AJNR. American journal of neuroradiology最新文献

{"title":"Associations between Paramagnetic Rim Lesions and Gadolinium Contrast Permeability of Perivascular Spaces in Patients with Multiple Sclerosis: A T1 mapping study.","authors":"Hye Hyeon Moon, Eunseon Jeong, Muhannad Alanazi, Yoonho Nam, Sugil Kim, Da-Young Seo, Eun-Jae Lee, Ho Sung Kim, Yangsean Choi","doi":"10.3174/ajnr.A9405","DOIUrl":"https://doi.org/10.3174/ajnr.A9405","url":null,"abstract":"<p><strong>Purpose: </strong>Paramagnetic rim lesions (PRLs) are established biomarkers of chronic active inflammation in patients with multiple sclerosis (MS). Gadolinium enhancement in basal ganglia perivascular spaces (BGPVS), reflecting blood-brain barrier (BBB) permeability, represents an emerging but underexplored marker of neurovascular dysfunction. This study primarily investigated whether PRL burden is independently associated with BGPVS gadolinium enhancement. Secondarily, choroid plexus (CP) volume and the DTI-based Analysis along the Perivascular Space (ALPS) index were compared between patients with MS and healthy controls as exploratory glymphatic markers.</p><p><strong>Materials and methods: </strong>This retrospective study (Nov 2023-Aug 2024) included patients with MS and age- and sex-matched controls who underwent 3T MRI with pre- and post-contrast T1 mapping and quantitative susceptibility mapping (QSM). PRLs were counted on QSM. Post-gadolinium BGPVS T1 enhancement, white matter hyperintensity (WMH) volume, CP volume fraction, and the ALPS index were quantified. Correlation, partial correlation adjusted for age and sex, and multivariable Poisson regression analyses with Benjamini-Hochberg false discovery rate correction identified predictors of PRL burden.</p><p><strong>Results: </strong>A total of 144 patients with MS (mean age, 44 years ± 13 years; 105 females) and 34 controls (mean age, 49.9 years ± 16.6 years; 18 females) were evaluated. Compared with the controls, patients with MS had a lower ALPS index (1.44 ± 0.20 vs 1.56 ± 0.17; P=0.01), higher CP volume fraction (0.21% ± 0.05% vs 0.19% ± 0.04%; P=0.04), and greater BGPVS enhancement (absolute ΔT1, 92.8 ms ± 22.9 ms vs 80.7 ms ± 16.8 ms; P=0.02). The PRL count was negatively correlated with age (r=-0.378, P<0.001) and positively correlated with WMH volume (r=0.437, P<0.001) and BGPVS enhancement (r=0.219, P=0.02). After adjusting for age and sex, partial correlations confirmed significant associations between PRL count and WMH volume (r=0.477, q<0.001), CP volume fraction (r=0.297, q<0.001), and BGPVS enhancement (r=0.346, q<0.001). Multivariable Poisson regression confirmed younger age (IRR=0.91, P<0.001), higher WMH volume (IRR=1.87, P<0.001), CP volume fraction (IRR=1.46, P<0.001), and BGPVS enhancement (IRR=1.47, P<0.001) as independent predictors of PRL count.</p><p><strong>Conclusion: </strong>PRL burden is independently associated with increased gadolinium permeability of BGPVS, linking focal chronic active inflammation to broader blood-brain-barrier dysfunction in patients with MS.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of an Integrated Photon-Counting Detector CT Angiography Reconstruction Protocol for Carotid Artery Stents.","authors":"Masahiro Nakashima, Tatsuya Kawai, Kazuhisa Matsumoto, Takatsune Kawaguchi, Nobuo Kitera, Seita Watanabe, Akio Hiwatashi","doi":"10.3174/ajnr.A9398","DOIUrl":"https://doi.org/10.3174/ajnr.A9398","url":null,"abstract":"<p><strong>Background and purpose: </strong>To evaluate an integrated protocol and to improve image quality for follow-up after carotid artery stenting (CAS) using photon-counting CT (PCD-CT) angiography.