Lu Jin, Zhen Yang, Xu Wang, Shixiao Wan, Huanhuan Zhao, Ying Zhang, Juan Jin, Jilai Tian
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引用次数: 0
Abstract
Objectives: Free gas micro-/nano-bubbles (MNBs) in water have demonstrated significant potential in various industrial applications, including water treatment, enhanced transport processes, and disinfection. However, the feasibility of utilizing MNBs water as a dispersed system for preparing ultrasound imaging vehicles is seldom explored. This study aims to investigate the potential of MNBs water for this purpose.
Methods: Initially, MNBs water containing sulfur hexafluoride (SF6) was prepared and characterized. Subsequently, the potential of SF6 MNBs water to form lipid-shelled bubbles for ultrasound imaging was evaluated. This involved the incubation of lyophilized phospholipids with SF6 MNBs water.
Results: The study confirmed the presence of SF6 MNBs in water. Through the incubation process, it was possible to obtain lipid-shelled bubbles with a nano-sized and narrow size distribution. These bubbles exhibited comparable echogenicity to those produced by conventional mechanical agitation methods during the initial 5 min of in vitro observation.
Conclusions: SF6 MNBs water represents a novel dispersion medium for generating nano-sized lipid-shelled bubbles. This approach offers a promising new method for extravascular ultrasound imaging and drug delivery, potentially expanding the applications of MNBs in medical imaging and therapeutic delivery systems.
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