Asian journal of andrology最新文献_第9页

Microdissection testicular sperm extraction for men with nonobstructive azoospermia who have a testicular tumor in situ at the time of sperm retrieval. 显微解剖睾丸精子提取对非梗阻性无精子症男性在精子提取时原位有睾丸肿瘤。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2025-02-28 DOI: 10.4103/aja2024109

Hao-Cheng Lin, Wen-Hao Tang, Yan Chen, Yang-Yi Fang, Kai Hong

{"title":"Microdissection testicular sperm extraction for men with nonobstructive azoospermia who have a testicular tumor in situ at the time of sperm retrieval.","authors":"Hao-Cheng Lin, Wen-Hao Tang, Yan Chen, Yang-Yi Fang, Kai Hong","doi":"10.4103/aja2024109","DOIUrl":"10.4103/aja2024109","url":null,"abstract":"Abstract: Oncological microdissection testicular sperm extraction (onco-micro-TESE) represents a significant breakthrough for patients with nonobstructive azoospermia (NOA) and a concomitant in situ testicular tumor, to be managed at the time of sperm retrieval. Onco-micro-TESE addresses the dual objectives of treating both infertility and the testicular tumor simultaneously. The technique is intricate, necessitating a comprehensive understanding of testicular anatomy, physiology, tumor biology, and advanced microsurgical methods. It aims to carefully extract viable spermatozoa while minimizing the risk of tumor dissemination. This review encapsulates the procedural intricacies, evaluates success determinants, including tumor pathology and spermatogenic tissue health, and discusses the implementation of imaging techniques for enhanced surgical precision. Ethical considerations are paramount, as the procedure implicates complex decision-making that weighs the potential oncological risks against the profound desire for fatherhood using the male gametes. The review aims to provide a holistic overview of onco-micro-TESE, detailing methodological advances, clinical outcomes, and the ethical landscape, thus offering an indispensable resource for clinicians navigating this multifaceted clinical scenario.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"423-427"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health risks associated with infertility and non-obstructive azoospermia. 与不孕和非阻塞性无精子症相关的健康风险。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2025-04-15 DOI: 10.4103/aja20256

Eric Huyghe, Peter Ka-Fung Chiu

{"title":"Health risks associated with infertility and non-obstructive azoospermia.","authors":"Eric Huyghe, Peter Ka-Fung Chiu","doi":"10.4103/aja20256","DOIUrl":"10.4103/aja20256","url":null,"abstract":"Abstract: Non-obstructive azoospermia is a common condition associated with significant health risks, including increased mortality, cancer, and chronic diseases such as metabolic and cardiovascular disorders. This review aims to highlight the potential health challenges faced by men with this condition compared to fertile counterparts. Through a comprehensive bibliographic search on PubMed, using the following algorithm: (\"infertility, male\" [MeSH Terms] OR \"azoospermia\" [MeSH Terms]) AND (\"mortality\" [MeSH Terms] OR \"neoplasms\" [MeSH Terms] OR \"chronic disease\" [MeSH Terms] OR \"diabetes mellitus\" [MeSH Terms] OR \"heart diseases\" [MeSH Terms]), we analyzed existing literature to explore the associations between infertility, specifically azoospermia, and adverse health outcomes. Findings indicate that infertile men are at a higher risk of death, various cancers (particularly testicular cancer), metabolic syndrome, diabetes, hypogonadism, and cardiovascular disease. Although research specifically addressing azoospermia is limited, available studies support the notion that men with this condition may experience heightened health vulnerabilities. Given these risks, it is imperative for healthcare professionals, especially urologists, to conduct thorough health assessments for men diagnosed with azoospermia. Informing patients of these potential health issues and integrating comprehensive evaluations into their care can facilitate early detection and intervention for life-threatening conditions. Ultimately, men with azoospermia should receive ongoing monitoring to address their specific health concerns, thus improving their long-term health outcomes.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":"27 3","pages":"428-432"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Varicocele and nonobstructive azoospermia. 精索静脉曲张和非梗阻性无精子症。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-08-06 DOI: 10.4103/aja202444

Parviz K Kavoussi, Chirag Gupta, Rupin Shah

引用次数: 0

Clinical predictors of successful outcomes for couples with nonobstructive azoospermic male partners undergoing micro-TESE. 非梗阻性无精子症男性伴侣接受显微 TESE 治疗成功率的临床预测因素。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-07-23 DOI: 10.4103/aja202436

Parviz K Kavoussi, Nazim Gherabi, Ramadan Saleh

引用次数: 0

Technologies to improve sperm retrieval in men undergoing micro-TESE for NOA. 改善因无脑畸形而接受显微取精术（micro-TESE）的男性取精情况的技术。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-08-16 DOI: 10.4103/aja202450

