Canadian journal of microbiology最新文献_第2页

Totarol exhibits antibacterial effects through antibiofilm and combined interaction against vancomycin-resistant Enterococcus faecalis. 托塔洛尔通过抗生物膜和联合作用对耐万古霉素粪肠球菌产生抗菌效果。

IF 1.8 4区生物学

Canadian journal of microbiology Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI: 10.1139/cjm-2024-0014

Ga-Eun Hyeon, Yong-Bin Eom

{"title":"Totarol exhibits antibacterial effects through antibiofilm and combined interaction against vancomycin-resistant Enterococcus faecalis.","authors":"Ga-Eun Hyeon, Yong-Bin Eom","doi":"10.1139/cjm-2024-0014","DOIUrl":"10.1139/cjm-2024-0014","url":null,"abstract":"The rise of vancomycin-resistant enterococci (VRE) due to antibiotic overuse poses a significant threat to long-term care patients and those with impaired immune systems. Therefore, it is imperative to seek alternatives to overcome multidrug resistance. This study aimed to evaluate totarol, a natural compound derived from Podocarpus totara, for its antibacterial activity against vancomycin-resistant Enterococcus faecalis (VREF). Totarol exhibited potent antibacterial activity at a very low concentration of 0.25 µg/mL and demonstrated antibiofilm effects through biofilm inhibitory concentration and biofilm eradication concentration assays. Confocal laser scanning microscopy confirmed that totarol inhibited not only biofilm mass but also bacterial cell viability. The combinatorial use of sublethal concentrations of totarol and vancomycin showed antibacterial activity, as observed in the time-kill assay. Quantitative polymerase chain reaction assays revealed a concentration-dependent downregulation of key virulence genes (vanA, ace, asa, efaA, and esp) in VREF when exposed to totarol. In summary, totarol emerges as a promising adjuvant with vancomycin for inhibiting VREF, addressing vancomycin resistance and biofilm formation-critical challenges associated with VRE infection. Since this was an in vitro study, the role of totarol in the clinical implications of VREF treatment remains to be demonstrated.","PeriodicalId":9381,"journal":{"name":"Canadian journal of microbiology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of key drivers of antimicrobial resistance in Enterococcus using machine learning. 利用机器学习识别肠球菌耐药性的关键驱动因素。

IF 1.8 4区生物学

Canadian journal of microbiology Pub Date : 2024-10-01 Epub Date: 2024-07-30 DOI: 10.1139/cjm-2024-0049

Jee In Kim, Alexander Manuele, Finlay Maguire, Rahat Zaheer, Tim A McAllister, Robert G Beiko

{"title":"Identification of key drivers of antimicrobial resistance in Enterococcus using machine learning.","authors":"Jee In Kim, Alexander Manuele, Finlay Maguire, Rahat Zaheer, Tim A McAllister, Robert G Beiko","doi":"10.1139/cjm-2024-0049","DOIUrl":"10.1139/cjm-2024-0049","url":null,"abstract":"With antimicrobial resistance (AMR) rapidly evolving in pathogens, quick and accurate identification of genetic determinants of phenotypic resistance is essential for improving surveillance, stewardship, and clinical mitigation. Machine learning (ML) models show promise for AMR prediction in diagnostics but require a deep understanding of internal processes to use effectively. Our study utilised AMR gene, pangenomic, and predicted plasmid features from 647 Enterococcus faecium and Enterococcus faecalis genomes across the One Health continuum, along with corresponding resistance phenotypes, to develop interpretive ML classifiers. Vancomycin resistance could be predicted with 99% accuracy with AMR gene features, 98% with pangenome features, and 96% with plasmid clusters. Top pangenome features overlapped with the resistance genes of the vanA operon, which are often laterally transmitted via plasmids. Doxycycline resistance prediction achieved approximately 92% accuracy with pangenome features, with the top feature being elements of Tn916 conjugative transposon, a tet(M) carrier. Erythromycin resistance prediction models achieved about 90% accuracy, but top features were negatively correlated with resistance due to the confounding effect of population structure. This work demonstrates the importance of reviewing ML models' features to discern biological relevance even when achieving high-performance metrics. Our workflow offers the potential to propose hypotheses for experimental testing, enhancing the understanding of AMR mechanisms, which are crucial for combating the AMR crisis.","PeriodicalId":9381,"journal":{"name":"Canadian journal of microbiology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of herbaceous litter thickness on bacterial community structure and physicochemical properties of aeolian sand. 草本垃圾厚度对风化沙细菌群落结构和理化特性的影响

