British Journal of Ophthalmology最新文献_第2页

Choroidal neovascularisation secondary toX-linked retinoschisis. 继发于 X 连锁视网膜裂孔症的脉络膜新生血管。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-10-22 DOI: 10.1136/bjo-2023-324165

Linyan Zhang, Xinyu Liu, Limei Sun, Xiaodi Zhou, Shuya Ke, Xiaoyan Ding

{"title":"Choroidal neovascularisation secondary toX-linked retinoschisis.","authors":"Linyan Zhang, Xinyu Liu, Limei Sun, Xiaodi Zhou, Shuya Ke, Xiaoyan Ding","doi":"10.1136/bjo-2023-324165","DOIUrl":"10.1136/bjo-2023-324165","url":null,"abstract":"Aims: Choroidal neovascularisation (CNV) in patients with X-linked retinoschisis (XLRS) has been poorly documented. This study aims to investigate the prevalence and clinical characteristics of CNV in patients with XLRS, as well as analyse the preliminary genotype-phenotype correlation.Methods: A retrospective case series of patients with genetically confirmed XLRS was included. Demographic, clinical and genetic features were analysed, with a comparison between CNV and non-CNV eyes.Results: Among 185 eyes of 129 patients with XLRS, the prevalence of CNV was 8.1% (15/185). The mean diagnostic age of all patients with CNV is 5.1±2.56 years. CNV eyes exhibited a mean best-corrected visual acuity (BCVA) (logarithm of the minimal angle of resolution) of 1.37±0.74. All CNVs were classified as subretinal and active. Peripapillary CNVs accounted for 80.0% (12/15), while subfoveal CNVs accounted for 20.0% (3/15). In CNV eyes, the prevalence of macular atrophy (5/15, 33.3%, p=0.013) and bullous peripheral schisis (14/15, 93.3%, p=0.000) was higher compared with non-CNV eyes. Additionally, CNV eyes exhibited poorer integrity of the outer retina and BCVA (p=0.007) compared with non-CNV eyes. All 15 eyes with CNV underwent anti-vascular endothelial growth factor (anti-VEGF) therapy. Genotype analysis revealed that 7 of 10 patients (70.0%, 10 eyes) were predicted to have missense variants, while 3 of 10 patients (30.0%, 5 eyes) exhibited severe variants.Conclusions: The prevalence of CNV in XLRS eyes was found to be 8.1%. All CNVs secondary to XLRS were active and classified as type 2. CNV eyes demonstrated poorer visual function and compromised retinal structures. Anti-VEGF therapy demonstrated effectiveness in treating XLRS-CNVs. No significant genotype-phenotype correlation was established.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choriocapillaris flow features in children with myopic anisometropia. 近视性斜视儿童的绒毛膜血流特征

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-10-22 DOI: 10.1136/bjo-2022-323020

