Asian journal of andrology最新文献

Genitourethral foreign bodies: 20-year experience and outcomes from a single center. 生殖泌尿道异物：一个中心 20 年的经验和结果。

Asian journal of andrology Pub Date : 2024-11-19 DOI: 10.4103/aja202497

Claris Oh, Darcy Noll, Athul John, Matthew Hong

{"title":"Genitourethral foreign bodies: 20-year experience and outcomes from a single center.","authors":"Claris Oh, Darcy Noll, Athul John, Matthew Hong","doi":"10.4103/aja202497","DOIUrl":"10.4103/aja202497","url":null,"abstract":"Abstract: The presentation of a foreign body in the lower urinary tract is a challenging urological emergency with highly variable management approaches. A retrospective cohort study was undertaken to identify the patients who presented with self-inserted genitourethral foreign body to adult tertiary centers within our local health network (Southern Adelaide Local Health Network, Adelaide, Australia) from October 2002 to October 2022. Patient demographics, type of foreign body, psychiatric comorbidities, retrieval techniques, complications, and readmission data were extracted. Twenty-seven cases were identified with a median age of 44 years. Twenty-three (85.2%) were male and 4 (14.8%) were female. Ten patients (37.0%) had a concurrent psychiatric illness. The most commonly inserted foreign bodies were plastic tubes/wires (29.6%). Twenty cases (74.1%) were retrieved endoscopically. Three patients (11.1%) required open cystotomy and one underwent a transperineal urethrotomy. Four patients (14.8%) represented after discharge. Two patients had repeat presentations for genitourinary foreign body insertion. A significant monotonic positive trend of foreign body presentations was identified (Mann-Kendall tau = 0.95, P = 0.043). Presentations of genitourethral foreign body insertions have trended upward over the past two decades. However, most cases were successfully managed endoscopically.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Androgen receptor inhibitors in treating prostate cancer. 治疗前列腺癌的雄激素受体抑制剂。

Asian journal of andrology Pub Date : 2024-11-19 DOI: 10.4103/aja202494

Ryan N Cole, Qinghua Fang, Kanako Matsuoka, Zhou Wang

{"title":"Androgen receptor inhibitors in treating prostate cancer.","authors":"Ryan N Cole, Qinghua Fang, Kanako Matsuoka, Zhou Wang","doi":"10.4103/aja202494","DOIUrl":"10.4103/aja202494","url":null,"abstract":"Abstract: Androgens play an important role in prostate cancer development and progression. Androgen action is mediated through the androgen receptor (AR), a ligand-dependent DNA-binding transcription factor. AR is arguably the most important target for prostate cancer treatment. Current USA Food and Drug Administration (FDA)-approved AR inhibitors target the ligand-binding domain (LBD) and have exhibited efficacy in prostate cancer patients, particularly when used in combination with androgen deprivation therapy. Unfortunately, patients treated with the currently approved AR-targeting agents develop resistance and relapse with castration-resistant prostate cancer (CRPC). The major mechanism leading to CRPC involves reactivation of AR signaling mainly through AR gene amplification, mutation, and/or splice variants. To effectively inhibit the reactivated AR signaling, new approaches to target AR are being actively explored. These new approaches include novel small molecule inhibitors targeting various domains of AR and agents that can degrade AR. The present review provides a summary of the existing FDA-approved AR antagonists and the current development of some of the AR targeting agents.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Ureaplasma urealyticum infection with male infertility and intrauterine insemination outcomes. 尿解支原体感染与男性不育症和宫腔内人工授精结果的关系。

Asian journal of andrology Pub Date : 2024-11-08 DOI: 10.4103/aja202489

Yang-Yang Wan, Xiao-Yun Shi, Wen-Jing Liu, Shun Bai, Xin Chen, Si-Yao Li, Xiao-Hua Jiang, Li-Min Wu, Xian-Sheng Zhang, Juan Hua

{"title":"Associations of Ureaplasma urealyticum infection with male infertility and intrauterine insemination outcomes.","authors":"Yang-Yang Wan, Xiao-Yun Shi, Wen-Jing Liu, Shun Bai, Xin Chen, Si-Yao Li, Xiao-Hua Jiang, Li-Min Wu, Xian-Sheng Zhang, Juan Hua","doi":"10.4103/aja202489","DOIUrl":"https://doi.org/10.4103/aja202489","url":null,"abstract":"Abstract: Ureaplasma urealyticum (UU) is one of the most commonly occurring pathogens associated with genital tract infections in infertile males, but the impact of seminal UU infection in semen on intrauterine insemination (IUI) outcomes is poorly understood. We collected data from 245 infertile couples who underwent IUI at The First Affiliated Hospital of USTC (Hefei, China) between January 2021 and January 2023. The subjects were classified into two groups according to their UU infection status: the UU-positive group and the UU-negative group. We compared semen parameters, pregnancy outcomes, and neonatal birth outcomes to investigate the impact of UU infection on IUI outcomes. There were no significantly statistical differences in various semen parameters, including semen volume, sperm concentration, total and progressive motility, sperm morphology, leukocyte count, the presence of anti-sperm antibody, and sperm DNA fragmentation index (DFI), between the UU-positive and UU-negative groups of male infertile patients (all P > 0.05). However, the high DNA stainability (HDS) status of sperm differed between the UU-positive and UU-negative groups, suggesting that seminal UU infection may affect sperm nuclear maturation (P = 0.04). Additionally, there were no significant differences in pregnancy or neonatal birth outcomes between the two groups (all P > 0.05). These results suggest that IUI remains a viable and cost-effective option for infertile couples with UU infection who are facing infertility issues.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repeated platelet-rich plasma injections improve erectile dysfunction in a rat model of hyperhomocysteinemia. 重复注射富血小板血浆可改善高同型半胱氨酸血症大鼠模型的勃起功能障碍。

