Asian journal of andrology最新文献_第3页

Management of non-obstructive azoospermia: advances, challenges, and expert recommendations. 非阻塞性无精子症的治疗：进展、挑战和专家建议。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2025-04-25 DOI: 10.4103/aja202539

Amarnath Rambhatla, Parviz K Kavoussi, Rupin Shah, Ashok Agarwal

引用次数: 0

Clinician's guide to the management of azoospermia induced by exogenous testosterone or anabolic-androgenic steroids. 外源性睾酮或合成代谢雄激素类固醇引起的无精子症的临床治疗指南。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2025-01-17 DOI: 10.4103/aja2024104

Manaf Al Hashimi, Germar-Michael Pinggera, Rupin Shah, Ashok Agarwal

{"title":"Clinician's guide to the management of azoospermia induced by exogenous testosterone or anabolic-androgenic steroids.","authors":"Manaf Al Hashimi, Germar-Michael Pinggera, Rupin Shah, Ashok Agarwal","doi":"10.4103/aja2024104","DOIUrl":"10.4103/aja2024104","url":null,"abstract":"Abstract: Azoospermia, defined as the absence of sperm in the ejaculate, is a well-documented consequence of exogenous testosterone (ET) and anabolic-androgenic steroid (AAS) use. These agents suppress the hypothalamic-pituitary-gonadal (HPG) axis, leading to reduced intratesticular testosterone levels and impaired spermatogenesis. This review examines the pathophysiological mechanisms underlying azoospermia and outlines therapeutic strategies for recovery. Azoospermia is categorized into pretesticular, testicular, and post-testicular types, with a focus on personalized treatment approaches based on the degree of HPG axis suppression and baseline testicular function. Key strategies include discontinuing ET and monitoring for spontaneous recovery, particularly in patients with shorter durations of ET use. For cases of persistent azoospermia, gonadotropins (human chorionic gonadotropin [hCG] and follicle-stimulating hormone [FSH]) and selective estrogen receptor modulators (SERMs), such as clomiphene citrate, are recommended, either alone or in combination. The global increase in exogenous testosterone use, including testosterone replacement therapy and AAS, underscores the need for improved management of associated azoospermia, which can be temporary or permanent depending on individual factors and the type of testosterone used. Additionally, the manuscript discusses preventive strategies, such as transitioning to short-acting testosterone formulations or incorporating low-dose hCG to preserve fertility during ET therapy. While guidelines for managing testosterone-related azoospermia remain limited, emerging research indicates the potential efficacy of hormonal stimulation therapies. However, there is a notable lack of well-structured, controlled, and long-term studies addressing the management of azoospermia related to exogenous testosterone use, highlighting the need for such studies to inform evidence-based recommendations.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"330-341"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetics of nonobstructive azoospermia. 非梗阻性无精子症的表观遗传学。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-09-03 DOI: 10.4103/aja202463

Sezgin Gunes, Asli Metin Mahmutoglu, Neslihan Hekim

引用次数: 0

Future prospects for the advancement of treatment of men with NOA: focus on gene editing, artificial sperm, stem cells, and use of imaging. 治疗男性无精子症的未来前景：关注基因编辑、人工精子、干细胞和成像技术的使用。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-10-11 DOI: 10.4103/aja202486