Zhihao Jiang, Wu Bo, Zhengfei Yang, Xiaoling Luo, Yao Ni, Junwen Zeng

{"title":"Choriocapillaris flow features in children with myopic anisometropia.","authors":"Zhihao Jiang, Wu Bo, Zhengfei Yang, Xiaoling Luo, Yao Ni, Junwen Zeng","doi":"10.1136/bjo-2022-323020","DOIUrl":"10.1136/bjo-2022-323020","url":null,"abstract":"Aims: To examine differences between the eyes in choriocapillaris perfusion and choroidal thickness in children with myopic anisometropia.Methods: In this observational and prospective study, 46 children with myopic anisometropia were enrolled. Choriocapillaris perfusion parameters, including the percentage of flow voids, the total number of flow voids and the average flow void area were obtained by optical coherence tomography angiography (OCTA). The OCTA image was divided into a 1 mm-diameter central circle (C1) and a 2.5 mm-diameter annulus (without the inner central 1 mm circle, C1-2.5). Both C1 and C1-2.5 are centred on the foveola. The C1-2.5 was divided into nasal (N1-2.5), temporal (T1-2.5), inferior (I1-2.5) and superior (S1-2.5) areas. Differences in these parameters in different regions between eyes were analysed.Results: There were no significant differences in the percentage of flow voids and the average flow void area between the fellow eyes. The total number of signal voids was significantly higher in the less myopic eyes in C1-2.5 (p=0.032), S1-2.5 (p=0.008) and N1-2.5 (p=0.019). Changes in spherical equivalent refraction and axial length were both correlated with the changes in the total number of flow voids in N1-2.5 (R=-0.431, p=0.03; R=-0.297, p=0.047).Conclusions: The choroid in the macular region becomes thinner and the total number of flow voids in the nasal macular region decreased with the amplitude of myopia. This suggests that a decrease in total number of flow voids may indicate an early change in myopia.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140288276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute spontaneous vortex vein occlusion: clinical features, multimodal imaging and natural course. 急性自发性涡状静脉闭塞：临床特征、多模态成像和自然病程。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-10-22 DOI: 10.1136/bjo-2023-324712

Kang Xue, Fengxi Meng, Hui Ren, Han Yue, Lin Jonathan He, Ruiqi Ma, Xintong Lin, Jiang Qian, Jie Guo

{"title":"Acute spontaneous vortex vein occlusion: clinical features, multimodal imaging and natural course.","authors":"Kang Xue, Fengxi Meng, Hui Ren, Han Yue, Lin Jonathan He, Ruiqi Ma, Xintong Lin, Jiang Qian, Jie Guo","doi":"10.1136/bjo-2023-324712","DOIUrl":"10.1136/bjo-2023-324712","url":null,"abstract":"Aims: To describe the clinical features, multimodal imaging, treatments and natural course of acute spontaneous vortex vein occlusion.Methods: Clinical data were collected on nine patients with acute vortex vein occlusion. The symptoms and signs, multimodal imaging, treatments and follow-up results were summarised.Results: Six patients (66.7%) were men and three (33.3%) were women. The mean age was 47.8±15.4 years. Patients were initially misdiagnosed as having choroidal tumour (66.7%), scleritis (22.2%) and peripheral exudative haemorrhagic chorioretinopathy (11.1%). The related clinical characteristics included choroidal pseudo-tumour (100%), anterior segment injection (88.9%), acute ocular pain (77.8%), transient blurred vision (66.7%) and subsequent scleral icterus (66.7%). Six patients (66.7%) experienced a definite Valsalva manoeuvre prior to the onset. In acute phase, ultrasonography showed a low-to-medium reflective lesion without inside blood flow signal (mean thickness, 2.7±0.6 mm). Swept-source optical coherence tomography angiography (SS-OCTA) demonstrated the dilated vortex veins and ampulla with suprachoroidal haemorrhage and exudation. Indocyanine green angiography (ICGA) demonstrated choroidal circulation abnormalities in the affected quadrant. MRI showed a well-defined mass with enhancement. The main treatment was medical observation (44.5%). The choroidal pseudo-tumour spontaneously resolved with a mean course of 4.1±1.9 weeks.Conclusions: Acute vortex vein occlusion is a rare condition and initial misdiagnosis is not uncommon. It is mainly identified as an evanescent choroidal pseudo-tumour with acute pain, red eye and blurred vision. Widefield ICGA and SS-OCTA can offer valuable diagnostic clues. Medical observation may be a treatment option.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140157610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual acuity and visual field as a function of disease duration in patients with birdshot chorioretinitis. 鸟枪状脉络膜视网膜炎患者的视力和视野与病程的关系。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-10-22 DOI: 10.1136/bjo-2023-324636

Jordan Loeliger, Dominique Monnet, Jennifer Thorne, Linda Imikerene, Souhila Kecili, Antoine P Brézin

