American journal of Alzheimer's disease and other dementias最新文献

{"title":"Aerobic Treadmill Exercise Upregulates Epidermal Growth Factor Levels and Improves Learning and Memory in d-galactose-Induced Aging in a Mouse Model.","authors":"Cheng Guo, Xiaoyang Kong, Yongzhao Fan, Rihui Zhang","doi":"10.1177/15333175231211082","DOIUrl":"10.1177/15333175231211082","url":null,"abstract":"<p><p>Previous studies have demonstrated that exercise improves cognitive function in Alzheimer's disease mice but the exact mechanism needs further studies. This research aimed to study the effects of aerobic treadmill exercise on epidermal growth factor (EGF) levels and learning and memory in d-galactose-induced aging in a mouse model. Forty male Kunming mice were analyzed in this study and randomly divided into 4 groups: control (C group), aerobic exercise (AE group), d-galactose (D-gal group), and d-galactose + aerobic exercise (D-gal + AE group). The C and AE groups received a daily mid-scapular subcutaneous injection of .9% saline for 40 days. Mice in the D-gal and D-gal + AE groups were subcutaneously injected with d-galactose (1.25 mg/kg) once daily for 40 days. The mice in the AE group and D-gal + AE group completed 40 days of aerobic treadmill exercise. Learning and memory were evaluated by step-down tests. Specifically, 24 h after the behavioral test, blood was collected and brain tissue was extracted, and superoxide dismutase (SOD) and acetylcholinesterase activities were detected. The neurons in the CA1 and CA3 regions of the hippocampus were counted by Nissl staining. The number of EGF-positive cells was observed by immunohistochemical methods. In the learning test, the reaction time in the D-gal group increased significantly (<i>P</i> < .05), while the error numbers in the D-gal group tended to decrease compared with AE, D-gal + AE, and C groups. In the memory test, the latency of mice in the D-gal group was lower, while the error in this group was higher than in the other groups (<i>P</i> < .05). The activities of SOD and acetylcholinesterase were lower in the D-gal group than in the other groups (<i>P</i> < .05). The number of EGF-positive cells and neurons in the hippocampal CA1 and CA3 regions in the D-gal + AE group was higher compared to those in the D-gal group (<i>P</i> < .05), and lower in groups with mice that were not injected with d-galactose. Aerobic treadmill exercise inhibited SOD activity, increased EGF-positive cells, and decreased neuronal death and apoptosis, thereby improving learning and memory in the mouse model of d-galactose-induced aging.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"38 ","pages":"15333175231211082"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136400728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Protective Effect of IDO1 Inhibition in Aβ-Treated Neurons and APP/PS1 Mice.","authors":"Zhenzhen Duan, Lei Shi, Zhen Ning Tony He, Chunxiang Kuang, Tianxiong Han, Qing Yang","doi":"10.1177/15333175231214861","DOIUrl":"10.1177/15333175231214861","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is an inflammatory associated disease, in which dysregulated kynurenine pathway (KP) plays a key role. Through KP, L-tryptophan is catabolized into neurotoxic and neuroprotective metabolites. The overactivation of indolamine 2,3-dioxygenase1 (IDO1), the first rate-limiting enzyme of KP, and the abnormal accumulation of KP metabolites have been noted in AD, and blocking IDO1 has been suggested as a therapeutic strategy. However, the expression patterns of KP enzymes in AD, and whether these enzymes are related to AD pathogenesis, have not been fully studied. Herein, we examined the expression patterns of inflammatory cytokines, neurotrophic factors and KP enzymes, and the activity of IDO1 and IDO1 effector pathway AhR (aryl hydrocarbon receptor) in AD mice. We studied the effects of IDO1 inhibitors on Aβ-related neuroinflammation in rat primary neurons, mouse hippocampal neuronal cells, and APP/PS1 mice. The results further demonstrated the importance of IDO1-catalyzed KP in neuroinflammation in Alzheimer's disease.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"38 ","pages":"15333175231214861"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72016432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Zumba on Cognition and Quality of Life is Independent of APOE4 Carrier Status in Cognitively Unimpaired Older Women: A 6-Month Randomized Controlled Pilot Study.","authors":"Cynthia M Stonnington, Janina Krell-Roesch, Dona E C Locke, Joseph G Hentz, Amylou C Dueck, Yonas E Geda, Pierre N Tariot, Richard J Caselli","doi":"10.1177/1533317519868370","DOIUrl":"10.1177/1533317519868370","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association of a 6-month Zumba intervention with cognition and quality of life among older cognitively unimpaired apolipoprotein ∊4 (APOE4) carrier and noncarrier women.</p><p><strong>Methods: </strong>Fifty-three women were randomly assigned to either twice-weekly Zumba group classes or maintenance of habitual exercise (control group) for 6 months. At baseline, 3, and 6 months, all participants underwent neuropsychological, physical activity, and quality-of-life assessments.</p><p><strong>Results: </strong>Overall, neuropsychological test scores and level of physical activity did not differ between intervention and control groups at any time. However, compared to the control group, quality of life was higher at 3 months, and visuospatial working memory and response inhibition improved more in the intervention group by 6 months. Apolipoprotein ∊4 status did not affect the results.</p><p><strong>Discussion: </strong>Zumba may strengthen performance on visuospatial working memory among cognitively unimpaired older women but this needs to be tested in a larger clinical trial.