AJNR. American journal of neuroradiology最新文献

{"title":"Stroke Thrombectomy for Large Infarcts with Limited Penumbra: Systematic Review and Meta-Analysis of Randomized Trials.","authors":"Huanwen Chen, Seemant Chaturvedi, Dheeraj Gandhi, Marco Colasurdo","doi":"10.3174/ajnr.A8553","DOIUrl":"10.3174/ajnr.A8553","url":null,"abstract":"<p><strong>Background: </strong>Middle meningeal artery embolization (MMAE) has emerged as a novel treatment for non-acute subdural hematoma (SDH), particularly for reducing the risk of SDH recurrence. Recently, five randomized controlled trials (RCT) of MMAE as an adjunct to conventional management (surgical or observant) have concluded their investigation and reported their outcomes.</p><p><strong>Purpose: </strong>To synthesize trial results to provide more definitive guidance on the role of MMAE in the management of non-acute SDH.</p><p><strong>Data sources: </strong>MEDLINE database from inception up to November 23, 2024. English-language clinical articles reporting large randomized controlled trials (<i>n</i> = 100 or more) investigating the efficacy and safety of MMAE for non-acute subdural hematoma patients were identified.</p><p><strong>Study selection: </strong>Five trials were identified - EMBOLISE, STEM, MAGIC-MT, EMPROTECT, and MEMBRANE.</p><p><strong>Data analysis: </strong>The primary efficacy endpoint was SDH treatment failure (broadly defined as SDH recurrence or requirement of surgical rescue) within 3 to 6 months. Safety endpoints include death and stroke.</p><p><strong>Data synthesis: </strong>There was significant heterogeneity in terms of patient populations as well as reported outcomes. Overall, MMAE was associated with significantly lower odds of SDH treatment failure (OR 0.51 [95% CI 0.39 to 0.67], <i>P</i> < 0.001), with minimal inter-study heterogeneity. Compared to conventional management, MMAE was not significantly associated with different odds of death (OR 1.03 [95% CI 0.36 to 2.99], <i>P</i> = 0.95) or stroke (OR 1.10 [95% CI 0.36 to 3.39], <i>P</i> = 0.86).</p><p><strong>Limitations: </strong>Our meta-analysis is limited by selection bias and high heterogeneity in study design and reported outcomes.</p><p><strong>Conclusions: </strong>This study provides high-level evidence that, for patients with non-acute SDH, MMAE is safe and effective an adjunct to conventional management for preventing treatment failure.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.3174/ajnr.A8740","DOIUrl":"https://doi.org/10.3174/ajnr.A8740","url":null,"abstract":"","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Diagnostic Value of Brain White Matter Hyperintensities and Clinical Symptoms in Predicting the Detection of CSF-Venous Fistula in Patients with Suspected Spontaneous Intracranial Hypotension.","authors":"Samantha L Pisani Petrucci, Nadya Andonov, Peter Lennarson, Marius Birlea, Chantal O'Brien, Danielle Wilhour, Abigail Anderson, Jeffrey L Bennett, Andrew L Callen","doi":"10.3174/ajnr.A8548","DOIUrl":"10.3174/ajnr.A8548","url":null,"abstract":"<p><strong>Background and purpose: </strong>Spontaneous intracranial hypotension (SIH) due to CSF-venous fistula (CVF) is increasingly recognized as a secondary cause of headaches, with symptoms often overlapping with primary headache syndromes such as migraine. While brain MRI studies have focused on features indicative of SIH, findings that support an alternate headache etiology, such as the bifrontal white matter hyperintensities (WMH) often seen in migraines, have not been explored in this context. This study assesses the following: 1) the quantity and distribution of WMH, and 2) the presenting clinical features in patients with and without CVF found on dynamic decubitus CT myelography (dCTM).</p><p><strong>Materials and methods: </strong>Seventy-two consecutive patients underwent clinical work-up for SIH due to suspected CVF, including preprocedural brain and spine MRI followed by dCTM. Brain imaging features were analyzed, including the Bern score, quantitative WMH burden, and WMH distribution. Demographics and clinical symptoms present at the time of presentation were recorded. Imaging features were compared between groups with and without CVF using parametric or nonparametric comparisons according to variable normality. Multivariate logistic regression explored the relationships among imaging features, clinical symptoms, and the presence of CVF.