{"title":"Visual acuity and visual field as a function of disease duration in patients with birdshot chorioretinitis.","authors":"Jordan Loeliger, Dominique Monnet, Jennifer Thorne, Linda Imikerene, Souhila Kecili, Antoine P Brézin","doi":"10.1136/bjo-2023-324636","DOIUrl":"10.1136/bjo-2023-324636","url":null,"abstract":"Background: Birdshot chorioretinitis (BSCR) is a chronic bilateral posterior uveitis, which can affect central as well as peripheral vision. The aim of this study was to assess how visual acuity and visual field evolved over time in patients with BSCR.Methods: This was a prospective, observational, single-centre study based on data from the CO-BIRD cohort. Patient visits were categorised based on the time elapsed since the first symptoms, and groups of patients with different disease duration were defined. The main outcome measures were the best corrected visual acuity (BCVA), the mean deviation (MD) and the standard pattern deviation (PSD).Results: The study included 447 Caucasian patients (181 males and 266 females), all of whom HLA-A29 carriers. From onset to 30 years of disease duration, the number of patients in each consecutive 5-year period was 237, 250, 196, 147, 78 and 32, respectively. Overall, the range of visual acuity and visual field results increased with disease duration. BCVA gradually decreased and showed a significant decline after 11-15 years after the first symptoms. Among the visual field indices, PSD significantly increased after 16-20 years, while MD showed a significant decline after 21-25 years. No major gender differences were found in visual outcomes, indicating comparable severity. The intereye correlations of MD and PSD were stronger than those of BCVA.Conclusions: BSCR resulted in a large heterogeneity of visual outcomes, which increased with time. Our data provide an overview of the visual consequences of BSCR as a function of disease duration.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140173777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and functional changes of binocular corneal innervation and ocular surface function after unilateral SMILE and tPRK. 单侧 SMILE 和 tPRK 术后双眼角膜神经支配和眼表功能的结构和功能变化。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-10-22 DOI: 10.1136/bjo-2023-324358

Qianwen Gong, Kaiyan Huang, Kexin Li, Yixuan Tong, Jian Zhao, Hui Wang, Zhiqiang Xu, Meng Lin, Fan Lu, Liang Hu

{"title":"Structural and functional changes of binocular corneal innervation and ocular surface function after unilateral SMILE and tPRK.","authors":"Qianwen Gong, Kaiyan Huang, Kexin Li, Yixuan Tong, Jian Zhao, Hui Wang, Zhiqiang Xu, Meng Lin, Fan Lu, Liang Hu","doi":"10.1136/bjo-2023-324358","DOIUrl":"10.1136/bjo-2023-324358","url":null,"abstract":"Aims: To evaluate the bilateral changes in the sub-basal nerve plexus of the cornea and ocular surface function after unilateral small incision lenticule extraction (SMILE) and transepithelial photorefractive keratectomy (tPRK) procedures.Methods: 34 patients were enrolled in the study and underwent unilateral SMILE (21 of 34 patients) or unilateral tPRK (13 of 34 patients). Complete ophthalmic examinations, tear film function tests and Cochet-Bonnet esthesiometry were conducted to assess the effects of the surgeries on the corneal nerves and tear function. Morphological changes were assessed using in vivo confocal microscopy to evaluate the corneal sub-basal nerve plexus and dendritic cells. ELISA was used to measure the tear neuromediators. Clinical and morphological data at each follow-up point were compared with preoperative baseline values.Results: All patients who underwent unilateral SMILE or tPRK procedures exhibited bilateral corneal nerve degenerative changes, decreased corneal sensitivity, worsening of dry eye symptoms and changes in bilateral tear neuromediators. In the SMILE group, bilateral corneal sensitivity was positively correlated with corneal nerve fibre length and negatively correlated with dendritic cell area. The dry eye severity was negatively correlated with corneal sensitivity. Tear levels of substance P and nerve growth factor were positively correlated with mean dendritic cell area and dry eye severity, but negatively correlated with corneal sensitivity. In the tPRK group, bilateral corneal sensitivity was positively correlated with corneal nerve fibre density.Conclusions: Unilateral refractive surgery may bilaterally affect the morphology and function of corneal nerves and ocular surface status postoperatively.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140288277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world application of a smartphone-based visual acuity test (WHOeyes) with automatic distance calibration. 基于智能手机的视力测试（WHOeyes）与自动距离校准的实际应用。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-10-22 DOI: 10.1136/bjo-2023-324913

