Asian journal of andrology最新文献_第2页

A propensity score-matched analysis on biopsy methods: enhanced detection rates of prostate cancer with combined cognitive fusion-targeted biopsy. 对活检方法的倾向评分匹配分析：联合认知融合靶向活检提高前列腺癌的检出率。

Asian journal of andrology Pub Date : 2025-05-02 DOI: 10.4103/aja202515

Bi-Ran Ye, Hui Wang, Yong-Qing Zhang, Guo-Wen Lin, Hua Xu, Zhe Hong, Bo Dai, Fang-Ning Wan

{"title":"A propensity score-matched analysis on biopsy methods: enhanced detection rates of prostate cancer with combined cognitive fusion-targeted biopsy.","authors":"Bi-Ran Ye, Hui Wang, Yong-Qing Zhang, Guo-Wen Lin, Hua Xu, Zhe Hong, Bo Dai, Fang-Ning Wan","doi":"10.4103/aja202515","DOIUrl":"https://doi.org/10.4103/aja202515","url":null,"abstract":"The choice of biopsy method is critical in diagnosing prostate cancer (PCa). This retrospective cohort study compared systematic biopsy (SB) or cognitive fusion-targeted biopsy combined with SB (CB) in detecting PCa and clinically significant prostate cancer (csPCa). Data from 2572 men who underwent either SB or CB in Fudan University Shanghai Cancer Center (Shanghai, China) between January 2019 and December 2023 were analyzed. Propensity score matching (PSM) was used to balance baseline characteristics, and detection rates were compared before and after PSM. Subgroup analyses based on prostate-specific antigen (PSA) levels and Prostate Imaging-Reporting and Data System (PI-RADS) scores were performed. Primary and secondary outcomes were the detection rates of PCa and csPCa, respectively. Of 2572 men, 1778 were included in the PSM analysis. Before PSM, CB had higher detection rates for both PCa (62.9% vs 52.4%, odds ratio [OR]: 1.54, P < 0.001) and csPCa (54.9% vs 43.3%, OR: 1.60, P < 0.001) compared to SB. After PSM, CB remained superior in detecting PCa (63.1% vs 47.9%, OR: 1.86, P < 0.001) and csPCa (55.0% vs 38.2%, OR: 1.98, P < 0.001). In patients with PSA 4-12 ng ml-1 (>4 ng ml-1 and ≤12 ng ml-1, which is also applicable to the following text), CB detected more PCa (59.8% vs 40.7%, OR: 2.17, P < 0.001) and csPCa (48.1% vs 27.7%, OR: 2.42, P < 0.001). CB also showed superior csPCa detection in those with PI-RADS 3 lesions (32.1% vs 18.0%, OR: 2.15, P = 0.038). Overall, CB significantly improves PCa and csPCa detection, especially in patients with PSA 4-12 ng ml-1 or PI-RADS 3 lesions.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel biallelic HFM1 variants cause severe oligozoospermia with favorable intracytoplasmic sperm injection outcome. 新的双等位基因HFM1变异导致严重的少精症与有利的卵胞浆内单精子注射结果。

Asian journal of andrology Pub Date : 2025-05-02 DOI: 10.4103/aja20259

Liu Liu, Yi-Ling Zhou, Wei-Dong Tian, Feng Jiang, Jia-Xiong Wang, Feng Zhang, Chun-Yu Liu, Hong Zhu

