High-sensitivity C-reactive protein and risk of retinal artery occlusion and ischaemic stroke: a cross-cohort study.

IF 3.7 2区 医学 Q1 OPHTHALMOLOGY
Yaxin Wang, Xiayin Zhang, Anyi Liang, Yongyi Niu, Daiyu Chen, Zijing Du, Wei Wu, Feng Zhang, Guanrong Wu, Ying Fang, Xianwen Shang, Zhuoting Zhu, Yijun Hu, Xiangjun Chen, Honghua Yu, Lidan Hu
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引用次数: 0

Abstract

Aims: Previous studies have suggested an association between retinal artery occlusion (RAO) and ischaemic stroke (IS), both associated with elevated inflammatory factors. However, the role of high-sensitivity C-reactive protein (hs-CRP) in the sequential onset of these two diseases is still unclear. Based on this evidence, we evaluated the association of hs-CRP with RAO and IS.

Methods: We examined hs-CRP from both the large multicentre cohort study UK Biobank and Chinese Retinal Artery Occlusion study. Cox proportional hazard models were used to study the association of hs-CRP with incident RAO and IS during the long-term follow-up in the UK Biobank. Logistic regression analysis was employed to assess the cross-sectional relationship between hs-CRP with RAO and IS in the Chinese cohort. A restricted cubic spline (RCS) approach was employed to evaluate potential non-linear associations of hs-CRP with IS.

Results: After exclusions, the analysis included 459 188 participants from the UK and 338 participants from China. Over a median follow-up of 12.2 years, 136 cases of incident RAO and 3206 cases of incident IS events were recorded in the UK Biobank. After multivariable adjustment, higher hs-CRP (per 10 mg/L) level was associated with increased risks of RAO (HR: 1.34, 95% CI: 1.01 to 1.76) and IS (HR: 1.24, 95% CI: 1.17 to 1.33). RCS analysis revealed a significant non-linear relationship between hs-CRP levels and incident IS (Pnon-linear<0.001). Furthermore, RAO patients with higher hs-CRP levels were more likely to be combined with IS (2.81 mg/L vs 10.14 mg/L, p<0.001). In the Chinese cohort, the association between hs-CRP with RAO and IS was further confirmed. Higher hs-CRP (per 1 mg/L) level was associated with increased risks of RAO (OR: 1.43, 95% CI: 1.15 to 1.78) and IS (OR: 1.13, 95% CI: 1.03 to 1.24).

Conclusions: Our findings underscore hs-CRP as a robust risk factor for both RAO and IS. Controlling hs-CRP levels might reduce the incidence of RAO and secondary stroke.

高敏 C 反应蛋白与视网膜动脉闭塞和缺血性中风的风险:一项交叉队列研究。
目的:先前的研究表明视网膜动脉闭塞(RAO)和缺血性脑卒中(IS)之间存在关联,两者都与炎症因子升高有关。然而,高敏c反应蛋白(hs-CRP)在这两种疾病的顺序发病中的作用尚不清楚。基于这些证据,我们评估了hs-CRP与RAO和IS的关系。方法:我们从英国生物银行和中国视网膜动脉闭塞研究的大型多中心队列研究中检测hs-CRP。采用Cox比例风险模型研究hs-CRP与英国生物银行长期随访期间发生的RAO和IS的关系。采用Logistic回归分析评估hs-CRP与中国队列中RAO和IS的横断面关系。采用限制性三次样条(RCS)方法评估hs-CRP与IS的潜在非线性关联。结果:排除后,分析包括来自英国的459 188名参与者和来自中国的338名参与者。在12.2年的中位随访中,英国生物银行记录了136例突发RAO和3206例突发IS事件。多变量调整后,较高的hs-CRP(每10 mg/L)水平与RAO (HR: 1.34, 95% CI: 1.01至1.76)和IS (HR: 1.24, 95% CI: 1.17至1.33)的风险增加相关。RCS分析显示hs-CRP水平与IS事件之间存在显著的非线性关系(非线性结论:我们的研究结果强调hs-CRP是RAO和IS的一个强有力的危险因素。控制hs-CRP水平可能降低RAO和继发性脑卒中的发生率。
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来源期刊
CiteScore
10.30
自引率
2.40%
发文量
213
审稿时长
3-6 weeks
期刊介绍: The British Journal of Ophthalmology (BJO) is an international peer-reviewed journal for ophthalmologists and visual science specialists. BJO publishes clinical investigations, clinical observations, and clinically relevant laboratory investigations related to ophthalmology. It also provides major reviews and also publishes manuscripts covering regional issues in a global context.
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