British Journal of Ophthalmology最新文献

{"title":"Biomarkers of risk of switching to dexamethasone implant for the treatment of diabetic macular oedema in real clinical practice: a multicentric study","authors":"Jorge Ruiz-Medrano, Patricia Udaondo Mirete, Marina Fernández-Jiménez, Monica Asencio-Duran, José Ignacio Fernández-Vigo, Marta Medina-Baena, Ignacio Flores-Moreno, Jesus Pareja-Esteban, Sara Touhami, Audrey Giocanti-Aurégan, Maria Vittoria Cicinelli, Anat Loewenstein, José M Ruiz-Moreno","doi":"10.1136/bjo-2024-325665","DOIUrl":"https://doi.org/10.1136/bjo-2024-325665","url":null,"abstract":"Objective To establish the influence of different optical coherence tomography (OCT) biomarkers at baseline treatment on the potential response to anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular oedema (DME). Methods Multicentric, retrospective, case-series study in patients with DME switched to dexamethasone implant injections (DEX-i) after anti-VEGF in real clinical practice. Biomarkers analysed on OCT images at baseline included intraretinal fluid (IRF), subretinal fluid (SRF), disorganisation of retinal inner layers (DRIL), disorganisation of retinal outer layers (DROL), hyperreflective foci (HRF), hyperreflective cystoid walls (HCW), dense intraretinal cyst (DIR) and vitreomacular interface (VMI) abnormalities. DME was classified according to the European School for Advanced Studies in Ophthalmology classification. Patients who were treated with anti-VEGF injections with an adequate response were selected as the control group. Results 275 eyes were analysed in this study; 209 eyes (76.0%) switched from anti-VEGF to DEX-i were compared with 66 control eyes (24.0%). Patients who required switching were statistically older, showed worse initial BCVA and higher CRT. Logistic regression analyses showed that female gender, age, central retinal thickness, type of diabetes, SRF, HCW, DIR and VMI increase the likelihood of switching. The OR regarding the need to switch generated by the presence of two of these three factors (SRF, HCW, VMI) was 48.95. Having all three multiplies it by 4.56×1016. Conclusion If baseline OCT shows two of SRF, HCW and VMI biomarkers at baseline, the risk of failure of anti-VEGF therapy is close to 50%. In the presence at baseline of all three biomarkers, failure of anti-VEGF therapy is almost certain. Data are available upon reasonable request.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"9 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-VEGF injections and macular atrophy progression in patients with neovascular age-related macular degeneration in remission","authors":"Nehal Nailesh Mehta, Ines Doris Nagel, Akshay Agnihotri, Fritz Gerald Paguiligan Kalaw, Anna Heinke, Lingyun Cheng, Dirk-Uwe Bartsch, William R Freeman","doi":"10.1136/bjo-2024-326124","DOIUrl":"https://doi.org/10.1136/bjo-2024-326124","url":null,"abstract":"Aims To determine the effect of continuing anti-vascular endothelial growth factor (VEGF) injections on the progression of macular atrophy (MA) during remission of neovascular age-related macular degeneration (nAMD). Methods In this retrospective cohort study, 59 eyes with nAMD with at least 6-month remission (disease inactivity) were analysed and were grouped into two. In group 1, anti-VEGF injections were stopped after remission (holiday). In group 2, injections were continued despite inactivity (maintenance). Using blue autofluorescence images via Heidelberg Spectralis, MA area was measured at initial injection, remission onset and the latest available remission point. The absence of subretinal haemorrhage, intraretinal fluid, subretinal fluid or subretinal hyper-reflective material associated with fluid on serial spectral domain optical coherence tomography scans was used to confirm the inactivity of the disease (remission). The rate of progression of MA during the period of remission was measured for the two groups. Results In group 1, 30 eyes received a mean of 16.97 injections over 39.2 months, followed by 21 months of drug holiday. In group 2, 29 eyes received a mean of 27.1 injections over 62.16 months, followed by a mean of 11.59 injections over 19.32 months for maintenance. The MA in the maintenance group progressed faster than the holiday group during remission (p=0.03). Conclusions Maintenance injections for nAMD in remission significantly increase progression of MA. Data are available on reasonable request. Data are available on reasonable request to WRF.