Biomedizinische Technik. Biomedical engineering最新文献

Chamber design and intensity-modulated ultraviolet-C LEDs for advanced pulsed photonic disinfection. 用于先进脉冲光子消毒的室设计和强度调制紫外- c led。

Biomedizinische Technik. Biomedical engineering Pub Date : 2025-05-06 DOI: 10.1515/bmt-2025-0070

Tan Tian Swee, Jahanzeb Sheikh, Syafiqah Saidin, Jose-Javier Serrano Olmedo, Sidra Abid Agha, Maheza Irna Binti Salim

{"title":"Chamber design and intensity-modulated ultraviolet-C LEDs for advanced pulsed photonic disinfection.","authors":"Tan Tian Swee, Jahanzeb Sheikh, Syafiqah Saidin, Jose-Javier Serrano Olmedo, Sidra Abid Agha, Maheza Irna Binti Salim","doi":"10.1515/bmt-2025-0070","DOIUrl":"https://doi.org/10.1515/bmt-2025-0070","url":null,"abstract":"Objectives: Contaminated apparatus and surgical tools pose serious health risks. For such purpose, disinfection chambers are employed. However, these systems rely on mercury-based UV lamps which comes with various drawbacks. These limitations have driven interest in Ultraviolet-C Light Emitting Diode (UV-C LED) technology as a safer and more efficient alternative. However, existing studies have not thoroughly explored the impact of varying intensities of pulse width modulation (PWM) on disinfection efficacy.Methods: To addess this, the present study designed and tested a LED-based disinfection chamber by employing 4-W 275 nm Surface Mount Device (SMD) LEDs against frequently isolated bacteria. By following prior approach, irradiation time was alternated at 30-s intervals and antibacterial efficacy was assessed through various parameters. Additionally, scanning electron microscopy (SEM) was performed to examine the morphological changes.Results: Results indicated that the reduction was significantly influenced (p<0.05) with varying PWM levels (60-100 %), achieving 2.05-log10 and 1.54-log10 inactivation against Escherichia coli and Staphylococcus aureus, respectively, upon exposure to 51.24 mJ/cm2 under maximum exposure settings. Moreover, complete cellular damage leading to bleb protrusion and cell-leakage confirmed the disruption of bacterial DNA.Conclusions: In conclusion, UV-LEDs show great potential for disinfection, with efficiency influenced by PWM and dosage.","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic loading leakage test of dental abutment/implant connections based upon a novel implant system with an abutment switch feature: an in vitro study. 基于基台开关特性的新型种植体系统的牙基/种植体连接动态载荷泄漏试验：体外研究。

Biomedizinische Technik. Biomedical engineering Pub Date : 2025-05-05 DOI: 10.1515/bmt-2025-0141

Timea Mezey, Christoph Bourauel, Ludger Keilig

{"title":"Dynamic loading leakage test of dental abutment/implant connections based upon a novel implant system with an abutment switch feature: an in vitro study.","authors":"Timea Mezey, Christoph Bourauel, Ludger Keilig","doi":"10.1515/bmt-2025-0141","DOIUrl":"https://doi.org/10.1515/bmt-2025-0141","url":null,"abstract":"Objectives: The objective of this study was to evaluate the sealing ability of the implant-abutment interface in a specific implant system in comparison to other implant systems under conditions of increasing dynamic loading.Methods: Three different implants and four abutment types were tested: one implant with a conical abutment connection, one implant with a flat abutment connection, and one implant with an abutment switch feature and two different abutment connections. The tests consisted of a phase of cyclic loading followed by a leakage test. The maximum loading force was increased, and the procedure was repeated, until either the implant-abutment connection failed, or a leakage was detected. Loading criteria were modified based on the ISO standard 14801:2016.Results: The conical implant abutment connections exhibited fracture prior to leakage at varying failure forces and loading cycles, whereas the platform abutment type showed leakage or fracture at a relatively low force. The two different abutment types used on the same implant system showed extremely different results.Conclusions: Literature shows similar high chewing forces mostly only for healthy subjects. For patients with dental implants, leakage is still preferable to fracture. In conclusion, the test showed that some implants with a conical abutment are more resistant to leakage and may be preferable if higher chewing forces are expected.","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of electrogastrography and bioelectric impedance techniques for the gastric motility assessment. 胃电图与生物电阻抗技术在胃运动评估中的相关性。

