Asian journal of andrology最新文献_第10页

Value of cognitive fusion targeted and standard systematic transrectal prostate biopsy for prostate cancer diagnosis. 认知融合靶向和标准系统经直肠前列腺活检术对前列腺癌诊断的价值。

Asian journal of andrology Pub Date : 2024-09-01 Epub Date: 2024-05-24 DOI: 10.4103/aja202414

Lu-Ping Yu, Yi-Qing Du, Yi-Ran Sun, Cai-Peng Qin, Wen-Bo Yang, Zi-Xiong Huang, Tao Xu

{"title":"Value of cognitive fusion targeted and standard systematic transrectal prostate biopsy for prostate cancer diagnosis.","authors":"Lu-Ping Yu, Yi-Qing Du, Yi-Ran Sun, Cai-Peng Qin, Wen-Bo Yang, Zi-Xiong Huang, Tao Xu","doi":"10.4103/aja202414","DOIUrl":"10.4103/aja202414","url":null,"abstract":"Abstract: The aim of this study was to compare the accuracies of cognitive fusion-guided targeted biopsy (TB), systematic biopsy (SB), and combined TB+SB for the detection of prostate cancer (PCa) and clinically significant PCa (csPCa) in males with lesions detected by magnetic resonance imaging (MRI). We conducted a retrospective analysis of individuals who underwent prostate biopsy at Peking University People's Hospital (Beijing, China), with an emphasis on patients with both transrectal TB and SB. The main objective was to determine the precisions of SB, TB, and TB+SB for diagnosing PCa and csPCa. We also evaluated the detection rates of TB, SB, TB+ipsilateral-SB (ipsi-SB), TB+contralateral-SB (contra-SB), and TB+SB for PCa and csPCa in patients with unilateral MRI lesions. We compared the diagnostic yields of the various biopsy schemes using the McNemar's test. A total of 180 patients were enrolled. The rates of PCa detection using TB, SB, and TB+SB were 52.8%, 62.2%, and 66.7%, respectively, and the corresponding rates for csPCa were 46.1%, 56.7%, and 58.3%, respectively. Among patients with unilateral MRI lesions, the PCa detection rates for TB, SB, TB+ipsi-SB, TB+contra-SB, and TB+SB were 53.3%, 64.8%, 65.6%, 61.5%, and 68.0%, respectively. TB+ipsi-SB detected 96.4% of PCa and 95.9% of csPCa cases. These findings suggest that the combination of TB+SB has better diagnostic accuracy compared with SB or TB alone. For patients with unilateral MRI lesions, the combination of TB+ipsi-SB may be suitable in clinical settings.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"479-483"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141089078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of low-intensity extracorporeal shock wave therapy in prostate disorders: in vitro and in vivo evidence. 低强度体外冲击波疗法治疗前列腺疾病的安全性：体外和体内证据。

Asian journal of andrology Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.4103/aja202448

Yi-Ran Wang, Bin Feng, Wen-Bo Qi, Yu-Wen Gong, Xiang-Bin Kong, Hui Cheng, Zhi-Long Dong, Jun-Qiang Tian, Zhi-Ping Wang

