Asian journal of andrology最新文献

Preoperative apical margin risk estimation from T2-weighted MRI radiomics in prostate cancer with MRI-visible apical tumors: toward multidisciplinary decision support. 基于t2加权MRI放射组学的前列腺癌伴MRI可见根尖肿瘤术前根尖边缘风险评估：面向多学科决策支持。

IF 2.7

Asian journal of andrology Pub Date : 2026-10-20 DOI: 10.4103/aja202625

Yi Liu, Yi-Ze Zhao, Shui Liu, Xian-Shu Gao, Ming-Wei Ma

{"title":"Preoperative apical margin risk estimation from T2-weighted MRI radiomics in prostate cancer with MRI-visible apical tumors: toward multidisciplinary decision support.","authors":"Yi Liu, Yi-Ze Zhao, Shui Liu, Xian-Shu Gao, Ming-Wei Ma","doi":"10.4103/aja202625","DOIUrl":"https://doi.org/10.4103/aja202625","url":null,"abstract":"This retrospective study developed and validated a T2-weighted imaging (T2WI)-based radiomics model for preoperative prediction of apical positive surgical margins (PSMs) in patients undergoing radical prostatectomy for prostate cancer. Overall, 235 patients (74 with apical PSMs and 161 without apical PSMs) were randomly divided into a training set (n = 164; 69.8%) and an independent test set (n = 71; 30.2%). Eligible patients had preoperative multiparametric magnetic resonance imaging within 6 weeks before surgery, an index lesion involving or abutting the prostatic apex, definitive apical margin status, and standard radical prostatectomy without nerve-sparing. Patients with inadequate imaging for apical assessment or region-of-interest delineation, prior transurethral resection of the prostate, or neoadjuvant androgen-deprivation therapy were excluded. A total of 1409 radiomic features were extracted from T2WI. After normalization and removal of highly correlated features (|r| > 0.99), six optimal features were selected by recursive feature elimination. A gradient boosting machine model was constructed, and performance was assessed using the area under the receiver operating characteristic curve (AUC), Brier score, and decision curve analysis. The apical PSM rate was 31.5%. In the test set, the model achieved an AUC of 0.874, Brier score of 0.120, accuracy of 87.3%, sensitivity of 81.8%, and specificity of 89.8%. Skewness was the most important feature, contributing 34.8% to the model. Apical PSMs were significantly associated with extraprostatic extension (P = 0.001), and the tumor-margin model provided the greatest net clinical benefit. T2WI-based radiomics may support individualized preoperative risk assessment and surgical planning for prostate cancer.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysregulation of the miR-29c-3p/collagen axis induces spermatogenic failure in heat stress and non-obstructive azoospermia. miR-29c-3p/胶原轴的失调可诱导热应激和非阻塞性无精子症的生精失败。

IF 2.7

Asian journal of andrology Pub Date : 2026-10-20 DOI: 10.4103/aja202623

Shou-Bo Zhang, Meng-Ke Zhou, Yuan-Shu Zhao, Yi-Yuan Zhan, Yi-You Mao, Hou-Hua Lai, Dao-Jun Lv, Wen-Bin Chen

{"title":"Dysregulation of the miR-29c-3p/collagen axis induces spermatogenic failure in heat stress and non-obstructive azoospermia.","authors":"Shou-Bo Zhang, Meng-Ke Zhou, Yuan-Shu Zhao, Yi-Yuan Zhan, Yi-You Mao, Hou-Hua Lai, Dao-Jun Lv, Wen-Bin Chen","doi":"10.4103/aja202623","DOIUrl":"https://doi.org/10.4103/aja202623","url":null,"abstract":"Rising global temperatures have intensified male infertility linked to testicular heat stress. While microRNAs play pivotal roles in spermatogenesis, the reason for aberrant microRNA expression following heat stress-induced spermatogenic disorders remains largely unclear. We established a murine heat stress model and performed small RNA sequencing. Candidate microRNAs were obtained via intersection with additional spermatogenic arrest and Sertoli cell-only syndrome datasets. The proliferation of germ cells was assessed by cholecystokinin-8 and 5-ethynyl-2'-deoxyuridine assays. Bioinformatic analysis was applied to predict downstream miRNA targets, and enrichment analysis was performed. Fluorescence in situ hybridization and immunofluorescence assays were utilized to determine the expression of miRNAs and their targets in Sertoli cell-only syndrome models and clinical testicular samples. In total, testicular heat stress resulted in 102 upregulated and 114 downregulated miRNAs. Four candidate microRNAs (miR-378a-3p, miR-29c-3p, let-7a-5p, and miR-9-5p) were screened for further investigation. Functional assays demonstrated that elevated expression of miR-378a-3p, miR-29c-3p, or silencing of miR-9-5p, notably inhibited the proliferation ability of spermatogonia (GC-1 cells). Common targets of these microRNAs were highly enriched in collagen-related pathways, predominantly through the inhibition of miR-29c-3p-targeted collagen type I alpha 1 and type III alpha 1 chain 1. Compared with normal tissue samples, tissue samples from Sertoli cell-only syndrome model mice and from those with spermatogenic disorders also exhibited high miR-29c-3p expression levels. In summary, our study identified microRNA expression patterns during testicular heat stress and preliminarily investigated the roles of specific microRNAs. miR-29c-3p and the collagen synthesis pathway could be utilized as biomarkers and therapeutic targets for heat-induced spermatogenic disorders.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abscopal effect-induced acephalic spermatozoa and testicular dysfunction implicate Cep112 and PI3K/Akt-mTOR signaling. 体外效应诱导的头型精子和睾丸功能障碍与Cep112和PI3K/Akt-mTOR信号通路有关。