Biomedizinische Technik. Biomedical engineering Pub Date : 2025-05-05 DOI: 10.1515/bmt-2024-0438

Francisco M Vargas-Luna, Maria-Raquel Huerta-Franco, Isabel Delgadillo-Holtfort, Marco Balleza-Ordaz, Regina M Murillo-Torres

{"title":"Correlation of electrogastrography and bioelectric impedance techniques for the gastric motility assessment.","authors":"Francisco M Vargas-Luna, Maria-Raquel Huerta-Franco, Isabel Delgadillo-Holtfort, Marco Balleza-Ordaz, Regina M Murillo-Torres","doi":"10.1515/bmt-2024-0438","DOIUrl":"https://doi.org/10.1515/bmt-2024-0438","url":null,"abstract":"Objectives: The electrical bioimpedance (EBI) technique has been used to measure gastric motility and emptying parameters. A well-known technique for this purpose is electrogastrography (EGG). No correlation between EGG signal and mechanical motility has been reported. In this study, a direct data comparison of these two techniques was performed.Methods: 23 volunteers underwent simultaneous gastric monitoring using EGG and EBI. Signal processing was performed to isolate the slow waves of 0.5-9 cpm. The parameters obtained from 70 % overlapped time slots of 3.5 min, included the dominant frequency and power of the normo-gastric region and the percentage of brady-, normo-, and tachy-gastric slow waves.Results: The EGG showed slightly higher values in dominant frequencies, whereas EBI displayed higher variability. High-frequency features were more significant in the EBI, with lower variability, and correlations were found in approximately half of the frequency spectra. Slow waves exhibited poor correlation, but were significant at 95 % of the timeslots.Conclusions: Comparing EBI and EGG, global parameters in the normogastric region had slight variances, which may not significantly impact clinical findings. The sensitivity of the EBI to higher frequencies is evident.","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How does research output and impact in medical informatics vary among EU member states? - A bibliometric analysis. 欧盟成员国在医学信息学方面的研究产出和影响有何不同？-文献计量分析。

Biomedizinische Technik. Biomedical engineering Pub Date : 2025-04-29 DOI: 10.1515/bmt-2025-0093

Giovani M Goron, Razvan M Chereches

{"title":"How does research output and impact in medical informatics vary among EU member states? - A bibliometric analysis.","authors":"Giovani M Goron, Razvan M Chereches","doi":"10.1515/bmt-2025-0093","DOIUrl":"https://doi.org/10.1515/bmt-2025-0093","url":null,"abstract":"Objectives: This study evaluates how research output and impact in medical informatics vary among EU member states before and during the COVID-19 pandemic by analyzing publication volume, impact metrics, collaboration patterns, and open-access trends. It seeks to identify regional disparities, highlight key research themes, and provide insights for researchers, the public, and policymakers to promote equitable access, collaboration, and investment in medical informatics across the EU.Methods: A bibliometric analysis was performed using Clarivate Web of Science and InCites databases, encompassing 6,620 articles from 47 medical informatics journals published between 2018 and 2022. Metrics such as cumulative impact factors, article counts, and collaboration trends were analyzed.Results: Our analysis identified substantial regional disparities in research output and impact. Western European countries, including Germany, the Netherlands, and Spain, consistently led in article volume and cumulative impact factors, while Eastern European countries showed lower engagement. Collaboration metrics revealed that 66 % of publications involved international partnerships, showcasing strong cross-border cooperation within the EU.Conclusions: This study highlights the uneven distribution of research productivity in medical informatics across the EU. The findings underline the importance of international partnerships and equitable access to research in advancing medical informatics and addressing evolving healthcare challenges.","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving the cleaning quality of tube lumen instruments by imaging analysis and deep learning techniques. 利用成像分析和深度学习技术提高管腔仪器的清洗质量。

