American journal of Alzheimer's disease and other dementias最新文献

{"title":"Anti-Aging of the Nervous System and Related Neurodegenerative Diseases With Chinese Herbal Medicine.","authors":"Xiaohui Du, Nanbin Lou, Sinan Hu, Ruopeng Xiao, Chu Chu, Qiankai Huang, Lin Lu, Shanshan Li, Jing Yang","doi":"10.1177/15333175231205445","DOIUrl":"10.1177/15333175231205445","url":null,"abstract":"<p><p>Human beings have always pursued a prolonged lifespan, while the aging of the nervous system is associated with a large variety of diseases. Pathological aging of the nervous system results in a series of neurodegenerative diseases and can cause disability and death in the elderly. Therefore, there is an urgent need for the prevention and treatment of nervous system aging. Chinese herbal medicines have a long history, featuring rich and safe ingredients, and have great potential for the development of anti-aging treatment. We searched the publications on PubMed with key words \"anti-aging of the nervous system\" and \"Chinese herbal medicine\" in recent 10 years, and found sixteen Chinese herbal medicines. Then by comparing their popularity of use as well as active components based on the research articles, five common Chinese herbal medicines namely <i>Ginseng Radix</i>, <i>Lycii Fructus</i>, <i>Astragali Radix</i>, <i>Coptidis Rhizoma</i> and <i>Ginkgo Folium</i>, were confirmed to be the most related to anti-nervous system aging and neural degenerative diseases. At the same time, the active ingredients, research models, action mechanisms and curative effects of these five common Chinese herbal medicines were reviewed. From the five common Chinese herbal medicines reviewed in this paper, many encouraging effects of Chinese herbal medicines on treating nervous system aging and related diseases were revealed and more potent herbs would be explored with the help of the proposed possible mechanisms.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"38 ","pages":"15333175231205445"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41223377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerobic Treadmill Exercise Upregulates Epidermal Growth Factor Levels and Improves Learning and Memory in d-galactose-Induced Aging in a Mouse Model.","authors":"Cheng Guo, Xiaoyang Kong, Yongzhao Fan, Rihui Zhang","doi":"10.1177/15333175231211082","DOIUrl":"10.1177/15333175231211082","url":null,"abstract":"<p><p>Previous studies have demonstrated that exercise improves cognitive function in Alzheimer's disease mice but the exact mechanism needs further studies. This research aimed to study the effects of aerobic treadmill exercise on epidermal growth factor (EGF) levels and learning and memory in d-galactose-induced aging in a mouse model. Forty male Kunming mice were analyzed in this study and randomly divided into 4 groups: control (C group), aerobic exercise (AE group), d-galactose (D-gal group), and d-galactose + aerobic exercise (D-gal + AE group). The C and AE groups received a daily mid-scapular subcutaneous injection of .9% saline for 40 days. Mice in the D-gal and D-gal + AE groups were subcutaneously injected with d-galactose (1.25 mg/kg) once daily for 40 days. The mice in the AE group and D-gal + AE group completed 40 days of aerobic treadmill exercise. Learning and memory were evaluated by step-down tests. Specifically, 24 h after the behavioral test, blood was collected and brain tissue was extracted, and superoxide dismutase (SOD) and acetylcholinesterase activities were detected. The neurons in the CA1 and CA3 regions of the hippocampus were counted by Nissl staining. The number of EGF-positive cells was observed by immunohistochemical methods. In the learning test, the reaction time in the D-gal group increased significantly (<i>P</i> < .05), while the error numbers in the D-gal group tended to decrease compared with AE, D-gal + AE, and C groups. In the memory test, the latency of mice in the D-gal group was lower, while the error in this group was higher than in the other groups (<i>P</i> < .05). The activities of SOD and acetylcholinesterase were lower in the D-gal group than in the other groups (<i>P</i> < .05). The number of EGF-positive cells and neurons in the hippocampal CA1 and CA3 regions in the D-gal + AE group was higher compared to those in the D-gal group (<i>P</i> < .05), and lower in groups with mice that were not injected with d-galactose. Aerobic treadmill exercise inhibited SOD activity, increased EGF-positive cells, and decreased neuronal death and apoptosis, thereby improving learning and memory in the mouse model of d-galactose-induced aging.