IF 1.8 4区生物学

Canadian journal of microbiology Pub Date : 2024-10-01 Epub Date: 2024-09-10 DOI: 10.1139/cjm-2023-0219

Jieru Kong, Huili Liu, Ruixia Wang, Jun Wang, Pin Zhai, Ruoshi Ma, Peng Kang, Bingru Liu

{"title":"Influence of herbaceous litter thickness on bacterial community structure and physicochemical properties of aeolian sand.","authors":"Jieru Kong, Huili Liu, Ruixia Wang, Jun Wang, Pin Zhai, Ruoshi Ma, Peng Kang, Bingru Liu","doi":"10.1139/cjm-2023-0219","DOIUrl":"10.1139/cjm-2023-0219","url":null,"abstract":"The change and mechanism of soil and soil bacterial diversity during the change of herbaceous litter thickness in desert areas is crucial to understand. In the study, the dominant herbaceous litter mixture in Baijitan National Nature Reserve was selected as the research material, and an experiment was established by adjusting the litter depth. The results showed that the measured values of soil physicochemical factors (total nitrogen, total protein, total potassium, available phosphorus, available potassium, pH, and soil water content) increased with the increase of herbaceous litter mixture thickness in 0-5 cm soil layer. Actinobacteria, Proteobacteria, Acidobacteria, Chloroflexi, and Gemmatimonadetes were the dominant bacterial phyla under different thicknesses of herbaceous litter in 0-5 and 5-10 cm soil layers. Balneimonas, Rubrobacter, and Geodermatophilus were the dominant bacterial genera under different thicknesses of herbaceous litter in 0-5 and 5-10 cm soil layers. There was no obvious change in the α-diversity index of bacterial community the same soil layer, but the α-diversity index in the 0-5 cm soil layer was lower compared to the 5-10 cm soil layer. The results of this study revealed that the change of herbaceous litter thickness had no significant effect on soil bacterial community structure in desert areas.","PeriodicalId":9381,"journal":{"name":"Canadian journal of microbiology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal Screening of Retail Milk from Canadian Provinces Reveals No Detections of Influenza A Virus RNA (April - July 2024): Leveraging a Newly-Established Pan-Canadian Network for Responding to Emerging Viruses. 对加拿大各省的零售牛奶进行纵向筛查，结果显示未检测到甲型流感病毒 RNA（2024 年 4 月至 7 月）：利用新建立的泛加拿大网络应对新兴病毒。

IF 1.8 4区生物学

Canadian journal of microbiology Pub Date : 2024-09-27 DOI: 10.1139/cjm-2024-0120

Hannah L Wallace, Jordan Wight, Mariana Baz, Barbara Dowding, Louis Flamand, Tom Hobman, François Jean, Jeffrey B Joy, Andrew S Lang, Sonya MacParland, Craig McCormick, Ryan Noyce, Rodney S Russell, Selena M Sagan, Jumari Snyman, Gabriela J Rzeszutek, Mustafa S Jafri, Isaac Bogoch, Jason Kindrachuk, Angela L Rasmussen

