Lu Jin, Zhen Yang, Xu Wang, Shixiao Wan, Huanhuan Zhao, Ying Zhang, Juan Jin, Jilai Tian
{"title":"游离气体微/纳米气泡水:一种制备超声成像载体的新型分散体系。","authors":"Lu Jin, Zhen Yang, Xu Wang, Shixiao Wan, Huanhuan Zhao, Ying Zhang, Juan Jin, Jilai Tian","doi":"10.1515/bmt-2024-0280","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Free gas micro-/nano-bubbles (MNBs) in water have demonstrated significant potential in various industrial applications, including water treatment, enhanced transport processes, and disinfection. However, the feasibility of utilizing MNBs water as a dispersed system for preparing ultrasound imaging vehicles is seldom explored. This study aims to investigate the potential of MNBs water for this purpose.</p><p><strong>Methods: </strong>Initially, MNBs water containing sulfur hexafluoride (SF<sub>6</sub>) was prepared and characterized. Subsequently, the potential of SF<sub>6</sub> MNBs water to form lipid-shelled bubbles for ultrasound imaging was evaluated. This involved the incubation of lyophilized phospholipids with SF<sub>6</sub> MNBs water.</p><p><strong>Results: </strong>The study confirmed the presence of SF<sub>6</sub> MNBs in water. Through the incubation process, it was possible to obtain lipid-shelled bubbles with a nano-sized and narrow size distribution. These bubbles exhibited comparable echogenicity to those produced by conventional mechanical agitation methods during the initial 5 min of <i>in vitro</i> observation.</p><p><strong>Conclusions: </strong>SF<sub>6</sub> MNBs water represents a novel dispersion medium for generating nano-sized lipid-shelled bubbles. This approach offers a promising new method for extravascular ultrasound imaging and drug delivery, potentially expanding the applications of MNBs in medical imaging and therapeutic delivery systems.</p>","PeriodicalId":93905,"journal":{"name":"Biomedizinische Technik. Biomedical engineering","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Free gas micro-/nano-bubble water: a novel dispersion system to prepare ultrasound imaging vehicles.\",\"authors\":\"Lu Jin, Zhen Yang, Xu Wang, Shixiao Wan, Huanhuan Zhao, Ying Zhang, Juan Jin, Jilai Tian\",\"doi\":\"10.1515/bmt-2024-0280\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Free gas micro-/nano-bubbles (MNBs) in water have demonstrated significant potential in various industrial applications, including water treatment, enhanced transport processes, and disinfection. However, the feasibility of utilizing MNBs water as a dispersed system for preparing ultrasound imaging vehicles is seldom explored. This study aims to investigate the potential of MNBs water for this purpose.</p><p><strong>Methods: </strong>Initially, MNBs water containing sulfur hexafluoride (SF<sub>6</sub>) was prepared and characterized. Subsequently, the potential of SF<sub>6</sub> MNBs water to form lipid-shelled bubbles for ultrasound imaging was evaluated. This involved the incubation of lyophilized phospholipids with SF<sub>6</sub> MNBs water.</p><p><strong>Results: </strong>The study confirmed the presence of SF<sub>6</sub> MNBs in water. Through the incubation process, it was possible to obtain lipid-shelled bubbles with a nano-sized and narrow size distribution. These bubbles exhibited comparable echogenicity to those produced by conventional mechanical agitation methods during the initial 5 min of <i>in vitro</i> observation.</p><p><strong>Conclusions: </strong>SF<sub>6</sub> MNBs water represents a novel dispersion medium for generating nano-sized lipid-shelled bubbles. This approach offers a promising new method for extravascular ultrasound imaging and drug delivery, potentially expanding the applications of MNBs in medical imaging and therapeutic delivery systems.</p>\",\"PeriodicalId\":93905,\"journal\":{\"name\":\"Biomedizinische Technik. Biomedical engineering\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedizinische Technik. Biomedical engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1515/bmt-2024-0280\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedizinische Technik. Biomedical engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/bmt-2024-0280","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Free gas micro-/nano-bubble water: a novel dispersion system to prepare ultrasound imaging vehicles.
Objectives: Free gas micro-/nano-bubbles (MNBs) in water have demonstrated significant potential in various industrial applications, including water treatment, enhanced transport processes, and disinfection. However, the feasibility of utilizing MNBs water as a dispersed system for preparing ultrasound imaging vehicles is seldom explored. This study aims to investigate the potential of MNBs water for this purpose.
Methods: Initially, MNBs water containing sulfur hexafluoride (SF6) was prepared and characterized. Subsequently, the potential of SF6 MNBs water to form lipid-shelled bubbles for ultrasound imaging was evaluated. This involved the incubation of lyophilized phospholipids with SF6 MNBs water.
Results: The study confirmed the presence of SF6 MNBs in water. Through the incubation process, it was possible to obtain lipid-shelled bubbles with a nano-sized and narrow size distribution. These bubbles exhibited comparable echogenicity to those produced by conventional mechanical agitation methods during the initial 5 min of in vitro observation.
Conclusions: SF6 MNBs water represents a novel dispersion medium for generating nano-sized lipid-shelled bubbles. This approach offers a promising new method for extravascular ultrasound imaging and drug delivery, potentially expanding the applications of MNBs in medical imaging and therapeutic delivery systems.