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"38 ","pages":"15333175231211082"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136400728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Protective Effect of IDO1 Inhibition in Aβ-Treated Neurons and APP/PS1 Mice.","authors":"Zhenzhen Duan, Lei Shi, Zhen Ning Tony He, Chunxiang Kuang, Tianxiong Han, Qing Yang","doi":"10.1177/15333175231214861","DOIUrl":"10.1177/15333175231214861","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is an inflammatory associated disease, in which dysregulated kynurenine pathway (KP) plays a key role. Through KP, L-tryptophan is catabolized into neurotoxic and neuroprotective metabolites. The overactivation of indolamine 2,3-dioxygenase1 (IDO1), the first rate-limiting enzyme of KP, and the abnormal accumulation of KP metabolites have been noted in AD, and blocking IDO1 has been suggested as a therapeutic strategy. However, the expression patterns of KP enzymes in AD, and whether these enzymes are related to AD pathogenesis, have not been fully studied. Herein, we examined the expression patterns of inflammatory cytokines, neurotrophic factors and KP enzymes, and the activity of IDO1 and IDO1 effector pathway AhR (aryl hydrocarbon receptor) in AD mice. We studied the effects of IDO1 inhibitors on Aβ-related neuroinflammation in rat primary neurons, mouse hippocampal neuronal cells, and APP/PS1 mice. The results further demonstrated the importance of IDO1-catalyzed KP in neuroinflammation in Alzheimer's disease.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"38 ","pages":"15333175231214861"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72016432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Dementia Development and COVID-19 among Individuals Who Tested Negative for COVID-19 in South Korea: A Nationwide Cohort Study.","authors":"Namwoo Kim,&nbsp;Sungtaek Son,&nbsp;Saemina Kim,&nbsp;Jieun Lee,&nbsp;Yong Min Ahn,&nbsp;Dong Keon Yon,&nbsp;Bong-Jin Hahm","doi":"10.1177/15333175211072387","DOIUrl":"https://doi.org/10.1177/15333175211072387","url":null,"abstract":"<p><p>We aim to assess whether the number of newly diagnosed dementia increases and whether comorbid psychiatric symptoms of patients with dementia worsen, in people who were tested for COVID-19. We used electronic medical records from a nationwide cohort consisting of people who tested positive (positive group), tested negative (negative group), and those who did not receive the test (control group) for COVID-19. For people with neither a history of dementia nor mild cognitive disorder (MCI), the negative group was more likely to develop dementia than the control group, and less likely to develop MCI than the positive group. For people who already had dementia, the negative group was more likely to develop comorbid psychiatric disorders than the control group, but less likely than the positive group. These findings suggest the necessity of managing mental health not only for patients with COVID-19 but also for people who tested negative for COVID-19.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":" ","pages":"15333175211072387"},"PeriodicalIF":3.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/2c/10.1177_15333175211072387.PMC8905049.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39698707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Differences in Neuropsychiatric Symptoms Among Community-Dwelling Mexican Americans Aged 80 and Older.","authors":"Sadaf Arefi Milani,&nbsp;Phillip A Cantu,&nbsp;Abbey B Berenson,&nbsp;Yong-Fang Kuo,&nbsp;Kyriakos S Markides,&nbsp;Mukaila A Raji","doi":"10.1177/15333175211042958","DOIUrl":"https://doi.org/10.1177/15333175211042958","url":null,"abstract":"<p><p>Background and ObjectivesTo assess gender differences in prevalence of neuropsychiatric symptoms (NPS) among community-dwelling Mexican Americans ≥80 years. <b>Research Design and Methods:</b> Using data from Wave 7 (2010-2011) of the Hispanic Established Population for the Epidemiological Study of the Elderly, we analyzed the NPS of 914 participants as determined by the Neuropsychiatric Inventory (NPI) with assessments conducted by their caregivers. Multivariate logistic regression models were used to test the association of individual NPS with gender, adjusting for relevant characteristics. <b>Results:</b> The average age of our sample was 86.1 years, and 65.3% were women. Over 60% of participants had at least one informant/caregiver reported NPS. After adjustment, women had lower odds than men of agitation/aggression but higher odds of dysphoria/depression and anxiety. <b>Discussion:</b> Recognizing gender differences in NPS phenotype could help guide development of culturally appropriate NPS screening and treatment programs.