{"title":"Longitudinal Screening of Retail Milk from Canadian Provinces Reveals No Detections of Influenza A Virus RNA (April - July 2024): Leveraging a Newly-Established Pan-Canadian Network for Responding to Emerging Viruses.","authors":"Hannah L Wallace, Jordan Wight, Mariana Baz, Barbara Dowding, Louis Flamand, Tom Hobman, François Jean, Jeffrey B Joy, Andrew S Lang, Sonya MacParland, Craig McCormick, Ryan Noyce, Rodney S Russell, Selena M Sagan, Jumari Snyman, Gabriela J Rzeszutek, Mustafa S Jafri, Isaac Bogoch, Jason Kindrachuk, Angela L Rasmussen","doi":"10.1139/cjm-2024-0120","DOIUrl":"https://doi.org/10.1139/cjm-2024-0120","url":null,"abstract":"Highly pathogenic avian influenza (HPAI) H5N1 has been associated with significant morbidity and mortality. Given recent detections of HPAI H5N1 in dairy cattle and RNA detections in pasteurized retail milk in the United States, we established the Pan-Canadian Milk Network in April 2024. Through this, retail milk was procured longitudinally and sent to a central laboratory to test for the presence of influenza A virus RNA. We tested 109 retail milk samples from all ten Canadian provinces and all samples tested negative. Our independent testing results have aligned with reporting from federal retail milk testing initiatives. Despite no known HPAI infections of dairy cattle in Canada to date, H5N1 poses a significant threat to the health of both humans and other animals. By performing routine surveillance of retail milk on a national scale, we have shown that academic networks and initiatives can rapidly establish nationwide emerging infectious disease surveillance that is cost-effective, standardized, scalable, and easily accessible. Our network can serve as an early detection system to help inform containment and mitigation activities if positive samples are identified and can be readily reactivated should H5N1 or other emerging zoonotic viruses be identified in agricultural or livestock settings.","PeriodicalId":9381,"journal":{"name":"Canadian journal of microbiology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracking the trajectory of frankia research through bibliometrics: trends and future directions. 通过文献计量学跟踪法兰克尼亚研究的轨迹：趋势和未来方向。

IF 1.8 4区生物学

Canadian journal of microbiology Pub Date : 2024-09-10 DOI: 10.1139/cjm-2024-0030

Ridha Mhamdi, Maher Gtari

{"title":"Tracking the trajectory of frankia research through bibliometrics: trends and future directions.","authors":"Ridha Mhamdi, Maher Gtari","doi":"10.1139/cjm-2024-0030","DOIUrl":"10.1139/cjm-2024-0030","url":null,"abstract":"Frankia represent a unique group of filamentous, sporangia-forming bacteria, renowned for their exceptional capacity to establish symbiotic partnerships with actinorhizal plants. The objective of this paper is to offer quantitative insights into the current state of frankia research and its future potential. A comprehensive bibliometric analysis covering the years 2000-2022 was conducted using Scopus and SciVal. A steady increase in both annual publication and international collaboration has been observed, particularly since 2013. Research performance metrics for the last 5 years (2018-2022) indicate China and India as leaders with high Field-Weighted Citation Impact scores. This analysis highlighted prominent authors, research groups, and the evolving research landscape, suggesting an increasing focus on molecular and genomic aspects. The genomic era has transformed our understanding of frankia biology, highlighting their significance in diverse ecological and agricultural contexts. This study comprehensively maps the evolving landscape of frankia research, emphasizing key milestones that have catalysed international interest in frankia-actinorhizal research, expanding our perception of frankia's capabilities beyond its traditional symbiotic role. As research in this field progresses, a deeper comprehension of frankia-plant interactions, symbiotic signalling, and the intricacies of metabolic pathways holds the promise of revealing innovative techniques for optimizing nitrogen fixation and broadening the spectrum of host plants.","PeriodicalId":9381,"journal":{"name":"Canadian journal of microbiology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The limit to evolutionary rescue depends on ploidy in yeast exposed to nystatin. 进化拯救的极限取决于暴露于硝酸菌素的酵母的倍性。

IF 1.8 4区生物学

Canadian journal of microbiology Pub Date : 2024-09-01 Epub Date: 2024-06-14 DOI: 10.1139/cjm-2023-0235