</p><p><strong>Materials and methods: </strong>Patients who underwent CT angiography (CTA) after CAS using PCD-CT in 2023-2025 were included. We predefined an integrated reconstruction protocol that combines multiple reconstruction parameters into a clinically applicable configuration under practical feasibility constraints, and that can be consistently applied to all cases. Reconstruction parameters were as follows: slice thickness, 0.4mm; field-of-view, 120mm; kernel, Qr56; iterative reconstruction, QIR3; virtual monoenergetic image, 55keV, metal artifact reduction algorithm, off. We quantitatively measured in-stent luminal contrast-to-noise ratio (CNR), stent edge rise slope (ERS), and in-stent luminal artifact index inside stents (AI). We qualitatively assessed in-stent luminal image quality (IQ), stent edge sharpness, and in-stent luminal noise. We compared integrated protocol to our institution conventional protocol. Linear mixed-effects models were used for statistical analyses.</p><p><strong>Results: </strong>31 patients (median 77 years [71-79], 31 men) were included. Using conventional protocol as the reference, integrated protocol showed β = 34.5 (95%CI, 30.0 to 39.0; P < 0.001) in CNR, β = 1727 (95%CI, 1697 to 1759; P < 0.001) in ERS, β = -39.6 (95%CI, -44.9 to -34.4; P < 0.001) in AI, β = 2.15 (95%CI, 2.04 to 2.27; P < 0.001) in OIQ, β = 1.75 (95%CI, 1.65 to 1.85; P < 0.001) in sharpness, β = 1.15 (95%CI, 1.04 to 1.27; P < 0.001) in noise.</p><p><strong>Conclusion: </strong>Integrated protocol for CAS using PCD-CT yielded superior qualitative and quantitative performance compared with the conventional protocol.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel neuroimaging biomarker of cortical gray/white border integrity in blast related-mTBI.","authors":"V Carlota Andreu Arasa, Francesca C Fortebaugh, Aubrey A Knoff, Catherine B Fortier, William P Milberg, David H Salat","doi":"10.3174/ajnr.A9347","DOIUrl":"10.3174/ajnr.A9347","url":null,"abstract":"<p><strong>Background: </strong>Recent studies suggest that blast or mid impact neurotrauma are characterized by scar-border forming astrogliosis at the gray-white matter junction. Individuals with mTBI and blast trauma have increased neuroinflammation and impairment of axonal remyelination on post-mortem histopathology. However, there are currently only limited methodologies to use in the assessment of the cortical gray/white interface using in vivo neuroimaging.</p><p><strong>Purpose: </strong>To investigate the gray-white matter contrast at the gray-white matter junction that may be linked to neuroinflammation/astrogliosis in the setting of blast exposure and/or mTBI, through 3D T1 weighted magnetization prepared rapid gradient-echo (MP-RAGE) images.</p><p><strong>Materials and methods: </strong>Post-9/11 Veterans (n=723) from the Translational Research Center for TBI and Stress disorders (TRACTS) completed MR imaging. Participants were grouped into 4 categories: Participants with a history of blast-related mTBI (blast-mTBI); participants with a history of mTBI due to other mechanical forces (blunt-mTBI); participants with history of close blast exposure but no mTBI; and those without history of lifetime mTBI or close bast exposure. MR imaging data processing for morphometry and cortical surface mapping was done using FreeSurfer image analysis. Signal intensities in gray and white matter along the cortical and white matter interface were used to calculate mean gray-white matter contrast value (GWC).</p><p><strong>Results: </strong>Veterans in the blast-mTBI group showed diffuse patterns of increased GWC relative to the other groups, particularly in the frontotemporal lobes. This effect was driven primarily by a greater number of high GWC in the blast-mTBI group compared to the no-neurotrauma and blunt-mTBI groups.</p><p><strong>Conclusion: </strong>There was diffuse increased GWC on MR in the blast-mTBI group compared to the no neurotrauma, close blast exposure and blunt-mTBI groups. These findings may be linked to astrogliosis and neuroinflammation in blast-mTBI patients. Histopathologic correlation with imaging findings will be necessary to better understand these effects.