British Journal of Ophthalmology最新文献

{"title":"Three-year outcomes of combined surgical peripheral iridectomy, goniosynechialysis and goniotomy for advanced primary angle-closure glaucoma: a multicentre study","authors":"Fengbin Lin,Li Tang,Xiaomin Zhu,Hengli Zhang,Tingli Wen,Guangxian Tang,Lan Lu,Sujie Fan,Meichun Xiao,Xin Zhang,Yunhe Song,Yuying Peng,Fengqi Zhou,Weirong Chen,Keith Barton,Ki Ho Park,Tin Aung,Robert N. Weinreb,Clement C. Tham,Dennis S.C. Lam,Lin Xie,Jiangang Xu,Ningli Wang,Xiulan Zhang","doi":"10.1136/bjo-2026-329527","DOIUrl":"https://doi.org/10.1136/bjo-2026-329527","url":null,"abstract":"Aims To assess the 3-year efficacy and safety of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL) and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract. Methods This was a multicentre prospective observational study with extended follow-up. We enrolled advanced PACG without cataract patients who underwent combined SPI+GSL+ GT and completed 36-month follow-up. Key outcomes included changes in intraocular pressure (IOP), best-corrected visual acuity (BCVA), usage of anti-glaucoma medications, surgical success rates, progression of peripheral anterior synechiae (PAS), endothelial cell density, visual field (VF) mean deviation (MD) and long-term postoperative complications. Results A total of 70 eyes from 58 patients were included in the final analysis. Baseline mean IOP (29.4±8.1 mm Hg) decreased to 16.4±4.01 mm Hg at 36 months (40.7±18.8% reduction, p<0.001), with anti-glaucoma medications declining from 2.0±1.4 to 0.7±0.9 (p<0.001), representing a 65.7% reduction in required medications postoperatively. At the 3-year follow-up, the cumulative complete and qualified success rates were 54.3% and 84.3%, respectively. Median BCVA worsened slightly (0.00 vs 0.10 logarithm of the minimum angle of resolution, p<0.001); 21.4% of eyes had significant vision loss (≥2 Snellen lines), attributable to cataract progression. MD of VF remained stable (p=0.217). Main late complications were cataract requiring surgery (n=10) and persistent PAS (n=11), with no vision-threatening events. Older age correlated with higher 3-year surgical success (p<0.05). Conclusions Combined SPI+GSL+GT provides sustained IOP reduction, stable visual function, and a favourable safety profile over 3 years, supporting its role as a reliable long-term treatment for advanced PACG without cataract.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"1 1","pages":"bjo-2026-329527"},"PeriodicalIF":4.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paracentral acute middle maculopathy in giant cell arteritis versus non-arteritic anterior ischaemic optic neuropathy","authors":"Angelica Hanna,Victoria Dezard,Shina Namakian,Jim Shenchu Xie,Jonathan A Micieli,Edward Margolin","doi":"10.1136/bjo-2026-330414","DOIUrl":"https://doi.org/10.1136/bjo-2026-330414","url":null,"abstract":"Background/aims To compare the prevalence of paracentral acute middle maculopathy (PAMM) on optical coherence tomography (OCT) in patients with giant cell arteritis (GCA) and non-arteritic anterior ischaemic optic neuropathy (NAION) and to evaluate its association with steroid treatment and presenting visual function. Methods This retrospective observational study included patients with GCA (with or without visual symptoms) and NAION identified from two tertiary care neuro-ophthalmology practices. Clinical data, visual acuity (VA) and visual field mean deviation (VFMD) were collected. OCT imaging was reviewed for the presence of PAMM. Results A total of 80 patients with biopsy-proven GCA and 179 patients with NAION were included. PAMM was identified in 28% of patients with GCA versus 0% of patients with NAION (p<0.001). Among patients with GCA, PAMM was observed in 33% of those with persistent visual symptoms, 8% with transient symptoms and 29% without