Li Ji, Leiye Yi, Haiwei Li, Wenjie Han, Ningning Zhang
{"title":"An exploratory study of pilot EEG features during the climb and descent phases of flight.","authors":"Li Ji, Leiye Yi, Haiwei Li, Wenjie Han, Ningning Zhang","doi":"10.1515/bmt-2024-0412","DOIUrl":"https://doi.org/10.1515/bmt-2024-0412","url":null,"abstract":"<p><strong>Objectives: </strong>The actions and decisions of pilots are directly related to aviation safety. Therefore, understanding the neurological and cognitive processes of pilots during flight is essential. This study aims to investigate the EEG signals of pilots to understand the characteristic changes during the climb and descent stages of flight.</p><p><strong>Methods: </strong>By performing wavelet packet decomposition on the EEG signals, we examined EEG maps during these critical phases and analyzed changes in signal intensity. To delve deeper, we calculated the log-transformed power of electroencephalograms to investigate the EEG responses under different flight conditions. Additionally, we conducted EEG spectral coherence analysis to evaluate the degree of synchronization between different electrodes during climb and descent.</p><p><strong>Results: </strong>This analysis helps us understand the functional connectivity changes in various brain regions during these phases. Understanding these complex interactions is crucial, as it provides insights into the cognitive processes of pilots during the critical climb and descent stages of flight, contributing to enhanced aviation safety.</p><p><strong>Conclusions: </strong>By identifying how brain activity fluctuates during these phases, we can better comprehend pilots' decision-making processes, ultimately leading to the development of more effective training programs and safety protocols. This research underscores the importance of neurological studies in safety.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of mesoporous polyaniline for glucose sensor under different pH electrolyte conditions.","authors":"Zinah N Alabdali, Amar Al-Keisy, Sinan S Hamdi","doi":"10.1515/bmt-2024-0141","DOIUrl":"10.1515/bmt-2024-0141","url":null,"abstract":"<p><strong>Objectives: </strong>Nonenzymatic biosensor-based-conductive polymers like polyaniline are highly electrochemically stable, cheap, and easy to synthesize biosensors, which is the main objective of research as well as testing applied in different pH conditions to get optimum sensitivity.</p><p><strong>Methods: </strong>A nonenzymatic glucose biosensor based on polyaniline was electrochemically deposited on a glassy carbon electrode; the cyclic voltammetry under range applied voltage -0.2 to 1.2 V vs. Ag/AgCl was employed to synthesize the biosensor electrode.</p><p><strong>Results: </strong>The polyaniline biosensor electrode properties were characterized, and the morphology surface photographic confirmed mesoporous architecture with many accessible pores, while chemical bonding analysis confirmed the synthesis of polyaniline. The initial investigation examined the pH levels of phosphate-buffered saline, including 5, 5.5, 6, and 6.5. The cyclic voltammetry measurement revealed that the pH=5.5 provides excellent sensitivity toward glucose detection. The sensitivity of pH=5.5 is 68.7 μA mM<sup>-1</sup> cm<sup>-2</sup>, and the low detection limit is 1 µM.</p><p><strong>Conclusions: </strong>The findings above indicate that the biosensor could be an excellent candidate for application in electrochemical glucose sensing under pH=5.5 conditions of phosphate-buffered saline.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jianning Li, Zongwei Zhou, Jiancheng Yang, Antonio Pepe, Christina Gsaxner, Gijs Luijten, Chongyu Qu, Tiezheng Zhang, Xiaoxi Chen, Wenxuan Li, Marek Wodzinski, Paul Friedrich, Kangxian Xie, Yuan Jin, Narmada Ambigapathy, Enrico Nasca, Naida Solak, Gian Marco Melito, Viet Duc Vu, Afaque R Memon, Christopher Schlachta, Sandrine De Ribaupierre, Rajnikant Patel, Roy Eagleson, Xiaojun Chen, Heinrich Mächler, Jan Stefan Kirschke, Ezequiel de la Rosa, Patrick Ferdinand Christ, Hongwei Bran Li, David G Ellis, Michele R Aizenberg, Sergios Gatidis, Thomas Küstner, Nadya Shusharina, Nicholas Heller, Vincent Andrearczyk, Adrien Depeursinge, Mathieu Hatt, Anjany Sekuboyina, Maximilian T Löffler, Hans Liebl, Reuben Dorent, Tom Vercauteren, Jonathan Shapey, Aaron Kujawa, Stefan Cornelissen, Patrick Langenhuizen, Achraf Ben-Hamadou, Ahmed Rekik, Sergi Pujades, Edmond Boyer, Federico Bolelli, Costantino