Christian Halbauer, Felix Capanni, Lucas Engelhardt, Andreas Paech, Christian Knop, Tobias Merkle, Tomas Da Silva
{"title":"Does helical plating for proximal humeral shaft fractures benefit bone healing? - an <i>in silico</i> analysis in fracture healing.","authors":"Christian Halbauer, Felix Capanni, Lucas Engelhardt, Andreas Paech, Christian Knop, Tobias Merkle, Tomas Da Silva","doi":"10.1515/bmt-2024-0445","DOIUrl":"https://doi.org/10.1515/bmt-2024-0445","url":null,"abstract":"<p><strong>Objectives: </strong>Helical plating is an established alternative to straight plating for humeral shaft fractures in order to prevent iatrogenic radial nerve damage. However, a previous biomechanical investigation indicated differences in fracture healing for helical plating due to a potential shift of interfragmentary movements compared to straight plating. Therefore, fracture healing simulations were performed to assess any differences in bone healing of helical vs. straight plating.</p><p><strong>Methods: </strong>A systematic workflow for fracture healing analytics was created, covering essential steps of bone modelling, implant modelling, finite element modelling, fracture healing simulation and result analysis. Computational humerus models with an AO12C2 fracture and straight and helical osteosynthesis were created. An established fracture healing model was used to simulate callus formation over 112 days under physiological loading. The predicted tissue differentiation and interfragmentary movement (IFM) was tracked over the entire simulated healing course.</p><p><strong>Results: </strong>Helical plating resulted in larger interfragmentary movements for compression and shear components, and in a greater proportion of near and far cortical movement. Vascularization and tissue formation were deferred, but cortical bridging was achieved.</p><p><strong>Conclusions: </strong>Helical plating resulted in slightly deferred bone healing due to larger interfragmentary shear movements. Considering the advantage of helical plating in clinical context, a slightly deferred bone healing is justifiable.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prediction of remaining surgery duration based on machine learning methods and laparoscopic annotation data.","authors":"Spiros Kostopoulos, Dionisis Cavouras, Dimitris Glotsos, Constantinos Loukas","doi":"10.1515/bmt-2024-0431","DOIUrl":"https://doi.org/10.1515/bmt-2024-0431","url":null,"abstract":"<p><strong>Objectives: </strong>The operating room is a fast-paced and demanding environment. Among the various factors involved in its optimization, predicting surgery duration is critical for scheduling and resource organization, ultimately resulting in improved quality of surgical care.</p><p><strong>Methods: </strong>We design, implement and evaluate a semi-automated machine learning method that takes as input the current phase and tools employed and provides prediction of the Remain Surgery Duration (RSD) in laparoscopic cholecystectomy operations. We use the annotated information of tools and phases provided in the publicly available dataset Cholec80. The method is based on a Random Forest regression model that considers two data streams: the surgical phase and the type of tools employed, at each time-frame of the operation. The data were split into Training-, Validation- and Test-sets. The Mean Absolute Error (MAE) was used as the performance metric for the various models examined.</p><p><strong>Results: </strong>Our approach managed to achieve a MAE=5.89 min across the overall duration of the surgeries in the test-set and MAE=4.61 min at 20 min before the end of the operation.</p><p><strong>Conclusions: </strong>The employment of two separate regression models switched at a specific elapsed time threshold provides significant improvement in RSD prediction compared to other methods that process the video from the endoscope.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design and optimization of a high-definition transcranial electrical stimulation device with envelope wave.","authors":"Renling Zou, Linpeng Jin, Yuhao Liu, Liang Zhao, Li Cao, Xiufang Hu, Xuezhi Yin","doi":"10.1515/bmt-2024-0284","DOIUrl":"https://doi.org/10.1515/bmt-2024-0284","url":null,"abstract":"<p><strong>Objectives: </strong>Transcranial electrical stimulation (tES) has been widely used in neuroscience research, and the spatial focusing and penetration of the process are currently the main constraints on the effectiveness of treatment.