Asian journal of andrology Pub Date : 2024-11-01 Epub Date: 2024-07-02 DOI: 10.4103/aja202418

Zhe Yu, Yuan-Zhi Xie, Xiao-Lan Huang, Su-Zhen Huang, Xiang-Min Luo, Jin-Xiang Wu

{"title":"Repeated platelet-rich plasma injections improve erectile dysfunction in a rat model of hyperhomocysteinemia.","authors":"Zhe Yu, Yuan-Zhi Xie, Xiao-Lan Huang, Su-Zhen Huang, Xiang-Min Luo, Jin-Xiang Wu","doi":"10.4103/aja202418","DOIUrl":"10.4103/aja202418","url":null,"abstract":"Abstract: Platelet-rich plasma (PRP) shows promise as a regenerative modality for mild-to-moderate erectile dysfunction (ED). However, its efficacy in treating severe ED remains unknown. Blood samples from 8-week-old male rats were used to prepare PRP through a two-step centrifugation procedure, followed by chitosan activation and freeze thaw cycle. A hyperhomocysteinemia (HHcy)-related ED model was established using a methionine-enriched diet, and an apomorphine (APO) test was conducted during the 4 th week. APO-negative rats were divided into two groups and were injected with PRP or saline every 2 weeks. Erectile function and histological analyses of the corpus cavernosum were performed during the 16 th week. The results revealed that erectile function was significantly impaired in rats with HHcy-related ED compared to that in age-matched rats but was improved by repeated PRP injections. Immunofluorescence staining revealed a reduction in reactive oxygen species and additional benefits on the recovery of structures within the corpus cavernosum in rats that received PRP treatment compared to those in the saline-injected control group. Therefore, PRP could enhance functional and structural recovery in a severe HHcy-related ED model. A notable strength of the present study lies in the use of a repeated intracavernous injection method, mirroring protocols used in human studies, which offers more reliable results for translating the findings to humans.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"622-627"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PSMA PET/CT in the low- to intermediate-risk prostate cancer: when and why? PSMA PET/CT 在中低风险前列腺癌中的应用：何时、为何？

Asian journal of andrology Pub Date : 2024-11-01 Epub Date: 2024-03-26 DOI: 10.4103/aja20244

Luca Sofia, Matteo Bauckneht

引用次数: 0

High-intensity focused ultrasound strategies for treating prostate cancer. 治疗前列腺癌的高强度聚焦超声策略。

Asian journal of andrology Pub Date : 2024-11-01 Epub Date: 2024-04-26 DOI: 10.4103/aja20245

Xiaobo Wu, Yupeng Wu, Chi-Fai Ng, Chi-Hang Yee, Peter Ka-Fung Chiu

{"title":"High-intensity focused ultrasound strategies for treating prostate cancer.","authors":"Xiaobo Wu, Yupeng Wu, Chi-Fai Ng, Chi-Hang Yee, Peter Ka-Fung Chiu","doi":"10.4103/aja20245","DOIUrl":"10.4103/aja20245","url":null,"abstract":"Abstract: Prostate cancer (PCa) is a significant health concern globally, necessitating effective treatment options. Typical treatment methods for early stage, particularly localized PCa, encompass radical procedures, such as radical prostatectomy (RP) and radiotherapy (RT), and nonradical focal therapy (FT). FT is a focused approach mainly used for treating small lesions limited to a specific zone of the prostate. Its objective is to achieve cancer control when minimizing damage to benign tissue. High-intensity focused ultrasound (HIFU) is one of the most used modalities in FT for the management of PCa. The progress in HIFU technology showcases continuous advancements, offering clinicians a variety of strategies to cater to diverse patient requirements. The advancements include the development of transrectal and transurethral HIFU machines that offer enhanced treatment distances, magnetic resonance imaging (MRI) fusion capabilities, real-time monitoring, and precise ablation. These improvements contribute to increased treatment effectiveness and better outcomes for patients. This narrative review aims to summarize the use of HIFU technology and its evolution, offering diverse options to clinicians, and explores the safety, effectiveness, and quality of different HIFU strategies, such as whole-gland ablation, hemigland ablation, and focal ablation. We conclude that nonwhole-gland HIFU offers similar cancer control with better short-term functional outcomes and fewer complications compared to whole-gland ablation. Combining HIFU with transurethral resection of the prostate (TURP) improves urinary function and reduces catheterization time. Focal ablation and hemigland ablation show promise in achieving cancer control when preserving continence and potency.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"595-599"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active surveillance in low- and intermediate-risk prostate cancer. 低危和中危前列腺癌的积极监控。