visual symptoms (p=0.23). PAMM was present in 29% of patients who received corticosteroids prior to OCT compared with 22% of those who had not (OR 1.43 (95% CI 0.41 to 4.94); p=0.76). There was no significant association between PAMM and presenting VA or VFMD. Conclusions PAMM occurs in over a quarter of GCA cases but not in NAION, persists after initiation of corticosteroid therapy and can detect subclinical retinal ischaemia in visually asymptomatic patients with normal visual function. These findings support the diagnostic utility of PAMM in differentiating between anterior ischaemic optic neuropathy and NAION and detecting GCA with subclinical ocular involvement.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"16 1","pages":"bjo-2026-330414"},"PeriodicalIF":4.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ambient temperature on intraocular pressure in patients with stable primary open-angle glaucoma under medical treatment.","authors":"Toru Ikushima, Morio Ueno, Yoko Ikeda, Hiroki Mieno, Kazuhiko Mori, Aiko Iwase, Chie Sotozono, Shigeru Kinoshita, Makoto Araie","doi":"10.1136/bjo-2026-330361","DOIUrl":"https://doi.org/10.1136/bjo-2026-330361","url":null,"abstract":"<p><strong>Aims: </strong>To investigate the effects of ambient temperature on intraocular pressure (IOP) in patients with stable primary open-angle glaucoma (POAG) under medical treatment.</p><p><strong>Methods: </strong>This retrospective study analysed longitudinal IOP data via Goldmann applanation tonometer of POAG patients treated at the Kyoto Prefectural University of Medicine Hospital from 2012 to 2023. Inclusion criteria were no history of ophthalmic surgeries, no change in medications, age ≥40 years and ≥3 visits/year for ≥3 years. Data were analysed using a linear mixed-effects model with individual eyes as the random effect. Fixed effects included age, mean deviation of Humphrey Visual Field Perimetry, corneal curvature radius, central corneal thickness (CCT), axial length, mean blood pressure (mBP), heart rate, ambient temperature, atmospheric pressure, relative humidity, wind speed, precipitation, sunshine duration, sex, glaucoma type, glaucoma stage, number of eye-drops used, season, time of day and weather.</p><p><strong>Results: </strong>A total of 2655 IOP measurements from 154 eyes of 77 patients (mean age: 65.8 years; mean observation period: 5.2 years) were analysed. IOP was negatively correlated with ambient temperature (estimate=-0.029; p=0.003) and positively correlated with mBP (estimate=0.021; p<0.001). CCT tended to be associated with IOP. The number of eye-drops used, glaucoma type, and time of day had a significant effect, and season tended to have an effect, on IOP fluctuation.</p><p><strong>Conclusions: </strong>In patients with stable POAG under medical treatment, ambient temperature showed a significant and negative correlation with IOP after correction for the effects of other confounding and possibly correlating factors.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central visual field defect patterns and progression in glaucoma: a multicentre 10-year study.","authors":"Euido Nishijima, Kei Sano, Yuka Igari, Takashi Nishida, Shunsuke Sumi, Keiji Yoshikawa, Aiko Iwase, Sasan Moghimi, Robert Weinreb, Tadashi Nakano","doi":"10.1136/bjo-2026-330374","DOIUrl":"https://doi.org/10.1136/bjo-2026-330374","url":null,"abstract":"<p><strong>Background/aims: </strong>To determine whether baseline central visual field defect (CVFD) distribution and archetypal 10-2 patterns are associated with subsequent central visual field (VF) progression in glaucoma.