British Journal of Ophthalmology最新文献

{"title":"Effect of laser peripheral iridotomy location on angle widening in primary angle closure suspects: the six-year ZAP trial.","authors":"Ryan S Shean, Benjamin Y Xu, Wei Wang, Yicheng K Bao, Paul J Foster, Tin Aung, David Friedman, Mingguang He","doi":"10.1136/bjo-2026-330306","DOIUrl":"https://doi.org/10.1136/bjo-2026-330306","url":null,"abstract":"","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ellipsoid zone defects in age-related macular degeneration: the Beijing Eye Study.","authors":"Jost B Jonas, Songhomitra Panda-Jonas, Zhe Pan, Jie Xu, Rahul A Jonas, Ya Xing Wang","doi":"10.1136/bjo-2025-327829","DOIUrl":"https://doi.org/10.1136/bjo-2025-327829","url":null,"abstract":"","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-arterial melphalan for the treatment of high-grade uveal lymphoma.","authors":"Robert Novo, Yves Pierre Gobin, Lisa R Koenig, Julia Canestraro, Daniel Kowalsky Moskaliuk, Cesar Michael Samson, David H Abramson, Jasmine H Francis","doi":"10.1136/bjo-2025-329312","DOIUrl":"https://doi.org/10.1136/bjo-2025-329312","url":null,"abstract":"","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can hyperbaric oxygen therapy revolutionise the management of central retinal artery occlusion? A systematic review and meta-analysis of its efficacy and safety.","authors":"Kai Yang Chen, Hoi-Chun Chan, Chi Ming Chan","doi":"10.1136/bjo-2025-328496","DOIUrl":"https://doi.org/10.1136/bjo-2025-328496","url":null,"abstract":"","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the digital flicker test in optic neuritis and optic neuropathies of different aetiologies.","authors":"Carina Kelbsch, Gorm Pihl-Jensen, Eva Mikolaschek, Felix Tonagel, Jette Frederiksen, Susanne Trauzettel-Klosinski, Stephan A Küster-Gruber","doi":"10.1136/bjo-2026-329731","DOIUrl":"https://doi.org/10.1136/bjo-2026-329731","url":null,"abstract":"","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal nerve fibre layer thickness change in the parapapillary region","authors":"Jost B Jonas,Rahul A Jonas,Ya Xing Wang,Songhomitra Panda-Jonas","doi":"10.1136/bjo-2026-330479","DOIUrl":"https://doi.org/10.1136/bjo-2026-330479","url":null,"abstract":"Purpose To assess radial changes in the retinal nerve fibre layer thickness (RNFLT) in the temporal parapapillary region. Methods Using radial optical coherence tomographic images of the optic nerve head, we measured in a sample of participants of the population-based Beijing Eye Study the RNFLT in the temporal horizontal parapapillary region at locations ‘A’ (intact inner (INL) and outer (ONL) nuclear layer), ‘B’ (INL/ONL end), ‘C’ (just beyond the INL/ONL end) in the parapapillary gamma zone centre and at the disc border. Exclusion criterion was any optic nerve damage including glaucoma. Results The study included 47 eyes (47 participants). RNFLT increased (p<0.001) from 86±24 µm at ‘A’ (optic disc centre distance (ODCD): 1523±477 µm) to 128±42 µm at ‘B’ (ODCD: 1192±394 µm) and to 190±64 µm at ‘C’ (ODCD: 1023±312 µm). The increasing RNFLT measurements from location ‘A’ to ‘B’ by 49% and from ‘B’ to ‘C’ by 49% were double as high as geometrically expected (‘A’ to ‘B’: 1523 µm/1192 µm (28%); ‘B’ to ‘C’: 1192 µm/1023 µm (17%)). In the temporal parapapillary gamma zone (detected in 23 eyes), RNFLT changed from the mid of gamma zone (ODCD: 1069±291 µm) to the disc border (ODCD: 618±228 µm) from 210±76 µm to 238±81 µm (or +13%), while the ODCD decreased by 42%. Conclusions RNFLT in the temporal horizontal parapapillary region markedly increased just beyond (in direction to the disc border) of the INL/ONL end while within gamma zone RNFLT changed only marginally. Absence of underlying INL/ONL was associated with pronounced RNFL thickening, without major further radial RNFLT changes in gamma zone. These findings may be of importance for RNFLT measurements in highly myopic eyes.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"4 1","pages":"bjo-2026-330479"},"PeriodicalIF":4.