D) linear bladder dimension formula, against actual bladder volumes in awake client-owned cats and identify the best scanning position for UBV estimations. Up to 3 paired sets of orthogonal longitudinal and transverse bladder ultrasound images were acquired by a trained clinician from 21 cats positioned in dorsal, right lateral, and left lateral recumbency. UBV estimation was performed with these images by 2 different observers using both methods. Actual bladder volumes were measured through urethral catheterization and compared to the estimated UBV using Lin's concordance correlation coefficient and Bland-Altman analyses. Considering all positions, both methods showed substantial strength-of-agreement with actual bladder volumes; the 3D bladder circumference method (ρ<i><sub>c</sub></i> = 0.963, 95% CI: 0.952 to 0.974) with a significant median bias of -4.08 mL (<i>P</i> < 0.001, IQR -7.63 to -0.68 mL, LOA -48.55 to 21.75 mL) and the 2D linear dimension method (ρ<i><sub>c</sub></i> = 0.974, 95% CI: 0.966 to 0.982) with a median bias of -0.82 mL (<i>P</i> = 0.686, IQR -3.89 to 4.05 mL, LOA -35.23 to 35.21 mL). Scanning in left lateral recumbency provided the strongest strengths-of-agreement and precision against actual bladder volumes for both methods. Regardless of scanning positions, the 2D linear dimension method is more accurate than the 3D bladder circumference method, although both methods are imprecise with increasing volumes and UBV assessment through urinary catheterization remains the gold standard.</p>","PeriodicalId":93919,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":"88 2","pages":"55-65"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11000429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}