AJNR. American journal of neuroradiology最新文献

{"title":"The Generation Gap in Work Values Has Hit Medical Training.","authors":"John C Benson","doi":"10.3174/ajnr.A8608","DOIUrl":"10.3174/ajnr.A8608","url":null,"abstract":"","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"225-226"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nidus of Brain AVMs: What If We Hadn't Understood Anything?","authors":"Frédéric Clarençon, Eimad Shotar, Charbel Mounayer, Nader-Antoine Sourour, René Chapot","doi":"10.3174/ajnr.A8515","DOIUrl":"10.3174/ajnr.A8515","url":null,"abstract":"","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"452-453"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor regarding \"Automated Volumetric Software in Dementia: Help or Hindrance to the Neuroradiologist?\"","authors":"Dirk Smeets","doi":"10.3174/ajnr.A8570","DOIUrl":"10.3174/ajnr.A8570","url":null,"abstract":"","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"454-455"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meningioma: Molecular Updates from the 2021 World Health Organization Classification of CNS Tumors and Imaging Correlates.","authors":"Neetu Soni, Manish Ora, Girish Bathla, Denes Szekeres, Amit Desai, Jay J Pillai, Amit Agarwal","doi":"10.3174/ajnr.A8368","DOIUrl":"10.3174/ajnr.A8368","url":null,"abstract":"<p><p>Meningiomas, the most common primary intracranial neoplasms, account for more than one-third of primary CNS tumors. While traditionally viewed as benign, meningiomas can be associated with considerable morbidity, and specific meningioma subgroups display more aggressive behavior with higher recurrence rates. The risk stratification for recurrence has been primarily associated with the World Health Organization (WHO) histopathologic grade and extent of resection. However, a growing body of literature has highlighted the value of molecular characteristics in assessing recurrence risk. While maintaining the previous classification system, the 5th edition of the 2021 WHO Classification of Central Nervous System tumors (CNS5) book expands upon the molecular information in meningiomas to help guide management. The WHO CNS5 stratifies meningioma into 3 grades (1-3) based on histopathology criteria and molecular profile. The telomerase reverse transcriptase promoter mutations and cyclin-dependent kinase inhibitor 2A/B (<i>CDKN2A</i>/<i>B)</i> deletions now signify a grade 3 meningioma with increased recurrence risk. Tumor location also correlates with underlying mutations. Cerebral convexity and most spinal meningiomas carry a 22q deletion and/or NF2 mutations, while skull base meningiomas have <i>AKT1</i>, <i>TRAF7</i>, <i>SMO</i>, and/or <i>PIK3CA</i> mutations. MRI is the primary imaging technique for diagnosing and treatment-planning of meningiomas, while DOTATATE PET imaging offers supplementary information beyond anatomic imaging. Herein, we review the evolving molecular landscape of meningiomas, emphasizing imaging/genetic biomarkers and treatment strategies relevant to neuroradiologists.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"240-250"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Expansion and Contraction of Multiple Sclerosis T2-Weighted Hyperintense Lesions Are Present below the Threshold of Visual Perception.","authors":"Darin T Okuda, Tatum M Moog, Morgan McCreary, Kevin Shan, Kasia Zubkow, Braeden D Newton, Alexander D Smith, Mahi A Patel, Katy W Burgess, Christine Lebrun-Frénay","doi":"10.3174/ajnr.A8453","DOIUrl":"10.3174/ajnr.A8453","url":null,"abstract":"<p><strong>Background and purpose: </strong>The study of T2-weighted hyperintense lesions resulting from autoimmune inflammatory injury and associated volumes within the CNS remains fundamental to the diagnosis and disease surveillance of MS. We investigated the dynamic changes of individual T2-weighted hyperintense MS lesions on MRI and hypothesized that variations may be present below the threshold of visual perception when evaluating longitudinal data.</p><p><strong>Materials and methods: </strong>A retrospective study was performed of people with MS, incorporating data from 3 consecutive MRI time points acquired within a single academic center. All included MRI studies lacked formal imaging interpretations of newly enlarging or contracting T2-weighted hyperintensities. Well-defined, noncoalescing, individual T2-weighted hyperintense lesions were targeted. A total of 8-12 lesions were randomly selected in a blinded fashion at MRI time point 1 and 3D lesion volumes were followed over MRI time points 2 and 3. The impact of treatment on lesion expansion and relationship to brain MRI advancement, patient-reported progression of disease, and physician-identified progression was also studied.