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between varicose veins and central serous chorioretinopathy","authors":"Bertan Cakir,Negin Yavari,Lucie Y Guo,Chase A Ludwig,Ehsan Rahimy,Elizabeth J Rossin,Prithvi Mruthyunjaya,Karen M Wai","doi":"10.1136/bjo-2026-330067","DOIUrl":"https://doi.org/10.1136/bjo-2026-330067","url":null,"abstract":"Aim To investigate the association between varicose veins and central serous chorioretinopathy (CSCR), based on emerging genetic evidence of a shared vascular mechanism. Methods Propensity score-matched retrospective cohort study using the TriNetX Global Collaborative Network. Patients with varicose veins (n=621 513) were matched 1:1 to controls without varicose veins on age, sex, race and ethnicity, with prior CSCR or serous pigment epithelial detachment (PED) excluded. A secondary analysis excluded glucocorticoid users and additionally matched on hypertension, sleep apnoea and healthcare utilisation. A tertiary analysis compared thromboembolic risk (pulmonary embolism (PE) and deep vein thrombosis (DVT)) in varicose vein patients with and without CSCR. Results Varicose veins were significantly associated with CSCR (risk ratio (RR) 2.16; 95% CI 1.86 to 2.52; p<0.0001) and serous PED (RR 1.97; 95% CI 1.69 to 2.93; p<0.0001). Associations persisted after excluding glucocorticoid users and adjusting for comorbidities (CSCR RR 1.83; 95% CI 1.22 to 2.75; p=0.003; PED RR 1.95; 95% CI 1.38 to 3.34; p=0.013). Among varicose vein patients, rates of DVT (RR 1.36; p=0.078) and PE (RR 1.41; p=0.14) did not differ significantly between those with and without CSCR. Conclusions Varicose veins were significantly associated with CSCR and serous PED, independent of glucocorticoid exposure and known comorbidities, supporting a possible systemic vascular mechanism in CSCR pathophysiology.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"21 1","pages":"bjo-2026-330067"},"PeriodicalIF":4.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiKid-QA: construction and performance evaluation of a paediatric myopia education question-answering model","authors":"Zixun Wang,Jingtao Yu,Tingyu Zhang,Daqian Lu,Yifan Li,Yabin Hu,Jun Zhou,Liqin Huang,Xiaoling Zhang,Xiaoxue Hu,Xueshuo Xie,Xu Yan,Jing Yang,Bei Du,Ruihua Wei","doi":"10.1136/bjo-2026-329816","DOIUrl":"https://doi.org/10.1136/bjo-2026-329816","url":null,"abstract":"Background The surging prevalence of paediatric myopia has overwhelmed clinical education services. While general-purpose large language models (LLMs) are increasingly used for medical information, they often lack the domain-specific precision required for specialised care. This study aimed to develop and evaluate Myopia in Kids Question-Answering (MiKid-QA), a paediatric myopia education question-answering model fine-tuned to support standardised patient education. Methods We conducted a cross-sectional evaluation study. MiKid-QA was developed by fine-tuning the Qwen2.5-32B model using low-rank adaptation (LoRA) on curated professional datasets (2015–2025), including textbooks and expert consensus. Performance was assessed against DeepSeek and GPT-4 through a multicentre, single-blind expert evaluation of 25 standardised clinical scenarios. A panel of specialists rated responses across five dimensions (correctness, completeness, readability, helpfulness and safety) using a 5-point Likert scale. Results MiKid-QA demonstrated superior automated performance compared with its base model (Bilingual Evaluation Understudy: 0.1423 vs 0.0967). In expert evaluations, MiKid-QA achieved significantly higher scores for correctness (4.43±0.63) and safety (4.38±0.59) compared with DeepSeek and GPT-4 (all p<0.001). While completeness and helpfulness were comparable (p>0.05), MiKid-QA produced more concise responses and lower reading difficulty than GPT-4 (p<0.001), suggesting a potentially favourable balance between information accuracy and patient accessibility in standardised educational scenarios. Conclusion Specialised fine-tuning on curated myopia-related datasets was associated with higher expert-rated correctness and safety in standardised myopia education scenarios. MiKid-QA may serve as an auxiliary educational tool to support patient communication in myopia care, although further external validation and prospective clinical studies are required before clinical deployment.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"91 1","pages":"bjo-2026-329816"},"PeriodicalIF":4.