</p><p><strong>Methods: </strong>A high-definition electrical stimulation (HD-tES) device with envelope waves was designed. The device utilized a 4 × 1 electrode structure and was designed with an impedance adjustment circuit to evenly distribute the current among the four return channels. The output performance and safety of the device were verified in in vitro experiments. The spatial focusing of the 4 × 1 electrode structure and the high penetration advantage of envelope waves are explored through simulations. Finally, experiments were performed on 10 healthy adults.</p><p><strong>Results: </strong>The 4 × 1 electrode structure has the best spatial focusing effect. Current frequencies above 1 kHz may have higher tissue penetration. In addition, the safety of envelope wave stimulation has been verified in human trials, and no adverse reactions occurred during stimulation.</p><p><strong>Conclusions: </strong>The low and medium frequency (<10 kHz) envelope wave HD-tES device is expected to have a positive impact in the field of medicine and neuroscience.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qingqing Wang, Ruyu Yuan, Yunjing Yi, Shizhen Du, Chen He, Ping Shi
{"title":"Design and evaluation of powered lumbar exoskeleton based on human biomechanics.","authors":"Qingqing Wang, Ruyu Yuan, Yunjing Yi, Shizhen Du, Chen He, Ping Shi","doi":"10.1515/bmt-2024-0232","DOIUrl":"10.1515/bmt-2024-0232","url":null,"abstract":"<p><strong>Objectives: </strong>In view of the gradual rejuvenation and acceleration of lumbar spondylosis, a wearable powered lumbar exoskeleton based on a 6-SPU/SP parallel mechanism is designed based on the rehabilitation treatment method of lumbar forward flexion/extension, left/right lateral flexion and rotation.</p><p><strong>Methods: </strong>First, the changes in human lumbar muscles are analyzed based on human biomechanics, and then the prototype design of the powered lumbar exoskeleton is implemented, including the mechanical mechanism design, and hardware module design. Finally, the simulation experiment of muscle force and output sensitivity test in the resistive mode are conducted.</p><p><strong>Results: </strong>The simulation results show that the external oblique muscle can be relieved about 20 % and the iliopsoas muscle can be decreased by 33 % when wearing the powered lumbar exoskeleton in the lateral flexion. The pressure sensors can measure the output force of each actuator in real-time when the resistance force reaches the set value of 15 N at the resistive model.</p><p><strong>Conclusions: </strong>The results show that the powered lumbar exoskeleton can assist the human lumbar spine in rehabilitation training of traction, forward flexion and extension, left and right lateral flexion, and rotation. This research provides new ideas for future clinical research.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Caries-segnet: multi-scale cascaded hybrid spatial channel attention encoder-decoder for semantic segmentation of dental caries.","authors":"Jayaraman Priya, Subramanian Kanaga Suba Raja","doi":"10.1515/bmt-2024-0439","DOIUrl":"https://doi.org/10.1515/bmt-2024-0439","url":null,"abstract":"<p><strong>Objectives: </strong>Dental caries is a prevalent oral health issue around the world that leads to tooth aches, root canal infections, and even tooth extractions. Existing dental caries diagnosis models may misdiagnose the disorder and take more time to segment the caries. This research work aims to provide an in-depth analysis of spatial and channel attention mechanism techniques used for semantic segmentation in an encoder-decoder network. For effective performance, the research implements novel techniques to segment the dental caries accurately.</p><p><strong>Methods: </strong>Deep Fully Connected Residual Block (DFCR) is designed to provide relevant features without the loss of significant information. A novel Hybrid Spatial Channel Attention (HSCA) module is developed for combining significant features with the help of multi-scale spatial features and cross-dimensional channel features.</p><p><strong>Results: </strong>The proposed methodology performs better than other cutting-edge algorithms by achieving 96.63 % accuracy, 95.77 % dice score, 96.28 % Intersection over Union (IOU) score for the caries dataset, and 96.93 % accuracy, 95.21 % dice value, and 96.1 % IOU for the Tufts dental dataset.</p><p><strong>Conclusions: </strong>The developed model facilitates in detection of cavities precisely at an earlier stage with the help of dental images. The semantic segmentation of dental caries provides accurate diagnosis by assisting medical professionals.