Bioscience of microbiota, food and health最新文献

Characterization of Bacillus subtilis isolated from the rumen contents of Mongolian pasture-grazing sheep. 蒙古放牧羊瘤胃内容物分离的枯草芽孢杆菌的鉴定。

IF 2.9

Bioscience of microbiota, food and health Pub Date : 2026-01-01 Epub Date: 2025-11-04 DOI: 10.12938/bmfh.2025-029

Tsogtbaatar Lkhagvajav, Purevtsogt Dorjgoo, Olzii-Uchral Davaasuren, Banzragch Sukhbat, Tumenjargal Bazarragchaa, Dugersuren Jamyan, Narantuya Ayushjav, Zolzaya Majigsuren, Yuan-Kun Lee, Jiro Nakayama, Jin Shan, Dacheng Liu, Demberel Shirchin

{"title":"Characterization of Bacillus subtilis isolated from the rumen contents of Mongolian pasture-grazing sheep.","authors":"Tsogtbaatar Lkhagvajav, Purevtsogt Dorjgoo, Olzii-Uchral Davaasuren, Banzragch Sukhbat, Tumenjargal Bazarragchaa, Dugersuren Jamyan, Narantuya Ayushjav, Zolzaya Majigsuren, Yuan-Kun Lee, Jiro Nakayama, Jin Shan, Dacheng Liu, Demberel Shirchin","doi":"10.12938/bmfh.2025-029","DOIUrl":"https://doi.org/10.12938/bmfh.2025-029","url":null,"abstract":"The aim of this study was to isolate and select biologically active local strains of Bacillus subtilis from the rumen contents of Mongolian pasture-grazing sheep and to evaluate their potential probiotic characteristics for application in ruminant health. Samples of rumen contents were collected from 15 sheep grazing in Bayan-Unjuul soum, Tuv province, Mongolia, and 62 primary isolates were obtained through culturing on selective solid and liquid media. The primary isolates were evaluated based on their morphological, biochemical, and physiological characteristics, enzymatic activities (amylase, protease, catalase), ability to produce acetoin, milk-coagulating ability, antagonistic activity, antibiotic susceptibility, and growth conditions. Phenotypic and genotypic analyses confirmed that these isolates belonged to the Bacillus subtilis species. Among the isolates, Bacillus subtilis c2-7c demonstrated superior probiotic properties for animal use, including strong enzymatic activity, antagonistic effects, and favorable antibiotic resistance profiles. The results show that the Bacillus subtilis c2-7c strain isolated and selected in this study has the most active probiotic characteristics, making it a promising candidate for applications in animal husbandry and veterinary medicine.","PeriodicalId":93908,"journal":{"name":"Bioscience of microbiota, food and health","volume":"45 2","pages":"115-126"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on the combination of Polygonatum sibiricum and Poria cocos for preventing constipation due to pi deficiency. 黄精与茯苓配伍预防肾虚便秘的研究。

IF 2.9

Bioscience of microbiota, food and health Pub Date : 2026-01-01 Epub Date: 2025-11-25 DOI: 10.12938/bmfh.2025-045