</p><p><strong>Results: </strong>The study cohort comprised 115 people (81 (70.4%) women; mean disease duration of 9.36 years [standard deviation: 7.72 years]) who were primarily White (79.1%). A total of 1426 focal T2-weighted hyperintense MS lesions were identified on MRI time point 1 and longitudinally followed over MRI time points 2 and 3. In the evaluation of raw changes in individual T2-weighted hyperintense lesion volumes from MRI time point 1 to MRI time point 2, a similar number of individuals were observed with predominantly expanding (49/115; 42.6%) or contracting (51/115; 44.3%) lesions. However, most lesions expanded in volume (48/115; 41.7%) versus those that contracted (45/115; 39.1%) when evaluating MRI time point 3 to time point 1. Those individuals not on active treatment had a 67.15% reduction in the odds of more individual lesions predominantly contracting in volume relative to those on low-efficacy disease modifying therapy treatment (95% CI = [-83.89% to -33.01%], <i>P</i> = .0008) and 74.02% reduction relative to high-efficacy treatment individuals (95% CI = [-87.37% to -46.56%], <i>P</i> < .0001).</p><p><strong>Conclusions: </strong>Dynamic changes in T2-weighted hyperintense lesions are abundant, occurring below the threshold of visual perception and are present more frequently in untreated individuals.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"443-450"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomics-Based Differentiation of Glioblastoma and Metastatic Disease: Impact of Different T1-Contrast-Enhanced Sequences on Radiomics Features and Model Performance.","authors":"Girish Bathla, Camila G Zamboni, Nicholas Larson, Yanan Liu, Honghai Zhang, Nam H Lee, Amit Agarwal, Neetu Soni, Milan Sonka","doi":"10.3174/ajnr.A8470","DOIUrl":"10.3174/ajnr.A8470","url":null,"abstract":"<p><strong>Background and purpose: </strong>Even though glioblastoma (GB) and brain metastases (BM) can be differentiated using radiomics, it remains unclear if the model performance may vary based on the contrast-enhanced sequence used. Our aim was to evaluate the radiomics-based model performance for differentiation between GB and brain metastases BM using MPRAGE and volumetric interpolated breath-hold examination (VIBE) T1-contrast-enhanced sequence.</p><p><strong>Materials and methods: </strong>T1 contrast-enhanced (T1-CE) MPRAGE and VIBE sequences acquired in 108 patients (31 GBs and 77 BM) during the same MRI session were retrospectively evaluated. After standardized image preprocessing and segmentation, radiomics features were extracted from necrotic and enhancing tumor components. Pearson correlation analysis of radiomics features from tumor subcomponents was also performed. A total of 90 machine learning pipelines were evaluated using a 5-fold cross-validation. Performance was measured by mean area under the curve (AUC)-receiver operating characteristic (ROC), log loss, and Brier scores.</p><p><strong>Results: </strong>A feature-wise comparison showed that the radiomics features between sequences were strongly correlated, with the highest correlation for shape-based features. The mean AUC across the top 10 pipelines ranged between 0.851 and 0.890 with T1-CE MPRAGE and between 0.869 and 0.907 with the T1-CE VIBE sequence. The top-performing models for the MPRAGE sequence commonly used support vector machines, while those for the VIBE sequence used either support vector machines or random forest. Common feature-reduction methods for top-performing models included linear combination filter and least absolute shrinkage and selection operator for both sequences. For the same machine learning feature-reduction pipeline, model performances were comparable (AUC-ROC difference range, -0.078-0.046).</p><p><strong>Conclusions: </strong>Radiomics features derived from T1-CE MPRAGE and VIBE sequences are strongly correlated and may have similar overall classification performance for differentiating GB from BM.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"321-329"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Vascular Loops within the Internal Auditory Meatus or Contacting the Vestibulo-Cochlear Nerve with Audiovestibular Symptoms: A Systematic Review and Meta-Analysis.","authors":"Jake E Cowen, Mehrshad Sultani Tehrani, Steve E J Connor","doi":"10.3174/ajnr.A8486","DOIUrl":"10.3174/ajnr.A8486","url":null,"abstract":"<p><strong>Background: </strong>Intrameatal vascular loops (IVL) entering the internal auditory meatus and neurovascular contact (NVC) with the vestibulocochlear nerve (cranial nerve [CN] VIII) have been proposed to have a relationship with audiovestibular symptoms.</p><p><strong>Purpose: </strong>This systematic review and meta-analysis aimed to determine whether the presence of IVLs and CN VIII NVC on MRI is associated with tinnitus, sensorineural hearing loss (SNHL), or vertigo and any specific subtypes.