</p><p><strong>Methods: </strong>This retrospective multicentre longitudinal cohort included 127 eyes of 94 adults with glaucoma, baseline CVFDs, baseline 24-2 mean deviation (MD) better than -6 dB and ≥10 years of Humphrey 10-2 Swedish Interactive Thresholding Algorithm (SITA) Standard follow-up at three centres in Japan. Baseline hemifield involvement, archetypal composition and clinical characteristics were evaluated. Time to progression, defined using clustered pointwise linear regression, was assessed with Cox models adjusted for age, mean intraocular pressure during follow-up and baseline 10-2 MD.</p><p><strong>Results: </strong>During 12.7 (1.8) years of follow-up, 53 eyes (41.7%) progressed. Inferior defects and both-hemifield defects were more common in progressing eyes than in non-progressing eyes (54.7% vs 16.2%, p<0.001; 41.5% vs 4.1%, p<0.001). In multivariable Cox models, inferior defects (HR 3.27, 95% CI 2.67 to 3.99; p<0.001) and both-hemifield defects (HR 3.71, 95% CI 3.02 to 4.57; p<0.001) were associated with progression. Higher weights of an inferonasal-predominant inferior defect pattern and a nasal both-hemifield pattern were also associated with progression.</p><p><strong>Conclusion: </strong>In glaucoma eyes with baseline CVFDs, inferior or both-hemifield involvement and specific archetypal 10-2 patterns were associated with long-term central VF progression. Baseline 10-2 defect distribution may support risk stratification and selection of eyes requiring closer central field surveillance.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of goniotomy incisional arc size on its efficacy and safety in juvenile open-angle glaucoma: a prospective multicentre study.","authors":"Zhixuan Wang, Zefeng Yang, Qingshu Ge, Peijie Lin, Yuhan Feng, Sujv Liu, Xiao Yang, Jinkun Liu, Yangfan Yang, Gong Chen, Xiaomin Zhu, Yadong Wang, Jing Ren, Aiguo Lv, Shumei Han, Heting Liu, Li Tan, Jiangang Xu, Yiting Zhang, Xiangxiang Ye, Yi Jiang, Kaiming Li, Fei Li, Yunhe Song, Fengbin Lin, Dilimulati Xiaokaiti, Zige Fang, Xiaoyi Liu, Ling Jin, Kai Zou, Yongjun Qi, Guihua Xu, Chukai Huang, Liming Tao, Pusheng Wang, Sujie Fan, Haijun Li, Peng Lu, Lin Xie, Jingming Shi, Yuhong Wang, Guangfu Dang, Liuzhi Zeng, Hongyang Zhang, Mingying Lai, Robert Weinreb, Xiaojing Pan, Xiulan Zhang","doi":"10.1136/bjo-2026-330493","DOIUrl":"https://doi.org/10.1136/bjo-2026-330493","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of goniotomy (GT) arc size on efficacy and safety in juvenile open-angle glaucoma (JOAG).</p><p><strong>Methods: </strong>This prospective, comparative, multicentre study enrolled 98 patients (126 eyes) with JOAG from 19 Chinese institutions. Patients who underwent GT were categorised into three groups based on the arc size of the incision: (1) 120° GT, (2) 240° GT and (3) 360° GT. Outcomes included intraocular pressure (IOP), surgical success rates, medication use and complications. Success was defined as postoperative IOP ≤21 mm Hg without (complete) or with (qualified) medications.</p><p><strong>Results: </strong>Mean patient age was 22.9±8.7 years. At 12 months postoperatively, complete success rates were comparable between the 240° GT (55.3%) and the 360° GT (64.7%) (p=0.447), and both were superior to the 120° GT (13.3%) (both p<0.001). Qualified success rates in the 120° GT, 240° GT and 360° GT groups were 80.0%, 93.6% and 91.2%, respectively, with no statistically significant difference (p=0.302). The 360° group required fewer medications than the other two groups at 6 months (both p<0.001), with no difference at 12 months (p=0.234). Hyphema was the most common complication, occurring more frequently in the 360° group (64.7%) than in the 240° (34.0%) and 120° (31.1%) groups (p=0.003).</p><p><strong>Conclusions: </strong>240° GT and 360° GT demonstrated comparable efficacy, both superior to 120° GT. 240° GT showed similar observed efficacy to 360° GT, along with procedural simplicity, fewer complications and no consumable use for JOAG; these findings warrant validation in randomised studies.