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"35 ","pages":"1533317519868370"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41165386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can We Help Care Providers Communicate More Effectively With Persons Having Dementia Living in Long-Term Care Homes?","authors":"K. McGilton, K. McGilton, E. Rochon, E. Rochon, S. Sidani, Alexander C. Shaw, Alexander C. Shaw, Boaz M. Ben-David, M. Saragosa, V. Boscart, Rozanne Wilson, Rozanne Wilson, Rozanne Wilson, Karmit K. Galimidi-Epstein, M. Pichora-Fuller, M. Pichora-Fuller","doi":"10.1177/1533317516680899","DOIUrl":"https://doi.org/10.1177/1533317516680899","url":null,"abstract":"Background: Effective communication between residents with dementia and care providers in long-term care homes (LTCHs) is essential to resident-centered care. Purpose: To determine the effects of a communication intervention on residents’ quality of life (QOL) and care, as well as care providers’ perceived knowledge, mood, and burden. Method: The intervention included (1) individualized communication plans, (2) a dementia care workshop, and (3) a care provider support system. Pre- and postintervention scores were compared to evaluate the effects of the intervention. A total of 12 residents and 20 care providers in an LTCH participated in the feasibility study. Results: The rate of care providers’ adherence to the communication plans was 91%. Postintervention, residents experienced a significant increase in overall QOL. Care providers had significant improvement in mood and perceived reduced burden. Conclusion: The results suggest that the communication intervention demonstrates preliminary evidence of positive effects on residents’ QOL and care providers’ mood and burden.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"1 1","pages":"41 - 50"},"PeriodicalIF":0.0,"publicationDate":"2016-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81099625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Education Intervention to Enhance Staff Self-Efficacy to Provide Dementia Care in an Acute Care Hospital in Canada","authors":"L. Schindel Martin, L. Gillies, E. Coker, Anne Pizzacalla, M. Montemuro, G. Suva, V. McLelland","doi":"10.1177/1533317516668574","DOIUrl":"https://doi.org/10.1177/1533317516668574","url":null,"abstract":"Education is needed for enhanced capacity of acute hospitals to provide dementia care. A nonrandomized controlled, repeated-measures design was used to evaluate a dementia education program delivered to an intervention group (IG, n = 468), compared to a wait-listed group (n = 277), representing separate sites of a multisite hospital. Participants completed self-efficacy for dementia and satisfaction measures and provided written descriptions of dementia care collected at baseline, postintervention (IG only), and at 8-week follow-up. Oral narratives were gathered from IG participants 8 weeks postintervention. The IG demonstrated significant improvement in self-efficacy scores from baseline to immediately postintervention (P < .001), sustained at 8 weeks. There were no changes from baseline to 8 weeks postintervention evident in the wait-listed group (P = .21). Intervention group participants described positive impacts including implementation of person-centered care approaches. Implementation of dementia care education programs throughout hospital settings is promising for the enhancement of dementia care.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"24 1","pages":"664 - 677"},"PeriodicalIF":0.0,"publicationDate":"2016-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79832903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NIH-funded research provides new clues on how ApoE4 affects Alzheimer's risk.","authors":"","doi":"10.1037/e591022012-001","DOIUrl":"https://doi.org/10.1037/e591022012-001","url":null,"abstract":"","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"6 1","pages":"356-7"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81529425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Submission Guidelines","authors":"","doi":"10.1177/153331750602100312","DOIUrl":"https://doi.org/10.1177/153331750602100312","url":null,"abstract":"","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"45 1","pages":"212 - 213"},"PeriodicalIF":0.0,"publicationDate":"2006-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74068062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"News Briefs","authors":"","doi":"10.1177/1533317506289486","DOIUrl":"https://doi.org/10.1177/1533317506289486","url":null,"abstract":"","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"37 1","pages":"209 - 210"},"PeriodicalIF":0.0,"publicationDate":"2006-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75222351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The Dementias","authors":"C. Rowland","doi":"10.1177/1533317506289989","DOIUrl":"https://doi.org/10.1177/1533317506289989","url":null,"abstract":"done with no worsening of symptoms. Alberto Marcos and colleagues present a Spanish study of neuropsychological markers of mild cognitive impairment progressing to Alzheimer’s disease. They find that the CAMCOG and memory and perception cognitive screening were the optimum screening tools to discover which patients will go on to acquire Alzheimer’s disease and which will not. This is important because early treatment is so crucial. Nagararatnam et al point out that 38% of patients in their study had accusatory behavior (average age of 74 years, and a male to female ratio of 2.6:1). This behavior is more prevalent in higher stages of dementia and is more often accompanied by hallucinations. They feel it would be more useful to view these behaviors as symptoms rather than as being primary. Sato and colleagues find that advanced glycation end products (AGE) are an important factor in diabetes and neurodegenerative diseases such as Alzheimer’s disease. They discuss the molecular mechanisms of Alzheimer’s disease and especially the toxic AGE-receptor AGE system.","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"17 1","pages":"146 - 146"},"PeriodicalIF":0.0,"publicationDate":"2006-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73095867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Book Review: Letters to My Sisters: An Alzheimer's Journal","authors":"S. Albrecht","doi":"10.1177/153331750602100102","DOIUrl":"https://doi.org/10.1177/153331750602100102","url":null,"abstract":"","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"43 1","pages":"55 - 55"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85823067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}