Grana, Luca Lumetti, Hamidreza Salehi, Jun Ma, Yao Zhang, Ramtin Gharleghi, Susann Beier, Arcot Sowmya, Eduardo A Garza-Villarreal, Thania Balducci, Diego Angeles-Valdez, Roberto Souza, Leticia Rittner, Richard Frayne, Yuanfeng Ji, Vincenzo Ferrari, Soumick Chatterjee, Florian Dubost, Stefanie Schreiber, Hendrik Mattern, Oliver Speck, Daniel Haehn, Christoph John, Andreas Nürnberger, João Pedrosa, Carlos Ferreira, Guilherme Aresta, António Cunha, Aurélio Campilho, Yannick Suter, Jose Garcia, Alain Lalande, Vicky Vandenbossche, Aline Van Oevelen, Kate Duquesne, Hamza Mekhzoum, Jef Vandemeulebroucke, Emmanuel Audenaert, Claudia Krebs, Timo van Leeuwen, Evie Vereecke, Hauke Heidemeyer, Rainer Röhrig, Frank Hölzle, Vahid Badeli, Kathrin Krieger, Matthias Gunzer, Jianxu Chen, Timo van Meegdenburg, Amin Dada, Miriam Balzer, Jana Fragemann, Frederic Jonske, Moritz Rempe, Stanislav Malorodov, Fin H Bahnsen, Constantin Seibold, Alexander Jaus, Zdravko Marinov, Paul F Jaeger, Rainer Stiefelhagen, Ana Sofia Santos, Mariana Lindo, André Ferreira, Victor Alves, Michael Kamp, Amr Abourayya, Felix Nensa, Fabian Hörst, Alexander Brehmer, Lukas Heine, Yannik Hanusrichter, Martin Weßling, Marcel Dudda, Lars E Podleska, Matthias A Fink, Julius Keyl, Konstantinos Tserpes, Moon-Sung Kim, Shireen Elhabian, Hans Lamecker, Dženan Zukić, Beatriz Paniagua, Christian Wachinger, Martin Urschler, Luc Duong, Jakob Wasserthal, Peter F Hoyer, Oliver Basu, Thomas Maal, Max J H Witjes, Gregor Schiele, Ti-Chiun Chang, Seyed-Ahmad Ahmadi, Ping Luo, Bjoern Menze, Mauricio Reyes, Thomas M Deserno, Christos Davatzikos, Behrus Puladi, Pascal Fua, Alan L Yuille, Jens Kleesiek, Jan Egger
{"title":"<i>MedShapeNet</i> - a large-scale dataset of 3D medical shapes for computer vision.","authors":"Jianning Li, Zongwei Zhou, Jiancheng Yang, Antonio Pepe, Christina Gsaxner, Gijs Luijten, Chongyu Qu, Tiezheng Zhang, Xiaoxi Chen, Wenxuan Li, Marek Wodzinski, Paul Friedrich, Kangxian Xie, Yuan Jin, Narmada Ambigapathy, Enrico Nasca, Naida Solak, Gian Marco Melito, Viet Duc Vu, Afaque R Memon, Christopher Schlachta, Sandrine De Ribaupierre, Rajnikant Patel, Roy Eagleson, Xiaojun Chen, Heinrich Mächler, Jan Stefan Kirschke, Ezequiel de la Rosa, Patrick Ferdinand Christ, Hongwei Bran Li, David G Ellis, Michele R Aizenberg, Sergios Gatidis, Thomas Küstner, Nadya Shusharina, Nicholas Heller, Vincent Andrearczyk, Adrien Depeursinge, Mathieu Hatt, Anjany Sekuboyina, Maximilian T Löffler, Hans Liebl, Reuben Dorent, Tom Vercauteren, Jonathan Shapey, Aaron Kujawa, Stefan Cornelissen, Patrick Langenhuizen, Achraf Ben-Hamadou, Ahmed Rekik, Sergi Pujades, Edmond Boyer, Federico Bolelli, Costantino Grana, Luca Lumetti, Hamidreza Salehi, Jun Ma, Yao Zhang, Ramtin Gharleghi, Susann Beier, Arcot Sowmya, Eduardo A Garza-Villarreal, Thania Balducci, Diego Angeles-Valdez, Roberto Souza, Leticia Rittner, Richard Frayne, Yuanfeng Ji, Vincenzo Ferrari, Soumick Chatterjee, Florian Dubost, Stefanie Schreiber, Hendrik Mattern, Oliver Speck, Daniel Haehn, Christoph John, Andreas Nürnberger, João Pedrosa, Carlos Ferreira, Guilherme Aresta, António Cunha, Aurélio Campilho, Yannick Suter, Jose Garcia, Alain Lalande, Vicky Vandenbossche, Aline Van Oevelen, Kate Duquesne, Hamza Mekhzoum, Jef Vandemeulebroucke, Emmanuel Audenaert, Claudia Krebs, Timo van Leeuwen, Evie Vereecke, Hauke Heidemeyer, Rainer Röhrig, Frank Hölzle, Vahid Badeli, Kathrin Krieger, Matthias Gunzer, Jianxu Chen, Timo van Meegdenburg, Amin Dada, Miriam Balzer, Jana Fragemann, Frederic Jonske, Moritz Rempe, Stanislav Malorodov, Fin H Bahnsen, Constantin Seibold, Alexander Jaus, Zdravko Marinov, Paul F Jaeger, Rainer Stiefelhagen, Ana Sofia Santos, Mariana Lindo, André Ferreira, Victor Alves, Michael Kamp, Amr Abourayya, Felix Nensa, Fabian Hörst, Alexander Brehmer, Lukas Heine, Yannik Hanusrichter, Martin Weßling, Marcel Dudda, Lars E Podleska, Matthias A Fink, Julius Keyl, Konstantinos Tserpes, Moon-Sung Kim, Shireen Elhabian, Hans Lamecker, Dženan Zukić, Beatriz Paniagua, Christian Wachinger, Martin Urschler, Luc Duong, Jakob Wasserthal, Peter F Hoyer, Oliver Basu, Thomas Maal, Max J H Witjes, Gregor Schiele, Ti-Chiun Chang, Seyed-Ahmad Ahmadi, Ping Luo, Bjoern Menze, Mauricio Reyes, Thomas M Deserno, Christos Davatzikos, Behrus Puladi, Pascal Fua, Alan L Yuille, Jens Kleesiek, Jan Egger","doi":"10.1515/bmt-2024-0396","DOIUrl":"10.1515/bmt-2024-0396","url":null,"abstract":"<p><strong>Objectives: </strong>The shape is commonly used to describe the objects. State-of-the-art algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from the growing popularity of ShapeNet (51,300 models) and Princeton ModelNet (127,915 models). However, a large collection of anatomical shapes (e.g., bones, organs, vessels) and 3D models of surgical instruments is missing.