Analysis of orthodontic aligner biocompatibility: leachable compounds of different aligner materials.

Thomas Wendl, Erich Leitner, Brigitte Wendl, Peter Proff
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Abstract

Objectives: the aim of this study was to clarify the biocompatibility of different tooth repositioning splints (aligners). This included the characterization of the volatile fraction by headspace solid phase microextraction coupled to gas chromatography mass spectrometry, simulation of leachable organic compounds using artificial saliva and the quantitation of bisphenol A and bisphenol S after extraction.

Methods: Four different aligners were characterized in this study, these included two splints with novel shape memory properties: a printable aligner made of the resin Tera Harz TC-85 DAC (Graphy Inc., South Korea) and a self-manufactured SMP-Aligner consisting of the components polypropylene carbonate and thermoplastic polyurethane. The other two aligners were conventional, thermoformable aligners: CA® Pro Clear Aligner (Scheu Dental GmbH, Germany) and Erkodur-al (Erkodent Erich Kopp GmbH, Germany).

Results: no BPA was found in all four samples after 72 h. BPS was found in one Aligner. The most leachable compounds were found in the samples of the SMP- and the direct printed Graphy-Aligner. Most of the compound release occurred during the first 24 h.

Conclusions: the cumulative exposure effect from aligner wear should be carefully considered, although the current research indicates that the levels of leachable compounds are generally low.

正畸矫正器生物相容性分析:不同矫正器材料的可浸出化合物。
目的:本研究的目的是阐明不同牙齿再定位夹板(矫正器)的生物相容性。这包括通过顶空固相微萃取和气相色谱-质谱法对挥发分进行表征,使用人工唾液模拟可浸出的有机化合物,以及提取后双酚A和双酚S的定量。方法:在本研究中对四种不同的矫正器进行了表征,其中包括两种具有新型形状记忆性能的夹板:一种是由Tera Harz TC-85 DAC树脂制成的可打印矫正器(Graphy Inc.,韩国),另一种是由碳酸聚丙烯和热塑性聚氨酯组成的自制smp矫正器。另外两种矫正器是传统的热成型矫正器:CA®Pro Clear Aligner (Scheu Dental GmbH,德国)和Erkodur-al (Erkodent Erich Kopp GmbH,德国)。结果:72 h后4份样品均未发现BPA。在一个矫正器中发现了BPS。在SMP-和直接印刷的图形校正器样品中发现了最易浸出的化合物。大部分化合物释放发生在前24 h。结论:尽管目前的研究表明,可浸出化合物的水平普遍较低,但应仔细考虑校准器磨损的累积暴露效应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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