BMC Biology最新文献

{"title":"Time, space and feature similarity determine attractive and repulsive serial biases in trustworthiness impressions.","authors":"Fiammetta Marini, Clare A M Sutherland, Linda Jeffery, Mauro Manassi","doi":"10.1186/s12915-026-02650-3","DOIUrl":"10.1186/s12915-026-02650-3","url":null,"abstract":"<p><strong>Background: </strong>Facial trustworthiness impressions influence important social decisions, including economic choices, hiring decisions and criminal justice outcomes. Most research has focused on the face attributes associated with various impressions, implicitly regarding these impressions as stable over time. However, our perception is dynamically shaped by past visual experience through two opposite serial effects: negative aftereffects (bias away from the past) and serial dependence (bias towards the past). Here, we investigated how past visual experience biases first impressions of trustworthiness by using a trustworthiness rating task. Specifically, we tested how basic stimulus properties such as exposure duration to a previous face, feature similarity, and spatial proximity to previous faces determine the direction and strength of the biases.</p><p><strong>Results: </strong>We found that (1) exposure duration determined the direction of the bias with negative aftereffects following prolonged adaptor exposure and (positive) serial dependence after brief adaptor exposure. Furthermore, (2) increased identity similarity between previous and current faces enhanced attractive biases, whereas different identities led to repulsion. Finally, (3) relative spatial distance between adaptor and test faces modulated the strength of serial dependence but not negative aftereffects.</p><p><strong>Conclusions: </strong>Our paradigm enabled us to provide evidence for, and to dissociate, attractive and repulsive serial biases in trustworthiness impressions. Our findings demonstrate the specific conditions under which these impressions can be dynamically shaped by past experience. Importantly, the influence of basic stimulus properties of time, space, and feature similarity on serial effects indicates that these biases cannot be entirely explained by high-level factors such as decision or memory.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"24 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13251037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148210240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuronal VPS13A depletion links diacylglycerol PKC signaling and synaptic spines.","authors":"Gisela Besa-Selva, Esther García-García, Alba Ramón-Lainez, Georgia Escaramis, Pol Garcia-Segura, Cristina Malagelada, Eulàlia Martí, Jordi Alberch, Mercè Masana, Manuel J Rodríguez","doi":"10.1186/s12915-026-02649-w","DOIUrl":"10.1186/s12915-026-02649-w","url":null,"abstract":"<p><strong>Background: </strong>Intermembrane lipid transfer protein VPS13A (VPS13A) is a large protein whose cellular functions are still under investigation. VPS13A gene mutations leading to the absence of protein expression cause Chorea-acanthocytosis (ChAc), an ultra-rare inherited neurodegenerative movement disorder. Although the molecular mechanisms linking VPS13A loss to neuronal dysfunction remain unclear, its role as a bulk lipid transfer protein suggests that impaired lipid distribution may represent a primary pathogenic mechanism leading to neurodegeneration in ChAc. In this study, we investigated the effect of neuronal silencing of VPS13A in a murine model to phenocopy the human disease.</p><p><strong>Results: </strong>Lipidomics analysis revealed an increase in the concentration of several diacylglycerol species induced by VPS13A knockdown. We then explored the downstream molecular pathways related to the altered diacylglycerol levels and found that VPS13A knockdown induces a decrease in protein kinase C (PKC)βII concentration but an increase in PKCα/βII phosphorylation in cultured neurons. Finally, pharmacological inhibition of PKCβII reverted aberrant neuronal morphology and loss of spine density induced by VPS13A KD. These results underscore the importance of VPS13A in regulating neuronal lipid distribution, showing that its absence perturbs the diacylglycerol/PKC signaling pathway, with measurable effects on neuronal structure and synaptic density.</p><p><strong>Conclusions: </strong>Overall, our results underscore a previously underappreciated role for VPS13A in the structural organization of neurons through lipid-mediated signaling mechanisms, providing insight into the cellular dysfunction underlying ChAc.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PepPharmaHub: a cloud-based platform integrating multimodel language architectures with curated data resources for therapeutic peptide discovery.","authors":"Dongya Qin, Xiang Qin, Hai Fang, Zheng Wang","doi":"10.1186/s12915-026-02625-4","DOIUrl":"10.1186/s12915-026-02625-4","url":null,"abstract":"<p><strong>Background: </strong>Therapeutic peptides represent a rapidly expanding class of drug candidates due to their diverse biological activities and high specificity. However, accurately predicting peptide functions directly from sequence information remains a major challenge in computational peptidomics. Current tools, typically standalone applications or functionally constrained web servers, lack the flexibility and scalability essential for modern peptide discovery workflows. Therefore, it is necessary to develop a cloud-based, no-code platform that enables customizable modeling and high-throughput functional screening of therapeutic peptides.