</p><p><strong>Methods: </strong>We present MedShapeNet to translate data-driven vision algorithms to medical applications and to adapt state-of-the-art vision algorithms to medical problems. As a unique feature, we directly model the majority of shapes on the imaging data of real patients. We present use cases in classifying brain tumors, skull reconstructions, multi-class anatomy completion, education, and 3D printing.</p><p><strong>Results: </strong>By now, MedShapeNet includes 23 datasets with more than 100,000 shapes that are paired with annotations (ground truth). Our data is freely accessible via a web interface and a Python application programming interface and can be used for discriminative, reconstructive, and variational benchmarks as well as various applications in virtual, augmented, or mixed reality, and 3D printing.</p><p><strong>Conclusions: </strong>MedShapeNet contains medical shapes from anatomy and surgical instruments and will continue to collect data for benchmarks and applications. The project page is: https://medshapenet.ikim.nrw/.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":"71-90"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High-performance breast cancer diagnosis method using hybrid feature selection method.","authors":"Mohammad Moradi, Abdalhossein Rezai","doi":"10.1515/bmt-2024-0185","DOIUrl":"10.1515/bmt-2024-0185","url":null,"abstract":"<p><strong>Objectives: </strong>One of the primary causes of the women death is breast cancer. Accurate and early breast cancer diagnosis plays an essential role in its treatment. Computer Aided Diagnosis (CAD) system can be used to help doctors in the diagnosis process. This study presents an efficient method to performance improvement of the breast cancer diagnosis CAD system using thermal images.</p><p><strong>Methods: </strong>The research strategy in the proposed CAD system is using efficient algorithms in feature extraction and classification phases, and new efficient feature selection algorithm. In the feature extraction phase, the Segmentation Fractal Texture Analysis (SFTA) algorithm that is a texture analysis algorithm is used.This algorithm utilizes two-threshold binary decomposition. In the feature selection phase, the developed feature selection algorithm, which is hybrid of binary grey wolf optimization algorithm and firefly optimization algorithm, is applied to extracted features. Then, the kNN, SVM, and DTree classification techniques are applied to check whether the selected features are efficiently discriminated the group successfully with minimal misclassifications.</p><p><strong>Results: </strong>The DMR database is utilized for performance evaluation of the proposed method. The results indicate that the obtained accuracy, specificity, sensitivity, and MCC are 97, 96, 98, and 94.17 %, respectively.</p><p><strong>Conclusions: </strong>The developed breast cancer diagnosis method has advantages compared to other breast cancer diagnosis using thermal images.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":"171-181"},"PeriodicalIF":0.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian Halbauer, Felix Capanni, Andreas Paech, Christian Knop, Tobias Merkle, Tomas Da Silva
{"title":"Straight and helical plating with locking plates for proximal humeral shaft fractures - a biomechanical comparison under physiological load conditions.","authors":"Christian Halbauer, Felix Capanni, Andreas Paech, Christian Knop, Tobias Merkle, Tomas Da Silva","doi":"10.1515/bmt-2024-0347","DOIUrl":"10.1515/bmt-2024-0347","url":null,"abstract":"<p><strong>Objectives: </strong>Helical plating is an established method for treating proximal humeral shaft fractures, mitigating the risk of iatrogenic radial nerve damage. However, biomechanical test data on helical plates under physiological load condition is limited. Hence, the aim of this study was to compare the biomechanical performance of helical and straight PHILOS<sup>®</sup> Long plates in AO12C2 fractures using static and cyclic implant system testing.