</p><p><strong>Summary statement: </strong>A novel neuroimaging biomarker of diffuse increases in contrast at the gray-white matter junction in bast-mTBI may be linked to neuroinflammation and may be related to changes in myelin and/or astrogliosis.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment-Related Factors Associated with Hemorrhagic Transformation and Hemorrhagic Subtypes after Mechanical Thrombectomy for Acute Ischemic Stroke.","authors":"Marie K Luff, Nicole Khezri, Salvador Miralbés, Bharath Naravetla, Alejandro M Spiotta, Christian Loehr, Mario Martínez-Galdámez, Ryan A McTaggart, Luc Defreyne, Vega Pedro, Osama O Zaidat, Lori Lyn Price, Rishi Gupta, Markus A Möhlenbruch, David S Liebeskind","doi":"10.3174/ajnr.A9401","DOIUrl":"https://doi.org/10.3174/ajnr.A9401","url":null,"abstract":"<p><strong>Background and purpose: </strong>Clinical studies rarely examine associations between acute ischemic stroke (AIS) treatment factors and the development of radiographic intracranial hemorrhage (ICH) that is independent of symptomatic change. Additionally, few studies perform detailed analysis of subtypes of ICH after mechanical thrombectomy (MT). The objective of this study was to examine the associations between participants and treatment-related interventions, radiographic ICH, and hemorrhagic subtypes in a large cohort of patients treated with MT for AIS.</p><p><strong>Materials and methods: </strong>A participant cohort across 71 global sites (n=1453) was analyzed using a multivariable imputed regression models to examine participant and treatment-related variables associated with ICH and with hemorrhagic subtypes.</p><p><strong>Results: </strong>581/1453 (40.0%) participants developed ICH at the 24-hour timepoint after MT. HI-1, HI-2, and SAH subtypes were most common. In a multivariable model, M2 occlusions (when compared with ICA occlusions) and achieving final pass eTICI of 2c or greater were protective against any ICH (OR = 0.68, CI [0.48, 0.96], p=0.03; OR = 0.79, CI [0.64, 0.97], p=0.02). M2 occlusions were significantly associated with SAH when compared to ICA occlusions (OR = 1.93, CI [1.11, 3.36], p=0.02).</p><p><strong>Conclusions: </strong>The treatment-related variables of treating a M2 occlusion and obtaining a final pass eTICI of 2c or greater were protective against ICH after adjusting for patient variables. More investigation is needed in determining the relationship between M2-segment occlusions and SAH.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Visualization of the Round Window Niche Veil using Photon-Counting Detector CT.","authors":"Kaden M Neuberger, Paul F Farnsworth, John I Lane, Matthew L Carlson, Blake A Kassmeyer, Shuai Leng, Daniele Marchioni, John C Benson","doi":"10.3174/ajnr.A9399","DOIUrl":"https://doi.org/10.3174/ajnr.A9399","url":null,"abstract":"<p><strong>Background and purpose: </strong>The round window niche veil (RWNV) is a potential anatomic barrier at the round window niche due to thickened middle ear mucosa or fibrosis that either partially or completely covers the niche and may prevent intratympanic medication efficacy. This study aimed to characterize the <i>in vivo</i> capability of photon-counting-detector (PCD) CT to visualize the RWNV.</p><p><strong>Materials and methods: </strong>80 PCD-CT temporal bones were included in the study between April and June 2025. Two experienced neuroradiologists independently reviewed each scan and assigned each with one of the following scores: 1: partial veil seen with or without fluid, 2: complete veil seen with or without fluid, 3: no round window niche veil, and 4: not seen, complete round window niche opacification.