Yi Wu, Stuart Keel, Vera Lúcia Alves Carneiro, Shiran Zhang, Wei Wang, Chi Liu, Xuanzhang Tang, Xiaotong Han, Mingguang He

{"title":"Real-world application of a smartphone-based visual acuity test (WHOeyes) with automatic distance calibration.","authors":"Yi Wu, Stuart Keel, Vera Lúcia Alves Carneiro, Shiran Zhang, Wei Wang, Chi Liu, Xuanzhang Tang, Xiaotong Han, Mingguang He","doi":"10.1136/bjo-2023-324913","DOIUrl":"10.1136/bjo-2023-324913","url":null,"abstract":"Background: To develop and assess the usability of a smartphone-based visual acuity (VA) test with an automatic distance calibration (ADC) function, the iOS version of WHOeyes.Methods: The WHOeyes was an upgraded version with a distinct feature of ADC of an existing validated VA testing app called V@home. Three groups of Chinese participants with different ages (≤20, 20-40, >40 years) were recruited for distance and near VA testing using both an Early Treatment Diabetic Retinopathy Study (ETDRS) chart and the WHOeyes. The ADC function would determine the testing distance. Infrared rangefinder was used to determine the testing distance for the ETDRS, and actual testing distance for the WHOeyes. A questionnaire-based interview was administered to assess the satisfaction.Results: The actual testing distance determined by the WHOeyes ADC showed an overall good agreement with the desired testing distance in all three age groups (p>0.50). Regarding the distance and near VA testing, the accuracy of WHOeyes was equivalent to ETDRS. The mean difference between the WHOeyes and ETDRS ranged from -0.084 to 0.012 logMAR, and the quadratic weighted kappa (QWK) values were >0.75 across all groups. The test-retest reliability of WHOeyes was high for both near and distance VA, with a mean difference ranging from -0.040 to 0.004 logMAR and QWK all >0.85. The questionnaire revealed an excellent user experience and acceptance of WHOeyes.Conclusions: WHOeyes could provide accurate measurement of the testing distance as well as the distance and near VA when compared to the gold standard ETDRS chart.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous 24-hour intraocular pressure monitoring in normal Chinese adults using a novel contact lens sensor system. 使用新型隐形眼镜传感器系统对中国正常成年人进行 24 小时连续眼压监测。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-10-22 DOI: 10.1136/bjo-2023-323361

Yuning Zhang, Yifan Wei, Ching Hymn Christopher Lee, Ping Wai Or, Isuru Kaweendra Karunaratne, Mingjie Deng, Wenxin Yang, Iok Tong Chong, Yangfan Yang, Zidong Chen, Yanmei Fan, David C C Lam, Minbin Yu