IF 2.7

Asian journal of andrology Pub Date : 2026-10-20 DOI: 10.4103/aja202620

Zhi-Xiang Mao, Li-Xiu Lv, Jin-Jin Chu, Ming-Zheng Li, Yao-Yao Dong, Fei Xue, Xiang-Long Li, Xiao-Ji Lin, Wen-Jian Guo, Wen-Jie Sun, Cong-Ying Xie, C Yan Cheng, Lin-Xi Li

{"title":"Abscopal effect-induced acephalic spermatozoa and testicular dysfunction implicate Cep112 and PI3K/Akt-mTOR signaling.","authors":"Zhi-Xiang Mao, Li-Xiu Lv, Jin-Jin Chu, Ming-Zheng Li, Yao-Yao Dong, Fei Xue, Xiang-Long Li, Xiao-Ji Lin, Wen-Jian Guo, Wen-Jie Sun, Cong-Ying Xie, C Yan Cheng, Lin-Xi Li","doi":"10.4103/aja202620","DOIUrl":"https://doi.org/10.4103/aja202620","url":null,"abstract":"The abscopal effect, a systemic phenomenon induced by localized irradiation and associated with inflammatory factor activation, has attracted significant interest in the context of radiotherapy combined with immunotherapy. While recognized as potentially beneficial in oncology, this effect can have detrimental off-target consequences. The underlying mechanisms for abscopal effect-induced testicular dysfunction remain unclear. In this study, we observed a pronounced testicular disruption phenotype characterized by abnormalities in meiosis, blood-testis barrier integrity, and spermatid orientation. Notably, we report the novel finding that the abscopal effect can induce acephalic spermatozoa (headless sperm). Transcriptional analysis by quantitative real-time polymerase chain reaction revealed the dysregulation of the expression of centrosomal proteins, known regulators of meiosis and spermiogenesis. By employing RNA interference to knock down centrosomal protein 112 (Cep112), we demonstrated its critical role in spermiogenesis and established its close association with the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and mechanistic target of rapamycin/ribosomal protein S6 (mTOR/rpS6) signaling pathways. Our findings indicate that Cep112 mediates cytoskeletal organization in testes and sperm formation via the PI3K/Akt and mTOR/rpS6 pathways, suggesting that Cep112 significantly contributes to abscopal effect-induced spermatogenic dysfunction.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel homozygous missense ODF2 variant in infertile siblings with multiple morphological abnormalities of the sperm flagella. 一种新的纯合错义ODF2变异在不育兄弟姐妹与多种形态异常的精子鞭毛。

IF 2.7

Asian journal of andrology Pub Date : 2026-10-16 DOI: 10.4103/aja202627

Ghulam Mustafa, Yue Wang, Muhammad Lateef, Huan Zhang, Tanveer Abbas, Musavir Abbas, Mujahid Hussain, Muhammad Shoaib, Abu Mansoor, Meftah Uddin, Yousuf Raza, Ansar Hussain, Bo Yang, Han-Wei Jiang, Sui-Xing Fan, Qing-Hua Shi

