Asian journal of andrology最新文献_第3页

Asian journal of andrology Pub Date : 2025-07-01 Epub Date: 2025-01-07 DOI: 10.4103/aja2024101

Guo-Rong Yang, Chao Lv, Kai-Kai Lv, Yang-Yang Wu, Xiao-Wei Hao, Qing Yuan, Tao Song

{"title":"Age-related changes in the impact of metabolic syndrome on prostate volume: a cross-sectional study.","authors":"Guo-Rong Yang, Chao Lv, Kai-Kai Lv, Yang-Yang Wu, Xiao-Wei Hao, Qing Yuan, Tao Song","doi":"10.4103/aja2024101","DOIUrl":"10.4103/aja2024101","url":null,"abstract":"Abstract: This study investigated the impact of metabolic syndrome (MetS) and its components on prostate volume (PV) in the general Chinese population. In total, 43 455 participants in The First Medical Center of the Chinese PLA General Hospital (Beijing, China) from January 1, 2012, to December 31, 2022, undergoing health examinations were included in the study. Participants were categorized into four groups according to PV quartiles: Q1 (PV ≤24.94 ml), Q2 (PV >24.94 ml and ≤28.78 ml), Q3 (PV >28.78 ml and ≤34.07 ml), and Q4 (PV >34.07 ml), with Q1 serving as the reference group. Logistic regression analyses were used to examine the association between MetS and PV, with subgroup analyses conducted by age. Among the participants, 18 787 (43.2%) were diagnosed with MetS. In the multivariate analysis model, a significant correlation between MetS and PV was observed, with odds ratios (ORs) increasing as PV increased (Q2, OR = 1.203, 95% confidence interval [CI]: 1.139-1.271; Q3, OR = 1.300, 95% CI: 1.230-1.373; and Q4, OR = 1.556, 95% CI: 1.469-1.648). Analysis of MetS components revealed that all components were positively associated with PV, with abdominal obesity showing the most significant effect. The number of MetS components was identified as a dose-dependent risk factor for elevated PV. The impact of MetS, its components, and component count on PV exhibited a decreasing trend with advancing age. Overall, the influence of MetS, its components, and component count on PV was predominantly observed in the age groups of 40-49 years and 50-59 years. Early intervention targeting MetS can significantly alleviate the increase in PV, particularly benefiting individuals aged 40-59 years who have abdominal obesity.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"475-481"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observation on the therapeutic effect of a modified Devine procedure with subcutaneous sliding fixation method for concealed penis. 改良Devine手术加皮下滑动固定治疗隐匿性阴茎的疗效观察。

Asian journal of andrology Pub Date : 2025-07-01 Epub Date: 2025-03-25 DOI: 10.4103/aja20251

Mohammed Abdulkarem Al-Qaisi, Hai-Fu Tian, Jia-Jin Feng, Ke-Ming Chen, Jin Zhang, Yun-Shang Tuo, Xue-Hao Wang, Bin-Cheng Huang, Muhammad Arslan Ul Hassan, Rui He, Guang-Yong Li

{"title":"Observation on the therapeutic effect of a modified Devine procedure with subcutaneous sliding fixation method for concealed penis.","authors":"Mohammed Abdulkarem Al-Qaisi, Hai-Fu Tian, Jia-Jin Feng, Ke-Ming Chen, Jin Zhang, Yun-Shang Tuo, Xue-Hao Wang, Bin-Cheng Huang, Muhammad Arslan Ul Hassan, Rui He, Guang-Yong Li","doi":"10.4103/aja20251","DOIUrl":"10.4103/aja20251","url":null,"abstract":"Abstract: To evaluate the therapeutic effect of a modified Devine procedure with a subcutaneous sliding fixation method for the treatment of congenital concealed penis, we retrospectively selected 45 patients with congenital concealed penises who were admitted to General Hospital of Ningxia Medical University (Yinchuan, China) between September 2020 and November 2023. In all cases, the penis was observed to be short, and retracting the skin at the base revealed a normal penile body, which immediately returned to its original position upon release. All patients underwent the modified Devine procedure with subcutaneous sliding fixation and completed a 12-week postoperative follow-up. A statistically significant increase in penile length was observed postoperatively, with the median length increasing from 4.0 (interquartile range [IQR]: 3.5-4.8; 95% confidence interval [CI]: 3.9-4.4) cm to 8.0 (IQR: 7.8-8.0; 95% CI: 7.7-7.9) cm, with P < 0.001. The parents were satisfied with the outcomes, including increased penile length, improved hygiene, and enhanced esthetics. Except for mild foreskin edema in all cases, no complications (such as infections, skin necrosis, or penile retraction) were observed. The edema was resolved within 4 weeks after the operation. This study demonstrates that the modified Devine procedure utilizing the subcutaneous sliding fixation method yields excellent outcomes with minimal postoperative complications, reduced penile retraction, and high satisfaction rates among patients and their families.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"470-474"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A strategy to reduce unnecessary prostate biopsies in patients with tPSA >10 ng ml -1 and PI-RADS 1-3. 一种减少tPSA患者不必要的前列腺活检的策略，tPSA为10 ng ml-1， PI-RADS为1-3。