Akeem Babatunde Sikiru, Manh Nguyen Truong, Wael Zohdy

{"title":"Future prospects for the advancement of treatment of men with NOA: focus on gene editing, artificial sperm, stem cells, and use of imaging.","authors":"Akeem Babatunde Sikiru, Manh Nguyen Truong, Wael Zohdy","doi":"10.4103/aja202486","DOIUrl":"10.4103/aja202486","url":null,"abstract":"Abstract: Nonobstructive azoospermia (NOA) affects about 60% of men with azoospermia, representing a severe form of male infertility. The current approach to manage NOA primarily involves testicular sperm retrieval methods such as conventional testicular sperm extraction (c-TESE) and microdissection testicular sperm extraction (micro-TESE). While combining testicular sperm retrieval with intracytoplasmic sperm injection (ICSI) offers hope for patients, the overall sperm retrieval rate (SRR) stands at around 50%. In cases where micro-TESE fails to retrieve sperm, limited options, like donor sperm or adoption, can be problematic in certain cultural contexts. This paper delves into prospective treatments for NOA management. Gene editing technologies, particularly clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) protein 9 (CRISPR/Cas9), hold potential for correcting genetic mutations underlying testicular dysfunction. However, these technologies face challenges due to their complexity, potential off-target effects, ethical concerns, and affordability. This calls for research to address key challenges associated with NOA management within the clinical settings. This also necessitate ongoing research essential for developing more sensitive diagnostic tests, validating novel treatments, and customizing current treatment strategies for individual patients. This review concluded that the future of NOA management may entail a combination of these treatment options, tailored to each patient's unique circumstances, providing a comprehensive approach to address NOA challenges.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"433-439"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Andrology laboratory technique for analysis of semen in men with azoospermia. 用于分析无精子症男性精液的 Andrology 实验室技术。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-05-17 DOI: 10.4103/aja202429

Andrian Japari, Dharani Moorthy, Amarnath Rambhatla

引用次数: 0

Second chance in fertility: a comprehensive narrative review of redo micro-TESE outcomes after initial failure. 生育的第二次机会：对初次失败后重新进行显微 TESE 结果的全面回顾。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-07-19 DOI: 10.4103/aja202446

Haitham Elbardisi, Emre Bakircioglu, Wen Liu, Darren Katz

{"title":"Second chance in fertility: a comprehensive narrative review of redo micro-TESE outcomes after initial failure.","authors":"Haitham Elbardisi, Emre Bakircioglu, Wen Liu, Darren Katz","doi":"10.4103/aja202446","DOIUrl":"10.4103/aja202446","url":null,"abstract":"Abstract: When microdissection testicular sperm extraction (micro-TESE) fails, a redo procedure may be the only option for patients who want a biological child. However, there are many gaps of knowledge surrounding the procedure, which need to be addressed to help clinicians and patients make informed decisions. This review explores redo micro-TESE in the context of nonobstructive azoospermia (NOA). Literature was searched using Google Scholar, Medline, and PubMed. Search terms were \"NOA\" AND \"second microdissection testicular sperm extractions\" AND \"redo microdissection testicles sperm extraction\" AND \"repeat microdissection testicular sperm extractions\" AND \"failed microdissection testicular sperm extractions\" AND \"salvage microdissection testicular sperm extractions\". Only original articles in English were included. A total of nine articles were included, consisting of four retrospective and five prospective studies. The time gap between the first and second micro-TESE varied from 6 months to 24 months. Most of the included studies reported successful surgical sperm retrieval (SSR) in the second micro-TESE in the range of 10%-21%, except in one study where it reached 42%. It has not been presented any definitive information about the use of hormonal treatment or the benefit of varicocelectomy prior to the second micro-TESE. Patients with hypospermatogenesis and Klinefelter syndrome (KS) had the highest chance of success in redo surgery. In conclusion, redo micro-TESE following a negative procedure can lead to sperm recovery in 10%-21%. Patients with hypospermatogenesis and KS have a higher chance of success. There is no enough evidence to conclude which is the best hormonal stimulation if any before a redo surgery.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"409-415"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fresh versus frozen micro-TESE sperm and outcomes. 新鲜与冷冻微精子及其结果。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2025-04-18 DOI: 10.4103/aja202513

Krishna Chaitanya Mantravadi, Marlon Martinez, Favian Ariiq Rahmat, Armand Achmadsyah, Missy Savira, Ponco Birowo

