Li Yang, Liang He, Zhibin Bu, Cheng Xuan, Caiyan Yu, Jiong Wu
{"title":"基于血清蛋白谱的阿尔茨海默病诊断模型。","authors":"Li Yang, Liang He, Zhibin Bu, Cheng Xuan, Caiyan Yu, Jiong Wu","doi":"10.1177/15333175231220166","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Determining a non-invasive, serum-based diagnostic panel for early diagnosis of AD will play a significant role in the prevention and treatment of the disease.</p><p><strong>Methods: </strong>We performed standardized clinical assessments and neuroimaging measurements in 45 patients with AD and an equal number of sex - and age-matched controls. 48 target peptides of 14 identified target proteins were quantitatively analyzed by PRM.</p><p><strong>Results: </strong>8 protein markers were screened, including SAA4, PPBP, PF4, APOA4, F10, CPB2, C1S and IGHM. An diagnosis panel including 8 proteins and demographic characteristics markers respectively was found to be the robust with a AUC of 92.3%.</p><p><strong>Conclusions: </strong>Our study developed a new panel including protein and demographic characteristics that could be used to distinguish AD from control candidates.</p>","PeriodicalId":93865,"journal":{"name":"American journal of Alzheimer's disease and other dementias","volume":"38 ","pages":"15333175231220166"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693785/pdf/","citationCount":"0","resultStr":"{\"title\":\"Serum Protein-Based Profiles for the Diagnostic Model of Alzheimer's Disease.\",\"authors\":\"Li Yang, Liang He, Zhibin Bu, Cheng Xuan, Caiyan Yu, Jiong Wu\",\"doi\":\"10.1177/15333175231220166\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Determining a non-invasive, serum-based diagnostic panel for early diagnosis of AD will play a significant role in the prevention and treatment of the disease.</p><p><strong>Methods: </strong>We performed standardized clinical assessments and neuroimaging measurements in 45 patients with AD and an equal number of sex - and age-matched controls. 48 target peptides of 14 identified target proteins were quantitatively analyzed by PRM.</p><p><strong>Results: </strong>8 protein markers were screened, including SAA4, PPBP, PF4, APOA4, F10, CPB2, C1S and IGHM. An diagnosis panel including 8 proteins and demographic characteristics markers respectively was found to be the robust with a AUC of 92.3%.</p><p><strong>Conclusions: </strong>Our study developed a new panel including protein and demographic characteristics that could be used to distinguish AD from control candidates.</p>\",\"PeriodicalId\":93865,\"journal\":{\"name\":\"American journal of Alzheimer's disease and other dementias\",\"volume\":\"38 \",\"pages\":\"15333175231220166\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693785/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of Alzheimer's disease and other dementias\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/15333175231220166\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of Alzheimer's disease and other dementias","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/15333175231220166","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Serum Protein-Based Profiles for the Diagnostic Model of Alzheimer's Disease.
Background: Determining a non-invasive, serum-based diagnostic panel for early diagnosis of AD will play a significant role in the prevention and treatment of the disease.
Methods: We performed standardized clinical assessments and neuroimaging measurements in 45 patients with AD and an equal number of sex - and age-matched controls. 48 target peptides of 14 identified target proteins were quantitatively analyzed by PRM.
Results: 8 protein markers were screened, including SAA4, PPBP, PF4, APOA4, F10, CPB2, C1S and IGHM. An diagnosis panel including 8 proteins and demographic characteristics markers respectively was found to be the robust with a AUC of 92.3%.
Conclusions: Our study developed a new panel including protein and demographic characteristics that could be used to distinguish AD from control candidates.
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