Xianqing Sun, Fan Jiang, Zhoujin Tan, Nenqun Xiao

{"title":"Research on the combination of Polygonatum sibiricum and Poria cocos for preventing constipation due to pi deficiency.","authors":"Xianqing Sun, Fan Jiang, Zhoujin Tan, Nenqun Xiao","doi":"10.12938/bmfh.2025-045","DOIUrl":"10.12938/bmfh.2025-045","url":null,"abstract":"This study investigated the preventive effects of combination of Polygonatum sibiricum and Poria cocos on constipation due to pi deficiency and aimed to explore a potential early intervention strategy. The administered groups were gavaged with medicinal liquids containing different ratios of Polygonatum sibiricum to Poria cocos (A, 3:1; B, 1:1; and C, 1:3) for 14 days. Subsequently, a mouse model of constipation due to pi deficiency was established through a combination of Folium Sennae decoction gavage, diet regulation, water restriction, and abnormal hunger and satiety. The normal group was fed normally for 29 days. After 14 days of normal feeding, the model group mice were modeled according to the above modeling method. The study compared fecal characteristics, water content, serum D-xylose levels, intestinal microbial counts, and enzyme activities among the different groups. The results showed that mice with constipation due to pi deficiency exhibited altered body weights and behavior, along with altered fecal features and reduced fecal water content. Dysbiosis of the intestinal microbiota and disturbances in enzyme activities were observed. The mice in the administered groups showed less fluctuation in body weight and improved behavior. Fecal traits were improved, and the water content of feces was increased. Notably, ratio B (1:1) demonstrated the most significant effects, effectively restoring the intestinal flora balance and alleviating enzyme activity disorders. These findings suggest that the combination of Polygonatum sibiricum and Poria cocos at a 1:1 ratio exerts the most beneficial preventive effects on constipation due to pi deficiency by improving intestinal health and microbial homeostasis.","PeriodicalId":93908,"journal":{"name":"Bioscience of microbiota, food and health","volume":"45 2","pages":"127-138"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal changes in the gut microbiota with the progression of obesity-associated type 2 diabetes in KK-Ay mice. KK-Ay小鼠肠道微生物群纵向变化与肥胖相关的2型糖尿病进展

IF 2.9

Bioscience of microbiota, food and health Pub Date : 2026-01-01 Epub Date: 2026-01-20 DOI: 10.12938/bmfh.2025-104

Moeka Yasui, Hinata Takahashi, Fumina Ohsaka, Kei Sonoyama

引用次数: 0

Milk fat globule membrane ameliorates depressive-like behaviors in chronic unpredictable mild stress rats by modulating the microbiota-gut-brain axis. 乳脂球膜通过调节微生物-肠-脑轴改善慢性不可预测轻度应激大鼠的抑郁样行为。

IF 2.9

Bioscience of microbiota, food and health Pub Date : 2026-01-01 Epub Date: 2025-10-03 DOI: 10.12938/bmfh.2025-031

Li Huang, Yunqin Zheng, Qianfeng Liu, Yiran Feng, Zewei Ma, Xinrui Zhao, Xinru Wei, Xinyue Yu, Xia Lv, Jie Lv, Liang Li, Huan Liu, Xiaolei Ze, Meilin Zhang

{"title":"Milk fat globule membrane ameliorates depressive-like behaviors in chronic unpredictable mild stress rats by modulating the microbiota-gut-brain axis.","authors":"Li Huang, Yunqin Zheng, Qianfeng Liu, Yiran Feng, Zewei Ma, Xinrui Zhao, Xinru Wei, Xinyue Yu, Xia Lv, Jie Lv, Liang Li, Huan Liu, Xiaolei Ze, Meilin Zhang","doi":"10.12938/bmfh.2025-031","DOIUrl":"10.12938/bmfh.2025-031","url":null,"abstract":"Depression is one of the common psychiatric disorders, and it has been reported that the imbalance in the microbiota-gut-brain (MGB) axis contributes to the pathogenesis of depression. Milk fat globule membrane (MFGM) can impact the gut-brain axis by regulating the intestinal flora and metabolite production. The aim of this study was to investigate whether MFGM could ameliorate depressive-like behaviors induced by chronic unpredictable mild stress (CUMS) and further elucidate the potential mechanism through a fecal microbiota transplantation (FMT) experiment. Male Sprague-Dawley rats were provided with an MFGM diet for 5 weeks after the induction with CUMS. Depressive-like behaviors were assessed, and the levels of neurotransmitters, neuroendocrine hormones, microbiota, short-chain fatty acids (SCFAs), and tight junction proteins, including occludin and zonula occludens-1 (ZO-1), were measured. It was revealed that MFGM could alleviate the depressive-like behaviors in CUMS rats. MFGM up-regulated the expression of occludin and ZO-1 and ameliorated intestine pathological changes in CUMS rats. Moreover, MFGM increased the levels of 5-hydroxytryptamine (5-HT), dopamine (DA), and norepinephrine and decreased the levels of neuroendocrine hormones in CUMS rats. Furthermore, it was confirmed that the concentrations of SCFAs, DA, 5-HT, and tight junction proteins significantly increased in the recipient rats that were inoculated with the fecal microbiota from the rats after MFGM treatment. These findings demonstrated that MFGM could alleviate depressive-like behaviors in CUMS rats and was possibly associated with modulation of the gut microbiota and up-regulation of SCFAs and monoamine neurotransmitters.","PeriodicalId":93908,"journal":{"name":"Bioscience of microbiota, food and health","volume":"45 1","pages":"66-78"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12765539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fermentation of soymilk with Lacticaseibacillus paracasei strain Shirota reduces soluble Gly m 4 levels and allergic reactions associated with soybean-related pollen-food allergy syndrome. 用副干酪乳杆菌Shirota菌株发酵豆浆可降低可溶性Gly - 4水平和与大豆相关的花粉-食物过敏综合征相关的过敏反应。

