Psychoradiology最新文献

{"title":"Advances in functional magnetic resonance imaging-based brain function mapping: a deep learning perspective.","authors":"Lin Zhao","doi":"10.1093/psyrad/kkaf007","DOIUrl":"10.1093/psyrad/kkaf007","url":null,"abstract":"<p><p>Functional magnetic resonance imaging (fMRI) provides a powerful tool for studying brain function by capturing neural activity in a non-invasive manner. Mapping brain function from fMRI data enables researchers to investigate the spatial and temporal dynamics of neural processes, providing insights into how the brain responds to various tasks and stimuli. In this review, we explore the evolution of deep learning-based methods for brain function mapping using fMRI. We begin by discussing various network architectures such as convolutional neural networks, recurrent neural networks, and transformers. We further examine supervised, unsupervised, and self-supervised learning paradigms for fMRI-based brain function mapping, highlighting the strengths and limitations of each approach. Additionally, we discuss emerging trends such as fMRI embedding, brain foundation models, and brain-inspired artificial intelligence, emphasizing their potential to revolutionize brain function mapping. Finally, we delve into the real-world applications and prospective impact of these advancements, particularly in the diagnosis of neural disorders, neuroscientific research, and brain-computer interfaces for decoding brain activity. This review aims to provide a comprehensive overview of current techniques and future directions in the field of deep learning and fMRI-based brain function mapping.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf007"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A functional anatomical shift from the lateral frontal pole to dorsolateral prefrontal cortex in emotion action control underpins elevated levels of anxiety: partial replication and generalization of Bramson <i>et al</i>., 2023.","authors":"Qian Zhuang, Shuxia Yao, Lei Xu, Shuaiyu Chen, Jialin Li, Xiaoxiao Zheng, Meina Fu, Keith M Kendrick, Benjamin Becker","doi":"10.1093/psyrad/kkaf009","DOIUrl":"10.1093/psyrad/kkaf009","url":null,"abstract":"<p><strong>Background: </strong>Emotion control represents a promising intervention target for mental disorders. In a recent study Bramson et al. (2023) demonstrate a functional-anatomical shift from the lateral frontal pole (FPl) to the dorsolateral prefrontal cortex (DLPFC) in anxious individuals during emotional action control. However, findings of neuroimaging experiments are often limited regarding generalizability and reproducibility. The present study examined the robustness of the reported functional shift across samples, cultures and paradigms.</p><p><strong>Methods: </strong>We capitalized on large-scale task fMRI data (<i>n</i> = 250 participants) using an affective linguistic Go/NoGo paradigm to examine the anxiety-related shift between FPl and DLPFC during emotional action control. Additionally, context-dependent functional connectivity analyses were employed to examine anxiety-related differences and associations on the network level.</p><p><strong>Results: </strong>Non-anxious individuals engaged the left FPl while highly anxious individuals specifically recruited the DLPFC, but non-significant between-group differences were found (see also Bramson et al.). The secondary analyses revealed moderate evidence for the absence of left FPl activation in the high-anxious as well as for left DLPFC activation in the non-anxious group. Additionally, trait anxiety scores were positively correlated with left DLPFC activity but negatively correlated with left FPl activity across groups. Furthermore, we found a context-specific connectivity shift between the subgenual anterior cingulate cortex (sgACC) with the FPl and DLPFC specifically in highly anxious individuals.</p><p><strong>Conclusion: </strong>The results partially confirmed the anxiety-related shift as reported by Bramson and colleagues across paradigms and samples. The findings provide further support for the functional shift in anxiety and can inform target-based interventions of persistent emotional control deficits in anxiety disorders.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf009"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter functional connectome gradient dysfunction in major depressive disorder.","authors":"Baoxin Yu, Xiaoyi Sun, Mingrui Xia","doi":"10.1093/psyrad/kkaf008","DOIUrl":"10.1093/psyrad/kkaf008","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) is a prevalent psychiatric disorder with disruptions in brain white matter (WM). While much research has focused on WM structure, the dysfunctional organization of WM in MDD remains poorly understood.</p><p><strong>Methods: </strong>Using resting-state functional magnetic resonance imaging data from 48 MDD patients and 68 healthy controls (HC), we characterized the WM functional connectome gradients across participants and identified both global and regional alterations in MDD. Furthermore, we examined the relationship between gradient properties and depressive symptom severity. External validation and sensitivity analyses were finally conducted to ensure the reliability of results.