{"title":"A novel homozygous missense ODF2 variant in infertile siblings with multiple morphological abnormalities of the sperm flagella.","authors":"Ghulam Mustafa, Yue Wang, Muhammad Lateef, Huan Zhang, Tanveer Abbas, Musavir Abbas, Mujahid Hussain, Muhammad Shoaib, Abu Mansoor, Meftah Uddin, Yousuf Raza, Ansar Hussain, Bo Yang, Han-Wei Jiang, Sui-Xing Fan, Qing-Hua Shi","doi":"10.4103/aja202627","DOIUrl":"https://doi.org/10.4103/aja202627","url":null,"abstract":"Male infertility is often linked to genetic mutations that impair sperm motility and morphology. Multiple morphological abnormalities of the sperm flagella (MMAF) are recognized as a significant cause of male infertility and are characterized by a spectrum of structural defects. However, the underlying etiology of MMAF remains largely unknown. In this study, we recruited a consanguineous family with a history of primary male infertility affecting two brothers diagnosed with MMAF, without obvious signs of primary ciliary dyskinesia. Whole-exome sequencing and Sanger sequencing were used to identify potentially pathogenic variants, and the effects of the identified mutation were evaluated in vitro and in silico. Papanicolaou staining, scanning electron microscopy, and transmission electron microscopy were performed to analyze sperm morphology. The localization and expression of outer dense fiber 2 (ODF2) in spermatozoa were examined by immunofluorescence and Western blot. We identified a novel homozygous missense mutation, c.539G>A (p.R180K), in ODF2 in the two infertile brothers. Sanger sequencing confirmed autosomal recessive inheritance. The patients exhibited asthenoteratozoospermia, with abnormal flagellar morphology and reduced motility. Further ultrastructural analysis revealed axonemal disorganization consistent with MMAF. Although the identified ODF2 mutation did not affect the overall protein expression, the mutant ODF2 protein was absent from the sperm flagella. Cell transfection experiments demonstrated the aberrant localization of the mutated protein, and bioinformatics analyses predicted the disruption of a conserved residue within a coiled-coil domain of ODF2. This study underscores the pivotal role of ODF2 in sperm flagellar development and broadens the mutational spectrum associated with human MMAF.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cavernous nerve visual imaging technologies: translational potential for radical prostatectomy. 海绵体神经视觉成像技术：根治性前列腺切除术的翻译潜力。

IF 2.7

Asian journal of andrology Pub Date : 2026-10-13 DOI: 10.4103/aja202642

Biljana Musicki, Arthur L Burnett

{"title":"Cavernous nerve visual imaging technologies: translational potential for radical prostatectomy.","authors":"Biljana Musicki, Arthur L Burnett","doi":"10.4103/aja202642","DOIUrl":"https://doi.org/10.4103/aja202642","url":null,"abstract":"Various technologies have been applied during nerve-sparing radical prostatectomy to visualize cavernous nerves involved in penile erection for the purpose of executing pelvic surgeries proficiently while maximizing erection preservation postoperatively. However, these technologies failed to identify the cavernous nerves reliably and guide surgical procedures for improving surgical outcomes. The development of new approaches that accurately and rapidly identify cavernous nerves relevant for penile erection (erectogenic cavernous nerves) in real time during surgery is warranted. In this review, we describe technologies for cavernous nerve visualization, which have been investigated mostly in small rodent animal models. We further discuss recent technological advancements for peripheral nerve localization generally, which may be transferable to cavernous nerve localization. While many of these innovative approaches remain under investigation in preclinical studies, they may serve as a foundation for designing and developing strategies in this arena clinically. Future research should aim to target novel molecular targets and apply these to existing and novel technologies for erectogenic cavernous nerve intraoperative visual imaging.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Penile length after inflatable penile prosthesis implant: a single-center, high-volume experience. 充气阴茎假体植入后的阴茎长度：单中心，高容量体验。

IF 2.7

Asian journal of andrology Pub Date : 2026-10-13 DOI: 10.4103/aja202649

Anna Ricapito, Marco Finati, Piero Fischetti, Matteo Rubino, Ugo Giovanni Falagario, Fabrizio Palumbo, Gian Maria Busetto, Luigi Cormio, Giuseppe Carrieri, Carlo Bettocchi