{"title":"Continuous 24-hour intraocular pressure monitoring in normal Chinese adults using a novel contact lens sensor system.","authors":"Yuning Zhang, Yifan Wei, Ching Hymn Christopher Lee, Ping Wai Or, Isuru Kaweendra Karunaratne, Mingjie Deng, Wenxin Yang, Iok Tong Chong, Yangfan Yang, Zidong Chen, Yanmei Fan, David C C Lam, Minbin Yu","doi":"10.1136/bjo-2023-323361","DOIUrl":"10.1136/bjo-2023-323361","url":null,"abstract":"Aims: To investigate the physiological nyctohemeral intraocular pressure (IOP) rhythms of normal Chinese adults using a novel contact lens sensor system (CLS) that can output IOP in millimetres of mercury (mm Hg) continuously.Methods: Fifty-nine eyes of 59 normal Chinese adults completed 24-hour IOP monitoring using the novel CLS. A descriptive analysis was conducted on the 24-hour IOP mean, peak and acrophase, trough and bathyphase, fluctuation, and mean amplitude of intraocular pressure excursion (MAPE). The continuous data were analysed at several periods (diurnal period, 08:00-20:00 hours; nocturnal period, 22:00-06:00 hours; sleep time, 0:00-06:00 hours), and compared between right and left eyes, males and females, and different age ranges (<30, and ≥30), respectively.Results: Normal adults had a lower peak, higher trough, smaller fluctuation and smaller MAPE (p<0.05 for all comparisons) but non-significantly different mean (p=0.695) in the nocturnal period or sleep time compared with the diurnal period. The 24-hour IOP peak and trough showed the frequency of occurrence ranging from 1.69% to 15.25% at an interval of 2 hours. No IOP parameter showed significant difference between right and left eyes (p>0.1 for all comparisons). The male group had larger 24-hour and diurnal IOP fluctuation and MAPE (p<0.05 for all comparisons). Subjects aged 30 or over had higher 24-hour and diurnal mean, higher peak, and larger MAPE (p<0.05 for all comparisons).Conclusion: Continuous 24-hour IOP output from the CLS in normal Chinese was stable with a comparable mean level between day and night, as well as scattered acrophase and bathyphase. The 24-hour IOP mean increased with age, and IOP variations were positively correlated to age and male sex.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dry eye symptoms and health-related quality of life among Chinese individuals: a national-based study. 中国人的干眼症状与健康相关生活质量：一项全国性研究。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-10-22 DOI: 10.1136/bjo-2023-324677

Jia-Yan Kai, Yi-Bo Wu, Bing Shi, Dan-Lin Li, Xing-Xuan Dong, Pei Wang, Chen-Wei Pan

{"title":"Dry eye symptoms and health-related quality of life among Chinese individuals: a national-based study.","authors":"Jia-Yan Kai, Yi-Bo Wu, Bing Shi, Dan-Lin Li, Xing-Xuan Dong, Pei Wang, Chen-Wei Pan","doi":"10.1136/bjo-2023-324677","DOIUrl":"10.1136/bjo-2023-324677","url":null,"abstract":"Aims: To assess the impact of dry eye symptoms (DESs) on health-related quality of life (HRQOL) among Chinese residents.Methods: A total of 21 916 participants were involved in this nationwide cross-sectional study. All of them completed the Ocular Surface Disease Index-6 and the five-level European Quality of Life 5-Dimensional (EQ-5D) Questionnaire to assess the severity of DES and HRQOL, respectively. Multiple linear regression models were used to explore the associations of DES with EQ-5D health utility score (HUS) and visual analogue scale (VAS) score. We used logistic regression models to assess the relationships between DES and self-reported problems in the EQ-5D dimensions.Results: Overall, 43.6% of participants reported DESs. Of them, 2511 (11.5%) were with mild symptoms, 2762 (12.6%) were with moderate symptoms and 4288 (19.6%) were with severe symptoms. Both EQ-5D HUS and VAS score were significantly negatively associated with the severity of DES. The difference in HUS between patients with no symptoms and severe symptoms (0.085) was larger than the minimally clinical important difference for EQ-5D. The loss in HRQOL was greater for patients with severe DES than those just with other comorbidities. Participants with DES had a significantly higher risk of reporting problems in all five EQ-5D dimensions, especially in pain/discomfort and anxiety/depression for patients with mild or moderate symptoms and in mobility, self-care and usual activities for severe patients.Conclusion: Patients with more severe DES tend to have lower HRQOL. Effective interventions targeted at different HRQOL dimensions should be taken according to the severity of DES.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproducibility of consecutive automated telemetric noctodiurnal IOP profiles as determined by an intraocular implant. 通过眼内植入物测定连续自动遥测夜间眼压曲线的再现性。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-10-22 DOI: 10.1136/bjo-2022-323080