</p><p><strong>Results: </strong>The principal WM connectome gradient extended from the forceps major and superior longitudinal fasciculus to the uncinate fasciculus (UF) and anterior thalamic radiation (ATR), exhibiting a superficial-to-deep pattern in both groups. Compared to HC, MDD patients displayed a narrower gradient range and lower spatial variation, indicating a contracted WM hierarchy. At the tract-specific level, MDD patients exhibited lower gradient scores in the forceps minor, left ATR and UF, and bilateral cingulate gyrus and cingulum hippocampus, but higher gradient scores in the forceps major, bilateral inferior longitudinal fasciculus and superior longitudinal fasciculus. WM tract gradient patterns explained 37.2% of the variance in clinical severity, with the strongest contributions from the inferior fronto-occipital fasciculus, cingulum hippocampus, ATR, UF, and corticospinal tract.</p><p><strong>Conclusions: </strong>These findings highlight altered WM functional connectome gradient in MDD and their association with clinical severity, offering novel insights into the neurobiological mechanisms of the disorder and potential biomarkers for symptom evaluation.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf008"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture effects on emotional reactivity of youth with self-reported depressive symptoms.","authors":"Qian Wu, Dehui Lin, Xiuyun Wen, Shanze Wang, Derek Fisher, Wenbin Fu, Jiajin Yuan","doi":"10.1093/psyrad/kkaf006","DOIUrl":"https://doi.org/10.1093/psyrad/kkaf006","url":null,"abstract":"<p><strong>Background: </strong>Emotional symptomatology is a hallmark of depression. Antidepressant often fail to effectively target emotional blunting, while acupuncture, by contrast, has emerged as a promising alternative. However, the exact electrophysiologic mechanisms remain unclear. This study aimed to investigate how acupuncture influences emotional reactivity in youth with self-reported depressive symptoms.</p><p><strong>Methods: </strong>A modified oddball paradigm incorporating a negative emotional valence deviant, combined with event-related potential analysis, was used to measure emotional reactivity before and after intervention. Seventy individuals exhibiting depressive symptoms in the previous 2 weeks, were randomly assigned to either a verum or sham acupuncture group. Electroencephalogram data from 59 participants were analyzed following preprocessing and quality assessment. Occipital P1, N170, frontal N1, N2, and parietal P3 components were extracted. The Positive and Negative Affect Schedule (PANAS) was completed after each oddball session. The Massachusetts General Hospital Acupuncture Sensation Scale (MASS) was completed after each intervention session.</p><p><strong>Results: </strong>The MASS Index was significantly higher in the verum group. However, significant increases in occipital P1, N170, frontal N1, N2, and parietal P3 amplitudes for high-negative, mild-negative, and neutral pictures were observed after the intervention in both the verum and sham groups, with no significant difference between the groups. Additionally, both groups induced PANAS changes, and positive effect changes were significantly correlated with N170 and P1 (in response to high-negative pictures) changes in the sham group.</p><p><strong>Conclusion: </strong>Acupuncture altered emotional reactivity in youth with depressive symptoms, highlighting its potential role, albeit possibly non-specific, in depression prevention and treatment.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf006"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimmune suppression and anhedonia in post-traumatic stress disorder: connecting central and peripheral immunity.","authors":"Hangyuan Jiang, Jing Lu","doi":"10.1093/psyrad/kkaf004","DOIUrl":"10.1093/psyrad/kkaf004","url":null,"abstract":"","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf004"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A commentary on frontostriatal salience network expansion in individuals in depression.","authors":"Sarah Katharina Buehler, Ruibin Zhang, Jonathan Roiser","doi":"10.1093/psyrad/kkaf005","DOIUrl":"10.1093/psyrad/kkaf005","url":null,"abstract":"","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf005"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Bipolar Lithium Imaging Scan Study (BLISS): protocol for a 7T lithium-7 magnetic resonance study in bipolar disorder.","authors":"Elvira Boere, Nic J A van der Wee, Albert M van Hemert, Andrew G Webb, Max de Leeuw","doi":"10.1093/psyrad/kkaf003","DOIUrl":"10.1093/psyrad/kkaf003","url":null,"abstract":"<p><strong>Introduction: </strong>Lithium treatment is considered the first-line option in the pharmacological treatment of bipolar disorder. At the same time, individual responses vary greatly, which complicates achieving rapid stabilization in many subjects with bipolar disorder. The neurobiological mechanism of action of lithium remains largely unknown, hindering the development of clinically applicable predictors of individual treatment responses. The recent introduction of ultra-high-field lithium magnetic resonance imaging (MRI) has opened up a promising avenue for better linking brain measures with clinical response to lithium treatment.</p><p><strong>Methods and analysis: </strong>This is an observational study involving 80 adults with bipolar disorder who begin lithium as part of their regular treatment. Within 4 weeks of reaching stable therapeutic serum lithium concentrations, brain lithium concentrations will be measured by employing a 3D lithium-7 chemical shift imaging (⁷Li CSI) sequence on a 7T MR system. The primary outcome is the clinical response to lithium treatment at 1 year follow-up, assessed using a validated questionnaire. Linear regression analysis will be used to establish correlations between brain lithium concentrations-measured through mean brain, voxel-wise, parcellation, and region-of-interest approaches-and clinical lithium response.