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin use is associated with lower risk of open-angle glaucoma incidence and treatment escalation","authors":"Forest Lin,Alexander T Hong,Robert N Weinreb","doi":"10.1136/bjo-2026-330339","DOIUrl":"https://doi.org/10.1136/bjo-2026-330339","url":null,"abstract":"Background Retrospective cohort study using the TriNetX database to explore the relationship between statin use and glaucoma. Methods The open-angle glaucoma (OAG) incidence analysis consisted of individuals over 40 years of age with statin use and ophthalmological follow-up within 1 year prior. The OAG treatment analysis consisted of individuals with glaucoma and concurrent statin use. Outcomes included rates of OAG onset, topical ocular hypotensive prescription, incisional glaucoma surgery, minimally invasive glaucoma surgery (MIGS) and selective laser trabeculoplasty (SLT). Results 210 701 matched patients were included in the OAG incidence analysis and 29 598 in the OAG treatment analysis. At 5 years, statin use was associated with lower risk of OAG incidence (HR 0.85 (95% CI 0.82 to 0.89)), as well as treatment escalation to incisional glaucoma surgery (HR 0.64 (95% CI 0.58 to 0.71)), MIGS (HR 0.45 (95% CI 0.41 to 0.50)) or SLT (HR 0.40 (95% CI 0.36 to 0.44)) and lower rates of topical ocular hypotensive prescription (HR 0.89 (95% CI 0.86 to 0.91)). At 10 years, statin use was associated with lower risk of OAG incidence (HR 0.90 (95% CI 0.87 to 0.93)), escalation to incisional glaucoma surgery (HR 0.68 (95% CI 0.63 to 0.75)), MIGS (HR 0.54 (95% CI 0.49 to 0.59)) or SLT (HR 0.49 (95% CI 0.45 to 0.52)) and lower rates of topical ocular hypotensive prescription (HR 0.88 (95% CI 0.86 to 0.91)). Conclusions Our results suggest that statin use is associated with lower risk of glaucoma onset and treatment escalation. Prospective trials are needed to further elucidate the relationship between statin usage and glaucoma.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"37 1","pages":"bjo-2026-330339"},"PeriodicalIF":4.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endphthalmitis after cataract surgery in Sweden 2018–2024: associations with preoperative visual acuity and intracameral antibiotic regimens","authors":"Tomas Bro,Mats Lundström,Per Montan","doi":"10.1136/bjo-2026-330164","DOIUrl":"https://doi.org/10.1136/bjo-2026-330164","url":null,"abstract":"Background/aims Cataract surgery is one of the world’s most common and successful procedures. Postoperative endophthalmitis (PE) is rare but may be devastating. This study investigated associations between preoperative visual acuity (VA), other patient-related and surgery-related characteristics and PE. As a secondary objective, outcomes associated with the most commonly used intracameral antibiotic regimens were explored. Methods This retrospective cohort study used data from the population-based Swedish National Cataract Register from 2018 to 2024. Results Among 979 534 procedures, PE incidence was 0.013% (131 cases). In a multivariate analysis, male sex, ocular comorbidity and capsule complication showed higher ORs for PE while preoperative VA≥20/40 and immediate sequential bilateral surgery showed lower ORs for PE. Patients with better preoperative VA were younger and had fewer ocular comorbidities, intraoperative challenges and complications, indicating a more favourable case mix. Endophthalmitis rates varied by intracameral antibiotic regimen: 0.017% with cefuroxime alone, 0.011% with cefuroxime plus ampicillin and 0.010% with moxifloxacin. No regimen demonstrated statistically significant superiority. Enterococci occurred more frequently with cefuroxime. Time to PE diagnosis was longer with combination therapy and moxifloxacin versus cefuroxime alone. Visual outcomes were generally poor (48%<20/200), but moxifloxacin cases achieved≥20/40 final VA more often than cefuroxime (50% vs 23%). Conclusions PE incidence was very low. Better preoperative VA and immediate sequential bilateral cataract surgery were associated with lower observed odds, probably reflecting favourable case mix and residual confounding rather than causal protection. No IC antibiotic regimen was independently associated with lower PE incidence.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"225 1","pages":"bjo-2026-330164"},"PeriodicalIF":4.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}