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":" ","pages":"15333175211042958"},"PeriodicalIF":3.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641300/pdf/nihms-1754394.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39449935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 2-Study Psychometric Evaluation of the Modified Dementia Worry Scale.","authors":"Jennifer R Roberts,&nbsp;Molly Maxfield","doi":"10.1177/1533317521995322","DOIUrl":"https://doi.org/10.1177/1533317521995322","url":null,"abstract":"<p><p>A modified version of the Dementia Worry Scale (DWS) used the terminology \"Alzheimer's disease and related dementias\" (versus the DWS' use of \"dementia\"). Two studies investigated psychometric properties of the modified DWS (MDWS). Study 1 compared the psychometric properties of the DWS and MDWS; both versions had single factor structures and exhibited excellent internal consistency (αs ≥ .95). The MDWS exhibited greater test-retest reliability after a 4-week interval (DWS r = .68; MDWS r = .90). In Study 2, the MDWS again displayed a single factor structure, excellent internal consistency (α = .95), and good test-retest reliability after an 8-week interval (r = .78). Additionally, results support convergent validity between the MDWS and fear of dementia, subjective memory, general anxiety, health anxiety, and neuroticism. The MDWS is psychometrically consistent with the DWS, maintains strong test-retest reliability, and is appropriate for use in cross-sectional and longitudinal research.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":" ","pages":"1533317521995322"},"PeriodicalIF":3.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1533317521995322","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25408586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of the COVID-19 Pandemic on Adult Day Services and the Families They Serve.","authors":"Lauren J Parker,&nbsp;Katherine Marx,&nbsp;Joseph E Gaugler,&nbsp;Laura N Gitlin","doi":"10.1177/15333175211050152","DOIUrl":"https://doi.org/10.1177/15333175211050152","url":null,"abstract":"<p><p>The COVID-19 pandemic forced adult day services (ADS) to close and abruptly end in-person services to clients. To understand the effect of the pandemic on ADS, a 20-item survey was used to examine services provided, staffing, finances, and plans to reopen. Data came from 22 sites participating in the Adult Day Service Plus a national randomized controlled trial. Of the 22 ADS sites responding to the survey, most (86.4%, n = 19) closed due to COVID-19 with nearly half closing due to a state mandate (52.6%, n = 10). Most sites reported the need to furlough or terminate staff (63.6%, n = 14). Services that sites continued to provide included telephone support (n = 22, 100%), delivery of food (n = 8, 36.4%), medical check-ins (n = 9, 40.1%), and activity <i>via</i> Zoom or YouTube (n = 14, 63.6%). Most of these services were provided without reimbursement. Adult day services have considerable potential as a platform for service innovation in community-based services.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":" ","pages":"15333175211050152"},"PeriodicalIF":3.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e8/6e/nihms-1761314.PMC8745481.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39517818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Zumba on Cognition and Quality of Life is Independent of APOE4 Carrier Status in Cognitively Unimpaired Older Women: A 6-Month Randomized Controlled Pilot Study.","authors":"Cynthia M Stonnington, Janina Krell-Roesch, Dona E C Locke, Joseph G Hentz, Amylou C Dueck, Yonas E Geda, Pierre N Tariot, Richard J Caselli","doi":"10.1177/1533317519868370","DOIUrl":"10.1177/1533317519868370","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association of a 6-month Zumba intervention with cognition and quality of life among older cognitively unimpaired apolipoprotein ∊4 (APOE4) carrier and noncarrier women.