{"title":"Penile length after inflatable penile prosthesis implant: a single-center, high-volume experience.","authors":"Anna Ricapito, Marco Finati, Piero Fischetti, Matteo Rubino, Ugo Giovanni Falagario, Fabrizio Palumbo, Gian Maria Busetto, Luigi Cormio, Giuseppe Carrieri, Carlo Bettocchi","doi":"10.4103/aja202649","DOIUrl":"https://doi.org/10.4103/aja202649","url":null,"abstract":"Penile shortening after inflatable penile prosthesis (IPP) implant represents one of the most common concerns in patients. In this study, our aim is to compare both flaccid and stretched penile length before, immediately after, and up to 1 year after surgery. We prospectively collected measurements in 142 patients undergoing IPP implant. Standardized measurements of flaccid and stretched penile length were performed before IPP. Penile length measurements in erect and flaccid positions were then performed at the end of the IPP and at 6 weeks, 12 weeks, and 1 year of follow-up visits. Data concerning age, body mass index (BMI), smoking status, and comorbidities were collected. Penile length was compared using Wilcoxon-paired test, after assessing lack of normal distribution through Shapiro-Wilk test. Linear regression was used to correlate comorbidities and time from erectile dysfunction diagnosis to IPP with postoperative length. Mean (standard deviation [s.d.]) of preoperative flaccid and stretched lengths was 10.3 (1.9) cm and 13.3 (1.9) cm, respectively. A statistically significant difference was shown between preoperative and postoperative stretched penile length (+0.21 cm, P < 0.001), while no difference was observed for flaccid length (+0.20 cm, 95% confidence interval [CI]: -0.01 to 0.08, P = 0.1). Erect length remained stable up to 1 year after surgery, with 21% of patients showing an increase of ≥1 cm. At linear regression, a higher BMI was associated with shorter postoperative flaccid length (P = 0.03). Erect penile length after IPP implant is shown to remain stable up to 1 year of follow-up visits. Higher BMI may negatively impact flaccid length, but no other factors were associated with changes.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico prediction and functional analysis of non-synonymous single-nucleotide polymorphisms (nsSNPs) in human ACTL7A gene associated with spermatogenesis. 与精子发生相关的人类ACTL7A基因非同义单核苷酸多态性（nssnp）的计算机预测和功能分析。

IF 2.7

Asian journal of andrology Pub Date : 2026-10-13 DOI: 10.4103/aja202628

Yi-Ni Zhang, Miao Liu, Yi-Si Sun, Xin-Yue Yang, Jun-Yan Chen, Hui-Juan Shi, Guo-Wu Chen, Ai-Jie Xin

{"title":"In silico prediction and functional analysis of non-synonymous single-nucleotide polymorphisms (nsSNPs) in human ACTL7A gene associated with spermatogenesis.","authors":"Yi-Ni Zhang, Miao Liu, Yi-Si Sun, Xin-Yue Yang, Jun-Yan Chen, Hui-Juan Shi, Guo-Wu Chen, Ai-Jie Xin","doi":"10.4103/aja202628","DOIUrl":"https://doi.org/10.4103/aja202628","url":null,"abstract":"Actin-like 7A (ACTL7A) is considered to play an important role in acrosome formation, fertilization, and early embryo development. Several single-nucleotide polymorphisms (SNPs) in ACTL7A have been reported to be associated with male infertility. However, the functional consequences of the most non-synonymous SNPs (nsSNPs) in ACTL7A remain largely unclear. Here, a total of 489 nsSNPs in the ACTL7A gene were retrieved from the Database of Single-Nucleotide Polymorphism (dbSNP) and systematically analyzed using a series of computational tools. Among these, 44 nsSNPs were predicted to be potentially deleterious. Further in vitro validation identified eight nsSNPs associated with significantly decreased ACTL7A protein levels, which were therefore considered candidate functional variants, including rs534593253, rs775405375, rs768576884, rs1308056655, rs779034458, rs779515458, rs1827186853, and rs1827186891. In addition, one deletion variant and three nonsense variants were identified. Structural modeling further suggested that these nsSNP-derived variants may induce conformational alterations in the ACTL7A protein. Overall, this study provides a framework for prioritizing functionally relevant ACTL7A nsSNPs for future investigation.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early diagnosis and resection of Müllerian duct remnants: a strategy to improve outcomes in hypospadias repair. 早期诊断和切除<s:1>勒氏管残余：一种改善尿道下裂修复效果的策略。

IF 2.7

Asian journal of andrology Pub Date : 2026-10-13 DOI: 10.4103/aja202648

Peng Luo, Zeng-Jing Yang, Ting-Ting Xue, Zhe Xu, Chun-Hua Deng, Hai-Ming Cao, Qi-Gen Xie