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"35 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal hysteresis as a biomarker in glaucoma development among patients with myopia: a prospective study based on the UK Biobank","authors":"Jae-Seung Yun, Sang-Hyuk Jung, Seung Min Jung, Hong-Hee Won, Dokyoon Kim, Jin A Choi","doi":"10.1136/bjo-2024-326817","DOIUrl":"https://doi.org/10.1136/bjo-2024-326817","url":null,"abstract":"Background/aims We investigated the impact of potential risk factors on the development of incident glaucoma in individuals with myopia. Methods This prospective cohort study investigated participants aged 40–69 years from the UK Biobank. Participants were classified based on the degree of myopia: non-myopic (spherical equivalent (SE)≤−0.5D), mild myopia (−3.0D<SE≤−0.5 D), moderate myopia (−6.0 D<SE≤−3.0 D) and high myopia (SE≤−6.0D). Cox proportional-hazard models assessed the relationship of ocular and systemic risk factors with new glaucoma events across the myopia subgroups. Results Of 105 548 participants who did not have prior glaucoma, 35 870 were classified as myopic and 69 678 as non-myopic. A total of 1877 incident glaucoma cases (1.78%) were documented during a median 11.1 years of follow-up. Those who developed glaucoma had lower SE, lower corneal hysteresis (CH) and higher intraocular pressure. Systemic factors such as type 2 diabetes, dyslipidaemia, baseline fasting blood sugar and haemoglobin A1c were significantly higher in those who developed glaucoma, but only in the non-myopia and mild myopia subgroups. Degree of myopia and low CH (≤10.1 mm Hg) were significantly associated with increased glaucoma incidence. When we explored the impact of CH on the risk of incident glaucoma according to myopia grade, consistent elevation of risk with low CH was observed, with the highest risk being exhibited in the high myopia population (HR 1.67 (95% CI 1.10 to 2.57)). Conclusions Our results demonstrated a significant joint association between CH and myopia regarding glaucoma development, suggesting that altered ocular biomechanical properties could play a pronounced role in glaucoma development, particularly within the highly myopic population. Data may be obtained from a third party and are not publicly available.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"196 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choriocapillaris impairment in dry AMD: insights from swept-source OCT angiography and associations with structural biomarkers.","authors":"Katherine Overbey,Francesco Romano,Xinyi Ding,Cade F Bennett,Isabella Stettler,Itika Garg,Ioanna Ploumi,Filippos Vingopoulos,Melissa Yuan,Peyman Razavi,Matthew Finn,Inês Laíns,Nimesh A Patel,Leo Kim,David Wu,Dean Eliott,Deeba Husain,Demetrios Vavvas,Joan W Miller,John B Miller","doi":"10.1136/bjo-2024-326416","DOIUrl":"https://doi.org/10.1136/bjo-2024-326416","url":null,"abstract":"AIMSTo assess choriocapillaris flow deficit percentage (CCFD%) across stages of dry age-related macular degeneration (AMD) using swept-source optical coherence tomography angiography (SS-OCTA).METHODSThis cross-sectional, observational study included 270 eyes (182 patients), classified as early (70 eyes), intermediate (121 eyes) and geographic atrophy (GA, 79 eyes).Participants underwent a complete examination including macular 6×6 mm SS-OCTA scans (PLEX Elite 9000). Scans were reviewed and analysed for subretinal drusenoid deposits (SDDs), retinal pigment epithelium (RPE) atrophy size, incomplete RPE and outer retinal atrophy (iRORA) and drusen volume (3 mm). CCFD% was calculated after compensation and binarisation using Phansalkar's method (r=4-15 pixels) in various early treatment for diabetic retinopathy study sectors. Linear mixed-effects models adjusted for age evaluated associations with AMD stages and other imaging biomarkers.RESULTSCCFD% progressively increased with advancing dry AMD stages. Intermediate AMD eyes showed higher CCFD% than early AMD ones across all regions (p<0.001). GA eyes exhibited significantly higher CCFD% compared with early (p<0.001) and intermediate AMD eyes (p<0.001).SDDs were significantly associated with higher CCFD% in early (p<0.01) and intermediate AMD (p<0.05) for almost all regions examined, but not in GA (p>0.05). iRORA presence in iAMD and larger RPE atrophy in GA correlated with increased CCFD% (p<0.001).CONCLUSIONSThis study provides a comprehensive reference database for CCFD% across the stages of dry AMD using SS-OCTA. CCFD% increased with AMD severity, iRORA, SDDs, particularly in early and intermediate stages, and RPE atrophy size. Our findings support CCFD% as a valuable biomarker for clinical and research applications, warranting longitudinal studies to validate its prognostic value.