IF 2.9

Bioscience of microbiota, food and health Pub Date : 2026-01-01 Epub Date: 2025-10-03 DOI: 10.12938/bmfh.2025-025

Takahiro Shiba, Toshihide Kobayashi, Emi Iwata, Kazuhiko Yoshizawa, Atsuko Adachi, Tatsuya Moriyama

{"title":"Fermentation of soymilk with Lacticaseibacillus paracasei strain Shirota reduces soluble Gly m 4 levels and allergic reactions associated with soybean-related pollen-food allergy syndrome.","authors":"Takahiro Shiba, Toshihide Kobayashi, Emi Iwata, Kazuhiko Yoshizawa, Atsuko Adachi, Tatsuya Moriyama","doi":"10.12938/bmfh.2025-025","DOIUrl":"10.12938/bmfh.2025-025","url":null,"abstract":"Soybean-related pollen-food allergy syndrome (PFAS) is a food allergy triggered by birch or alder pollen-specific immunoglobulin E, which cross-reacts with soybean proteins homologous to pollen proteins. Although soybean-related PFAS generally causes mild symptoms, some individuals develop severe symptoms, including anaphylaxis, especially after consuming soymilk. This study attempted to reduce the risk of allergy by fermenting soymilk with Lacticaseibacillus paracasei strain Shirota (YIT 9029, LcS). The levels of Gly m 4, which causes soybean-related PFAS, in soymilk and fermented soymilk were analyzed using enzyme-linked immunosorbent assay (ELISA) and western blotting. Reactions to soymilk and fermented soymilk were evaluated in patients with soybean-related PFAS using skin prick tests to compare allergic risks. Gly m 4 levels in the soluble fraction of fermented soymilk were significantly lower than those in soymilk. The reduction in Gly m 4 levels was associated with alterations in the fermentation process, including pH reduction. Additionally, compared with soymilk, fermented soymilk reduced skin prick test reactions in patients with soybean-related PFAS. In conclusion, fermenting soymilk with LcS reduced soluble Gly m 4 levels and alleviated allergic reactions associated with soybean-related PFAS. This study demonstrates the potential of fermented soymilk as a safe and effective alternative for individuals with soybean-related PFAS.","PeriodicalId":93908,"journal":{"name":"Bioscience of microbiota, food and health","volume":"45 1","pages":"58-65"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12765538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological study on the effects of gut microbiota and nutrients on breath hydrogen and methane concentrations. 肠道菌群和营养物质对呼吸氢和甲烷浓度影响的流行病学研究。

IF 2.9

Bioscience of microbiota, food and health Pub Date : 2026-01-01 Epub Date: 2025-08-21 DOI: 10.12938/bmfh.2025-044