</p><p><strong>Results: </strong>The cohort included 40 patients with (CVF+) and 32 patients without (CVF-) CVFs, with no significant age or sex differences. Patients with CVF+ had significantly higher Bern scores and significantly fewer WMH. There were significant differences in the frequencies of WMH patterns between groups, with a migrainous pattern observed most frequently in patients with CVF-. Logistic regression combining the Bern score, WMH burden, and WMH pattern demonstrated a better fit for predicting CVF than using the Bern score or WMH features alone. Fourteen clinical symptoms showed the greatest differences between CVF+ and CVF- groups. Logistic regression demonstrated a positive association between CVF detection and a pressure/throbbing headache quality and negative associations for neck pain, facial pain, phonophobia, and anhedonia/depression.</p><p><strong>Conclusions: </strong>These findings suggest a negative association between CVF detection, increased burden of WMH, and a migrainous WMH pattern. Symptom analysis describes distinct clinical phenotypes, challenging orthostatic headache as a defining characteristic. These results support a comprehensive assessment of imaging and clinical presentations in the work-up of suspected SIH.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Density and Time Characteristics of CSF-Venous Fistulas on CT Myelography in Patients with Spontaneous Intracranial Hypotension.","authors":"Diogo G L Edelmuth, Timothy J Amrhein, Peter G Kranz","doi":"10.3174/ajnr.A8516","DOIUrl":"10.3174/ajnr.A8516","url":null,"abstract":"<p><strong>Background and purpose: </strong>The conspicuity of CSF-venous fistulas (CVFs) on specialized myelographic imaging protocols varies, and the factors that determine their visibility have not yet been extensively studied. The purpose of this study was to determine the relative effect of 2 variables on CVF visibility: timing of imaging and intrathecal contrast attenuation.</p><p><strong>Materials and methods: </strong>A retrospective cohort of 24 patients with spontaneous intracranial hypotension due to a CVF who underwent a total of 34 CT myelographies was studied. All CTM acquisitions that included the level of the known definite CVF were evaluated for 1) time passed after injection of contrast, 2) attenuation of the adjacent subarachnoid space, 3) subjective visibility of the CVF on that series, 4) attenuation of the corresponding draining vein, and 5) contrast dose used.</p><p><strong>Results: </strong>A total of 131 acquisitions included the level of the known CVFs. Attenuation values of the thecal sac were significantly higher in acquisitions where the CVFs were definitely visible (average 2283 HU) than in acquisitions where the CVFs were equivocal or not visible (764 HU and 583 HU, respectively). No significant difference was shown in the timing of the acquisitions between the 3 groups (12.8 minutes, 20.4 minutes, and 17.5 minutes, respectively). Multivariate linear regression showed thecal sac attenuation to be the only independent predictor of the attenuation of the CVF draining vein. Time passed after contrast injection was not independently correlated.</p><p><strong>Conclusions: </strong>Intrathecal contrast attenuation has a strong positive relationship with the visibility of CVF. Timing of the acquisition was not an independent predictor of CVF visibility under our acquisition protocol.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"832-839"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"There Is Poor Agreement between the Subjective and Quantitative Adjudication of Aneurysm Wall Enhancement.","authors":"Carlos Dier, Kerby Justin, Sultan Alhajahjeh, Sebastian Sanchez, Linder Wendt, Fernanda Avalos, Elena Sagues, Andres Gudino, Daniela Molina, Navami Shenoy, Connor Aamot, Paul Silva, Leonardo Furtado Freitas, Edgar A Samaniego","doi":"10.3174/ajnr.A8508","DOIUrl":"10.3174/ajnr.A8508","url":null,"abstract":"<p><strong>Background and purpose: </strong>The determination of aneurysm wall enhancement (AWE) by human readers on visual inspection alone is subjective and prone to error. A 3D method for quantifying the signal intensity (SI) of the aneurysm enables objective determination of AWE. Interreader agreement and agreement between subjective and objective determination of AWE were assessed in this study.</p><p><strong>Materials and methods: </strong>Patients with saccular intracranial aneurysms (IAs) were imaged with high-resolution MRI. In the subjective assessment, 2 internal adjudicators visually determined AWE if the degree of enhancement was equal to or higher than that of the pituitary stalk. An experienced internal neuroradiologist resolved disagreements. This internal adjudication was compared with an external adjudication to assess interrater agreement among centers. In the objective assessment, the distribution of SI across the aneurysm wall after normalizing the SI to the corpus callosum was determined with an in-house code. The normalized mean SI on postcontrast T1 MRI was defined as 3D-circumferential AWE (3D-CAWE). If the 3D-CAWE value was higher than 1, an IA was defined as objectively \"enhancing.