{"title":"Fresh versus frozen micro-TESE sperm and outcomes.","authors":"Krishna Chaitanya Mantravadi, Marlon Martinez, Favian Ariiq Rahmat, Armand Achmadsyah, Missy Savira, Ponco Birowo","doi":"10.4103/aja202513","DOIUrl":"10.4103/aja202513","url":null,"abstract":"Abstract: The use of fresh versus frozen spermatozoa in men with nonobstructive azoospermia (NOA) undergoing in vitro fertilization (IVF) has been a debated hot topic among reproductive specialists. Each approach presents distinct advantages and disadvantages, with fresh sperm typically showing superior sperm quality, while frozen sperm offers logistical flexibility and a reliable backup for repeated cycles. This review summarizes the latest advancements in sperm retrieval and cryopreservation techniques, providing practitioners with a comprehensive analysis of each option's strengths and limitations. Comparative studies indicate that, although fresh sperm often has better quality metrics, cryopreservation methods such as vitrification have significantly improved postthaw outcomes, making frozen sperm a viable choice in assisted reproductive technologies (ART). The findings show comparable rates for fertilization, implantation, clinical pregnancy, and live birth between fresh and frozen microdissection testicular sperm extraction (micro-TESE) sperm in many cases, although patient-specific factors such as timing, cost-effectiveness, and procedural convenience should guide the final decision. Ultimately, the choice of using fresh or frozen sperm should align with the individual needs and conditions of patients. This tailored approach, supported by the latest advancements, can optimize ART outcomes and provide personalized reproductive care.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":"27 3","pages":"399-408"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Historical perspective of surgical sperm retrieval techniques for nonobstructive azoospermia. 非梗阻性无精子症手术取精技术的历史回顾。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-09-10 DOI: 10.4103/aja202465

Rupin Shah, Amarnath Rambhatla, Parviz K Kavoussi

引用次数: 0

Ex vivo microscopic testicular sperm extraction at the time of radical orchiectomy in men with nonobstructive azoospermia (NOA): a scoping review. 非梗阻性无精子症（NOA）男性根治性睾丸切除术时的体外显微睾丸取精：范围综述。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-02-06 DOI: 10.4103/aja202387

Carlo Giulioni, Nguyen Ho Vinh Phuoc, Selahittin Cayan

{"title":"Ex vivo microscopic testicular sperm extraction at the time of radical orchiectomy in men with nonobstructive azoospermia (NOA): a scoping review.","authors":"Carlo Giulioni, Nguyen Ho Vinh Phuoc, Selahittin Cayan","doi":"10.4103/aja202387","DOIUrl":"10.4103/aja202387","url":null,"abstract":"Abstract: Testicular tumor is the most common solid malignancy in males under 40 years of age. This malignancy is known to have a negative impact on male fertility. Therefore, several techniques for sperm retrieval have been proposed, including microdissection testicular sperm extraction (mTESE). The objective of this study was to review the literature on the outcomes of oncological (Onco)-mTESE at the time of radical orchiectomy. We conducted a comprehensive literature search through PubMed, Scopus, and Cochrane Central Controlled Register of Trials. Only studies reporting ex vivo mTESE in patients with testicular tumor were considered. Twelve papers met the inclusion criteria and were included in this review. Tumor size was identified as the sole preoperative factor influencing spermatogenesis. The considered studies demonstrated a satisfactory success rate for Onco-mTESE, associated with a similarly valid percentage of live healthy births through assisted reproductive technology. Currently, no comparison has been made between Onco-mTESE and conventional Onco-TESE, hence further assessment is required. In cases where the tumor completely replaces the cancer-bearing testicle, a contralateral micro-TESE may be a viable alternative. However, the surgeon should evaluate associated risks and benefits preoperatively. In conclusion, Onco-mTESE at the time of radical orchiectomy appears to be a promising therapeutic option for young patients with testicular tumors. Nevertheless, additional studies are necessary to achieve a definitive conclusion.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"416-422"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiation between nonobstructive azoospermia and obstructive azoospermia: then and now. 区分非梗阻性无精子症和梗阻性无精子症：过去和现在。

Asian journal of andrology Pub Date : 2025-05-01 Epub Date: 2024-09-13 DOI: 10.4103/aja202475

Logan Hubbard, Amarnath Rambhatla, Giovanni M Colpi

引用次数: 0