Satoshi Sato, Daisuke Chinda, Shigeyuki Nakaji, Masakazu Tobinai, Nao Ishidoya, Keisuke Furusawa, Kaede Miyashiro, Kenta Yoshida, Chikara Iino, Kaori Sawada, Tatsuya Mikami, Hirotake Sakuraba

{"title":"Epidemiological study on the effects of gut microbiota and nutrients on breath hydrogen and methane concentrations.","authors":"Satoshi Sato, Daisuke Chinda, Shigeyuki Nakaji, Masakazu Tobinai, Nao Ishidoya, Keisuke Furusawa, Kaede Miyashiro, Kenta Yoshida, Chikara Iino, Kaori Sawada, Tatsuya Mikami, Hirotake Sakuraba","doi":"10.12938/bmfh.2025-044","DOIUrl":"10.12938/bmfh.2025-044","url":null,"abstract":"Breath hydrogen concentration measurement is a valuable tool for assessing the intestinal environment; however, few epidemiological studies have investigated the relationship between exhaled hydrogen and gut microbiota in healthy subjects. This study aimed to epidemiologically elucidate the relationships between exhaled hydrogen, gut microbiota, and nutrient intake in healthy residents of the Iwaki area of Hirosaki City, Aomori Prefecture, including those who exhaled methane. We categorized participants into low- and high-exhaled hydrogen groups based on the median exhaled hydrogen concentration of 6.13 ppm and matched background factors by propensity score matching for age, body mass index, and defecation habits. In the high exhaled hydrogen group, intestinal butyrate-producing bacteria such as Faecalibacterium, Anaerostipes, and Roseburia increased, and Bacteroides strains decreased. In addition, the group with high exhaled hydrogen concentrations had a high dietary fiber intake, and positive correlation was observed between dietary fiber intake and butyrate-producing bacteria. This trend was particularly pronounced for soluble dietary fiber. The exhaled methane concentration decreased in the higher exhaled hydrogen concentration group, and intestinal Methanobrevibacter was positively correlated with the exhaled methane concentration, although in extremely small amounts. No significant relationship was found between each nutrient intake and Methanobrevibacter strain. Measurement of the exhaled hydrogen concentration is useful for assessing the intestinal environment associated with nutritional intake. However, methane gas production was not changed by dietary intake, suggesting that intervention with prebiotics may be necessary.","PeriodicalId":93908,"journal":{"name":"Bioscience of microbiota, food and health","volume":"45 1","pages":"9-18"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12765536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of plasma and cecal quercetin in Enterococcus sp. rutin_18 mono-associated and germ-free mice fed rutin-supplemented diet. 饲粮中添加芦丁的小肠球菌（Enterococcus spp . rutin_18）与无菌小鼠血浆和盲肠槲皮素含量的比较

IF 2.9

Bioscience of microbiota, food and health Pub Date : 2026-01-01 Epub Date: 2025-09-23 DOI: 10.12938/bmfh.2025-021