</p><p><strong>Results: </strong>PepPharmaHub provides a cloud-based, end-to-end platform that integrates advanced sequence-based language modeling with curated benchmark datasets and interactive visualization modules. The platform features a high-throughput screening module powered by a diverse set of 24 models targeting 20 therapeutic properties, alongside a customizable model training pipeline for user-defined screening tasks. Comprehensive benchmarking on 24 public datasets demonstrates that PepPharmaHub matches or surpasses state-of-the-art predictors, significantly improving the efficiency of large-scale peptide screening. Compared with existing public web servers, PepPharmaHub attains a higher, more tightly distributed accuracy on 3475 newly reported bioactive peptides from 1 January 2023 to 1 June 2025 (20 independent tasks), indicating stronger generalization and practical utility.</p><p><strong>Conclusions: </strong>PepPharmaHub enables accurate, high-throughput prediction of peptide functions through customizable deep learning models and a no-code interface. By outperforming existing tools across multiple benchmarks and supporting interpretable sequence analysis, the platform offers a practical solution for accelerating peptide-based drug discovery.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13474599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FSSM-DDI: Fusion State Space Model for predicting drug-drug interaction using social-media and drug descriptions.","authors":"Shanwen Zhang, Ting Zhang, Dengwu Wang, Xiaohua Zhang","doi":"10.1186/s12915-026-02648-x","DOIUrl":"10.1186/s12915-026-02648-x","url":null,"abstract":"<p><strong>Background: </strong>Predicting drug-drug interactions (DDIs) from social-media and drug descriptions is crucial for healthcare, drug regulation, and pharmaceutical research, yet remains a challenging task. Existing deep learning and Transformer-based approaches often struggle with modeling long-range dependencies within sentences or entail high computational costs, limiting their practical applicability in large-scale drug safety screening.</p><p><strong>Results: </strong>To overcome these limitations, we propose a Fusion State Space Model (FSSM) for DDI prediction (DDIP). FSSM leverages a selective State Space Model (SSM) to efficiently capture long-range syntactic and semantic dependencies within sentences, while an Interaction-based Selective Filtering (ISF) module mitigates information redundancy from multimodal inputs. Experiments on the DDIExtraction-2013 corpus demonstrate that FSSM achieves an F1-score of 75.23%, matching state-of-the-art Transformer models while requiring significantly less training time. Ablation studies confirm that each architectural component contributes meaningfully, with social-media embedding providing the largest performance gain (8.93% drop upon removal) and the ISF module contributing a 4.80% improvement.</p><p><strong>Conclusions: </strong>FSSM offers a promising balance of predictive performance and computational efficiency for drug-drug interaction prediction. The model's linear complexity enables large-scale screening, real-time applications, and deployment in resource-constrained settings, making it a valuable tool for drug discovery and drug safety assessment.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"24 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148142799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastics reshape rhizosphere microbial communities and nutrient cycling in tomato agroecosystems.","authors":"Yongshi Liang, Manying Zhang, Mingzhu Guan, Sijia Liu, Jiugeng Chen, Rongchao Yang, Yueqin Zhang","doi":"10.1186/s12915-026-02633-4","DOIUrl":"10.1186/s12915-026-02633-4","url":null,"abstract":"<p><strong>Background: </strong>Microplastics (MPs) are emerging soil contaminants increasingly recognized for their capacity to alter agroecosystem functioning; however, their impacts on horticultural crops and rhizosphere microbial processes remain insufficiently understood.</p><p><strong>Results: </strong>We examined the impacts of MPs, polyethylene (PE), polypropylene (PP), and polyvinyl chloride (PVC), on rhizosphere soil physicochemical properties, bacterial community structure, and functional genes associated with carbon (C), nitrogen (N), and phosphorus (P) cycling in tomato (Solanum lycopersicum L.), a major horticultural crop cultivated worldwide. Both PVC-MPs and PE-MPs significantly reduced soil ammonium nitrogen and available phosphorus contents, modifying rhizosphere elemental composition. In contrast, PP-MPs had no significant effects on these nutrients but significantly increased soil pH by 0.76% compared with the control (p < 0.05). PE-MPs exposure markedly reduced bacterial α-diversity and selectively enriching bacterial taxa involved in recalcitrant organic matter degradation and nitrogen cycling. High-throughput quantitative PCR (qPCR) revealed that MPs suppressed the degradation of labile carbon substrates, including starch, cellulose, and hemicellulose (as evidenced by downregulation of apu, manB, and xylA), as well as methane metabolism, while promoting carbon fixation and phosphorus cycling.