{"title":"Safety of low-intensity extracorporeal shock wave therapy in prostate disorders: in vitro and in vivo evidence.","authors":"Yi-Ran Wang, Bin Feng, Wen-Bo Qi, Yu-Wen Gong, Xiang-Bin Kong, Hui Cheng, Zhi-Long Dong, Jun-Qiang Tian, Zhi-Ping Wang","doi":"10.4103/aja202448","DOIUrl":"10.4103/aja202448","url":null,"abstract":"Abstract: Recent evidence suggests that low-intensity extracorporeal shock wave therapy (Li-ESWT) is a promising treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); however, its safety in pelvic organs, particularly prostate tissues and cells, remains unclear. The current study evaluates the risks of prostate cell damage or oncogenesis following the administration of Li-ESWT for prostatitis. To this end, a robust in vitro model (Cell Counting Kit-8 [CCK-8] assay, clone formation assay, cell scratch assay, lactate dehydrogenase [LDH] release assay, flow cytometry, and immunoblotting assay) was designed to examine the effects of Li-ESWT on cell proliferation, clonogenicity, migration, membrane integrity, and DNA damage. Exome sequencing of Li-ESWT-treated cells was performed to determine the risk of carcinogenesis. Furthermore, an in vivo rat model ( n = 20) was employed to assess the effects of Li-ESWT on cancer biomarkers (carcinoembryonic antigen [CEA], Ki67, proliferating cell nuclear antigen [PCNA], and gamma-H2A histone family member X, phosphorylation of the H2AX Ser-139 [ γ -H2AX]) in prostate tissue. Based on our findings, Li-ESWT promotes cellular growth and motility without inducing significant cell membrane or DNA damage or alterations. Genetic analyses did not demonstrate an increase in mutations, and no damage to prostate tissue or upregulation of cancer biomarkers was detected in vivo. This comprehensive in vitro and in vivo assessment confirms the safety of Li-ESWT in managing prostate disorders.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"535-543"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel mutations in LRRC23 cause asthenozoospermia in a nonconsanguineous family. LRRC23的新型突变导致一个非血缘家族出现无精子症。

Asian journal of andrology Pub Date : 2024-09-01 Epub Date: 2024-07-26 DOI: 10.4103/aja202435

Song-Xi Tang, Si-Yu Liu, Hong Xiao, Xin Zhang, Zhuang Xiao, Shan Zhou, Yi-Lang Ding, Peng Yang, Qiang Chen, Hai-Lin Huang, Xi Chen, Xi Lin, Hui-Liang Zhou, Ming-Xi Liu

{"title":"Novel mutations in LRRC23 cause asthenozoospermia in a nonconsanguineous family.","authors":"Song-Xi Tang, Si-Yu Liu, Hong Xiao, Xin Zhang, Zhuang Xiao, Shan Zhou, Yi-Lang Ding, Peng Yang, Qiang Chen, Hai-Lin Huang, Xi Chen, Xi Lin, Hui-Liang Zhou, Ming-Xi Liu","doi":"10.4103/aja202435","DOIUrl":"10.4103/aja202435","url":null,"abstract":"Abstract: The cause of asthenozoospermia (AZS) is not well understood because of its complexity and heterogeneity. Although some gene mutations have been identified as contributing factors, they are only responsible for a small number of cases. Radial spokes (RSs) are critical for adenosine triphosphate-driven flagellar beating and axoneme stability, which is essential for flagellum motility. In this study, we found novel compound heterozygous mutations in leucine-rich repeat-containing protein 23 ( LRRC23 ; c.1018C>T: p.Q340X and c.881_897 Del: p.R295Gfs*32) in a proband from a nonconsanguineous family with AZS and male infertility. Diff-Quik staining and scanning electron microscopy revealed no abnormal sperm morphology. Western blotting and immunofluorescence staining showed that these mutations suppressed LRRC23 expression in sperm flagella. Additionally, transmission electron microscopy showed the absence of RS3 in sperm flagella, which disrupts stability of the radial spoke complex and impairs motility. Following in vitro fertilization and embryo transfer, the proband's spouse achieved successful pregnancy and delivered a healthy baby. In conclusion, our study indicates that two novel mutations in LRRC23 are associated with AZS, but successful fertility outcomes can be achieved by in vitro fertilization-embryo transfer techniques.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"484-489"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive parameters of the efficacy of varicocele repair: a review. 精索静脉曲张修补术疗效的预测参数：综述。

Asian journal of andrology Pub Date : 2024-09-01 Epub Date: 2024-05-24 DOI: 10.4103/aja202420

Andrea Crafa, Rossella Cannarella, Rosita A Condorelli, Laura M Mongioì, Sandro La Vignera, Aldo E Calogero