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"12 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a self-administered Home ETDRS visual acuity testing (H-ETDRS) for self-monitoring vision changes in retinal diseases.","authors":"Zitian Liu,Yanjing Huang,Ling Jin,Caineng Pan,Xiaotong Han,Yingfeng Zheng","doi":"10.1136/bjo-2024-326283","DOIUrl":"https://doi.org/10.1136/bjo-2024-326283","url":null,"abstract":"OBJECTIVETo validate a self-administered Home Early Treatment Diabetic Retinopathy Study (H-ETDRS) visual acuity (VA) test and to assess its accuracy in detecting VA decline in patients with retinal diseases.METHODSA validation group of 156 participants and a testing group of 100 participants with diabetic retinopathy and age-related macular degeneration were recruited. All participants underwent monocular distance best-corrected VA (BCVA) tests in the study eye using the standard ETDRS (S-ETDRS) charts in clinic and the H-ETDRS device in a simulated home setting. Participants in the validation group repeated both methods. H-ETDRS letter scores were compared with S-ETDRS scores, evaluating mean difference and test-retest reliability (TRR). Intraclass correlation coefficients (ICCs) were calculated to measure the agreement. Participants in the testing group repeated both methods with a Bangerter filter density of 0.6 to simulate BCVA change. The performance of H-ETDRS in detecting acuity change was evaluated, with S-ETDRS serving as the standard.RESULTSFor the validation group, the mean difference between S-ETDRS and H-ETDRS scores was -1.38 letters (95% limits of agreement (LOA) -6.99 to 4.22). The scores of the two tests were highly correlated with an ICC of 0.98. The mean differences between initial test and retest scores were 0.11 letters (95% LOA -2.62 to 2.84) for S-ETDRS and -0.13 letters (95% LOA -5.64 to 5.38) for H-ETDRS. The ICCs of test-retest letter scores were 1.00 for S-ETDRS and 0.98 for H-ETDRS. For participants in the testing group who showed BCVA decline of one line or more with Bangerter filter, 96.7% were able to detect VA changes using H-ETDRS.CONCLUSIONS AND RELEVANCEThe H-ETDRS test demonstrates high TRR and good concordance with S-ETDRS test for retinal patients. The H-ETDRS is viable for self-monitoring VA changes in retinal diseases, however, further validation studies in actual home settings are warranted.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"26 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based system for automatic identification of benign and malignant eyelid tumours.","authors":"Wanlin Fan,Martine Johanna Jager,Weiwei Dai,Ludwig M Heindl","doi":"10.1136/bjo-2025-327127","DOIUrl":"https://doi.org/10.1136/bjo-2025-327127","url":null,"abstract":"AIMSOur aim is to develop a deep learning-based system for automatically identifying and classifying benign and malignant tumours of the eyelid to improve diagnostic accuracy and efficiency.METHODSThe dataset includes photographs of normal eyelids, benign and malignant eyelid tumours and was randomly divided into a training and validation dataset in a ratio of 8:2. We used the training dataset to train eight convolutional neural network models to classify normal eyelids, benign and malignant eyelid tumours. These models included VGG16, ResNet50, Inception-v4, EfficientNet-V2-M and their variants. The validation dataset was used to evaluate and compare the performance of the different deep learning models.RESULTSAll eight models achieved an average accuracy greater than 0.746 for identifying normal eyelids, benign and malignant eyelid tumours, with an average sensitivity and specificity exceeding 0.790 and 0.866, respectively. The mean area under the receiver operating characteristic curve (AUC) for the eight models was more than 0.904 in correctly identifying normal eyelids, benign and malignant eyelid tumours. The dual-path Inception-v4 network demonstrated the highest performance, with an AUC of 0.930 (95% CI 0.900 to 0.954) and an F1-score of 0.838 (95% CI 0.787 to 0.882).CONCLUSIONThe deep learning-based system shows significant potential in improving the diagnosis of eyelid tumours, providing a reliable and efficient tool for clinical practice. Future work will validate the model with more extensive and diverse datasets and integrate it into clinical workflows for real-time diagnostic support.