</p><p><strong>Conclusions: </strong>Our results indicate selective reprogramming of bacterial carbon metabolism, enhancing recalcitrant carbon turnover while constraining labile carbon mineralization, thereby disrupting C-P metabolic coupling and promoting soil organic carbon accumulation. Additionally, MPs stimulated nitrogen fixation and nitrification while inhibiting denitrification, particularly under PE- and PVC-MPs treatments. These findings provide bacterial ecological insights into MPs-induced reshape rhizosphere processes and nutrient cycling dynamics in horticultural systems.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13439850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolutionary landscape of host immunity genes involved in respiratory and other immune-related diseases, and the identification of TLR2 variation associated with severe COVID-19.","authors":"Christopher N Cross, Alessandro Lisi, Faith C Simmonds, Marisol Fermin Flores, Kareem Washington, Thomas Heinbockel, Michael C Campbell","doi":"10.1186/s12915-026-02623-6","DOIUrl":"10.1186/s12915-026-02623-6","url":null,"abstract":"<p><strong>Background: </strong>Given its high mortality and broad societal impact, the COVID-19 pandemic is arguably one of the most consequential public health crises of the twenty-first century. Although previous studies have identified several genes associated with COVID-19 susceptibility, relatively little is known about the genes contributing to severe COVID-19, including their evolutionary histories. In the current study, we analyzed IL-4, TLR2, CCL2, and SLC11A1-immunity genes that have previously been implicated in severe COVID-19 and other immune-related diseases-in globally diverse populations from the 1000 Genomes Project. We also tested for associations between genetic variation at these genes and clinical COVID-19 phenotypes in nearly 4000 laboratory-confirmed COVID-19-positive individuals across two datasets from the GEN-COVID Multicenter Study in Italy.</p><p><strong>Results: </strong>Based on our analyses, we identified striking signatures of positive selection within and around all four genes, including extensive haplotype structure, elevated population differentiation, and significant selection coefficients consistent with both ancient and more recent adaptive events. Notably, many of these signals were population-specific, highlighting the role of local selection in shaping immune gene diversity. Several selected alleles were also present in Neanderthal and/or Denisovan genomes, reflecting both shared ancestral polymorphism and archaic introgression within these genes. Functional predictions based on in silico analyses further revealed that a subset of selected alleles maps to transcription factor binding sites and is predicted to influence binding affinity. In addition, our genotype-phenotype analyses uncovered coding variants in TLR2 that were correlated with COVID-19 severity and a related comorbidity, with estimated effect sizes ranging from moderate to large. Interestingly, these significantly associated alleles occur at rare or low frequency in western European and East Asian populations but are absent in populations of African and South Asian descent, indicative of a relatively recent origin.</p><p><strong>Conclusions: </strong>Overall, our study provides new insights into the evolution of biologically relevant immunity genes in modern human populations and identifies genetic variation that may contribute to differences in risk for severe COVID-19.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating substrate specificity in arogenate versus prephenate dehydratases.","authors":"Emily J Clayton, Megan Smith-Uffen, Travis W Tribble, Martin L Duennwald, Susanne E Kohalmi","doi":"10.1186/s12915-026-02586-8","DOIUrl":"10.1186/s12915-026-02586-8","url":null,"abstract":"<p><strong>Background: </strong>Phenylalanine is an essential aromatic amino acid that can only be synthesized de novo by microorganisms and plants. In microorganisms, phenylalanine is synthesized through the prephenate pathway, requiring the activity of a prephenate dehydratase (PDT). In plants, phenylalanine is synthesized instead mostly through the arogenate pathway, requiring the enzyme arogenate dehydratase (ADT). In Arabidopsis, there is a family of six ADTs that catalyze this final step of phenylalanine biosynthesis. However, two of the AtADTs, AtADT1 and AtADT2, can also act as PDTs. All six AtADTs have a high sequence similarity, making it difficult to determine in silico which amino acids determine substrate specificity.</p><p><strong>Results: </strong>Here, we use domain swapping, targeted mutagenesis, and pha2 yeast complementation to investigate amino acids that confer PDT activity in pha2 yeast. In addition, we established a novel in vivo test of ADT activity to determine how these amino acid changes affect ADT and PDT activity of the AtADTs.</p><p><strong>Conclusions: </strong>Our results demonstrate that a combination of amino acids in the regulatory ACT domain contributes to both ADT and PDT activity in the AtADTs.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"24 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13217925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New exceptionally preserved arthropod from the Furongian of Canada.","authors":"Russell D C Bicknell, Julien Kimmig, Aaron Goodman, Thomas Turner, Patrick M Smith","doi":"10.1186/s12915-026-02617-4","DOIUrl":"10.1186/s12915-026-02617-4","url":null,"abstract":"<p><strong>Background: </strong>Corcoraniidae is a rare and understudied family of lower Paleozoic euarthropods that are important for understanding early chelicerate evolution. However, the diversity, morphology, and distribution of this group remain poorly resolved, particularly during the late Cambrian.