</p><p><strong>Results: </strong>PCD-CT visualized either partial or complete RWNV in 43.8% of ears. Further, the RWNV was not visualized in 48.8% of ears when the round window was clear. In 7.5% of ears, complete opacification of the round window niche was noted without visualization of a RWNV. The presence or absence of RWNV visualization demonstrated high inter-rater reliability with unweighted kappa of 0.81 (0.69, 0.92).</p><p><strong>Conclusions: </strong>PCD-CT may visualize the round window niche veil <i>in vivo</i> and may be helpful in determining if the round window niche is patent.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Slices to Surfaces: The Feasibility of Fetal Brain Biometry Using 3D Slice-to-Volume MRI in Clinical Practice.","authors":"Nicole Steinhardt, Darragh Brady, Anna Baer, Kartik Reddy, Zhulin He, Ayushi Vashishtha, Eswar Damaraju, Binjian Sun, Amy R Mehollin-Ray, Adam E Goldman-Yassen","doi":"10.3174/ajnr.A9397","DOIUrl":"https://doi.org/10.3174/ajnr.A9397","url":null,"abstract":"<p><strong>Background and purpose: </strong>Fetal brain biometry on magnetic resonance imaging (MRI) is essential for assessing neurodevelopment, but the standard-of-care two-dimensional (2D) acquisitions are susceptible to motion artifact and planar obliquity, which can compromise measurement accuracy. This study aimed to evaluate the feasibility, reliability, and efficiency of performing standard fetal brain biometry on multiplanar reconstructions (MPRs) generated with slice-to-volume reconstruction (SVR) compared with the conventional 2D approach.</p><p><strong>Materials and methods: </strong>This IRB-approved retrospective study included twenty consecutive fetal MRI examinations with normal-appearing brains and indications other than central nervous system abnormalities. Three fellowship-trained pediatric neuroradiologists independently measured eight key biometric parameters on both standard 2D Half-Fourier Acquisition Single-shot Turbo spin-Echo (HASTE) images and on MPRs from SVR volumes. Inter-rater reliability was assessed using the intraclass correlation coefficient (ICC). Measurement differences, subjective image quality (0-3 scale), and measurement time were compared using the paired Wilcoxon signed-rank test.</p><p><strong>Results: </strong>Excellent inter-rater reliability was observed for all biometric parameters on both 2D (ICC range, 0.87-0.99) and SVR images (ICC range, 0.93-0.99). The median image quality score was significantly higher for 3D SVR images (3) compared with 2D images (2) across all raters (p <0.001). Measurement time was significantly shorter with SVR than with 2D images. While overall 2D and SVR measurements were similar across raters, corpus callosum length was consistently and significantly smaller on SVR images for all raters.</p><p><strong>Conclusions: </strong>Fetal brain biometry using SVR is a feasible, reliable, and efficient alternative to standard 2D imaging. The technique provides superior image quality and reduces measurement time while maintaining excellent inter-rater reliability. The systematic difference in corpus callosum measurements suggests that 3D SVR may improve accuracy by correcting for measurement bias inherent in oblique 2D acquisitions.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Motion-Sensitized Driven Equilibrium-Prepared Inversion Recovery TSE Sequence for Ulnar Nerve MR Neurography.","authors":"Guanghui Hong, Junhuan Hong, Dongmei Jiang, Xiang Lin, Yuwei Pan, Pingping He, Minxuan Tian, Dejun She","doi":"10.3174/ajnr.A9393","DOIUrl":"https://doi.org/10.3174/ajnr.A9393","url":null,"abstract":"<p><strong>Background and purpose: </strong>Conventional inversion recovery TSE for ulnar neuropathy has limited venous and muscle suppression, requiring contrast agents. Improved motion-sensitized driven equilibrium (iMSDE) utilizes T2 magnetization preparatory pulse and diffuse gradient field to suppress venous and muscle signal. This study aimed to evaluate ability of inversion recovery TSE with iMSDE for visualizing ulnar neuropathy.