Asian journal of andrology Pub Date : 2025-07-01 Epub Date: 2025-01-28 DOI: 10.4103/aja202499

Qi-Fei Dong, Yi-Xun Liu, Yu-Han Chen, Yi-Fan Ma, Tao Zhou, Xue-Feng Fan, Xiang Yu, Chang-Ming Wang, Jun Xiao

{"title":"A strategy to reduce unnecessary prostate biopsies in patients with tPSA >10 ng ml -1 and PI-RADS 1-3.","authors":"Qi-Fei Dong, Yi-Xun Liu, Yu-Han Chen, Yi-Fan Ma, Tao Zhou, Xue-Feng Fan, Xiang Yu, Chang-Ming Wang, Jun Xiao","doi":"10.4103/aja202499","DOIUrl":"10.4103/aja202499","url":null,"abstract":"Abstract: We propose a strategy to reduce unnecessary prostate biopsies in Chinese patients with total prostate-specific antigen (tPSA) >10 ng ml -1 and Prostate Imaging Reporting and Data System (PI-RADS) scores between 1 and 3. Clinical data derived from 517 patients of The First Affiliated Hospital of USTC (Hefei, China) from January 2020 to December 2023 who met the screening criteria for the study were retrospectively collected. Independent predictors were identified via univariate and multivariate logistic regression analysis. The diagnostic capacity of clinical variables was evaluated using the receiver operating characteristic (ROC) curves and area under the curve (AUC). A prostate biopsy strategy was developed via risk stratification. Of the 517 patients, 17/348 (4.9%) with PI-RADS 1-2 were diagnosed with clinically significant prostate cancer (csPCa), and 27/169 (16.0%) patients with PI-RADS 3 were diagnosed with csPCa. The appropriate prostate-specific antigen density (PSAD) cut-off values were 0.45 ng ml -2 for PI-RADS 1-2 patients and 0.3 ng ml -2 for PI-RADS 3 patients. The appropriate prostate volume (PV) cut-off values were 40 ml for PI-RADS 1-2 patients and 50 ml for PI-RADS 3 patients. The prostate biopsy strategy based on PSAD and PV developed in this study can reduce unnecessary prostate biopsies in patients with tPSA >10 ng ml -1 and PI-RADS 1-3. In the study, 66.5% (344/517) patients did not need to undergo prostate biopsy, at the expense of missing only 1.7% (6/344) patients with csPCa.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":"531-536"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re: Commentary on "Testis tissue cryopreservation may be considered in boys with cryptorchidism". 回复：关于“睾丸组织冷冻保存可用于隐睾男孩”的评论。

Asian journal of andrology Pub Date : 2025-07-01 Epub Date: 2025-03-18 DOI: 10.4103/aja20255

Linn Salto Mamsen, Simone Hildorf, Elissavet Ntemou, Danyang Wang, Dina Cortes, Jens Fedder, Jørgen Thorup, Claus Yding Andersen

引用次数: 0

The dark side of transurethral access for LUTS/BPH surgery: a narrative review. 经尿道LUTS/BPH手术的阴暗面：叙述回顾。

Asian journal of andrology Pub Date : 2025-06-20 DOI: 10.4103/aja202523

Bruno Bucca, Christian Gozzi, Luca Matteo Gobbi, Eugenio Bologna, Leslie Claire Licari, Vincenzo Asero, Orietta Dalpiaz, Thomas Alber, Alessandro Calarco, Marco Martini, Fabrizio Presicce