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"35 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic report generation for macular diseases by natural language processing algorithms.","authors":"Xufeng Zhao,Chunshi Li,Jingyuan Yang,Xingwang Gu,Bing Li,Yuelin Wang,Bi-Lei Zhang,Xirong Li,Jianchun Zhao,Jie Wang,Weihong Yu","doi":"10.1136/bjo-2024-326064","DOIUrl":"https://doi.org/10.1136/bjo-2024-326064","url":null,"abstract":"AIMSTo investigate rule-based and deep learning (DL)-based methods for the automatically generating natural language diagnostic reports for macular diseases.METHODSThis diagnostic study collected the ophthalmic images of 2261 eyes from 1303 patients. Colour fundus photographs and optical coherence tomography images were obtained. Eyes without retinal diseases as well as eyes diagnosed with four macular diseases were included. For each eye, a diagnostic report was written with a format consisting of lesion descriptions, diagnoses and recommendations. Subsequently, a rule-based natural language processing (NLP) and a DL-based NLP system were developed to automatically generate a diagnostic report. To assess the effectiveness of these models, two junior ophthalmologists wrote diagnostic reports for the collected images independently. A questionnaire was designed and judged by two retina specialists to grade each report's readability, correctness of diagnosis, lesion description and recommendations.RESULTSThe rule-based NLP reports achieved higher grades over junior ophthalmologists in correctness of diagnosis (9.13±1.52 vs 9.03±1.42 points) and recommendations (8.55±2.74 vs 8.50±2.53 points). Furthermore, the DL-based NLP reports got slightly lower grades to those of junior ophthalmologists in lesion description (8.82±1.84 vs 9.12±1.20 points, p<0.05), correctness of diagnosis (8.72±2.36 vs 9.08±1.55 points, p<0.05) and recommendations (8.81±2.52 vs 9.15±1.65 points, p<0.05). For readability, the DL-based reports performed better than junior ophthalmologists, with scores of 9.98±0.17 vs 9.94±0.25 points (p=0.094).CONCLUSIONSThe multimodal AI system, coupled with the NLP algorithm, has demonstrated competence in generating reports for four macular diseases compared with junior ophthalmologists.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"125 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feature developments in artificial corneal devices: a review.","authors":"Gavin Li,Michael X Lin,Maria S Cortina,Esen Karamursel Akpek","doi":"10.1136/bjo-2024-326211","DOIUrl":"https://doi.org/10.1136/bjo-2024-326211","url":null,"abstract":"Corneal disease ranks as the fifth leading cause of global blindness, affecting more than 10 million individuals. Donor corneal transplantation, keratoplasty, remains the mainstay of addressing loss of corneal clarity. Historically, full-thickness penetrating keratoplasty (PK) has been one of the most successful and widely performed transplant procedures, although predominantly available in developed countries. The landscape for corneal transplantation has changed dramatically over the last two decades with the emergence of partial-thickness transplantation techniques and corneal cross-linking, which provide less invasive means of treating diseases like Fuchs' dystrophy and keratoconus, respectively. Currently, PK is often performed in eyes with complex problems and at high risk of graft failure. In fact, repeat grafting has become the second most common indication for PK. Furthermore, a significant shortage of donor corneas persists, with half of the global population lacking access to tissues. This shortage is particularly pronounced in developing countries, which lack the necessary infrastructure to support corneal transplantation despite bearing the highest burden of corneal blindness. Artificial corneal devices, known as keratoprostheses, have been posited as a remedy for various constraints of conventional keratoplasty and have demonstrated promising outcomes, particularly in high-risk cases. Synthetic devices are not subject to the risk of allograft rejection or endothelial failure. In resource-limited areas, keratoprostheses could potentially replace donor keratoplasty by eliminating the costly eye banking system to access, preserve and distribute the short-lived fresh donor tissues. Herein, we report the design, surgical technique, indications and early outcomes of clinical-stage fully synthetic keratoprostheses currently undergoing trials globally.