{"title":"Novel biallelic HFM1 variants cause severe oligozoospermia with favorable intracytoplasmic sperm injection outcome.","authors":"Liu Liu, Yi-Ling Zhou, Wei-Dong Tian, Feng Jiang, Jia-Xiong Wang, Feng Zhang, Chun-Yu Liu, Hong Zhu","doi":"10.4103/aja20259","DOIUrl":"https://doi.org/10.4103/aja20259","url":null,"abstract":"Male factors contribute to 50% of infertility cases, with 20%-30% of cases being solely attributed to male infertility. Helicase for meiosis 1 (HFM1) plays a crucial role in ensuring proper crossover formation and synapsis of homologous chromosomes during meiosis, an essential process in gametogenesis. HFM1 gene mutations are associated with male infertility, particularly in cases of non-obstructive azoospermia and severe oligozoospermia. However, the effects of intracytoplasmic sperm injection (ICSI) in HFM1-related infertility cases remain inadequately explored. This study identified novel biallelic HFM1 variants through whole-exome sequencing (WES) in a Chinese patient with severe oligozoospermia, which was confirmed by Sanger sequencing. The pathogenicity of these variants was assessed using real-time quantitative polymerase chain reaction (RT-qPCR) and immunoblotting, which revealed a significant reduction in HFM1 mRNA and protein levels in spermatozoa compared to those in a healthy control. Transmission electron microscopy revealed morphological abnormalities in sperm cells, including defects in the head and flagellum. Despite these abnormalities, ICSI treatment resulted in a favorable fertility outcome for the patient, indicating that assisted reproductive techniques (ART) can be effective in managing HFM1-related male infertility. These findings offer valuable insights into the management of such cases.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of testicular histopathology in nonobstructive azoospermia. 非梗阻性无精子症睾丸组织病理学综述。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-08-02 DOI: 10.4103/aja202454

Taymour Mostafa, Kadir Bocu, Vineet Malhotra

{"title":"A review of testicular histopathology in nonobstructive azoospermia.","authors":"Taymour Mostafa, Kadir Bocu, Vineet Malhotra","doi":"10.4103/aja202454","DOIUrl":"10.4103/aja202454","url":null,"abstract":"Abstract: One major challenge in male factor infertility is nonobstructive azoospermia (NOA), which is characterized by spermatozoa-deficient semen without physical duct blockage. This review offers a thorough overview of the histopathology of the testes in NOA cases, clarifying its complex etiology and emphasizing the possible value of histopathology inspection for both diagnosis and treatment. Variable histopathological findings have been linked to NOA, such as tubular hyalinization, Sertoli cell-only syndrome, hypospermatogenesis, and germ cell arrest. Understanding the pathophysiology and forecasting the effectiveness of treatment are further enhanced by both morphometric and ultrastructural analyses. The potential significance of testicular biopsy in forecasting reproductive outcomes is assessed, especially concerning assisted reproductive technologies like intracytoplasmic sperm injection (ICSI). Besides, testicular microlithiasis, serum hormone profiles, and testicular size are investigated concerning NOA histopathology. It is concluded that understanding the histopathological patterns in NOA is crucial for its accurate diagnosis and appropriate management. Further research is still warranted to improve understanding of the complex pathophysiology underlying NOA.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"370-374"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Andrology laboratory techniques for micro-TESE/IVF/ICSI: a narrative review. 微tese /IVF/ICSI的男科实验室技术：叙述性回顾。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2025-03-18 DOI: 10.4103/aja2024122

Krishna Chaitanya Mantravadi, Christina Anagnostopoulou, Firuza R Parikh

{"title":"Andrology laboratory techniques for micro-TESE/IVF/ICSI: a narrative review.","authors":"Krishna Chaitanya Mantravadi, Christina Anagnostopoulou, Firuza R Parikh","doi":"10.4103/aja2024122","DOIUrl":"10.4103/aja2024122","url":null,"abstract":"Abstract: Since the early days of assisted reproductive technology (ART), the importance of sperm processing, employed to separate the motile, morphologically normal sperm from the semen, has been shown to be beneficial. The aim of the semen processing technique has been to remove seminal plasma and facilitate capacitation. Additionally, the presence of leukocytes, bacteria, and dead spermatozoa has been shown to be detrimental as it may cause oxidative stress that has an adverse effect on oocyte fertilization and embryo development. Hence, removal of leukocytes, bacteria, and dead spermatozoa is an important step of sperm processing for assisted reproduction. Currently, several sperm processing techniques have been evolved and optimized in the field of assisted reproduction. The requirements for in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and testicular sperm extraction (TESE) are different than those of intrauterine insemination (IUI). The yield of as many motile, morphologically normal sperm as possible is a prerequisite for the success of IVF insemination procedure. In ICSI, where injection of a single spermatozoon into the oocyte is performed by the embryologist, sperm selection techniques play a crucial role in the ICSI procedure. Finally, sperm retrieval in TESE samples with very low number of sperm may be challenging and requires extra care during sample processing. Additionally, sperm cryopreservation is necessary in TESE cases in order to avoid multiple biopsies.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"383-391"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical treatment prior to micro-TESE. 显微tese前的医疗治疗。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-12-24 DOI: 10.4103/aja202492