{"title":"The dark side of transurethral access for LUTS/BPH surgery: a narrative review.","authors":"Bruno Bucca, Christian Gozzi, Luca Matteo Gobbi, Eugenio Bologna, Leslie Claire Licari, Vincenzo Asero, Orietta Dalpiaz, Thomas Alber, Alessandro Calarco, Marco Martini, Fabrizio Presicce","doi":"10.4103/aja202523","DOIUrl":"10.4103/aja202523","url":null,"abstract":"The transurethral route is the access of choice for benign prostatic hyperplasia (BPH) surgical treatment. Transurethral resection of the prostate (TURP) has been the gold standard in surgical intervention for BPH; however, the advent of novel surgical techniques and the exploration of new energy sources in recent decades have seen this primacy contested. Nevertheless, the transurethral route harbors numerous challenges and pitfalls that can pose significant risks even for the most experienced endoscopic urologists. Complications associated with transurethral access are well documented yet often underestimated by endoscopic surgeons, primarily because the pathological conditions arising from transurethral surgery typically fall within the realm of those specializing in genitourinary reconstructive surgery. This narrative review describes and critically discusses the specific pitfalls associated with transurethral surgery for BPH. Urethral strictures, transient or permanent postoperative incontinence, reintervention, and de novo/persistent lower urinary tract symptoms (LUTS) represent the main complications of transurethral treatments for BPH. These problems still stand as the foremost challenge for all endoscopists despite recent technological advancements. The use of increasingly miniaturized instruments, more mindful energy application, sphincter-sparing enucleation techniques, and the advent of so-called minimally invasive surgical techniques (MISTs) all contribute to a more conscious and anatomically respectful transurethral approach. An endoscopic transvesical suprapubic access may be another alternative strategy to minimize the complications of transurethral route in the future.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical approaches to varicocele: a systematic review and network meta-analysis. 精索静脉曲张的手术入路：系统回顾和网络荟萃分析。

Asian journal of andrology Pub Date : 2025-06-20 DOI: 10.4103/aja202541

Lin-Jie Lu, Kai Xiong, Sheng-Lan Yuan, Bang-Wei Che, Jian-Cheng Zhai, Chuan-Chuan Wu, Yang Zhang, Hong-Yan Zhang, Kai-Fa Tang

{"title":"Surgical approaches to varicocele: a systematic review and network meta-analysis.","authors":"Lin-Jie Lu, Kai Xiong, Sheng-Lan Yuan, Bang-Wei Che, Jian-Cheng Zhai, Chuan-Chuan Wu, Yang Zhang, Hong-Yan Zhang, Kai-Fa Tang","doi":"10.4103/aja202541","DOIUrl":"10.4103/aja202541","url":null,"abstract":"Surgical methods for varicocele remain controversial. This study intends to evaluate the efficacy and safety of different surgical approaches for treating varicocele through a network meta-analysis (NMA). PubMed, Embase, Cochrane, and Web of Science databases were thoroughly searched. In total, 13 randomized controlled trials (RCTs) and 24 cohort studies were included, covering 9 different surgical methods. Pairwise meta-analysis and NMA were performed by means of random-effects models, and interventions were ranked based on the surface under the cumulative ranking curve (SUCRA). According to the SUCRA, microsurgical subinguinal varicocelectomy (MSV; 91.6%), microsurgical retroperitoneal varicocelectomy (MRV; 78.2%), and microsurgical inguinal varicocelectomy (MIV; 76.7%) demonstrated the highest effectiveness in reducing postoperative recurrence rates. In this study, sclerotherapy embolization (SE; 87.2%), MSV (77.9%), and MIV (67.7%) showed the best results in lowering the risk of hydrocele occurrence. MIV (82.9%), MSV (75.9%), and coil embolization (CE; 58.7%) were notably effective in increasing sperm motility. Moreover, CE (76.7%), subinguinal approach varicocelectomy (SV; 69.2%), and SE (55.7%) were the most effective in increasing sperm count. SE (82.5%), transabdominal laparoscopic varicocelectomy (TLV; 76.5%), and MRV (52.7%) were superior in shortening the length of hospital stay. The incidence rates of adverse events for MRV (0), SE (3.3%), and MIV (4.1%) were notably low. Cluster analyses indicated that MSV was the most effective in the treatment of varicocele. Based on the existing evidence, MSV may represent the optimal choice for varicocele surgery. However, selecting clinical surgical strategies requires consideration of various factors, including patient needs, surgeon experience, and the learning curve.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Should couples with a low total progressively motile sperm count in the first intrauterine insemination cycle continue this treatment? 在第一个宫内人工授精周期中精子总数较低的夫妇是否应该继续这种治疗？

Asian journal of andrology Pub Date : 2025-06-13 DOI: 10.4103/aja202524

Zheng Wang, Yuan-Yuan Wang, Shuo Huang, Hai-Yan Wang, Rong Li, Ben Willem Mol, Jie Qiao