</p><p><strong>Methods: </strong>Helical and straight PHILOS<sup>®</sup> Long plates on artificial bone substitutes were tested under physiological axial static (n=6) and cyclic loading (n=12). The axial construct stiffness was the main parameter for comparing the biomechanical performance of the two groups. Mimicking a clinical scenario, the helical deformation was performed consecutively by an experienced surgeon using iron bending tools. The torsional angle was determined computationally from 3D-scanning models afterwards.</p><p><strong>Results: </strong>Helical plating resulted in a significantly reduced axial construct stiffness in all test scenarios compared to conventional straight plating (static testing: p=0.012; cyclic testing: p≤0.010). No failure occurred within the range of physiological loading in both groups.</p><p><strong>Conclusions: </strong>Helical plating favors multidimensional deformation of the test sample in lateral-ventral direction under axial loading, resulting in a reduced axial construct stiffness and in an increased interfragmentary movement. No biomechanical failure is to be expected within physiological load boundaries.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":"125-133"},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recognition analysis of spiral and straight-line drawings in tremor assessment.","authors":"Attila Z Jenei, Dávid Sztahó, István Valálik","doi":"10.1515/bmt-2023-0080","DOIUrl":"10.1515/bmt-2023-0080","url":null,"abstract":"<p><strong>Objectives: </strong>No standard, objective diagnostic procedure exists for most neurological diseases causing tremors. Therefore, drawing tests have been widely analyzed to support diagnostic procedures. In this study, we examine the comparison of Archimedean spiral and line drawings, the possibilities of their joint application, and the relevance of displaying pressure on the drawings to recognize Parkinsonism and cerebellar dysfunction. We further attempted to use an automatic processing and evaluation system.</p><p><strong>Methods: </strong>Digital images were developed from raw data by adding or omitting pressure data. Pre-trained (MobileNet, Xception, ResNet50) models and a Baseline (from scratch) model were applied for binary classification with a fold cross-validation procedure. Predictions were analyzed separately by drawing tasks and in combination.</p><p><strong>Results: </strong>The neurological diseases presented here can be recognized with a significantly higher macro f1 score from the spiral drawing task (up to 95.7 %) than lines (up to 84.3 %). A significant improvement can be achieved if the spiral is supplemented with line drawing. The pressure inclusion in the images did not result in significant information gain.</p><p><strong>Conclusions: </strong>The spiral drawing has a robust recognition power and can be supplemented with a line drawing task to increase the correct recognition. Moreover, X and Y coordinates appeared sufficient without pressure with this methodology.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":"147-156"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A type-2 fuzzy inference-based approach enables walking speed estimation that adapts to inter-individual gait patterns.","authors":"Linrong Li, Wenxiang Liao, Hongliu Yu","doi":"10.1515/bmt-2024-0230","DOIUrl":"10.1515/bmt-2024-0230","url":null,"abstract":"<p><strong>Objectives: </strong>Individuals change walking speed by regulating step frequency (SF), stride length (SL), or a combination of both (FL combinations). However, existing methods of walking speed estimation ignore this regulatory mechanism. This paper aims to achieve accurate walking speed estimation while enabling adaptation to inter-individual speed regulation strategies.</p><p><strong>Methods: </strong>We first extracted thigh features closely related to individual speed regulation based on a single thigh mounted IMU. Next, an interval type-2 fuzzy inference system was used to infer and quantify the individuals' speed regulation intentions, enabling speed estimation independent of inter-individual gait patterns. Experiments with five subjects walking on a treadmill at different speeds and with different gait patterns validated our method.</p><p><strong>Results: </strong>The overall root mean square error (RMSE) for speed estimation was 0.0704 ± 0.0087 m/s, and the RMSE for different gait patterns was no more than 0.074 ± 0.005 m/s.