Sujoy Dasgupta, Thanh Sang Le, Amarnath Rambhatla, Rupin Shah, Ashok Agarwal

引用次数: 0

Anatomical considerations, testicular, and scrotal anatomy of nonobstructive azoospermia patients. 非阻塞性无精子症患者的解剖考虑、睾丸和阴囊解剖。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2025-02-14 DOI: 10.4103/aja2024102

Hao-Cheng Lin, Yan Chen, Yang-Yi Fang, Kai Hong

引用次数: 0

Sperm cryopreservation protocol for micro-TESE-retrieved sperm. 显微 TESE 取回精子的精子冷冻保存方案。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-09-10 DOI: 10.4103/aja202466

Vijay Mangoli, Evangelini Evgeni, Christine Wyns

引用次数: 0

Hypogonadotropic hypogonadism as a cause of NOA and its treatment. 作为 NOA 病因之一的促性腺激素性腺功能减退症及其治疗。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-10-22 DOI: 10.4103/aja202483

Gianmaria Salvio, Giancarlo Balercia, Ates Kadioglu

引用次数: 0

Management of non-obstructive azoospermia: advances, challenges, and expert recommendations. 非阻塞性无精子症的治疗：进展、挑战和专家建议。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2025-04-25 DOI: 10.4103/aja202539

Amarnath Rambhatla, Parviz K Kavoussi, Rupin Shah, Ashok Agarwal

引用次数: 0

Clinician's guide to the management of azoospermia induced by exogenous testosterone or anabolic-androgenic steroids. 外源性睾酮或合成代谢雄激素类固醇引起的无精子症的临床治疗指南。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2025-01-17 DOI: 10.4103/aja2024104

Manaf Al Hashimi, Germar-Michael Pinggera, Rupin Shah, Ashok Agarwal

{"title":"Clinician's guide to the management of azoospermia induced by exogenous testosterone or anabolic-androgenic steroids.","authors":"Manaf Al Hashimi, Germar-Michael Pinggera, Rupin Shah, Ashok Agarwal","doi":"10.4103/aja2024104","DOIUrl":"10.4103/aja2024104","url":null,"abstract":"Abstract: Azoospermia, defined as the absence of sperm in the ejaculate, is a well-documented consequence of exogenous testosterone (ET) and anabolic-androgenic steroid (AAS) use. These agents suppress the hypothalamic-pituitary-gonadal (HPG) axis, leading to reduced intratesticular testosterone levels and impaired spermatogenesis. This review examines the pathophysiological mechanisms underlying azoospermia and outlines therapeutic strategies for recovery. Azoospermia is categorized into pretesticular, testicular, and post-testicular types, with a focus on personalized treatment approaches based on the degree of HPG axis suppression and baseline testicular function. Key strategies include discontinuing ET and monitoring for spontaneous recovery, particularly in patients with shorter durations of ET use. For cases of persistent azoospermia, gonadotropins (human chorionic gonadotropin [hCG] and follicle-stimulating hormone [FSH]) and selective estrogen receptor modulators (SERMs), such as clomiphene citrate, are recommended, either alone or in combination. The global increase in exogenous testosterone use, including testosterone replacement therapy and AAS, underscores the need for improved management of associated azoospermia, which can be temporary or permanent depending on individual factors and the type of testosterone used. Additionally, the manuscript discusses preventive strategies, such as transitioning to short-acting testosterone formulations or incorporating low-dose hCG to preserve fertility during ET therapy. While guidelines for managing testosterone-related azoospermia remain limited, emerging research indicates the potential efficacy of hormonal stimulation therapies. However, there is a notable lack of well-structured, controlled, and long-term studies addressing the management of azoospermia related to exogenous testosterone use, highlighting the need for such studies to inform evidence-based recommendations.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"330-341"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0