</p><p><strong>Data sources: </strong>All studies comparing the presence of IVL or CN VIII NVC in ears with these audiovestibular symptoms and controls were identified through MEDLINE, EMBASE, the Web of Science Core Collection, Scopus, and the Cochrane Register of Controlled Trials databases.</p><p><strong>Study selection: </strong>Sixteen studies and 3455 ears (1526 symptomatic ears and 1929 control ears) were included.</p><p><strong>Data analysis: </strong>Meta-analysis was performed using a bivariate random effects model. Pooled ORs were calculated, and heterogeneity was evaluated with the Cochran Q test with statistical significance defined as <i>P</i> < .05.</p><p><strong>Data synthesis: </strong>There was no significant association between the presence of undefined tinnitus or SNHL and IVL (OR, 0.90; 95% CI, 0.47-1.70; OR, 0.67; 95% CI, 0.36-1.25) or CN VIII NVC (OR, 1.15; 95% CI, 0.68-1.95; OR, 0.89; 95% CI, 0.33-2.40). However, the subgroup of sudden onset SNHL was associated with IVL (OR, 1.34; 95% CI, 1.04-1.73) (<i>P</i> = .02). There was no significant difference in the prevalence of IVL (OR, 0.97; 95% CI 0.64-1.48) or CN VIII NVC (OR, 0.99; 95% CI, 0.42-2.32) between ears with undefined vertigo and control ears. However, there was an association between the presence of CN VIII NVC and the specific diagnosis of vestibular paroxysmia (OR, 13.19; 95% CI, 2.09-83.16) (<i>P</i> = .006).</p><p><strong>Limitations: </strong>Our meta-analysis is limited by selection bias, the small number of eligible studies, and moderate heterogeneity.</p><p><strong>Conclusions: </strong>IVL or CN VIII NVC on MRI is unrelated to symptoms of undefined tinnitus, SNHL, and vertigo. However, CN VIII NVC is associated with vestibular paroxysmia, while IVL is associated with sudden onset SNHL.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"372-379"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Technical Performance of Bilateral Decubitus CT Myelography Using Standard versus Increased Intrathecal Iodinated Contrast Volume.","authors":"Diogo G L Edelmuth, Renata V Leão, Eduardo N K Filho, Marcio N P Souza, Marcelo Calderaro, Peter G Kranz","doi":"10.3174/ajnr.A8436","DOIUrl":"10.3174/ajnr.A8436","url":null,"abstract":"<p><strong>Background and purpose: </strong>Lateral decubitus CT myelography (LDCTM) is one of the main studies for the detection of CSF-venous fistulas, but detection of CSF-venous fistulas is dependent on intrathecal contrast attenuation. The purpose of this investigation was to assess the tolerability and technical performance of increased intrathecal doses of myelographic contrast compared with standard doses.</p><p><strong>Materials and methods: </strong>This is a retrospective series of 24 patients who underwent LDCTM following administration of either 10 or 20 mL of intrathecal iodinated contrast media (300 or 320 mg/mL of iodine content). Patients were scanned in the initial lateral decubitus position and then turned to the contralateral side and re-scanned in the same session. The safety and tolerability of the 20 mL dose was assessed from clinical records. The technical performance of the studies was compared between groups (10 or 20 mL) by measuring attenuation values over the lateral thecal sac at standardized levels. Both the initial scan and the scan after turning the patient to the contralateral side were assessed.</p><p><strong>Results: </strong>No moderate or severe adverse event was recorded in either group. The 20-mL group showed higher attenuation values, which were statistically greater on the second side examined compared with the standard-dose group.</p><p><strong>Conclusions: </strong>Increased volume of intrathecal contrast was well-tolerated and improved the technical performance of LDCTM in this limited series. Further assessment of the safety and impact on diagnostic yield using larger patient cohorts is warranted.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"401-407"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular Thrombectomy versus Medical Management for Acute Basilar Artery Occlusion Stroke in the Elderly.","authors":"Huanwen Chen, Marco Colasurdo, Mihir Khunte, Ajay Malhotra, Dheeraj Gandhi","doi":"10.3174/ajnr.A8473","DOIUrl":"10.3174/ajnr.A8473","url":null,"abstract":"<p><strong>Background and purpose: </strong>The efficacy and safety of endovascular thrombectomy (EVT) for elderly patients with basilar artery occlusion (BAO) stroke is unclear. The purpose of this study is to investigate the safety and efficacy of EVT for elderly BAO stroke patients.</p><p><strong>Materials and methods: </strong>This was an explorative retrospective analysis of the 2016-21 National Inpatient Sample in the United States. Elderly patients with BAO stroke (80 years of age or older) with an NIHSS score of at least 5 were included. Primary outcome was discharge home. Secondary outcomes included in-hospital mortality and intracranial hemorrhage (ICH). Outcomes were compared between patients treated with EVT and those treated with medical management (MM) alone. Propensity score matching (PSM) was performed to control confounders. Subgroup analyses were conducted for patients who did and did not receive IV thrombolysis (IVT).