Asian journal of andrology Pub Date : 2024-11-01 Epub Date: 2024-06-07 DOI: 10.4103/aja202423

Linda Cerbone, Giovanni Regine, Fabio Calabrò

引用次数: 0

Histopathological evaluation and grading for prostate cancer: current issues and crucial aspects. 前列腺癌的组织病理学评估和分级：当前的问题和关键环节。

Asian journal of andrology Pub Date : 2024-11-01 Epub Date: 2024-09-10 DOI: 10.4103/aja202440

Vittorio Agosti, Enrico Munari

{"title":"Histopathological evaluation and grading for prostate cancer: current issues and crucial aspects.","authors":"Vittorio Agosti, Enrico Munari","doi":"10.4103/aja202440","DOIUrl":"10.4103/aja202440","url":null,"abstract":"Abstract: A crucial aspect of prostate cancer grading, especially in low- and intermediate-risk cancer, is the accurate identification of Gleason pattern 4 glands, which includes ill-formed or fused glands. However, there is notable inconsistency among pathologists in recognizing these glands, especially when mixed with pattern 3 glands. This inconsistency has significant implications for patient management and treatment decisions. Conversely, the recognition of glomeruloid and cribriform architecture has shown higher reproducibility. Cribriform architecture, in particular, has been linked to the worst prognosis among pattern 4 subtypes. Intraductal carcinoma of the prostate (IDC-P) is also associated with high-grade cancer and poor prognosis. Accurate identification, classification, and tumor size evaluation by pathologists are vital for determining patient treatment. This review emphasizes the importance of prostate cancer grading, highlighting challenges like distinguishing between pattern 3 and pattern 4 and the prognostic implications of cribriform architecture and intraductal proliferations. It also addresses the inherent grading limitations due to interobserver variability and explores the potential of computational pathology to enhance pathologist accuracy and consistency.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"575-581"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142303272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel missense mutation of CCDC34 causes male infertility with oligoasthenoteratozoospermia in a consanguineous Pakistani family. 在一个巴基斯坦近亲结婚家庭中，CCDC34的新型错义突变导致男性不育和少精子症。

Asian journal of andrology Pub Date : 2024-11-01 Epub Date: 2024-06-11 DOI: 10.4103/aja202432

Nisar Ahmad, Meng-Lei Yang, Aurang Zeb, Jian-Teng Zhou, Muhammad Zubair, Tanveer Abbas, Xiao-Hua Jiang, Yuan-Wei Zhang, Huan Zhang, Wasim Shah, Qing-Hua Shi

{"title":"A novel missense mutation of CCDC34 causes male infertility with oligoasthenoteratozoospermia in a consanguineous Pakistani family.","authors":"Nisar Ahmad, Meng-Lei Yang, Aurang Zeb, Jian-Teng Zhou, Muhammad Zubair, Tanveer Abbas, Xiao-Hua Jiang, Yuan-Wei Zhang, Huan Zhang, Wasim Shah, Qing-Hua Shi","doi":"10.4103/aja202432","DOIUrl":"10.4103/aja202432","url":null,"abstract":"Abstract: Male infertility is a worldwide health issue, affecting 8%-12% of the global population. Oligoasthenoteratozoospermia (OAT) represents a severe type of male infertility, characterized by reduced sperm count and motility and an increased frequency of sperm with aberrant morphology. Using whole-exome sequencing, this study identified a novel missense mutation (c.848C>A, p.A283E) in the coiled-coil domain-containing 34 gene (CCDC34) in a consanguineous Pakistani family. This rare mutation was predicted to be deleterious and to affect the protein stability. Hematoxylin and eosin staining of spermatozoa from the patient with OAT revealed multiple morphological abnormalities of the flagella and transmission electron microscopy indicated axonemal ultrastructural defects with a lack of outer dynein arms. These findings indicated that CCDC34 plays a role in maintaining the axonemal ultrastructure and the assembly or stability of the outer dynein arms, thus expanding the phenotypic spectrum of CCDC34 missense mutations.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"605-609"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence in andrology - fact or fiction: essential takeaway for busy clinicians. 人工智能在男性学中的应用--事实还是虚构：忙碌的临床医生的必修课。

Asian journal of andrology Pub Date : 2024-11-01 Epub Date: 2024-07-09 DOI: 10.4103/aja202431

Aldo E Calogero, Andrea Crafa, Rossella Cannarella, Ramadan Saleh, Rupin Shah, Ashok Agarwal

引用次数: 0