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of disease severity and outcomes in periorbital necrotising fasciitis","authors":"Lara Buhl,Siegfried Priglinger,Christoph R Hintschich,Anna Schuh","doi":"10.1136/bjo-2026-329530","DOIUrl":"https://doi.org/10.1136/bjo-2026-329530","url":null,"abstract":"Background/aims To identify predictors of disease severity in periorbital necrotising fasciitis (PNF) and evaluate outcomes according to surgical approach. Methods All patients treated for PNF at a tertiary eye department between 2014 and 2024 were included. Demographic and clinical data were collected, including symptom onset, visual acuity and tissue involvement. Tissue involvement was quantified using a score assigning one point for each affected area (upper eyelid, lower eyelid, forehead, cheek and neck). The Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) score was calculated from admission laboratory values. Patient variables were correlated with length of hospitalisation (intensive care unit (ICU) days &lt;10 vs ≥10). Treatment strategies were analysed according to surgical approach—radical (radical debridement (RD)) versus tissue-sparing debridement (non-RD). Post-treatment complications, including eyelid disfigurement and need for reconstructive surgery, were assessed. Results 12 patients were included (median age: 71 years, range: 5–86). One died from multiorgan failure. An ICU stay exceeding 10 days was significantly associated with older age (55 (5–72) years, vs 81 (71–86), p=0.004) and higher LRINEC scores (4.5 (1–8) vs 10 (3–10), p=0.04). RD patients had significantly greater tissue involvement (2 (1–3) (non-RD) vs 3.5 (3–5) (RD), p=0.02). RD was associated with longer ICU stays (2.5 (0–10) vs 23 (4–77) days, p=0.04) and showed a trend toward more long-term complications (14% (non-RD) vs 100% (RD), p=0.08). Conclusion LRINEC score and age were predictors of PNF severity and prolonged ICU care. Non-RD did not demonstrate inferior outcomes compared with RD.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"13 1","pages":"bjo-2026-329530"},"PeriodicalIF":4.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant proton beam irradiation for invasive conjunctival squamous cell carcinoma: systemic, ocular and visual outcomes","authors":"Hugo Le Boité,Rémi Dendale,Sylvain Dureau,Valentin Calugaru,Pierre Loap,Catherine Nauraye,Sophie Gardrat,Juliette Sauge,Paul Fréneaux,Nathalie Algret,Alexia Savignoni,Jean Pierre Caujolle,Denis Malaise,Livia Lumbroso-Le Rouic,Nathalie Cassoux,Alexandre Matet","doi":"10.1136/bjo-2025-328127","DOIUrl":"https://doi.org/10.1136/bjo-2025-328127","url":null,"abstract":"Aims Invasive conjunctival squamous cell carcinoma (cSCC) carries a risk of local/distant recurrence after surgical excision. Adjuvant treatment is therefore required. We aimed to evaluate the outcome of adjuvant proton beam therapy (PBT) after excision of cSCC, in terms of overall survival, local/distant recurrence, eye conservation and vision. Methods Consecutive patients with invasive cSCC, who received PBT (60 Gy in 8 fractions based on preoperative photographs/drawings without tantalum clips) within 4 months of excision between 2006 and 2019, were retrospectively included. Cases with xeroderma pigmentosum were excluded. Follow-up included neck ultrasound or positron emission tomography-scan every 6 months for at least 2 years. Results 66 patients were included (50 men, 16 women, mean age 67.4±13.4 years). Two presented immunosuppression. Over a mean follow-up of 3.7 years, tumour control was achieved in 63 patients (95.5%). Three patients presented local recurrence (4.5%), including two in situ cSCC and one dysplasia with a mean delay of 12.6-month after PBT. Relapsing patients had larger lesions (p=0.041) and more frequent fornix/tarsal conjunctiva involvement (p=0.010) at diagnosis. No patient developed metastases from cSCC. Four patients died during follow-up (6.0%): two from other cancers and two from unknown causes. One patient developed neovascular glaucoma requiring secondary enucleation. 