</p><p><strong>Methods: </strong>Fifty-three women were randomly assigned to either twice-weekly Zumba group classes or maintenance of habitual exercise (control group) for 6 months. At baseline, 3, and 6 months, all participants underwent neuropsychological, physical activity, and quality-of-life assessments.</p><p><strong>Results: </strong>Overall, neuropsychological test scores and level of physical activity did not differ between intervention and control groups at any time. However, compared to the control group, quality of life was higher at 3 months, and visuospatial working memory and response inhibition improved more in the intervention group by 6 months. Apolipoprotein ∊4 status did not affect the results.</p><p><strong>Discussion: </strong>Zumba may strengthen performance on visuospatial working memory among cognitively unimpaired older women but this needs to be tested in a larger clinical trial.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"35 ","pages":"1533317519868370"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41165386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can We Help Care Providers Communicate More Effectively With Persons Having Dementia Living in Long-Term Care Homes?","authors":"K. McGilton, K. McGilton, E. Rochon, E. Rochon, S. Sidani, Alexander C. Shaw, Alexander C. Shaw, Boaz M. Ben-David, M. Saragosa, V. Boscart, Rozanne Wilson, Rozanne Wilson, Rozanne Wilson, Karmit K. Galimidi-Epstein, M. Pichora-Fuller, M. Pichora-Fuller","doi":"10.1177/1533317516680899","DOIUrl":"https://doi.org/10.1177/1533317516680899","url":null,"abstract":"Background: Effective communication between residents with dementia and care providers in long-term care homes (LTCHs) is essential to resident-centered care. Purpose: To determine the effects of a communication intervention on residents’ quality of life (QOL) and care, as well as care providers’ perceived knowledge, mood, and burden. Method: The intervention included (1) individualized communication plans, (2) a dementia care workshop, and (3) a care provider support system. Pre- and postintervention scores were compared to evaluate the effects of the intervention. A total of 12 residents and 20 care providers in an LTCH participated in the feasibility study. Results: The rate of care providers’ adherence to the communication plans was 91%. Postintervention, residents experienced a significant increase in overall QOL. Care providers had significant improvement in mood and perceived reduced burden. Conclusion: The results suggest that the communication intervention demonstrates preliminary evidence of positive effects on residents’ QOL and care providers’ mood and burden.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"1 1","pages":"41 - 50"},"PeriodicalIF":0.0,"publicationDate":"2016-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81099625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Education Intervention to Enhance Staff Self-Efficacy to Provide Dementia Care in an Acute Care Hospital in Canada","authors":"L. Schindel Martin, L. Gillies, E. Coker, Anne Pizzacalla, M. Montemuro, G. Suva, V. McLelland","doi":"10.1177/1533317516668574","DOIUrl":"https://doi.org/10.1177/1533317516668574","url":null,"abstract":"Education is needed for enhanced capacity of acute hospitals to provide dementia care. A nonrandomized controlled, repeated-measures design was used to evaluate a dementia education program delivered to an intervention group (IG, n = 468), compared to a wait-listed group (n = 277), representing separate sites of a multisite hospital. Participants completed self-efficacy for dementia and satisfaction measures and provided written descriptions of dementia care collected at baseline, postintervention (IG only), and at 8-week follow-up. Oral narratives were gathered from IG participants 8 weeks postintervention. The IG demonstrated significant improvement in self-efficacy scores from baseline to immediately postintervention (P < .001), sustained at 8 weeks. There were no changes from baseline to 8 weeks postintervention evident in the wait-listed group (P = .21). Intervention group participants described positive impacts including implementation of person-centered care approaches. Implementation of dementia care education programs throughout hospital settings is promising for the enhancement of dementia care.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"24 1","pages":"664 - 677"},"PeriodicalIF":0.0,"publicationDate":"2016-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79832903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}