Motoi Tamura, Ayumi Nakano, Hiroyuki Nakagawa, Kazuhiro Hirayama

{"title":"Comparison of plasma and cecal quercetin in Enterococcus sp. rutin_18 mono-associated and germ-free mice fed rutin-supplemented diet.","authors":"Motoi Tamura, Ayumi Nakano, Hiroyuki Nakagawa, Kazuhiro Hirayama","doi":"10.12938/bmfh.2025-021","DOIUrl":"10.12938/bmfh.2025-021","url":null,"abstract":"Rutin is a functional compound with both antioxidant and anti-cancer properties. The hydrolysis of rutin glycosides by intestinal bacteria is important for rutin absorption. We isolated Enterococcus sp. rutin_18, an intestinal bacterium that can convert rutin to quercetin, and investigated the possibility of Enterococcus sp. rutin_18-mediated rutin conversion to quercetin in vivo using mono-associated mice. We compared the plasma and cecal quercetin levels in rutin-metabolizing Enterococcus sp. rutin_18 mono-associated (Entero) and germ-free (GF) mice fed a rutin-supplemented diet. The plasma quercetin, isorhamnetin, and tamarixetin concentrations were significantly higher in the Entero mice than in the GF mice. The cecal rutin concentration was significantly lower in the Entero mice than in the GF mice (p<0.001). We found that Enterococcus sp. rutin_18 converted rutin to quercetin in the Entero mice. We infer that the Enterococcus sp. rutin_18 used in this study is an important intestinal bacterium that converts rutin to quercetin.","PeriodicalId":93908,"journal":{"name":"Bioscience of microbiota, food and health","volume":"45 1","pages":"51-57"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12765535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Administration of bifidobacteria and dietary fiber improves cognitive function by increasing short-chain fatty acid-producing bacteria and reducing inflammation. 双歧杆菌和膳食纤维通过增加短链脂肪酸产生细菌和减少炎症来改善认知功能。

IF 2.9

Bioscience of microbiota, food and health Pub Date : 2026-01-01 Epub Date: 2025-12-04 DOI: 10.12938/bmfh.2025-026

Naoki Azuma, Natsumi Wada, Ryo Aoki, Masatoshi Sampei, Takashi Mawatari, Yasuo Saito

{"title":"Administration of bifidobacteria and dietary fiber improves cognitive function by increasing short-chain fatty acid-producing bacteria and reducing inflammation.","authors":"Naoki Azuma, Natsumi Wada, Ryo Aoki, Masatoshi Sampei, Takashi Mawatari, Yasuo Saito","doi":"10.12938/bmfh.2025-026","DOIUrl":"https://doi.org/10.12938/bmfh.2025-026","url":null,"abstract":"Bifidobacterium animalis subsp. lactis GCL2505 (GCL2505), commercially known as the \"BifiX\" strain in Japan, reaches the intestine alive, proliferates after a single intake, and is associated with several positive health effects. A randomized, double-blind, placebo-controlled, parallel-group clinical trial of this probiotic strain in combination with inulin (a prebiotic) reported an improvement of cognitive function in the elderly. In the present study, a follow-up analysis was performed to elucidate the underlying mechanism, using a multi-omics approach that integrated a high-throughput assay of blood inflammatory markers and metagenomic analysis of the fecal bacterial composition. After probiotic and prebiotic administration, short-chain fatty acid producers such as Faecalibacterium and Bifidobacterium were increased in the gut. Moreover, in the subgroup with greater improvement in cognitive function scores, the levels of inflammatory markers were decreased. Subgroup analysis revealed that the improvement of cognitive function was associated with a reduction of inflammation and an increase of Faecalibacterium. These results suggest that GCL2505 and inulin can improve cognitive function by alleviating inflammation via an increase of short-chain fatty acid-producing bacteria, which appears to elevate levels of short-chain fatty acids, particularly acetate and butyrate, in the gut. The present results contribute to a deeper comprehension of the gut-brain axis and propose new avenues for potential therapeutic intervention in cognitive disorders.","PeriodicalId":93908,"journal":{"name":"Bioscience of microbiota, food and health","volume":"45 2","pages":"139-148"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting autism spectrum disorder through the gut microbiota composition using machine learning. 利用机器学习通过肠道菌群组成预测自闭症谱系障碍。

IF 2.9

Bioscience of microbiota, food and health Pub Date : 2026-01-01 Epub Date: 2025-09-23 DOI: 10.12938/bmfh.2025-018