{"title":"Early diagnosis and resection of Müllerian duct remnants: a strategy to improve outcomes in hypospadias repair.","authors":"Peng Luo, Zeng-Jing Yang, Ting-Ting Xue, Zhe Xu, Chun-Hua Deng, Hai-Ming Cao, Qi-Gen Xie","doi":"10.4103/aja202648","DOIUrl":"https://doi.org/10.4103/aja202648","url":null,"abstract":"This retrospective study evaluated whether early diagnosis and resection of Müllerian duct remnants (MDRs) improve outcomes in hypospadias repair. We analyzed patients with hypospadias and coexisting MDRs treated at The First Affiliated Hospital of Sun Yat-sen University (Guangzhou, China) from August 2003 and June 2024. Patients were divided into a study group (n = 22, MDR resection before urethroplasty) and a control group (n = 40, no MDR resection before urethroplasty). MDRs were diagnosed using voiding cystourethrography and cystoscopy. Compared with the control group, the study group had more severe MDRs and hypospadias. No major intraoperative complications occurred during MDR resection, except for urine leakage from the remnant stump in two patients. The success rate of urethroplasty was significantly greater in the study group than that in the control group (36.4% vs 10.0%, P = 0.019). In the control group, seven patients required salvage MDR resection because of recurrent fistulas. The incidence of postoperative epididymitis was significantly greater in the control group (20.0% vs 0, P = 0.042). Compared with the control group, the study group underwent significantly fewer total reoperations (mean ± s.d.: 1.0 ± 1.6 vs 2.8 ± 3.5, P = 0.003), fewer fistula repairs (mean ± s.d.: 0.6 ± 0.7 vs 1.9 ± 2.2, P = 0.044), and fewer urethral dilations (mean ± s.d.: 0.2 ± 0.5 vs 1.1 ± 2.2, P = 0.047). These findings suggest that early diagnosis and resection of MDRs improve urethroplasty outcomes, reduce complications, and decrease reoperations, supporting the incorporation of this approach into routine clinical management for hypospadias.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond tumor control: reproductive implications of polo-like kinase 1 inhibition. 超越肿瘤控制：马球样激酶1抑制的生殖意义。

IF 2.7

Asian journal of andrology Pub Date : 2026-10-13 DOI: 10.4103/aja202654

Maria Zelinda Romano, Rosaria Meccariello

引用次数: 0

Repetitive pulsed magnetic stimulation attenuates neurogenic erectile dysfunction associated with the upregulation of the BDNF/NGF axis in a rat model of cavernous nerve injury. 在海绵状神经损伤大鼠模型中，重复脉冲磁刺激可减弱与BDNF/NGF轴上调相关的神经源性勃起功能障碍。

IF 2.7

Asian journal of andrology Pub Date : 2026-10-13 DOI: 10.4103/aja202638

Yun-Long Ge, Zhi Cao, Pan Gao, Yu-Kuai Ma, Peng Yang, Rui Gao, Jing-Jing Gao, Li Zhang, Xian-Sheng Zhang

{"title":"Repetitive pulsed magnetic stimulation attenuates neurogenic erectile dysfunction associated with the upregulation of the BDNF/NGF axis in a rat model of cavernous nerve injury.","authors":"Yun-Long Ge, Zhi Cao, Pan Gao, Yu-Kuai Ma, Peng Yang, Rui Gao, Jing-Jing Gao, Li Zhang, Xian-Sheng Zhang","doi":"10.4103/aja202638","DOIUrl":"https://doi.org/10.4103/aja202638","url":null,"abstract":"Iatrogenic cavernous nerve (CN) injury remains a prevalent complication following radical prostatectomy, leading to refractory erectile dysfunction (ED). While magnetic stimulation has shown neuroregenerative potential in other contexts, its therapeutic efficacy and molecular mechanisms in post-prostatectomy ED remain poorly defined. The aim of this study was to investigate whether repetitive pulsed magnetic stimulation (rPMS) facilitates neurovascular preservation and erectile function recovery in a rat model of bilateral CN crush injury. Thirty adult male Sprague Dawley rats were randomly assigned to three groups (n = 10 per group): sham surgery (Sham group), bilateral CN crush alone (BCNC group), and BCNC followed by rPMS treatment (rPMS group). The BCNC model was established by bilateral compression of the CNs. Starting three days postoperatively, the rPMS group underwent a two-week regimen of 10 Hz stimulation (15% maximum output; 2400 pulses per session) every other day, totaling six sessions. Erectile function was evaluated via CN electrostimulation. Penile tissue and CN samples were subsequently harvested to assess nerve repair and corpus cavernosum histology. A functional assessment demonstrated that rPMS significantly restored the maximum intracavernosal pressure (Max ICP)/mean arterial pressure (MAP) ratio. At both the molecular level and the ultrastructural level, rPMS therapy reduced corporal fibrosis and apoptosis while promoting axonal repair. These structural improvements correlated with the upregulation of the brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) neurotrophic signaling pathways within the injured CN. rPMS significantly improved erectile hemodynamics in a rat model of CN injury. This functional recovery is closely associated with an enhanced neurotrophic microenvironment involving BDNF and NGF.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0