Li Yang, Liang He, Zhibin Bu, Cheng Xuan, Caiyan Yu, Jiong Wu
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引用次数: 0
Abstract
Background: Determining a non-invasive, serum-based diagnostic panel for early diagnosis of AD will play a significant role in the prevention and treatment of the disease.
Methods: We performed standardized clinical assessments and neuroimaging measurements in 45 patients with AD and an equal number of sex - and age-matched controls. 48 target peptides of 14 identified target proteins were quantitatively analyzed by PRM.
Results: 8 protein markers were screened, including SAA4, PPBP, PF4, APOA4, F10, CPB2, C1S and IGHM. An diagnosis panel including 8 proteins and demographic characteristics markers respectively was found to be the robust with a AUC of 92.3%.
Conclusions: Our study developed a new panel including protein and demographic characteristics that could be used to distinguish AD from control candidates.
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