</p><p><strong>Conclusions: </strong>The proposed method provides high-accuracy speed estimation. Moreover, our method can be adapted to different FL combinations without the need for individualised tuning or training of individuals with varying limb lengths and gait habits. We anticipate that the proposed method will help provide more intuitive speed adaptive control for rehabilitation robots, especially intelligent lower limb prostheses.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":"11-20"},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hydrogel promotes bone regeneration through various mechanisms: a review.","authors":"Yuanyuan Zheng, Zengguang Ke, Guofeng Hu, Songlin Tong","doi":"10.1515/bmt-2024-0391","DOIUrl":"10.1515/bmt-2024-0391","url":null,"abstract":"<p><p>Large defects in bone tissue due to trauma, tumors, or developmental abnormalities usually require surgical treatment for repair. Numerous studies have shown that current bone repair and regeneration treatments have certain complications and limitations. With the in-depth understanding of bone regeneration mechanisms and biological tissue materials, a variety of materials with desirable physicochemical properties and biological functions have emerged in the field of bone regeneration in recent years. Among them, hydrogels have been widely used in bone regeneration research due to their biocompatibility, unique swelling properties, and ease of fabrication. In this paper, the development and classification of hydrogels were introduced, and the mechanism of hydrogels in promoting bone regeneration was described in detail, including the promotion of bone marrow mesenchymal stem cell differentiation, the promotion of angiogenesis, the enhancement of the activity of bone morphogenetic proteins, and the regulation of the microenvironment of bone regeneration tissues. In addition, the future research direction of hydrogel in bone tissue engineering was discussed.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":"103-114"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142690064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuan Zou, Jie Yu, Lingkai Cai, Chunxiao Chen, Ruoyu Meng, Yueyue Xiao, Xue Fu, Xiao Yang, Peikun Liu, Qiang Lu
{"title":"Prediction of muscular-invasive bladder cancer using multi-view fusion self-distillation model based on 3D T2-Weighted images.","authors":"Yuan Zou, Jie Yu, Lingkai Cai, Chunxiao Chen, Ruoyu Meng, Yueyue Xiao, Xue Fu, Xiao Yang, Peikun Liu, Qiang Lu","doi":"10.1515/bmt-2024-0333","DOIUrl":"10.1515/bmt-2024-0333","url":null,"abstract":"<p><strong>Objectives: </strong>Accurate preoperative differentiation between non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC) is crucial for surgical decision-making in bladder cancer (BCa) patients. MIBC diagnosis relies on the Vesical Imaging-Reporting and Data System (VI-RADS) in clinical using multi-parametric MRI (mp-MRI). Given the absence of some sequences in practice, this study aims to optimize the existing T2-weighted imaging (T2WI) sequence to assess MIBC accurately.</p><p><strong>Methods: </strong>We analyzed T2WI images from 615 BCa patients and developed a multi-view fusion self-distillation (MVSD) model that integrates transverse and sagittal views to classify MIBC and NMIBC. This 3D image classification method leverages z-axis information from 3D MRI volume, combining information from adjacent slices for comprehensive features extraction. Multi-view fusion enhances global information by mutually complementing and constraining information from the transverse and sagittal planes. Self-distillation allows shallow classifiers to learn valuable knowledge from deep layers, boosting feature extraction capability of the backbone and achieving better classification performance.</p><p><strong>Results: </strong>Compared to the performance of MVSD with classical deep learning methods and the state-of-the-art MRI-based BCa classification approaches, the proposed MVSD model achieves the highest area under the curve (AUC) 0.927 and accuracy (Acc) 0.880, respectively. DeLong's test shows that the AUC of the MVSD has statistically significant differences with the VGG16, Densenet, ResNet50, and 3D residual network. Furthermore, the Acc of the MVSD model is higher than that of the two urologists.</p><p><strong>Conclusions: </strong>Our proposed MVSD model performs satisfactorily distinguishing between MIBC and NMIBC, indicating significant potential in facilitating preoperative BCa diagnosis for urologists.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":"37-47"},"PeriodicalIF":0.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}