{"title":"Should couples with a low total progressively motile sperm count in the first intrauterine insemination cycle continue this treatment?","authors":"Zheng Wang, Yuan-Yuan Wang, Shuo Huang, Hai-Yan Wang, Rong Li, Ben Willem Mol, Jie Qiao","doi":"10.4103/aja202524","DOIUrl":"https://doi.org/10.4103/aja202524","url":null,"abstract":"Abstract: This study aimed to investigate the associations between the post-wash total progressively motile sperm count (TPMSC) in the first intrauterine insemination (IUI) cycle and pregnancy outcomes of the second IUI cycle. Data were retrieved from the clinical database at the Reproductive Center of Peking University Third Hospital (Beijing, China) between January 2011 and December 2022. Couples were included in this retrospective cohort study if they had unexplained or mild male factor infertility and were treated with IUI for two consecutive cycles using the same protocol. A total of 8290 couples were included in the analysis. The mean ± standard deviation (s.d.) age of women was 32.0 ± 3.5 years. We categorized groups based on the post-wash TPMSC (×106) levels in the first IUI cycle: group 1 (0 < TPMSC < 1, n = 1290), group 2 (1 ≤ TPMSC < 2, n = 863), group 3 (2 ≤ TPMSC < 3, n = 800), group 4 (3 ≤ TPMSC < 4, n = 783), group 5 (4 ≤ TPMSC < 5, n = 1541), group 6 (5 ≤ TPMSC < 6, n = 522), group 7 (6 ≤ TPMSC < 7, n = 547), group 8 (7 ≤ TPMSC < 8, n = 175), group 9 (8 ≤ TPMSC < 9, n = 556), group 10 (9 ≤ TPMSC < 10, n = 192), and group 11 (TPMSC ≥ 10), n = 1021). The primary outcome was live birth rate of the second IUI cycle. Live birth rates were 7.9%, 5.8%, 7.6%, 7.4%, 7.3%, 8.4%, 7.5%, 7.4%, 8.8%, 8.9%, and 7.6% in each group, respectively. There were no statistically significant differences in clinical pregnancy rates or live birth rates between any groups and those with the post-wash TPMSC <1 × 106. In an IUI program for unexplained and mild male factor infertility, the post-wash TPMSC in the first IUI cycle was not significantly associated with the live birth rate in the second IUI cycle.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel frameshift variant in AXDND1 may cause multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family. 一种新的移码变异的AXDND1可能导致精子鞭毛的多种形态异常在一个近亲巴基斯坦家庭。

Asian journal of andrology Pub Date : 2025-06-03 DOI: 10.4103/aja202538

Imtiaz Ali, Meng-Lei Yang, Fazal Rahim, Haider Ali, Aurang Zeb, Nisar Ahmad, Yousaf Raza, Wang Yue, Muhammad Shoaib, Tanveer Abbas, Wasim Shah, Hui Ma, Huan Zhang, Hao Yin, Qing-Hua Shi

{"title":"A novel frameshift variant in AXDND1 may cause multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family.","authors":"Imtiaz Ali, Meng-Lei Yang, Fazal Rahim, Haider Ali, Aurang Zeb, Nisar Ahmad, Yousaf Raza, Wang Yue, Muhammad Shoaib, Tanveer Abbas, Wasim Shah, Hui Ma, Huan Zhang, Hao Yin, Qing-Hua Shi","doi":"10.4103/aja202538","DOIUrl":"https://doi.org/10.4103/aja202538","url":null,"abstract":"The syndrome of multiple morphological abnormalities of the sperm flagella (MMAF) is one of the most serious kinds of sperm defects, leading to asthenoteratozoospermia and male infertility. In this study, we use whole-exome sequencing to identify genetic factors that account for male infertility in a patient born from a consanguineous Pakistani couple. A homozygous frameshift mutation (c.1399_1402del; p.Gln468ArgfsTer2) in axonemal dynein light chain domain containing 1 (AXDND1) was identified in the patient. Sanger sequencing data showed that the mutation was cosegregated recessively with male infertility in this family. Papanicolaou staining and scanning electron microscopy analysis of the sperm revealed severely abnormal flagellar morphology in the patient. Immunofluorescence and western blot showed undetectable AXDND1 expression in the sperm of the patient. Transmission electron microscopy analysis showed disorganized sperm axonemal structure in the patient, particularly missing the central pair of microtubules. Immunofluorescence staining showed the absence of sperm-associated antigen 6 (SPAG6) and dynein axonemal light intermediate chain 1 (DNALI1) signals in the sperm flagella of the patient. These findings indicate that AXDND1 is essential for the organization of flagellar axoneme and provide direct evidence that AXDND1 is a MMAF gene in humans, thus expanding the phenotypic spectrum of AXDND1 frameshift mutations.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-intensity pulsed ultrasound treatment in erectile dysfunction. 低强度脉冲超声治疗勃起功能障碍。