Parviz K Kavoussi, Widi Atmoko, Germar-Michael Pinggera

引用次数: 0

Association of higher serum follicle-stimulating hormone levels with successful microdissection testicular sperm extraction outcomes in nonobstructive azoospermic men with reduced testicular volumes. 高血清促卵泡激素水平与睾丸体积减小的非阻塞性无精子症男性成功显微解剖睾丸精子提取结果的关系

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-12-24 DOI: 10.4103/aja202493

Ming-Zhe Song, Li-Jun Ye, Wei-Qiang Xiao, Wen-Si Huang, Wu-Biao Wen, Shun Dai, Li-Yun Lai, Yue-Qin Peng, Tong-Hua Wu, Qing Sun, Yong Zeng, Jing Cai

{"title":"Association of higher serum follicle-stimulating hormone levels with successful microdissection testicular sperm extraction outcomes in nonobstructive azoospermic men with reduced testicular volumes.","authors":"Ming-Zhe Song, Li-Jun Ye, Wei-Qiang Xiao, Wen-Si Huang, Wu-Biao Wen, Shun Dai, Li-Yun Lai, Yue-Qin Peng, Tong-Hua Wu, Qing Sun, Yong Zeng, Jing Cai","doi":"10.4103/aja202493","DOIUrl":"10.4103/aja202493","url":null,"abstract":"Abstract: To investigate the impact of preoperative serum follicle-stimulating hormone (FSH) levels on the probability of testicular sperm retrieval, we conducted a study of nonobstructive azoospermic (NOA) men with different testicular volumes (TVs) who underwent microdissection testicular sperm extraction (micro-TESE). A total of 177 NOA patients undergoing micro-TESE for the first time from April 2019 to November 2022 in Shenzhen Zhongshan Obstetrics and Gynecology Hospital (formerly Shenzhen Zhongshan Urology Hospital, Shenzhen, China) were retrospectively reviewed. The subjects were divided into four groups based on average TV quartiles. Serum hormone levels in each TV group were compared between positive and negative sperm retrieval subgroups. Overall sperm retrieval rate was 57.6%. FSH levels (median [interquartile range]) were higher in the positive sperm retrieval subgroup compared with the negative outcome subgroup when average TV was <5 ml (first quartile [Q1: TV <3 ml]: 43.32 [17.92] IU l -1 vs 32.95 [18.56] IU l -1 , P = 0.048; second quartile [Q2: 3 ml ≤ TV <5 ml]: 31.31 [15.37] IU l -1 vs 25.59 [18.40] IU l -1 , P = 0.042). Elevated serum FSH levels were associated with successful micro-TESE sperm retrieval in NOA men whose average TVs were <5 ml (adjusted odds ratio [OR]: 1.06 per unit increase; 95% confidence interval [CI]: 1.01-1.11; P = 0.011). In men with TVs ≥5 ml, larger TVs were associated with lower odds of sperm retrieval (adjusted OR: 0.84 per 1 ml increase; 95% CI: 0.71-0.98; P = 0.029). In conclusion, elevated serum FSH levels were associated with positive sperm retrieval in micro-TESE in NOA men with TVs <5 ml. In men with TV ≥5 ml, increases in average TVs were associated with lower odds of sperm retrieval.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"440-446"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonobstructive azoospermia: an etiologic review. 非梗阻性无精子症：病因综述。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-09-06 DOI: 10.4103/aja202472

Logan Hubbard, Amarnath Rambhatla, Sidney Glina

{"title":"Nonobstructive azoospermia: an etiologic review.","authors":"Logan Hubbard, Amarnath Rambhatla, Sidney Glina","doi":"10.4103/aja202472","DOIUrl":"10.4103/aja202472","url":null,"abstract":"Abstract: Azoospermia is the complete absence of spermatozoa in the ejaculate in two or more semen analyses after centrifugation. Nonobstructive azoospermia (NOA) represents the most severe form of male factor infertility accounting for 10%-15% of cases and stems from an impairment to spermatogenesis. Understanding of the hypothalamic-pituitary-testicular axis has allowed NOA to be subcategorized by anatomic and/or pathophysiologic level. The etiologies of NOA, and therefore, the differential diagnoses when considering NOA as a cause of male factor infertility, can be subcategorized and condensed into several distinct classifications. Etiologies of NOA include primary hypogonadism, secondary hypogonadism, defects in androgen synthesis and/or response, defective spermatogenesis and sperm maturation, or a mixed picture thereof. This review includes up-to-date clinical, diagnostic, cellular, and histologic features pertaining to the multitude of NOA etiologies. This in turn will provide a framework by which physicians practicing infertility can augment their clinical decision-making, patient counseling, thereby improving upon the management of men with NOA.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"279-287"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the management of male infertility. 男性不育治疗的最新进展。