{"title":"Predictive parameters of the efficacy of varicocele repair: a review.","authors":"Andrea Crafa, Rossella Cannarella, Rosita A Condorelli, Laura M Mongioì, Sandro La Vignera, Aldo E Calogero","doi":"10.4103/aja202420","DOIUrl":"10.4103/aja202420","url":null,"abstract":"Abstract: Varicocele has a prevalence of 15% in the population and represents a primary cause of infertility in 40% of cases and a secondary cause in approximately 80% of cases. It is considered the major correctable cause of male infertility. Despite its high prevalence in the infertile population, a large number of patients with varicocele do not experience reproductive difficulties. For this reason, it is still highly debated which parameters could be used to predict which patients with varicocele will be most likely to benefit from its repair. The main international and European guidelines state that treatment should only be considered in infertile patients with abnormal sperm quality. However, these guidelines do not help physicians to identify which of these patients may benefit from the treatment. Therefore, this narrative review collects the evidence in the literature on the usefulness of some factors as predictors of improvement, highlighting how some of them may be effective in an initial selection of patients to be treated, while others are promising but further studies are needed. Finally, a brief consideration on the possible role of artificial intelligence is proposed.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"441-450"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141089075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scriptaid is a prospective agent for improving human asthenozoospermic sample quality and fertilization rate in vitro. Scriptaid 是一种可改善人类无精子样本质量和体外受精率的前瞻性药物。

Asian journal of andrology Pub Date : 2024-09-01 Epub Date: 2024-06-11 DOI: 10.4103/aja202416

Yi-Ting Yang, Bin Yan, Li-Na Guo, Miao Liu, Yu-Hua Li, Zhi-Yu Shao, Hua Diao, Su-Ying Liu, He-Guo Yu

{"title":"Scriptaid is a prospective agent for improving human asthenozoospermic sample quality and fertilization rate in vitro.","authors":"Yi-Ting Yang, Bin Yan, Li-Na Guo, Miao Liu, Yu-Hua Li, Zhi-Yu Shao, Hua Diao, Su-Ying Liu, He-Guo Yu","doi":"10.4103/aja202416","DOIUrl":"10.4103/aja202416","url":null,"abstract":"Abstract: Male infertility is a global issue caused by poor sperm quality, particularly motility. Enhancement of the sperm quality may improve the fertilization rate in assisted reproductive technology (ART) treatment. Scriptaid, with a novel human sperm motility-stimulating activity, has been investigated as a prospective agent for improving sperm quality and fertilization rate in ART. We evaluated the effects of Scriptaid on asthenozoospermic (AZS) semen, including its impact on motility stimulation and protective effects on cryopreservation and duration of motility, by computer-aided sperm analysis (CASA). Sperm quality improvement by Scriptaid was characterized by increased hyaluronan-binding activity, tyrosine phosphorylation, adenosine triphosphate (ATP) concentration, mitochondrial membrane potential, and an ameliorated AZS fertilization rate in clinical intracytoplasmic sperm injection (ICSI) experiments. Furthermore, our identification of active Scriptaid analogs and different metabolites induced by Scriptaid in spermatozoa lays a solid foundation for the future biomechanical exploration of sperm function. In summary, Scriptaid is a potential candidate for the treatment of male infertility in vitro as it improves sperm quality, prolongs sperm viability, and increases the fertilization rate.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"490-499"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11449406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intralesional and topical treatments for Peyronie's disease: a narrative review of current knowledge. 佩罗尼氏病的内服和外用疗法：现有知识综述。

Asian journal of andrology Pub Date : 2024-08-23 DOI: 10.4103/aja202460

Antonio Minore, Loris Cacciatore, Fabrizio Presicce, Andrea Iannuzzi, Antonio Testa, Gianluigi Raso, Rocco Papalia, Marco Martini, Roberto Mario Scarpa, Francesco Esperto