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"35 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atropine and Spectacle lens Combination Treatment (ASPECT): 12-month results of a randomised controlled trial for myopia control using a combination of Defocus Incorporated Multiple Segments (DIMS) lenses and 0.025% atropine.","authors":"Noemi Guemes-Villahoz,Paula Talavero González,Paloma Porras-Ángel,Rafael Bella-Gala,Alicia Ruiz-Pomeda,Beatriz Martin-Garcia,Elena Hernandez-Garcia,Nunila Gomez de Liaño,Rakhee Shah,Julian Garcia-Feijoo,Rosario Gomez-de-Liaño","doi":"10.1136/bjo-2024-326852","DOIUrl":"https://doi.org/10.1136/bjo-2024-326852","url":null,"abstract":"AIMTo evaluate and compare the efficacy of combination treatment using 0.025% atropine and Defocus Incorporated Multiple Segments (DIMS) spectacle lenses to 0.025% atropine and single vision (SV) spectacle lenses in slowing myopia progression in children with myopia.METHODSRandomised controlled trial conducted on children aged 4-16 years with myopia between -1.00D and -6.00D and astigmatism ≤2.00D. Children were randomly allocated into two groups: 0.025% atropine and SV spectacle lenses treatment group (group A), and 0.025% atropine and DIMS spectacle lenses treatment group (group B). Cycloplegic spherical equivalent refraction (SER) and axial length were measured at baseline, 6 and 12 months.RESULTS102 patients completed the 12-month follow-up: n=49 in group A, mean age 9.50±2.78 years and n=53 in group B, mean age 9.90±2.47 years. At 12 months, the mean AL±SD change was 0.18±0.16 mm in group A and 0.07±0.16 mm in group B (mean difference: 0.11, 95% CI: 0.05 to 0.17; p≤0.001). Mean SER±SD progression at 12 months was -0.19±0.42D and -0.09±0.35D in groups A and B, respectively (p=0.13). 39.6% of children in group B had no axial elongation over 12 months compared with 12.2% of the children in group A (p=0.002).CONCLUSIONSCombination treatment with 0.025% atropine and DIMS spectacle lenses is more effective in controlling axial elongation than 0.025% atropine with SV lenses. Although not significant, SER differences between groups were lower in group B. These findings support a potential additive effect of the two treatments.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"53 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stage-specific dynamics of macular pigment optical density as a prognostic biomarker in epiretinal membrane surgery.","authors":"Alberto Quarta,Lisa Toto,Matteo Gironi,Maria Ludovica Ruggeri,Agbeanda Aharrh-Gnama,Annamaria Porreca,Lucio Zeppa,Matteo Di Censo,Pierpaolo Ferrante,Marta Di Nicola,Rodolfo Mastropasqua","doi":"10.1136/bjo-2024-327109","DOIUrl":"https://doi.org/10.1136/bjo-2024-327109","url":null,"abstract":"PURPOSETo explore macular pigment optical density (MPOD) dynamics in stage 2 and stage 3 epiretinal membranes (ERMs) and to evaluate its pre and postoperative modifications. Furthermore, the study assessed the potential of MPOD as a prognostic biomarker in ERM management.METHODSA cohort of stage 2 (n=21) and 3 (n=20) ERM patients, matched for age and gender, underwent clinical evaluation at baseline and postoperative follow-up. Correlations between MPOD and optical coherence tomography parameters were analysed within each group.RESULTSPostoperative MPOD levels significantly differed between stage 2 and 3 ERM patients (p=0.027). Changes in MPOD over time (ΔMPOD) were significantly greater in stage 3 compared with stage 2 participants (p=0.018). In stage 2, ΔMPOD correlated with changes in best-corrected visual acuity (ΔBCVA) (r=0.398, p=0.074) and demonstrated a strong correlation with changes in outer nuclear layer thickness (r=0.672, p<0.001). In stage 3, ΔMPOD exhibited a significant negative correlation with changes in central foveal thickness (r=-0.547, p=0.013) and a positive correlation with ΔBCVA (r=0.510, p=0.022).CONCLUSIONSMPOD exhibited stage-specific dynamics and significant postoperative changes. Correlation between ΔMPOD and ΔBCVA in both stages highlights its potential role as a prognostic functional biomarker.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"19 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}