Asian journal of andrology Pub Date : 2025-04-25 DOI: 10.4103/aja20257

Rashed Rowaiee, Omar Almidani, Omer A Raheem

引用次数: 0

Microfluidic systems in testicular in vitro culture: a powerful model tool for spermatogenesis and reprotoxicity studies. 睾丸体外培养中的微流体系统：精子发生和生殖毒性研究的强大模型工具。

Asian journal of andrology Pub Date : 2025-04-22 DOI: 10.4103/aja20254

Botho Maximilian Schneider, Hande Irem Hamurcu, Andrea Salzbrunn, Kathrein von Kopylow

{"title":"Microfluidic systems in testicular in vitro culture: a powerful model tool for spermatogenesis and reprotoxicity studies.","authors":"Botho Maximilian Schneider, Hande Irem Hamurcu, Andrea Salzbrunn, Kathrein von Kopylow","doi":"10.4103/aja20254","DOIUrl":"https://doi.org/10.4103/aja20254","url":null,"abstract":"Abstract: As prepubertal boys do not yet produce spermatozoa, they cannot rely on sperm cryopreservation for fertility preservation before gonadotoxic therapy, such as high-dose alkylating agents or radiotherapy in the case of childhood cancers. According to the current guidelines, cryopreservation of testicular biopsies containing spermatogonial stem cells (SSCs) may be proposed to high-risk patients for potential later therapeutic use to fulfill the patients' wish for a biological child. One promising technique for human in vitro spermatogenesis and in vitro propagation of human SSCs is microfluidic (MF) culture, in which cells or tissues are subjected to a continuous flow of medium. This provides exact control over such parameters as nutrient content and gradients, as well as the removal of waste metabolites. While MF has been shown to maintain tissues and cell populations of organs for longer than conventional in vitro culture techniques, it has not been widely used for testicular in vitro culture. MF could advance human testicular in vitro culture and is also applicable to reprotoxicity studies. This review summarizes the findings and achievements of testis-on-chip (ToC) setups to date and discusses the benefits and limitations of these for spermatogenesis in vitro and toxicity assessment.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exogenous administration of heparin-binding epidermal growth factor-like growth factor improves erectile function in mice with bilateral cavernous nerve injury. 外源性肝素结合表皮生长因子样生长因子可改善双侧海绵状神经损伤小鼠的勃起功能。

Asian journal of andrology Pub Date : 2025-04-18 DOI: 10.4103/aja2024125

Minh Nhat Vo, Mi-Hye Kwon, Fang-Yuan Liu, Fitri Rahma Fridayana, Yan Huang, Soon-Sun Hong, Ju-Hee Kang, Guo Nan Yin, Ji-Kan Ryu

{"title":"Exogenous administration of heparin-binding epidermal growth factor-like growth factor improves erectile function in mice with bilateral cavernous nerve injury.","authors":"Minh Nhat Vo, Mi-Hye Kwon, Fang-Yuan Liu, Fitri Rahma Fridayana, Yan Huang, Soon-Sun Hong, Ju-Hee Kang, Guo Nan Yin, Ji-Kan Ryu","doi":"10.4103/aja2024125","DOIUrl":"https://doi.org/10.4103/aja2024125","url":null,"abstract":"Prostate cancer is the second most common malignancy and the sixth leading cause of cancer-related death in men worldwide. Radical prostatectomy (RP) is the standard treatment for localized prostate cancer, but the procedure often results in postoperative erectile dysfunction (ED). The poor efficacy of phosphodiesterase 5 inhibitors after surgery highlights the need to develop new therapies to enhance cavernous nerve regeneration and improve the erectile function of these patients. In the present study, we aimed to examine the potential of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in preserving erectile function in cavernous nerve injury (CNI) mice. We found that HB-EGF expression was reduced significantly on the 1st day after CNI in penile tissue. Ex vivo and in vitro studies showed that HB-EGF promotes major pelvic ganglion neurite sprouting and neuro-2a (N2a) cell migration. In vivo studies showed that exogenous HB-EGF treatment significantly restored the erectile function of CNI mice to 86.9% of sham levels. Immunofluorescence staining showed that mural and neuronal cells were preserved by inducing cell proliferation and reducing apoptosis and reactive oxygen species production. Western blot analysis showed that HB-EGF upregulated protein kinase B and extracellular signal-regulated kinase activation and neurotrophic factor expression. Overall, HB-EGF is a major promising therapeutic agent for treating ED in postoperative RP.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0