{"title":"Chronic Exposure to PM 2.5 Can Be Deadly for People with COPD.","authors":"Shawn D Aaron","doi":"10.1513/AnnalsATS.202507-703ED","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202507-703ED","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluating Deployment-related Respiratory Diseases in Military Veterans.","authors":"Robert M Tighe, Le Roy Torres, Robert Miller","doi":"10.1513/AnnalsATS.202411-1126FR","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202411-1126FR","url":null,"abstract":"<p><p>Deployed military personnel often develop respiratory symptoms and disorders due to exposure to particulate matter such as dust, blast materials and burn pit emissions. A range of deployment-related respiratory diseases have been reported, including toxic lung injury, eosinophilic pneumonia, asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis, and interstitial lung disease (ILD). The Sergeant First Class Heath Robinson Honoring our Promise to Address Comprehensive Toxics Act of 222 (PACT Act), which was enacted in 2022, expanded coverage of medical care for veterans and improved awareness of deployment-related respiratory diseases. This law added 23 diagnoses presumed to be connected to deployment, but has failed to address issues related to the diagnosis of deployment-related respiratory disorders. Diagnosing some of the respiratory disorders associated with deployment can be challenging, as symptoms are often non-specific. Veterans who present with respiratory symptoms should undergo a comprehensive assessment, including a detailed medical and exposure history, pulmonary function tests, imaging and serologic screening for autoimmune disorders. A decision on whether a surgical lung biopsy should be obtained should be made on a case-by-case basis based on multidisciplinary review and an informed discussion with the patient. The clinical care team should discuss pharmacological and non-pharmacological treatment options with the patient and direct them to reliable sources of information. Long-term follow-up is essential to monitor for worsening of pulmonary function or symptoms. Further research is needed to characterize associations between deployment-related exposures and respiratory health outcomes and to inform better means of assessment and treatment of military veterans.</p>","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Breathing Under Pressure? Air Pollution and Mortality in Pulmonary Hypertension.","authors":"Andrew J Synn, Nicholas J Nassikas","doi":"10.1513/AnnalsATS.202507-710ED","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202507-710ED","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endothelial Glycocalyx Integrity as a Prognostic Key in Sepsis: New Insights from the CLOVERS Trial.","authors":"Jaime Fernández-Sarmiento","doi":"10.1513/AnnalsATS.202506-692ED","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202506-692ED","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neil R MacIntyre, Nirav R Bhakta, Sanja Stanojevic, Teal S Hallstrand, Daniel J Weiner, Zachary Healy, Aparna Balasubramanian, Gregg Ruppel
{"title":"Translating Pulmonary Function Test Results into Practical Clinical Interpretations.","authors":"Neil R MacIntyre, Nirav R Bhakta, Sanja Stanojevic, Teal S Hallstrand, Daniel J Weiner, Zachary Healy, Aparna Balasubramanian, Gregg Ruppel","doi":"10.1513/AnnalsATS.202501-063PS","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202501-063PS","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Europe Is Tightening Its Air Quality Standards: When Will Britain Follow Suit?","authors":"Ebba Malmqvist, Frank Kelly, Bert Brunekreef","doi":"10.1513/AnnalsATS.202502-244VP","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202502-244VP","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sonal G Mallya, Alka Upadhyay, Kevin J Psoter, Meredith A Case, Michael T Vest, Nirupama Putcha, Nadia N Hansel, Michelle N Eakin
{"title":"Association between Difficulty Affording Medications and Outcomes in Chronic Obstructive Pulmonary Disease.","authors":"Sonal G Mallya, Alka Upadhyay, Kevin J Psoter, Meredith A Case, Michael T Vest, Nirupama Putcha, Nadia N Hansel, Michelle N Eakin","doi":"10.1513/AnnalsATS.202410-1020OC","DOIUrl":"10.1513/AnnalsATS.202410-1020OC","url":null,"abstract":"<p><p><b>Rationale:</b> Medications, including inhaled bronchodilators, are essential for effective management of chronic obstructive pulmonary disease (COPD) and to improve clinical outcomes. However, medications are a major driver of out-of-pocket costs for individuals with COPD. The impact of cost of medications on clinical outcomes in COPD has not been studied. <b>Objectives:</b> To examine the association between difficulty affording medications and COPD morbidity, psychological well-being, and medication adherence. <b>Methods:</b> Individuals with a physician's diagnosis of COPD who were prescribed at least one daily maintenance medication were recruited from centers in the Mid-Atlantic area and followed for 12 months as part of the Medication Adherence Research in COPD (MARC) cohort. Patient-reported COPD outcomes, measures of psychological well-being, exacerbation data, and difficulty affording medications were assessed at 6-month intervals. Medication adherence was measured during the 12-month period using electronic monitors. The association between difficulty affording medications at baseline and outcomes at 12 months was evaluated using multivariable regression models. A fixed effects regression model was conducted to evaluate how changes in difficulty affording medications are associated with outcomes over time. <b>Results:</b> Of the 249 participants with completed baseline assessments, a total of 44 (18%) participants reported delaying refilling medications because of cost at baseline. Over the course of the 12-month period, 68 (27%) participants reported delaying refilling medications at any time point because of cost. After adjusting for baseline covariates, no associations between difficulty affording medications at baseline and outcomes at 12 months were observed. In the fixed effects model, changes in difficulty affording medications were associated with worse COPD health status, dyspnea, and health-related quality of life; increased symptoms of anxiety and depression; and lower objectively measured medication adherence but not occurrence of exacerbations. <b>Conclusions:</b> In this multicenter cohort of individuals with physician-diagnosed COPD, we found an association between changes in self-reported difficulty affording medications and increased patient-reported respiratory morbidity, increased anxiety and depression symptoms, and decreased objectively measured medication adherence over time, but no association with exacerbations. These findings suggest that cost of COPD-specific treatments is an important and potentially modifiable social determinant of health for individuals with COPD.</p>","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":"984-991"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Right Ventricular Dysfunction Is Associated with Mortality in Non-Small Cell Lung Cancer.","authors":"Lindsay M Forbes","doi":"10.1513/AnnalsATS.202505-506ED","DOIUrl":"10.1513/AnnalsATS.202505-506ED","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":"979-981"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Right Diagnosis Comes to Those Who Measure Correctly.","authors":"Haya Jamali, Andrew M Luks","doi":"10.1513/AnnalsATS.202412-1320CC","DOIUrl":"https://doi.org/10.1513/AnnalsATS.202412-1320CC","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":"22 7","pages":"1079-1083"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Consent Approach and Patient Notification in Pragmatic Comparative Effectiveness Trials in Critical Care.","authors":"Dustin C Krutsinger, Katherine R Courtright","doi":"10.1513/AnnalsATS.202502-218ED","DOIUrl":"10.1513/AnnalsATS.202502-218ED","url":null,"abstract":"","PeriodicalId":93876,"journal":{"name":"Annals of the American Thoracic Society","volume":" ","pages":"977-978"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}