Jasmine Ono, Anastasia Kuzmin, Lesley Miller, Sarah P Otto

{"title":"The limit to evolutionary rescue depends on ploidy in yeast exposed to nystatin.","authors":"Jasmine Ono, Anastasia Kuzmin, Lesley Miller, Sarah P Otto","doi":"10.1139/cjm-2023-0235","DOIUrl":"10.1139/cjm-2023-0235","url":null,"abstract":"The number of copies of each chromosome, or ploidy, of an organism is a major genomic factor affecting adaptation. We set out to determine how ploidy can impact the outcome of evolution, as well as the likelihood of evolutionary rescue, using short-term experiments with yeast (Saccharomyces cerevisiae) in a high concentration of the fungicide nystatin. In similar experiments using haploid yeast, the genetic changes underlying evolutionary rescue were highly repeatable, with all rescued lines containing a single mutation in the ergosterol biosynthetic pathway. All of these beneficial mutations were recessive, which led to the expectation that diploids would find alternative genetic routes to adaptation. To test this, we repeated the experiment using both haploid and diploid strains and found that diploid populations did not evolve resistance. Although diploids are able to adapt at the same rate as haploids to a lower, not fully inhibitory, concentration of nystatin, the present study suggests that diploids are limited in their ability to adapt to an inhibitory concentration of nystatin, while haploids may undergo evolutionary rescue. These results demonstrate that ploidy can tip the balance between adaptation and extinction when organisms face an extreme environmental change.","PeriodicalId":9381,"journal":{"name":"Canadian journal of microbiology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141320630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constraint on boric acid resistance and tolerance evolvability in Candida albicans. 白念珠菌对硼酸抗性和耐受性进化的制约因素

IF 1.8 4区生物学

Canadian journal of microbiology Pub Date : 2024-09-01 Epub Date: 2024-07-31 DOI: 10.1139/cjm-2023-0225

Yana Syvolos, Ola E Salama, Aleeza C Gerstein

{"title":"Constraint on boric acid resistance and tolerance evolvability in Candida albicans.","authors":"Yana Syvolos, Ola E Salama, Aleeza C Gerstein","doi":"10.1139/cjm-2023-0225","DOIUrl":"10.1139/cjm-2023-0225","url":null,"abstract":"Boric acid is a broad-spectrum antimicrobial used to treat vulvovaginal candidiasis when patients relapse on the primary azole drug fluconazole. Candida albicans is the most common cause of vulvovaginal candidiasis, colloquially referred to as a \"vaginal yeast infection\". Little is known about the propensity of C. albicans to develop BA resistance or tolerance (the ability of a subpopulation to grow slowly in high levels of drug). We evolved 96 replicates from eight diverse C. albicans strains to increasing BA concentrations to test the evolvability of BA resistance and tolerance. Replicate growth was individually assessed daily, with replicates passaged when they had reached an optical density consistent with exponential growth. Many replicates went extinct quickly. Although some replicates could grow in much higher levels of BA than the ancestral strains, evolved populations isolated from the highest terminal BA levels (after 11 weeks of passages) surprisingly showed only modest growth improvements and only at low levels of BA. No large increases in resistance or tolerance were observed in the evolved replicates. Overall, our findings illustrate that there may be evolutionary constraints limiting the emergence of BA resistance and tolerance, which could explain why it remains an effective treatment for recurrent yeast infections.","PeriodicalId":9381,"journal":{"name":"Canadian journal of microbiology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and genome analysis of a broad host range lytic phage vB_SenS_TUMS_E19 against Salmonella enterica and its efficiency evaluation in the liquid egg. 针对肠炎沙门氏菌的宽宿主范围噬菌体 vB_SenS_TUMS_E19 的特征和基因组分析及其在液态蛋中的效率评估。

IF 1.8 4区生物学

Canadian journal of microbiology Pub Date : 2024-09-01 Epub Date: 2024-07-04 DOI: 10.1139/cjm-2024-0013

Narges Torkashvand, Haniyeh Kamyab, Ahmad Reza Shahverdi, Mohammad Reza Khoshayand, Mohammad Amir Karimi Tarshizi, Zargham Sepehrizadeh