</p><p><strong>Materials and methods: </strong>Twenty-nine patients (52.3 ± 15.8 years; 17 men) with suspected ulnar neuropathy at the elbow underwent 3T MRI including non-contrast, contrast-enhanced, iMSDE inversion recovery TSE. A four-point Likert scale was used to evaluate overall image quality, nerve visualization, muscle/fat/vein suppression, and diagnostic confidence. The SNR contrast-to-noise ratio for nerve-to-background, and contrast ratio for nerve-to-background were calculated. The nerve cross-sectional area was evaluated between MR and ultrasound.</p><p><strong>Results: </strong>The iMSDE inversion recovery TSE yielded the highest subjective muscle suppression scores and greatest nerve-to-muscle contrast ratio (<i>p</i> < 0.001) among sequences. Compared with non-contrast sequence, iMSDE inversion recovery TSE provided superior nerve visualization, venous suppression, diagnostic confidence, and nerve-to-vein contrast-to-noise (all <i>p</i> < 0.001). Relative to contrast-enhanced sequence, iMSDE inversion recovery TSE demonstrated equivalent nerve visualization, venous suppression, and diagnostic confidence (<i>p</i> > 0.05). The iMSDE inversion recovery TSE showed excellent agreement with ultrasound cross-sectional area measurements. The cross-sectional area values correlated moderately with compound muscle action potential amplitudes (<i>r</i> = -0.679, <i>p</i> = 0.02).</p><p><strong>Conclusions: </strong>The iMSDE inversion recovery TSE can clearly visualize the morphology and pathologic changes of ulnar nerve, providing a feasible alternative method to detect ulnar neuropathy.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI Features for Differentiation of Meningioma DNA Methylation Groups.","authors":"Theresa J Yu, Tracy Luks, Evan Calabrese, Abrar Choudhury, William C Chen, Michael W McDermott, Stephen T Magill, David R Raleigh, Javier E Villanueva-Meyer","doi":"10.3174/ajnr.A9396","DOIUrl":"https://doi.org/10.3174/ajnr.A9396","url":null,"abstract":"<p><strong>Background: </strong>DNA methylation profiling is a predictor of meningioma behavior and outcomes. We aimed to identify qualitative and quantitative MRI features to distinguish between three meningioma methylation groups: Merlin-intact, Immune-enriched, and Hypermitotic, each with distinct clinical outcomes, biologic features, and therapeutic vulnerabilities.</p><p><strong>Materials and methods: </strong>Preoperative MRIs were retrospectively analyzed in meningiomas with previous DNA methylation profiling. Pearson's Chi-square, Fisher exact, and ANOVA tests were used to compare features between the three groups. ROC AUCs were used to assess the accuracy in discriminating between groups.</p><p><strong>Results: </strong>165 patients (54 years ± 14 SD; 58 men) were analyzed. 60 meningiomas were Merlin-intact, 55 Immune-enriched, and 50 Hypermitotic. Qualitative reduced diffusion (<i>p</i>< .001), nADC (<i>p</i>< .001), T2WI signal intensity (<i>p</i>= .02), T1 CE volume (<i>p</i><.005), and tumor site (<i>p</i><.001) varied between the groups. Merlin-intact meningiomas had higher T2WI signal intensity than Immune-enriched tumors (1.97 ± 0.98 vs 1.63 ± 0.45, <i>p</i>= .04). Hypermitotic meningiomas had the highest proportion of tumors with qualitative reduced diffusion (67%) and lowest nADC values (1.07 ± 0.14) compared to Merlin-intact (18%, <i>p</i>< .001; 1.41 ± 0.30, <i>p</i>< .001) and Immune-enriched (31%, <i>p</i>= .02; 1.29 ± 0.29, <i>p</i>= .002) meningiomas. The presence of qualitative reduced diffusion (AUC 0.71, <i>p</i>= .001) and lower nADC (AUC 0.82, <i>p</i>< .001) were able to