\" Interrater agreement was analyzed with κ coefficients. Intertechnique agreement between the subjective and objective assessments was performed using κ statistics. Univariate regressions were used to identify which morphologic characteristics influenced subjective adjudication of enhancement.</p><p><strong>Results: </strong>A total of 113 IAs were analyzed. The agreement of the internal assessment was moderate (κ = 0.63), 49.5% of IAs (56) were classified as \"enhancing;\" and 50.5% (57) as \"nonenhancing\" after consensus. Interrater agreement between internal and external adjudication was weak (κ = 0.52) for the presence of AWE. There was no agreement between the subjective assessment of AWE and objective 3D-CAWE (κ = 0.16, <i>P</i> = .02). Subjective assessment was less likely to reliably adjudicate enhancement when assessing multiple aneurysms (OR, 0.4; 95% CI, 0.16-0.97; <i>P</i> = .04) and IAs larger than >7 mm (OR, 0.22; 95% CI, 0.09-0.55; <i>P</i> = .002) despite being objectively nonenhancing.</p><p><strong>Conclusions: </strong>Subjective adjudication of AWE has poor interrater agreement, and no agreement with an objective 3D method of determining AWE. It is also less likely than objective quantification to identify enhancement in aneurysms of >7 mm or when multiple aneurysms are present. Objective 3D quantification, such as the technique used in this study, should, therefore, be considered when assessing AWE, especially in patients with multiple aneurysms and aneurysms of >7 mm in size.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"689-697"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Super-Resolution in Clinically Available Spinal Cord MRIs Enables Automated Atrophy Analysis.","authors":"Blake E Dewey, Samuel W Remedios, Muraleetharan Sanjayan, Nicole Bou Rjeily, Alexandra Zambriczki Lee, Chelsea Wyche, Safiya Duncan, Jerry L Prince, Peter A Calabresi, Kathryn C Fitzgerald, Ellen M Mowry","doi":"10.3174/ajnr.A8526","DOIUrl":"10.3174/ajnr.A8526","url":null,"abstract":"<p><strong>Background and purpose: </strong>Measurement of the mean upper cervical cord area (MUCCA) is an important biomarker in the study of neurodegeneration. However, dedicated high-resolution (HR) scans of the cervical spinal cord are rare in standard-of-care imaging due to timing and clinical usability. Most clinical cervical spinal cord imaging is sagittally acquired in 2D with thick slices and anisotropic voxels. As a solution, previous work describes HR T1-weighted brain imaging for measuring the upper cord area, but this is still not common in clinical care.</p><p><strong>Materials and methods: </strong>We propose using a zero-shot super-resolution technique, synthetic multi-orientation resolution enhancement (SMORE), already validated in the brain, to enhance the resolution of 2D-acquired scans for upper cord area calculations. To incorporate super-resolution in spinal cord analysis, we validate SMORE against HR research imaging and in a real-world longitudinal data analysis.</p><p><strong>Results: </strong>Super-resolved (SR) images reconstructed by using SMORE showed significantly greater similarity to the ground truth than low-resolution (LR) images across all tested resolutions (<i>P</i> < .001 for all resolutions in peak signal-to-noise ratio [PSNR] and mean structural similarity [MSSIM]). MUCCA results from SR scans demonstrate excellent correlation with HR scans (<i>r</i> > 0.973 for all resolutions) compared with LR scans. Additionally, SR scans are consistent between resolutions (<i>r</i> > 0.969), an essential factor in longitudinal analysis. Compared with clinical outcomes such as walking speed or disease severity, MUCCA values from LR scans have significantly lower correlations than those from HR scans. SR results have no significant difference. In a longitudinal real-world data set, we show that these SR volumes can be used in conjunction with T1-weighted brain scans to show a significant rate of atrophy (-0.790, <i>P</i> = .020 versus -0.438, <i>P</i> = .301 with LR).</p><p><strong>Conclusions: </strong>Super-resolution is a valuable tool for enabling large-scale studies of cord atrophy, as LR images acquired in clinical practice are common and available.