{"title":"Intralesional and topical treatments for Peyronie's disease: a narrative review of current knowledge.","authors":"Antonio Minore, Loris Cacciatore, Fabrizio Presicce, Andrea Iannuzzi, Antonio Testa, Gianluigi Raso, Rocco Papalia, Marco Martini, Roberto Mario Scarpa, Francesco Esperto","doi":"10.4103/aja202460","DOIUrl":"https://doi.org/10.4103/aja202460","url":null,"abstract":"Abstract: Peyronie's disease (PD) presents a multifaceted challenge in contemporary urological practice, marked by penile deformity, pain, and the potential for erectile dysfunction. We meticulously explored the existing literature of intralesional/topical interventions, aiming to provide clinicians with a nuanced understanding of available options for comprehensive PD management. To conduct this review, we performed a systematic search using the PubMed, Scopus, and ScienceDirect databases, including the keywords of combination of the \"Peyronie's disease/plastic induration of the penis (PIP) and intralesional/topical treatments\". The study selection was based on adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, resulting in the inclusion of 16 articles. We delve into the effectiveness and safety profiles of collagenase Clostridium histolyticum (CCH), interferon, platelet-rich plasma (PRP), hyaluronic acid, botulinum toxin, stem cell, extracorporeal shock wave therapy (ESWT), and traction therapy, assessing their impact on penile curvature, length improvement, and patient-reported symptoms and outcomes. The best options evaluated are intralesional injections of CCH and penile traction devices, alone or in combination. Despite PD remains a challenge for urologists, the objective of this review is to contribute to the evolving landscape of PD management, fostering informed decision-making, and personalized care for individuals grappling with this challenging condition.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technologies to improve sperm retrieval in men undergoing micro-TESE for NOA. 改善因无脑畸形而接受显微取精术（micro-TESE）的男性取精情况的技术。

Asian journal of andrology Pub Date : 2024-08-16 DOI: 10.4103/aja202450

Parviz K Kavoussi, Widi Atmoko, Germar-Michael Pinggera

引用次数: 0

Varicocele and nonobstructive azoospermia. 精索静脉曲张和非梗阻性无精子症。

Asian journal of andrology Pub Date : 2024-08-06 DOI: 10.4103/aja202444

Parviz K Kavoussi, Chirag Gupta, Rupin Shah

引用次数: 0

A review of testicular histopathology in nonobstructive azoospermia. 非梗阻性无精子症睾丸组织病理学综述。

Asian journal of andrology Pub Date : 2024-08-02 DOI: 10.4103/aja202454

Taymour Mostafa, Kadir Bocu, Vineet Malhotra

{"title":"A review of testicular histopathology in nonobstructive azoospermia.","authors":"Taymour Mostafa, Kadir Bocu, Vineet Malhotra","doi":"10.4103/aja202454","DOIUrl":"https://doi.org/10.4103/aja202454","url":null,"abstract":"One major challenge in male factor infertility is nonobstructive azoospermia (NOA), which is characterized by spermatozoa-deficient semen without physical duct blockage. This review offers a thorough overview of the histopathology of the testes in NOA cases, clarifying its complex etiology and emphasizing the possible value of histopathology inspection for both diagnosis and treatment. Variable histopathological findings have been linked to NOA, such as tubular hyalinization, Sertoli cell-only syndrome, hypospermatogenesis, and germ cell arrest. Understanding the pathophysiology and forecasting the effectiveness of treatment are further enhanced by both morphometric and ultrastructural analyses. The potential significance of testicular biopsy in forecasting reproductive outcomes is assessed, especially concerning assisted reproductive technologies like intracytoplasmic sperm injection (ICSI). Besides, testicular microlithiasis, serum hormone profiles, and testicular size are investigated concerning NOA histopathology. It is concluded that understanding the histopathological patterns in NOA is crucial for its accurate diagnosis and appropriate management. Further research is still warranted to improve understanding of the complex pathophysiology underlying NOA.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical predictors of successful outcomes for couples with nonobstructive azoospermic male partners undergoing micro-TESE. 非梗阻性无精子症男性伴侣接受显微 TESE 治疗成功率的临床预测因素。

Asian journal of andrology Pub Date : 2024-07-23 DOI: 10.4103/aja202436

Parviz K Kavoussi, Nazim Gherabi, Ramadan Saleh

引用次数: 0