Biomedizinische Technik. Biomedical engineering Pub Date : 2025-04-18 DOI: 10.1515/bmt-2023-0527

Changjun Chen, Yewen Feng, Lijun Lu, Linze Qian, Ling Wang, Quchao Zou, Yonghua Chu, Panpan Xu, Yuhang Pan

{"title":"Improving the cleaning quality of tube lumen instruments by imaging analysis and deep learning techniques.","authors":"Changjun Chen, Yewen Feng, Lijun Lu, Linze Qian, Ling Wang, Quchao Zou, Yonghua Chu, Panpan Xu, Yuhang Pan","doi":"10.1515/bmt-2023-0527","DOIUrl":"https://doi.org/10.1515/bmt-2023-0527","url":null,"abstract":"Objectives: The complex structure of tube lumen instruments (TLIs) makes them more difficult to clean compared to solid instruments. This study aims to improve the cleaning quality inspection of reusable TLIs, ensuring patient safety and clinical reliability.Methods: This study improves the inspection of TLI cleaning quality using imaging analysis and deep learning techniques. Internally cleaned TLIs were imaged using an electronic endoscope by clinical staff, and the resulting images formed the original dataset. To enhance the quality of the TLI images and augment the dataset, image preprocessing techniques such as enhancement, slicing, and threshold filtering were applied. Based on the sliced image dataset, baseline models with relatively better performance were selected by comparing the performance of multiple deep learning models in TLI image classification. To further improve the model's performance, two attention mechanisms were introduced to focus on important features.Results: The optimized model outperforms the baseline model in both performance and stability. Specifically, the FA-ResNet18 model with the concurrent space and channel squeeze and excitation (scSE) attention mechanism performs the best, with accuracy, macro precision, macro recall and macro F2 metrics all exceeding 98.3 %.Conclusions: This method can effectively reduce the risk of errors caused by subjective factors and visual fatigue in manual inspection.","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-analysis of animal experiments on osteogenic effects of trace element doped calcium phosphate ceramic/PLGA composites. 微量元素掺杂磷酸钙陶瓷/PLGA复合材料成骨作用的动物实验荟萃分析。

Biomedizinische Technik. Biomedical engineering Pub Date : 2025-04-18 DOI: 10.1515/bmt-2024-0593

Hongwei He, Meng Zhong, Panxianzhi Ni, Tun Yuan, Jie Liang, Yujiang Fan, Xingdong Zhang

{"title":"Meta-analysis of animal experiments on osteogenic effects of trace element doped calcium phosphate ceramic/PLGA composites.","authors":"Hongwei He, Meng Zhong, Panxianzhi Ni, Tun Yuan, Jie Liang, Yujiang Fan, Xingdong Zhang","doi":"10.1515/bmt-2024-0593","DOIUrl":"https://doi.org/10.1515/bmt-2024-0593","url":null,"abstract":"Objectives: Investigate the impact of the components in element-doped calcium phosphate ceramic/PLGA composites on bone repair outcomes in animal experiments.Methods: Computer search of CNKI, Wanfang, Pub Med, Web of science, and EMbase databases to collect related randomized controlled animal experimental studies. Using the SYRCLE Animal Experimental Bias Risk Assessment form to evaluate research quality. The outcome measures were statistically analyzed using the Rev Man 5.4 software.Results: Included 11 randomized controlled animal studies. Meta-analysis showed that: (1) Element doping can promote the proliferation of osteoblasts in vitro. (2) Element doping can increase the activity of ALP in cells. (3) Element doping can increase bone volume fraction. (4) Element doping can increase trabecular number.Conclusions: Trace element doping has been found to enhance the osteogenic effect of the composite material. The type of calcium phosphate ceramics may be a significant source of heterogeneity that influences the effectiveness of bone repair in vivo.","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning prediction of effective radiation doses in various computed tomography applications: a virtual human phantom study. 各种计算机断层扫描应用中有效辐射剂量的机器学习预测：虚拟人体模型研究。