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"823-831"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging Physics-Based Synthetic MR Images and Deep Transfer Learning for Artifact Reduction in Echo-Planar Imaging.","authors":"Catalina Raymond, Jingwen Yao, Bryan Clifford, Thorsten Feiweier, Sonoko Oshima, Donatello Telesca, Xiaodong Zhong, Heiko Meyer, Richard G Everson, Noriko Salamon, Timothy F Cloughesy, Benjamin M Ellingson","doi":"10.3174/ajnr.A8566","DOIUrl":"10.3174/ajnr.A8566","url":null,"abstract":"<p><strong>Backgound and purpose: </strong>This study utilizes a physics-based approach to synthesize realistic MR artifacts and train a deep learning generative adversarial network (GAN) for use in artifact reduction on EPI, a crucial neuroimaging sequence with high acceleration that is notoriously susceptible to artifacts.</p><p><strong>Materials and methods: </strong>A total of 4,573 anatomical MR sequences from 1,392 patients undergoing clinically indicated MRI of the brain were used to create a synthetic data set using physics-based, simulated artifacts commonly found in EPI. By using multiple MRI contrasts, we hypothesized the GAN would learn to correct common artifacts while preserving the inherent contrast information, even for contrasts the network has not been trained on. A modified <i>Pix2PixGAN</i> architecture with an <i>Attention-R2UNet</i> generator was used for the model. Three training strategies were employed: (1) An \"all-in-one\" model trained on all the artifacts at once; (2) a set of \"single models\", one for each artifact; and a (3) \"stacked transfer learning\" approach where a model is first trained on one artifact set, then this learning is transferred to a new model and the process is repeated for the next artifact set. Lastly, the \"Stacked Transfer Learning\" model was tested on ADC maps from single-shot diffusion MRI data in <i>N</i> = 49 patients diagnosed with recurrent glioblastoma to compare visual quality and lesion measurements between the natively acquired images and AI-corrected images.</p><p><strong>Results: </strong>The \"stacked transfer learning\" approach had superior artifact reduction performance compared to the other approaches as measured by Mean Squared Error (MSE = 0.0016), Structural Similarity Index (SSIM = 0.92), multiscale SSIM (MS-SSIM = 0.92), peak signal-to-noise ratio (PSNR = 28.10), and Hausdorff distance (HAUS = 4.08mm), suggesting that leveraging pre-trained knowledge and sequentially training on each artifact is the best approach this application. In recurrent glioblastoma, significantly higher visual quality was observed in model predicted images compared to native images, while quantitative measurements within the tumor regions remained consistent with non-corrected images.</p><p><strong>Conclusions: </strong>The current study demonstrates the feasibility of using a physics-based method for synthesizing a large data set of images with realistic artifacts and the effectiveness of utilizing this synthetic data set in a \"stacked transfer learning\" approach to training a GAN for reduction of EPI-based artifacts.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"733-741"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Improvement after Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus Can Be Quantified by Diffusion Tensor Imaging.","authors":"Adéla Bubeníková, Vojtěch Sedlák, Petr Skalický, Ondřej Rýdlo, Kryštof Haratek, Aleš Vlasák, Róbert Leško, David Netuka, Vladimír Beneš, Vladimír Beneš, Ondřej Bradáč","doi":"10.3174/ajnr.A8571","DOIUrl":"10.3174/ajnr.A8571","url":null,"abstract":"<p><strong>Background and purpose: </strong>White matter changes assessed by DTI typically reflect tract functionality. This study aimed to investigate DTI parameter alterations in important regions pre- and postshunt implantation in patients with idiopathic normal pressure hydrocephalus (iNPH), alongside assessing the relationship between DTI parameters and clinical improvement.</p><p><strong>Materials and methods: </strong>Patients with probable iNPH underwent prospective preoperative MRI and comprehensive clinical work-up between 2017-2022. Patients with clinical symptoms of iNPH, positive result on a lumbar infusion test, and/or gait improvement after 120-hour lumbar drainage were diagnosed with iNPH and underwent shunt-placement surgery. Fractional anisotropy and mean diffusivity values for individual regions of interest were extracted from preoperative and postoperative MRI. These values were correlated with the clinical picture of individual patients.