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An analysis of initial force and moment delivery of different aligner materials.","authors":"Thomas Wendl, Brigitte Wendl, Peter Proff","doi":"10.1515/bmt-2025-0003","DOIUrl":"10.1515/bmt-2025-0003","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to clarify the applied initial forces and moments by different aligners of various materials and manufacturing methods.</p><p><strong>Methods: </strong>The finite-element-method was used to analyze the forces and moments generated by the aligners on a maloccluded tooth. Plaster models of dental arches with a mesiorotated tooth 11 were fabricated, digitized and virtually analyzed. Four types of aligners with various layer thicknesses were selected: two splints with novel shape memory properties: a printable aligner made of the resin Tera Harz TC-85 DAC (Graphy Inc., South Korea) and a self-manufactured aligner consisting of the components polypropylene carbonate and thermoplastic polyurethane. The other two aligners were conventional, thermoformable aligners: CA<sup>®</sup> Pro Clear Aligner (Scheu Dental GmbH, Germany) and Erkodur-al (Erkodent Erich Kopp GmbH, Germany).</p><p><strong>Results: </strong>The force and moment analyses showed that the thermoformable CA<sup>®</sup> Pro Clear Aligner exhibited the highest values. The thermoformed Erkodur-al aligner showed the lowest force loads for all layer thicknesses. The Graphy printed splint showed similar results compared to Erkodur-al at layer thicknesses of 0.40 mm and 0.50 mm.</p><p><strong>Conclusions: </strong>To avoid periodontal overloading, aligners with lower force and moment delivery should be chosen for this type of tooth movement.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143528090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ying Xiang, Wei Zheng, Jiajia Tang, You Dong, Yuhao Pang
{"title":"Gesture recognition from surface electromyography signals based on the SE-DenseNet network.","authors":"Ying Xiang, Wei Zheng, Jiajia Tang, You Dong, Yuhao Pang","doi":"10.1515/bmt-2024-0282","DOIUrl":"10.1515/bmt-2024-0282","url":null,"abstract":"<p><strong>Objectives: </strong>In recent years, significant progress has been made in the research of gesture recognition using surface electromyography (sEMG) signals based on machine learning and deep learning techniques. The main motivation for sEMG gesture recognition research is to provide more natural, convenient, and personalized human-computer interaction, which makes research in this field have considerable application prospects in rehabilitation technology. However, the existing gesture recognition algorithms still need to be further improved in terms of global feature capture, model computational complexity, and generalizability.</p><p><strong>Methods: </strong>This paper proposes a fusion model of Squeeze-and-Excitation Networks (SE) and DenseNet, inserting attention mechanism between DenseBlock and Transition to focus on the most important information, improving feature representation ability, and effectively solving the problem of gradient vanishing.</p><p><strong>Results: </strong>This proposed method was tested on the electromyographic gesture datasets NinaPro DB2 and DB4, achieving accuracies of 85.93 and 82.39 % respectively. Through ablation experiments, it was found that the method based on DenseNet-101 as the backbone model produced the best results.</p><p><strong>Conclusions: </strong>Compared with existing models, this proposed method has better robustness and generalizability in gesture recognition, providing new ideas for the development of sEMG signal gesture recognition applications in the future.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annika Holtz, Manfred Grüner, Ludger Keilig, Christoph Bourauel, Helmut Stark, Istabrak Dörsam
{"title":"Wear investigation of implant-supported upper removable prothesis with electroplated gold or PEKK secondary crowns.","authors":"Annika Holtz, Manfred Grüner, Ludger Keilig, Christoph Bourauel, Helmut Stark, Istabrak Dörsam","doi":"10.1515/bmt-2024-0038","DOIUrl":"10.1515/bmt-2024-0038","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study was to investigate, whether polyetherketoneketone (PEKK) secondary crowns could be considered as alternative to gold standard in terms of their physical properties and manufacturing costs.</p><p><strong>Methods: </strong>An upper jaw model with six implants was used. Frameworks with either 6 PEKK- or 6 electroplated secondary crowns were cemented in a wear simulator. A total of 20 specimens (10 PEKK, 10 gold) run 10,000 cycles in the wear simulator with a lubricant. Additionally, 10,000 cycles in the thermocycling baths with 5 °C and 55 °C have gone through, before running extra 10,000 cycles in the wear simulator again. Finally, the abutments were analysed for signs of wear under the electron microscope.