</p><p><strong>Results: </strong>Here, we describe a new corcoraniid from the late Cambrian (Furongian) Rivière-du-Loup Formation of Quebec, Canada. The distinctive morphology of this specimen warrants erection of a new genus and species, Magnicornaspis garwoodi gen. et sp. nov. This new taxon expands the morphological disparity in Corcoraniidae and suggests that a shift in location of large cephalic spines arose within older members of the clade. The presence of a corcoraniid within the Rivière-du-Loup Formation provides a crucial data point within the \"Furongian Gap\" suggesting that perceived biodiversity declines may be an artifact of sampling bias rather than anoxia-driven extinction.</p><p><strong>Conclusions: </strong>This material highlights the potential for exceptional soft-bodied preservation within deeper-water lithofacies and warrants renewed investigation of the Rivière-du-Loup Formation. The deposit has a high probability of representing a new Furongian Konservat-Lagerstätte that will present important insight into late Cambrian biodiversity and the evolutionary history of early arthropods.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":"24 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13220627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148052801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondria-ER contact sites (MERCS) in the cell cycle: molecular architecture and functional remodeling across cellular states.","authors":"Eduardo Silva-Pavez, Bruno Torres-Gonzalez, Michelle Sotomayor, Benjamín Cartes-Saavedra, Dorian V Ziegler, Yessia Hidalgo-Fadic, Ulises Ahumada-Castro","doi":"10.1186/s12915-026-02645-0","DOIUrl":"10.1186/s12915-026-02645-0","url":null,"abstract":"<p><p>Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are nanoscopic, dynamic platforms integrating metabolism, signaling, and stress responses to regulate cell fate. These nanoscopic interfaces remodel continuously to meet the demands of proliferating, quiescent, and senescent cells. We synthesize evidence that MERCS actively coordinate local Ca²⁺ signaling, non-vesicular lipid transfer, and proteostasis to shape mitochondrial function and cellular homeostasis. We discuss how MERCS architecture changes across the cell cycle and during arrest, distinguishing adaptive from maladaptive remodeling, and consider therapeutic potential in aging and age-related disease.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13397733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon-fixing bacteria and sediment organic carbon response to the introduction of mangrove plant Sonneratia caseolaris.","authors":"Xiaofang Huang, Junde Dong, Youshao Wang, Hongbin Liu, Weiguo Zhou, Hao Cheng, Xi Yang, Tongyin Liang, Bing Yang, Juan Ling","doi":"10.1186/s12915-026-02631-6","DOIUrl":"10.1186/s12915-026-02631-6","url":null,"abstract":"<p><strong>Background: </strong>The fast-growing Sonneratia caseolaris has been widely used in restoration efforts to accelerate the recovery of degraded mangrove ecosystems. Carbon-fixing bacteria (CFB) are recognized as major microbial contributors to sediment carbon accumulation in the mangrove wetlands. However, the response of the CFB community and sediment organic carbon (SOC) to introduced S. caseolaris is still unknown.</p><p><strong>Results: </strong>In this study, the sediment properties (especially SOC), the abundances of carbon-fixing genes (cbbL and cbbM), as well as the CFB community composition based on cbbL and cbbM functional genes and their interaction network, were compared between the introduced mangrove species (S. caseolaris) and native species (Kandelia obovata, Aegiceras corniculatum, and Acanthus ilicifolius) in the Niutianyang Mangrove Forest, Shantou, China. Our results showed that S. caseolaris markedly enhanced the SOC content and the abundances of the carbon-fixing genes (P < 0.05). The dominant CFB taxa were \"purple sulfur bacteria\" (PSB) (e.g., Chromatiales) and \"purple nonsulfur bacteria\" (PNSB) (e.g., Rhodobacterales). The relative abundances of some well-known plant growth-promoting rhizobacteria (PGPR), especially the Rhizobiales and Burkholderiales, were significantly increased (P < 0.05) by the S. caseolaris introduction. In addition, there was a more complex but less stable CFB community interaction network in the S. caseolaris sediments. It was well worth noting that a large number of the keystone taxa in the network were the sulfur-oxidizing bacteria (SOB), such as Sulfuriferula and Thioalkalivibrio, suggesting a tight connection between the carbon and sulfur cycles in mangrove wetlands, and these key genera might have decisive roles in reshaping CFB community structure and functioning.</p><p><strong>Conclusions: </strong>These findings confirmed that introduced S. caseolaris can strongly affect the CFB communities and the SOC content, and provided new insights into the microbial carbon sequestration in the mangrove wetlands.</p>","PeriodicalId":9339,"journal":{"name":"BMC Biology","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13393795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}