predict Hypermitotic meningiomas. Merlin-intact tumors were predicted by the absence of qualitative reduced diffusion (AUC 0.66, <i>p</i>= 0.01), higher nADC (AUC 0.74, <i>p</i>< .001), and higher T2WI signal intensity (AUC 0.64, <i>p</i>= .047). Hypermitotic tumors (64.3 cm³ ± 49.1) had larger T1CE volumes than Merlin-intact (42.5 cm³ ± 37.9, <i>p</i>= .02) and Immune-enriched (38.2 cm³ ± 37.7, <i>p</i>=<.002) tumors, with tumor size a predictor of Hypermitotic (AUC 0.65, <i>p</i>=.003) and Immune-enriched (AUC 0.62, <i>p</i>=.02) meningiomas. Merlin-intact tumors were predicted by presence at the skull base (AUC 0.67, <i>p</i><.001) while Immune-enriched tumors were predicted by location outside of the skull base (AUC 0.61; 95% CI 0.70, 0.52, <i>p</i>= .02).</p><p><strong>Conclusions: </strong>MR imaging has the potential to discriminate between different molecular groups of meningioma and to serve as a surrogate non-invasive marker of tumor behavior.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flow Diverter Braid Deformation: Anatomy of a Controversy.","authors":"Luca Scarcia, Frédéric Clarençon","doi":"10.3174/ajnr.A9202","DOIUrl":"10.3174/ajnr.A9202","url":null,"abstract":"","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internal Cerebral Vein Doppler Velocities Reflect Maturational Changes and Hemorrhage Risk in Preterm Infants.","authors":"Fleur A Camfferman, Paul Govaert, Floris Groenendaal, Tim Vanderhasselt, Filip Cools, Jeroen Dudink","doi":"10.3174/ajnr.A9137","DOIUrl":"10.3174/ajnr.A9137","url":null,"abstract":"<p><strong>Background and purpose: </strong>Preterm infants are at risk of brain injury due to immature cerebral autoregulation. However, reliable assessment of cerebral perfusion remains difficult: Advanced imaging is rarely feasible at the bedside, and surrogate markers such as blood pressure or oxygen saturation correlate poorly with actual CBF. This study aimed to evaluate the velocity and waveform characteristics in the internal cerebral veins (ICVs) of preterm infants born before 32 weeks and to explore the relationship among these velocities, clinical parameters, and term-equivalent MRI.</p><p><strong>Materials and methods: </strong>Prospectively, a cohort of 47 preterm infants (postmenstrual age, 28.9 [SD, 2.2] weeks, birth weight 1304 [SD, 386] g) admitted to the neonatal intensive care unit at the University Hospital Brussels was studied. ICV velocities were measured at multiple time points using Doppler ultrasound as a noninvasive marker of cerebral hemodynamics. Mixed-model analysis compared ICV velocities with clinical and term-equivalent MRI results.</p><p><strong>Results: </strong>ICV velocity/weight at scanning was significantly associated with postmenstrual age (<i>P</i> < .001), postnatal age and postnatal age squared (both <i>P</i> < .001), intraventricular hemorrhage (IVH) during admission (<i>P</i> = .003), and the interaction between gestational age and IVH (<i>P</i> = .005), reflecting developmental changes in cerebral circulation. IVH was observed in 5 infants. ICV velocity/weight was 1 cm/s/kg higher with IVH at 25 weeks' gestational age, decreasing to -0.1 cm/s/kg with IVH at 29 weeks' gestational age. Although the number of IVH cases was limited, these findings suggest that ICV velocity monitoring may provide useful information regarding IVH risk.</p><p><strong>Conclusions: </strong>ICV velocity in preterm infants reflects cerebral maturation. Infants developing IVH showed significantly higher venous velocities, corrected for body weight. Despite limited case numbers, these findings indicate that ICV velocity monitoring could serve as an early marker of hemorrhage risk. Larger studies are needed to confirm its predictive value and explore potential neuroprotective strategies.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}