Asian journal of andrology Pub Date : 2025-06-03 DOI: 10.4103/aja202518

Shi-Yun Liu, Si-Yu Liu, Bang-Min Han, Shu-Jie Xia

{"title":"Low-intensity pulsed ultrasound treatment in erectile dysfunction.","authors":"Shi-Yun Liu, Si-Yu Liu, Bang-Min Han, Shu-Jie Xia","doi":"10.4103/aja202518","DOIUrl":"https://doi.org/10.4103/aja202518","url":null,"abstract":"Low-intensity pulsed ultrasound (LIPUS) is a non-invasive sonodynamic therapy that has been approved by the U.S. Food and Drug Administration for clinical use. Clinical trials have demonstrated that LIPUS ameliorates mild-to-moderate erectile dysfunction without adverse events. Histological analysis of the corpus cavernosum suggests that the therapeutic benefits of LIPUS may be attributed to alleviation of fibrosis, enhanced neovascularization, and promotion of innervation. Further investigations have revealed that LIPUS facilitates cavernous tissue repair through non-thermal mechanisms, including a cavitation effect, acoustic streaming, mass transfer enhancement, and direct mechanical stimulation. Mechanobiological transduction triggers molecular signaling cascades within endogenous cavernous cells, thereby stimulating cell proliferation, angiogenesis, extracellular matrix remodeling, and stem cell differentiation. Although LIPUS has the potential to induce cavernous rehabilitation in the treatment of erectile dysfunction, further investigations are necessary to elucidate the mechanisms via which LIPUS regulates each type of cavernous cell to determine the optimal parameters for this innovative therapy.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproductive function and sperm parameters in men with sickle cell disease: a systematic review. 男性镰状细胞病的生殖功能和精子参数：系统综述

Asian journal of andrology Pub Date : 2025-05-30 DOI: 10.4103/aja202510

Clarisse Leblanc, Nathalie Sermondade, Ludmilla Ogouma-Aworet, Anna Ly, Diane Rivet-Danon, Guillaume Bachelot, François Lionnet, Aline Santin, Anne-Gaël Cordier, Kamila Kolanska, Rachel Lévy, Isabelle Berthaut, Charlotte Dupont

{"title":"Reproductive function and sperm parameters in men with sickle cell disease: a systematic review.","authors":"Clarisse Leblanc, Nathalie Sermondade, Ludmilla Ogouma-Aworet, Anna Ly, Diane Rivet-Danon, Guillaume Bachelot, François Lionnet, Aline Santin, Anne-Gaël Cordier, Kamila Kolanska, Rachel Lévy, Isabelle Berthaut, Charlotte Dupont","doi":"10.4103/aja202510","DOIUrl":"https://doi.org/10.4103/aja202510","url":null,"abstract":"Sickle cell disease (SCD) is one of the most common hereditary diseases in the world. It leads to hemolytic anemia and painful vaso-occlusive crises that can damage target organs at the cardiopulmonary, cerebrovascular, and renal levels. SCD has also significant consequences on reproductive functions and fertility. Moreover, the treatments designed to alleviate and reduce vaso-occlusive crises directly impact male reproductive functions. Nevertheless, literature assessing the impact of SCD and its treatments on male reproductive functions remains limited and lacks robust evidence. A systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendation was carried out on the reproductive functions of men with SCD and the reproductive options available to them. Most studies have found that men with SCD frequently exhibit impaired sperm parameters. In addition, hydroxyurea (HU), proposed to relieve and reduce vaso-occlusive crises, is also known to impact male reproductive functions, and the reversibility of these consequences on sperm parameters remains hypothetical. Hematopoietic stem cell transplantation (HSCT) is currently the only curative treatment. However, conditioning treatments are highly gonadotoxic and can permanently alter spermatogenesis. Young men with SCD should therefore be informed about fertility at an early stage, and fertility preservation should be discussed in pubescent men, especially if treatment with HU or HSCT is to be initiated. In prepubertal boys about to undergo HSCT, immature testicular tissue freezing should be discussed, even though this technique is still experimental.","PeriodicalId":93889,"journal":{"name":"Asian journal of andrology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0