</p><p><strong>Results: </strong>The mean pulling out force value for PEKK was 21 N. For the electroplated gold secondary crowns an average of 19 N was measured. Multiple fluctuations were observed in the gold series of tests. After 20,000 cycles in the wear simulator and 10,000 cycles in the thermocycling machine, there were no major losses to be measured in terms of wear for both materials. In the microscopic analysis of the abutments, traces of wear could be seen in pull-out direction, mainly in the gold samples.</p><p><strong>Conclusions: </strong>PEKK secondary crowns have lower costs, more stable retention force values and are easier to produce than the gold standard. On average, the pull-out force values were 11 N higher than recommended.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":"115-123"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Integration of neuromuscular control for multidirectional horizontal planar reaching movements in a portable upper limb exoskeleton for enhanced stroke rehabilitation.","authors":"Yongkun Zhao, Juzheng Mao, Mingquan Zhang, Haijun Wu, Jiatong Jiang, Shibo Jing","doi":"10.1515/bmt-2023-0622","DOIUrl":"10.1515/bmt-2023-0622","url":null,"abstract":"<p><p>Globally, the prevalence of stroke is significant and increasing annually. This growth has led to a demand for rehabilitation services that far exceeds the supply, leaving many stroke survivors without adequate rehabilitative care. In response to this challenge, this study introduces a portable exoskeleton system that integrates neural control mechanisms governing human arm movements. This design leverages neuroplasticity principles to simulate natural movements, aiming to reactivate and strengthen neuromuscular connections and thus enhance rehabilitation outcomes. A tailored musculoskeletal model of the human arm and an associated cost function were developed to accurately replicate the planar motion trajectories of a healthy human arm across 32 directions. The application of a Proportional-Derivative (PD) controller enables precise tracking of these trajectories by the exoskeleton. Individual testing has demonstrated high consistency between the exoskeleton-driven motion paths and the simulated trajectories, especially in trajectory accuracy along the X and Y axes. These findings support the efficacy of integrating advanced neural control strategies with practical exoskeleton designs in stroke rehabilitation.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":"135-146"},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Empirical analysis on retinal segmentation using PSO-based thresholding in diabetic retinopathy grading.","authors":"Bhuvaneswari Sekar, Subashini Parthasarathy","doi":"10.1515/bmt-2024-0299","DOIUrl":"10.1515/bmt-2024-0299","url":null,"abstract":"<p><strong>Objectives: </strong>Diabetic retinopathy (DR) is associated with long-term diabetes and is a leading cause of blindness if it is not diagnosed early. The rapid growth of deep learning eases the clinicians' DR diagnosing procedure. It automatically extracts the features and performs the grading. However, training the image toward the majority of background pixels can impact the accuracy and efficiency of grading tasks. This paper proposes an auto-thresholding algorithm that reduces the negative impact of considering the background pixels for feature extraction which highly affects the grading process.</p><p><strong>Methods: </strong>The PSO-based thresholding algorithm for retinal segmentation is proposed in this paper, and its efficacy is evaluated against the Otsu, histogram-based sigma, and entropy algorithms. In addition, the importance of retinal segmentation is analyzed using Explainable AI (XAI) to understand how each feature impacts the model's performance. For evaluating the accuracy of the grading, ResNet50 was employed.</p><p><strong>Results: </strong>The experiments were conducted using the IDRiD fundus dataset. Despite the limited data, the retinal segmentation approach provides significant accuracy than the non-segmented approach, with a substantial accuracy of 83.70 % on unseen data.</p><p><strong>Conclusions: </strong>The result shows that the proposed PSO-based approach helps automatically determine the threshold value and improves the model's accuracy.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}