Dejun Li, Ziyu Huang, Ailing Wei, Kaixian Long, Yunxuan Su, Shiqin Wang, Xing Li

{"title":"Predicting autism spectrum disorder through the gut microbiota composition using machine learning.","authors":"Dejun Li, Ziyu Huang, Ailing Wei, Kaixian Long, Yunxuan Su, Shiqin Wang, Xing Li","doi":"10.12938/bmfh.2025-018","DOIUrl":"10.12938/bmfh.2025-018","url":null,"abstract":"The human gut microbiota plays a crucial role in overall health, impacting various diseases, including autism spectrum disorder (ASD). This study explores the relationship between gut microbiota changes and ASD by analyzing microbial compositions and abundances of 692 gut microbiota samples using public 16S rRNA sequencing datasets. Data preprocessing included normalization and redundancy reduction, retaining 367 microbial features. A machine learning model was then developed to predict ASD, utilizing feature-selected random forest algorithms that showed superior performance in both training and independent test sets. Identified microbial features with high correlation to ASD included Clostridiales bacterium VE202-08, Solobacterium moorei gene, and other features. The findings suggest that modulating the gut microbiota composition could mitigate ASD risk or alleviate symptoms. These insights pave the way for novel ASD diagnostic methods through microbiota analysis, although further research is required to validate these possibilities. This study offers a new perspective on the etiology and progression of ASD and proposes potential predictive tools for its diagnosis.","PeriodicalId":93908,"journal":{"name":"Bioscience of microbiota, food and health","volume":"45 1","pages":"27-41"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12765537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of probiotic Limosilactobacillus reuteri on a serum sex-hormone- and metabolic-syndrome-related health evaluation: a single-arm open-label pilot study. 益生菌罗伊氏乳酸杆菌对血清性激素和代谢综合征相关健康评估的影响：一项单臂开放标签试点研究

IF 2.9

Bioscience of microbiota, food and health Pub Date : 2026-01-01 Epub Date: 2025-09-09 DOI: 10.12938/bmfh.2025-020

Masafumi Noda, Narandalai Danshiitsoodol, Keishi Kanno, Sayaka Yonezawa, Ryoko Ishida, Masanori Sugiyama

{"title":"Effect of probiotic Limosilactobacillus reuteri on a serum sex-hormone- and metabolic-syndrome-related health evaluation: a single-arm open-label pilot study.","authors":"Masafumi Noda, Narandalai Danshiitsoodol, Keishi Kanno, Sayaka Yonezawa, Ryoko Ishida, Masanori Sugiyama","doi":"10.12938/bmfh.2025-020","DOIUrl":"10.12938/bmfh.2025-020","url":null,"abstract":"The oral administration of living Limosilactobacillus reuteri (formerly Lactobacillus reuteri) ATCC PTA 6475 cells has been shown preliminarily to prevent obesity in diet-derived obese mice and to act to ameliorate the decline in serum testosterone in old male mice. Through a clinical trial comprising a single-arm open-label pilot study in which all subjects received the same intervention, the present study aimed to evaluate whether L. reuteri ATCC PTA 6475 cells can also ameliorate the decline in serum testosterone levels in senior citizens and explore how the strain changes the intestinal microbiota. The trial was conducted with 10 eligible subjects (aged 50-69) at Hiroshima University from January to April 2024. They were instructed to take two capsules that contained a total of 1.0 × 1010 living lyophilized cells of ATCC PTA 6475 strain every day. After the 12 weeks, although remarkable changes in sex hormones were not observed, significant decreases were observed in body fat percentage, blood pressure, and some inflammation-related parameters. In addition, analysis of the fecal microbiota indicated that intake of ATCC PTA 6475 cells significantly increased the relative abundance of the genera Butyricimonas, Holdemania, and Odoribacter, which have been reported to contribute to the amelioration of obesity phenotypes. In conclusion, although the present study was carried out as a pilot study with only 10 subjects, making a placebo-controlled study necessary in the future, it demonstrates the probiotic potential of the ATCC PTA 6475 strain.","PeriodicalId":93908,"journal":{"name":"Bioscience of microbiota, food and health","volume":"45 1","pages":"42-50"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12765532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0