</p><p><strong>Ethics and dissemination: </strong>The BLISS study protocol (NL80214.058.22) has been approved by the Medical Ethics Committee of Leiden, The Hague, and Delft in The Netherlands. Results will be submitted for publication in peer-reviewed journals and shared with the key population.Registration Online at clinicaltrials.gov (NCT06134349), 20 November 2023.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf003"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An interview with Professor Vincent Dousset: psychoradiology is a pioneering field, our aspiration is to unite psychiatrists with radiologists in France.","authors":"Ping Jiang","doi":"10.1093/psyrad/kkaf002","DOIUrl":"https://doi.org/10.1093/psyrad/kkaf002","url":null,"abstract":"<p><p>From 20 to 22 July 2024, the International Society for Magnetic Resonance in Medicine (ISMRM)-endorsed workshop on Magnetic Resonance (MR) for Psychiatry was held in Chengdu City, China. This prestigious event attracted numerous academic elites worldwide. Vincent Dousset is a professor of medicine and radiology at the University of Bordeaux, France, and the chairman of Medical Imaging at the University Hospital of Bordeaux. The hospital is running a completely new project dedicated to applying MRI technology in the field of psychiatry, and Professor Dousset will manage the project. However, this is an entirely new domain for the radiologists and technicians in the hospital. Therefore, Professor Dousset attended the ISMRM-endorsed Workshop on MR for Psychiatry in Chengdu to gain insight into the latest advancements in psychoradiology and hoped to apply valuable experience to their project. Following the conference, the <i>Psychoradiology</i> journal interviewed Professor Dousset. In the interview, Professor Dousset was enthusiastic about merging radiology and psychiatry teams and regarded the term \"psychoradiology\" as a bridge to unite these fields. Despite the challenges of distinguishing normal from abnormal brains in psychiatric disorders, he was optimistic about the future of psychoradiology and its clinical applications. He recognized the significance and prospects of the term \"psychoradiology\", and offered valuable suggestions for the development of the <i>Psychoradiology</i> journal.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf002"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal arteriolar blood volume measured by 3D inflow-based vascular-space-occupancy (iVASO) MRI and resting-state BOLD fluctuations at 7 T in individuals with recent-onset schizophrenia.","authors":"Andor L Bodnár, Daniel A Stevens, Adrian G Paez, Kia Ultz, Christopher A Ross, Jun Hua, Russell L Margolis","doi":"10.1093/psyrad/kkaf001","DOIUrl":"10.1093/psyrad/kkaf001","url":null,"abstract":"<p><strong>Background: </strong>We previously reported lower baseline arteriolar cerebral blood volumes (CBVa) in almost all gray matter regions in a cohort of individuals with schizophrenia of varying ages and disease duration. The extent to which decreased CBVa is also present in recent-onset schizophrenia, and how this impacts neurovascular coupling, remains to be determined. In this study, we sought to determine the extent of CBVa deficits in recent-onset schizophrenia and the relationship of CBVa to region-specific resting-state neural activity.</p><p><strong>Methods: </strong>Using 7 T MRI, CBVa was measured in 90 regions using 3D inflow-based vascular-space-occupancy (iVASO) imaging in 16 individuals with recent-onset schizophrenia (disease duration: x̄ = 1.18 ± 1.4 years) and 12 age-matched controls. Resting-state functional MRI (rs-fMRI) was used to determine fractional amplitudes of low-frequency fluctuations (fALFF) and intrinsic connectivity (ICC) in spontaneous blood oxygen level-dependent (BOLD) signal. The region-specific relationship between CBVa and fALFF was determined as an index of neurovascular coupling.</p><p><strong>Results: </strong>Compared with healthy participants, CBVa was lower in individuals with schizophrenia in almost all brain regions, with a global effect size of 0.23 and regional effect sizes up to 0.41. Individuals with schizophrenia also exhibited lower fALFF diffusely across cortical and subcortical gray matter regions. Ratios of mean regional CBVa to fALFF and ICC were significantly lower in patients in numerous brain regions.</p><p><strong>Conclusion: </strong>These findings indicate that early-stage schizophrenia is characterized by widespread microvascular abnormalities and associated resting-state deficits in neural activity, suggesting that abnormalities in neurovascular coupling may contribute to the pathophysiology of schizophrenia.</p>","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"5 ","pages":"kkaf001"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing typical developmental trajectories to reflect brain abnormalities in autism spectrum disorder.","authors":"Long-Biao Cui, Xian-Yang Wang, Hua-Ning Wang","doi":"10.1093/psyrad/kkae024","DOIUrl":"10.1093/psyrad/kkae024","url":null,"abstract":"","PeriodicalId":93496,"journal":{"name":"Psychoradiology","volume":"4 ","pages":"kkae024"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}