{"title":"Characterization and genome analysis of a broad host range lytic phage vB_SenS_TUMS_E19 against Salmonella enterica and its efficiency evaluation in the liquid egg.","authors":"Narges Torkashvand, Haniyeh Kamyab, Ahmad Reza Shahverdi, Mohammad Reza Khoshayand, Mohammad Amir Karimi Tarshizi, Zargham Sepehrizadeh","doi":"10.1139/cjm-2024-0013","DOIUrl":"10.1139/cjm-2024-0013","url":null,"abstract":"Salmonella enterica serovars are zoonotic bacterial that cause foodborne enteritis. Due to bacteria's antibiotic resistance, using bacteriophages for biocontrol and treatment is a new therapeutic approach. In this study, we isolated, characterized, and analyzed the genome of vB_SenS_TUMS_E19 (E19), a broad host range Salmonella bacteriophage, and evaluated the influence of E19 on liquid eggs infected with Salmonella enterica serovar Enteritidis. Transmission electron microscopy showed that the isolated bacteriophage had a siphovirus morphotype. E19 showed rapid adsorption (92% in 5 min), a short latent period (18 min), a large burst size (156 PFU per cell), and a broad host range against different Salmonella enterica serovars. Whole-genome sequencing analysis indicated that the isolated phage had a 42 813 bp long genome with 49.8% G + C content. Neither tRNA genes nor those associated with antibiotic resistance, virulence factors, or lysogenic formation were detected in the genome. The efficacy of E19 was evaluated in liquid eggs inoculated with S. Enteritidis at 4 and 25 °C, and results showed that it could effectively eradicate S. Enteritidis in just 30 min and prevented its growth up to 72 h. Our findings indicate that E19 can be an alternative to a preservative to control Salmonella in food samples and help prevent and treat salmonellosis.","PeriodicalId":9381,"journal":{"name":"Canadian journal of microbiology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive evolution of Clostridium thermocellum ATCC 27405 on alternate carbon sources leads to altered fermentation profiles. 热梭菌 ATCC 27405 在替代碳源上的适应性进化导致了发酵曲线的改变。

IF 1.8 4区生物学

Canadian journal of microbiology Pub Date : 2024-09-01 Epub Date: 2024-06-04 DOI: 10.1139/cjm-2024-0004

Steve R Daley, Samantha Kirby, Richard Sparling

{"title":"Adaptive evolution of Clostridium thermocellum ATCC 27405 on alternate carbon sources leads to altered fermentation profiles.","authors":"Steve R Daley, Samantha Kirby, Richard Sparling","doi":"10.1139/cjm-2024-0004","DOIUrl":"10.1139/cjm-2024-0004","url":null,"abstract":"Consolidated bioprocessing candidate, Clostridium thermocellum, is a cellulose hydrolysis specialist, with the ability to ferment the released sugars to produce bioethanol. C. thermocellum is generally studied with model substrates Avicel and cellobiose to understand the metabolic pathway leading to ethanol. In the present study, adaptive laboratory evolution, allowing C. thermocellum DSM 1237 to adapt to growth on glucose, fructose, and sorbitol, with the prospect that some strains will adapt their metabolism to yield more ethanol. Adaptive growth on glucose and sorbitol resulted in an approximately 1 mM and 2 mM increase in ethanol yield per millimolar glucose equivalent, respectively, accompanied by a shift in the production of the other expected fermentation end products. The increase in ethanol yield observed for sorbitol adapted cells was due to the carbon source being more reduced compared to cellobiose. Glucose and cellobiose have similar oxidation states thus the increase in ethanol yield is due to the rerouting of electrons from other reduced metabolic products excluding H2 which did not decrease in yield. There was no increase in ethanol yield observed for fructose adapted cells, but there was an unanticipated elimination of formate production, also observed in sorbitol adapted cells suggesting that fructose has regulatory implications on formate production either at the transcription or protein level.","PeriodicalId":9381,"journal":{"name":"Canadian journal of microbiology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial resistance in Klebsiella pneumoniae: an overview of common mechanisms and a current Canadian perspective. 肺炎克雷伯氏菌的抗菌药耐药性：常见机制概述和当前加拿大的观点。

IF 1.8 4区生物学

Canadian journal of microbiology Pub Date : 2024-08-30 DOI: 10.1139/cjm-2024-0032

Hannah G Braun, Sumudu R Perera, Yannick Dn Tremblay, Jenny-Lee Thomassin

引用次数: 0