42 patients (64%) retained visual acuity better than 20/30 at the last visit. Conclusion Adjuvant PBT for invasive cSCC provides excellent local control and is associated with favourable systemic, ocular and visual outcomes. PBT with tantalum clips, or alternative irradiation modalities, should be considered for large tumours extending to the tarsal conjunctiva.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"31 1","pages":"bjo-2025-328127"},"PeriodicalIF":4.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10-year analysis of selective dissemination in glaucoma research from major conferences to journals","authors":"Alessandro Ghirardi,Ludovica Camisa,Stefano De Cillà,Alessandro Rabiolo","doi":"10.1136/bjo-2026-329990","DOIUrl":"https://doi.org/10.1136/bjo-2026-329990","url":null,"abstract":"Aims To evaluate the rates and determinants of full-text publication of abstracts presented at international glaucoma meetings and the impact factors (IFs) of the journals in which they were published. Methods Abstracts presented at American Glaucoma Society (AGS), European Glaucoma Society (EGS), International Congress on Glaucoma Surgery (ICGS) and World Glaucoma Congress (WGC) between 2010 and 2020 were classified by society, year of presentation, number of authors, first and last author sex, first author geographic affiliation, study design, single-centre versus multicentric design and positiveness of findings. Corresponding full-text publications and journals were identified using PubMed. Publication rates were estimated using the Kaplan-Meier curve, while associations with publication likelihood and journals’ IF were assessed using Cox and linear regressions, respectively. Results 6129 abstracts were analysed, with a 6-year publication rate of 40.5% (95% CI 39.2% to 41.8%). Higher likelihood of publication was observed for positive findings (HR 1.54 (95% CI 1.25 to 1.91), p&lt;0.001), AGS (EGS: HR 0.35 (95% CI 0.21 to 0.59), p&lt;0.001; ICGS: HR 0.42 (95% CI 0.25 to 0.68), p&lt;0.001; WGC: HR 0.37 (95% CI 0.23 to 0.58), p&lt;0.001), more recent years (HR 1.06 for 1-year increase (95% CI 1.02 to 1.10), p=0.01), larger research group (HR 1.02 per additional author (95% CI 1.00 to 1.04), p=0.03), multicentric design (HR 1.46 (95% CI 1.19 to 1.79), p&lt;0.001) and male first authorship (HR 1.45 (95% CI 1.22 to 1.72), p&lt;0.001). Multicentric design (estimate 0.69 (95% CI 0.37 to 1.02), p&lt;0.001) and male last authorship (estimate 0.25 (95% CI 0.02 to 0.47), p=0.03) were associated with higher IF. Conclusions Glaucoma research dissemination appears selective and non-random, resulting in systematic loss of information with implications for evidence synthesis.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"11 1","pages":"bjo-2026-329990"},"PeriodicalIF":4.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative framework for synthesising defocus-curve evidence in simultaneous-vision intraocular lenses","authors":"Maria Laura Passaro,Ferdinando Giuliano,Matilde Buzzi,Mariacarmela Ventura,Rita Mencucci,Ersilia Lucenteforte,Mor M Dickman,Gianni Virgili,Vito Romano","doi":"10.1136/bjo-2026-329959","DOIUrl":"https://doi.org/10.1136/bjo-2026-329959","url":null,"abstract":"Background/aims To develop a quantitative, meta-analytic framework to synthesise defocus-curve evidence and describe functional visual performance of simultaneous vision intraocular lenses (SVIOLs) across clinically relevant visual ranges. Methods PubMed was searched from inception through June 2025 using predefined terms related to cataract surgery, intraocular lenses and defocus curves. Studies of cataract surgery or refractive lens