Biomedizinische Technik. Biomedical engineering Pub Date : 2025-04-08 DOI: 10.1515/bmt-2024-0620

Handan Tanyildizi-Kokkulunk

{"title":"Machine learning prediction of effective radiation doses in various computed tomography applications: a virtual human phantom study.","authors":"Handan Tanyildizi-Kokkulunk","doi":"10.1515/bmt-2024-0620","DOIUrl":"https://doi.org/10.1515/bmt-2024-0620","url":null,"abstract":"Objectives: In this work, it was aimed to employ machine learning (ML) algorithms to accurately forecast the radiation doses for phantoms while accounting for the most popular CT protocols.Methods: A cloud-based software was utilized to calculate the effective doses from different CT protocols. To simulate a range of adult patients with different weights, eight entire body mesh-based computational phantom sets were used. The head, neck, and chest-abdomen-pelvis CT scan characteristics were combined to create a dataset with 33 rows for each phantom and 792 rows total. At the ML stage, linear (LR), random forest (RF) and support vector regression (SVR) were used. Mean absolute error, mean squared error and accuracy were used to evaluate the performances.Results: The female phantoms received higher doses (7.8 %) than males. Furthermore, an average of 11 % more dose was taken to the normal weight phantom than to the overweight, the overweight in comparison to the obese I, and the obese I in comparison to the obese II. Among the ML algorithms, the LR showed 0 error rate and 100 % accuracy in predicting CT doses.Conclusions: The LR was shown to be the best approach out of those used in the ML estimation of CT-induced doses.","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classification of anemic condition based on photoplethysmography signals and clinical dataset. 基于光容积脉搏波信号和临床数据集的贫血状况分类。

Biomedizinische Technik. Biomedical engineering Pub Date : 2025-04-08 DOI: 10.1515/bmt-2024-0433

Neven Saleh, Ahmed M Salaheldin, Yasser Ismail, Heba M Afify

{"title":"Classification of anemic condition based on photoplethysmography signals and clinical dataset.","authors":"Neven Saleh, Ahmed M Salaheldin, Yasser Ismail, Heba M Afify","doi":"10.1515/bmt-2024-0433","DOIUrl":"10.1515/bmt-2024-0433","url":null,"abstract":"Objectives: One of the worldwide public health issues mostly affecting children and expectant mothers is Anemia. Recently, non-invasive hemoglobin (Hb) measurements, such as machine learning (ML) algorithms, can diagnose Anemia more quickly and efficiently.Methods: To diagnose Anemia using photoplethysmography (PPG), two tracks are investigated in this paper, based on clinical data and PPG signals. We use state-of-the-art data for Hb levels, extracted from PPG signals. This first track's methodology is divided into three stages: the labelling of the data as normal and abnormal; the data pre-processing; and applying ML algorithms based on four given features. We extracted nineteen features for red and infrared measurements in the second track. The second track's methodology is broken down into five stages: labelling of the data; data processing; signal augmentation; feature extraction; and applying ML algorithms. A five-fold cross-validation technique was applied for both tracks.Results: We succeeded in classifying the anemic condition with 100 % classification accuracy. Our accurate detection of anemic status will promote preventive healthcare.Conclusions: Ultimately, this proposed ML model in this paper validated the effectiveness of the ML algorithms as non-invasive techniques for identifying Anemia.","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MEMS-based narrow-bandwidth magnetic field sensors: preliminary assessment of prototypes regarding coercivity, remanence, and sensitivity. 基于mems的窄带宽磁场传感器：关于矫顽力、剩余物和灵敏度原型的初步评估。

Biomedizinische Technik. Biomedical engineering Pub Date : 2025-04-04 DOI: 10.1515/bmt-2024-0415

Negar Ziehm, Johan Arbustini, Eric Elzenheimer, Mohsen Samadi, Giuseppe Barbieri, Martina Gerken, Michael Höft, Robert Rieger, Andreas Bahr