</p><p><strong>Results: </strong>We identified 2520 elderly patients with BAO stroke; 830 received EVT and 1690 received MM alone. After PSM, 1115 patients and 715 patients remained in the MM and EVT groups, respectively. Compared with PSM controls, EVT was not significantly associated with different rates of home discharge (17.5% versus 12.2%; OR, 1.36 [95% CI, 0.76-2.44], <i>P</i> = .30) or in-hospital mortality (31.5% versus 32.9%; OR, 1.00 [95% CI, 0.63-1.60], <i>P</i> = .99), but it was significantly associated with higher rates of ICH (18.2% versus 7.3%; OR, 2.69 [95% CI, 1.41-5.15], <i>P</i> = .003). Among patients who did not receive IVT, EVT was significantly associated with higher rates of home discharge (21.5% versus 11.5%; OR, 1.93 [95% CI, 1.02-3.66], <i>P</i> = .044), whereas EVT was not significantly associated with a different rate of home discharge among those treated with IVT (5.6% versus 15.0%; OR, 0.28 [95% CI, 0.05-1.46], <i>P</i> = .13). Interaction analysis revealed that IVT was a negative modulator of the positive association of EVTs with home discharge (interaction <i>P</i> = .031).</p><p><strong>Conclusions: </strong>EVT was not significantly associated with more favorable hospitalization outcomes for elderly patients with BAO stroke, and it was significantly associated with an increased risk of ICH. EVT may be an effective treatment for patients who did not receive IVT.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"278-284"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Imaging Findings between Granulomatosis with Polyangiitis and Eosinophilic Granulomatosis with Polyangiitis on Sinus CT: Importance of High-Density Opacification of the Paranasal Sinuses.","authors":"Inseon Ryoo, Serena Poésy, Artem Kaliaev, Karen Buch, Osamu Sakai","doi":"10.3174/ajnr.A8485","DOIUrl":"10.3174/ajnr.A8485","url":null,"abstract":"<p><strong>Background and purpose: </strong>Granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA) are the most common causes of chronic sinusitis from systemic granulomatous diseases. While both are small- to medium-sized vasculitis with necrotizing granulomas, they have different clinical courses and prognoses. High-density sinus opacification has been reported in allergic fungal sinusitis with eosinophilic infiltrates. Given that EGPA also has eosinophilic tissue infiltrates, we evaluated the differences in sinus CT findings, focusing on the sinus secretion attenuation between patients with GPA and EGPA, along with other previously described findings.</p><p><strong>Materials and methods: </strong>This study included 31 patients with GPA and 22 patients with EGPA who underwent sinus CT. The attenuation of secretions within the paranasal sinuses was visually assessed, and the Hounsfield unit (HU) of the highest-density portions within each sinus was measured. Lund-Mackay scores (LMS), bony destruction, sclerotic wall changes, adjacent organ involvement, and nasal polyps were evaluated and compared between patients with GPA and EGPA. Multiple logistic regression analyses were conducted to determine which factors independently discriminated GPA from EGPA, and the diagnostic ability to differentiate between these 2 diseases was evaluated by using a receiver operating characteristic curve analysis.</p><p><strong>Results: </strong>More patients in the GPA group showed bony destructions, bone sclerosis, and involvement of organs adjacent to paranasal sinuses than in the EGPA group (<i>P</i> = .006, 0.048, and 0.035, respectively). The EGPA group had higher LMS and more nasal polyps than the GPA group (<i>P</i> = .078 and 0.333, respectively). More patients in the EGPA group showed internal high-density opacification than in the GPA group, and patients with EGPA had higher mean HUs (both <i>P</i> < .0001). The presence of high-density opacification or mean HUs independently distinguished GPA from EGPA (OR, 53.67 and 1.07; 95% CI, 4.07-708.03 and 1.02-1.13, respectively) and showed a greater ability to discriminate between these diseases compared with other findings.</p><p><strong>Conclusions: </strong>Patients with EGPA had more high-density sinus opacification and higher mean HU on sinus CT than the patients with GPA. In addition to the previously reported CT findings, such as bony destruction, bone sclerosis, and adjacent organ involvement, evaluating secretion attenuation can assist in distinguishing between GPA and EGPA.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":"355-361"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}