exchange with capsular bag implantation of SVIOLs reporting postoperative defocus curves were included. Randomised and non-randomised studies, cohort studies and case series were eligible. Defocus-curve data were extracted from tables or digitised from figures and summarised within predefined ranges: far (+1.00 to –0.50 D), intermediate (–0.50 to –2.00 D) and near (–2.00 to –3.50 D). Random-effects meta-analyses were performed for each IOL model. Exploratory latent class analysis (LCA) and meta-regression assessed performance patterns and associations with patient-reported outcomes. Outcomes included mean logMAR visual acuity across visual ranges, data-driven clustering of IOL performance and association with spectacle independence. Results A total of 125 studies including 18 077 eyes and 84 IOL models were analysed. Across IOL models, 97.1% achieved mean far acuity of 0.2 logMAR or better compared with 71.6% for intermediate and 67.5% for near. Considerable between-study heterogeneity was observed across all ranges. LCA identified four clusters reflecting a continuum from full-range to distance-dominant visual performance. Better near visual acuity was significantly associated with higher spectacle independence, explaining 45.2% of its variance. Conclusions Range-based descriptors enable reproducible comparison across heterogeneous studies and support evidence synthesis. This framework provides a practical approach to operationalise functional classification of SVIOLs and link visual performance to patient-reported outcomes.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"19 1","pages":"bjo-2026-329959"},"PeriodicalIF":4.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of intravitreal conbercept injection in treating macular oedema secondary to branch retinal vein occlusion: results from the BRAVE study","authors":"Wenbin Wei,Xuehui Shi,Xiaoxin Li,Xiaorong Li,Quanhong Han,Qing Zhang,Xiaodong Sun,Jian Ye,Youxin Chen,Xiao-Ling Liu,Pei Wang,Ming Zhang,Guanfang Su,Linnong Wang,Yanling Wang,Yongjin Zhang,Qinghuai Liu,Qi Zhang,Minli Huang,Luosheng Tang,Fei Yuan,Hongliang Dou,Yanping Song,Lin Lu,Shaowei Wang,Li Qin,Liu Yang,Tiecheng Liu,Ke Yao,Zhe-Li Liu,Xueyi Chen,Yan Shao,Zunhong Ke,Xiao Ke,Zhili Niu,Wang Xinguo,Xu Han,Zhujun Zhang,Tongxin Diao,Qiang Zheng","doi":"10.1136/bjo-2024-326355","DOIUrl":"https://doi.org/10.1136/bjo-2024-326355","url":null,"abstract":"Background/Aims To investigate the efficacy and safety of intravitreal conbercept injection for treating macular oedema secondary to branch retinal vein occlusion (BRVO-ME). Methods This study included 255 patients with BRVO-ME who were randomly divided in a 1:1 ratio into conbercept and control groups. From month 6, the conbercept group received PRN conbercept, while the control group received one conbercept injection followed by PRN dosing. The primary efficacy outcome was a least square mean change in the best-corrected visual acuity (BCVA) letter score from baseline at 6 months. Results The least square mean change in BCVA letter score from baseline was 16.9±0.9 and 8.9±0.9 (p&lt;0.0001) at 6 months and 17.1±0.9 and 14.1±1.0 (p=0.0252) at 12 months in the conbercept and control groups, respectively. Further, the least square mean change in central retinal thickness from baseline was −296.4±9.0 µm and −233.9±9.2 µm (p&lt;0.0001) at 6 months and −270.0±8.4 µm and −301.4±8.6 µm (p=0.0095) at 12 months in the conbercept and control groups, respectively. Conclusion Intravitreal injections of a 0.5 mg conbercept provided improvement in visual and anatomical outcomes in BRVO-ME patients with low rates of ocular and non-ocular safety events. Trial registration number NCT03108352 .","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"1 1","pages":"bjo-2024-326355"},"PeriodicalIF":4.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}