{"title":"MEMS-based narrow-bandwidth magnetic field sensors: preliminary assessment of prototypes regarding coercivity, remanence, and sensitivity.","authors":"Negar Ziehm, Johan Arbustini, Eric Elzenheimer, Mohsen Samadi, Giuseppe Barbieri, Martina Gerken, Michael Höft, Robert Rieger, Andreas Bahr","doi":"10.1515/bmt-2024-0415","DOIUrl":"https://doi.org/10.1515/bmt-2024-0415","url":null,"abstract":"Objectives: This study evaluates micro-electro-mechanical systems (MEMS) devices comprising cantilever piezoelectric resonators with powder-based permanent magnets (micromagnets) at the tip. Fabricated using a well-known PowderMEMS process given by the Fraunhofer Institute for Silicon Technology, these devices function as magnetic field sensors based on the magnetic torque detection principle, which arises from the interaction between the given micromagnets' dipole moment and the to-be-measured magnetic field. The study investigates how the magnetic state of the micromagnets influences the overall sensitivity of the provided Prototype MEMS-devices.Methods: The performance of the first prototypes of this narrow-band magnetic field sensor was evaluated using two approaches: (1) a Vibrating Sample Magnetometer (VSM) to analyze the magnetic hysteresis loop and (2) sensitivity measurements at resonance frequency to determine the provided sensitivity under a predefined external magnetic flux density.Results: Among the four prototypes analyzed, the device with the highest remanence and coercivity demonstrated superior sensing performance, achieving a sensitivity of 1,090 kV/T at the resonance frequency. The analysis showcased substantial variations in noise amplitude spectral density, and sensitivity, emphasizing the importance of magnetic hysteresis properties in sensor performance.Conclusions: These findings highlight the potential of MEMS-devices with enhanced coercivity and remanence for enhanced sensing capabilities in compact sensor designs, particularly useful for array sensor configurations in narrow-bandwith medical applications.","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Free gas micro-/nano-bubble water: a novel dispersion system to prepare ultrasound imaging vehicles. 游离气体微/纳米气泡水：一种制备超声成像载体的新型分散体系。

Biomedizinische Technik. Biomedical engineering Pub Date : 2025-03-28 DOI: 10.1515/bmt-2024-0280

Lu Jin, Zhen Yang, Xu Wang, Shixiao Wan, Huanhuan Zhao, Ying Zhang, Juan Jin, Jilai Tian

{"title":"Free gas micro-/nano-bubble water: a novel dispersion system to prepare ultrasound imaging vehicles.","authors":"Lu Jin, Zhen Yang, Xu Wang, Shixiao Wan, Huanhuan Zhao, Ying Zhang, Juan Jin, Jilai Tian","doi":"10.1515/bmt-2024-0280","DOIUrl":"https://doi.org/10.1515/bmt-2024-0280","url":null,"abstract":"Objectives: Free gas micro-/nano-bubbles (MNBs) in water have demonstrated significant potential in various industrial applications, including water treatment, enhanced transport processes, and disinfection. However, the feasibility of utilizing MNBs water as a dispersed system for preparing ultrasound imaging vehicles is seldom explored. This study aims to investigate the potential of MNBs water for this purpose.Methods: Initially, MNBs water containing sulfur hexafluoride (SF6) was prepared and characterized. Subsequently, the potential of SF6 MNBs water to form lipid-shelled bubbles for ultrasound imaging was evaluated. This involved the incubation of lyophilized phospholipids with SF6 MNBs water.Results: The study confirmed the presence of SF6 MNBs in water. Through the incubation process, it was possible to obtain lipid-shelled bubbles with a nano-sized and narrow size distribution. These bubbles exhibited comparable echogenicity to those produced by conventional mechanical agitation methods during the initial 5 min of in vitro observation.Conclusions: SF6 MNBs water represents a novel dispersion medium for generating nano-sized lipid-shelled bubbles. This approach offers a promising new method for extravascular ultrasound imaging and drug delivery, potentially expanding the applications of MNBs in medical imaging and therapeutic delivery systems.","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0