</p><p><strong>Results: </strong>A total of 32 patients (73.59 ± 4.59 years) with definite iNPH were analyzed. Preoperative DTI characteristics of internal capsule and corona radiata correlated with the 1-year improvement in the Dutch Gait Scale postoperatively (all <i>P</i> < .036). Cognitive domain improvement after surgery in memory and psychomotor speed correlated with preoperative DTI values of cingulate gyrus (<i>P</i> = .050), uncinate fasciculus (<i>P</i> = .029), superior longitudinal fasciculus (<i>P</i> = .020), or corpus callosum (<i>P</i> < .045).</p><p><strong>Conclusions: </strong>DTI characteristics of white matter regions reflect clinical improvement after shunt surgery in patients with iNPH. They tend to improve toward physiologic DTI values, thus further accentuating the benefit of shunt surgery in both clinical and radiologic pictures.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"766-773"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement Beyond Peripheral Nerves in Pure Neuritic Leprosy: An MR Imaging Study.","authors":"Sanjeev Kumar Bhoi, Suprava Naik, Yuvraj Lahre, Menka Jha, Suvendu Purkait, Priyanka Samal, Gautom Kumar Saharia, V R Sree Charan, Pritimayee Behera","doi":"10.3174/ajnr.A8562","DOIUrl":"10.3174/ajnr.A8562","url":null,"abstract":"<p><strong>Background and purpose: </strong>Pure neuritic leprosy (PNL) is an uncommon form of leprosy involving peripheral nerves alone. Some isolated case reports and observational studies have shown imaging changes in the CNS in patients with leprosy. This prospective observational study evaluates the involvement of the nervous system beyond peripheral nerve among patients with PNL with MR imaging.</p><p><strong>Materials and methods: </strong>We screened patients presenting with features of neuropathy and/or thickened nerves. Patients were subjected to detailed clinical examination, routine tests along with nerve conduction study, and biopsy of peripheral nerve, usually the sural nerve. MRI of brachial and lumbar plexus, dorsal root ganglia, spinal cord, and brain were evaluated in patients with histopathologically confirmed Hansen neuritis.</p><p><strong>Results: </strong>Of 86 patients screened for PNL, 52 were positive on nerve biopsy. Most patients were men (86.53%) and the mean age was 45.72 ± 15.25 years. Asymmetrical polyneuropathy was the most common nerve conduction study pattern in 55.76% (29/52) patients. We found abnormal imaging findings in 21 (40.38%) patients. Ganglionitis was the most common finding seen in 14 (26.92%) patients followed by plexitis (15.38%) and myelitis (11.53%). Patients with MRI lesions were younger and were found to have more functional impairment and raised CSF protein.</p><p><strong>Conclusions: </strong>In PNL, many patients have subclinical involvement of dorsal root ganglion, brachial plexus, lumbar plexus, and spinal cord. Exact pathophysiology of CNS involvement is not clear; however, imaging of the above-mentioned regions may help in early diagnosis and prevent complications. These MRI findings in PNL are important considerations when assessing patients with peripheral neuropathy.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"784-791"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging the Internal Auditory Canal with an 8 × 2 Transceiver Array Head Coil at 7T.","authors":"A Nada, J P Cousins, A Rivera, S B Carr, J Jones, C Minor, H P Hetherington, J H Kim, J W Pan","doi":"10.3174/ajnr.A8569","DOIUrl":"10.3174/ajnr.A8569","url":null,"abstract":"<p><p>7T neuroimaging has known problems with B₁ ⁺ strength, homogeneity and B₀ susceptibility that make imaging in the inferior brain regions difficult. We investigated the utility of a decoupled 8 × 2 transceiver coil and shim insert to image the internal auditory canal (IAC) and inferior brain in comparison to the standard Nova 8/32 coil. B₁ ⁺, B₀, and the T2 sampling perfection with application-optimized contrasts by using flip angle evolution sequence (SPACE) were compared by using research and standard methods in <i>n</i> = 8 healthy adults by using a Terra system. A T2 TSE was also acquired, and 2 neuroradiologists evaluated structures in and around the IAC, blinded to the acquisition, by using a 5-point Likert scale. The Nova 8/32 coil gave lower B₁ ⁺ inferiorly compared with the whole brain while the transceiver maintained similar B₁ ⁺ throughout. SPACE images showed that the transceiver performed significantly better, e.g., the transceiver scored 4.0 ± 0.8 in the left IAC, compared with 2.5 ± 0.8 with the Nova 8/32. With T2-weighted imaging that places a premium on refocusing pulses, these results show that with improved B₁ ⁺ performance inferiorly, good visualization of the structure of the IAC and inferior brain regions is possible at 7T.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"852-858"},"PeriodicalIF":0.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}