Jacqueline J O N van den Bosch, Vincenzo Pennisi, Harsha Laxmana Rao, Kaweh Mansouri, Robert Weinreb, Hagen Thieme, Michael B Hoffmann, Lars Choritz

{"title":"Reproducibility of consecutive automated telemetric noctodiurnal IOP profiles as determined by an intraocular implant.","authors":"Jacqueline J O N van den Bosch, Vincenzo Pennisi, Harsha Laxmana Rao, Kaweh Mansouri, Robert Weinreb, Hagen Thieme, Michael B Hoffmann, Lars Choritz","doi":"10.1136/bjo-2022-323080","DOIUrl":"10.1136/bjo-2022-323080","url":null,"abstract":"Background: Intraocular pressure (IOP) monitoring in glaucoma management is evolving with novel devices. We investigated the reproducibility of 24 hour profiles on two consecutive days and after 30 days of self-measurements via telemetric IOP monitoring.Methods: Seven primary patients with open-angle glaucoma previously implanted with a telemetric IOP sensor in one eye underwent automatic measurements throughout 24 hours on two consecutive days ('day 1' and 'day 2'). Patients wore an antenna adjacent to the study eye connected to a reader device to record IOP every 5 min. Also, self-measurements in six of seven patients were collected for a period of 30 days. Analysis included calculation of hourly averages to correlate time-pairs of day 1 versus day 2 and the self-measurements vers day 2.Results: The number of IOP measurements per patient ranged between 151 and 268 on day 1, 175 and 268 on day 2 and 19 and 1236 during 30 days of self-measurements. IOP time-pairs of automatic measurements on day 1 and day 2 were significantly correlated at the group level (R=0.83, p<0.001) and in four individual patients (1, 2, 6 and 7). IOP time-pairs of self-measurements and day 2 were significantly correlated at the group level (R=0.4, p<0.001) and in four individual patients (2, 5, 6 and 7).Conclusions: Twenty-four hour automatic measurements of IOP are correlated on consecutive days and, though to a lesser degree, with self-measurements. Therefore a virtual 24-hour IOP curve might be constructed from self-measurements. Both options provide an alternative to frequent in-office IOP measurements.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcomes of glued (sutureless) amniotic membrane transplantation in acute Stevens-Johnson syndrome/toxic epidermal necrolysis: a comparative study. 胶合（无缝合）羊膜移植治疗急性史蒂文斯-约翰逊综合征/中毒性表皮坏死症的长期疗效：一项比较研究。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2024-10-22 DOI: 10.1136/bjo-2023-324076

Ramy Rashad, James T Kwan, Swapna S Shanbhag, Panotsom Ngowyutagon, Musa Saeed, Mohammad A Tahboub, Abid Haseeb, James Chodosh, Hajirah N Saeed

{"title":"Long-term outcomes of glued (sutureless) amniotic membrane transplantation in acute Stevens-Johnson syndrome/toxic epidermal necrolysis: a comparative study.","authors":"Ramy Rashad, James T Kwan, Swapna S Shanbhag, Panotsom Ngowyutagon, Musa Saeed, Mohammad A Tahboub, Abid Haseeb, James Chodosh, Hajirah N Saeed","doi":"10.1136/bjo-2023-324076","DOIUrl":"10.1136/bjo-2023-324076","url":null,"abstract":"Purpose: To compare the effectiveness and efficiency of a glued (sutureless) technique for amniotic membrane transplantation (AMT) with a traditional sutured one in the setting of acute Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN).Methods: This retrospective cohort study evaluated all patients diagnosed with SJS/TEN between 2008 and 2020 within our hospital network who received AMT in the acute phase according to our protocol and had at least one ophthalmic follow-up in the chronic phase. Primary outcomes included best-corrected visual acuity (BCVA) at the most recent visit, presence of a severe ocular complication (SOC) via predefined criteria, time to procedure and duration of procedure. Random effects model analysis was used to evaluate the impact of potential covariates on outcome measures.Results: A total of 23 patients (45 eyes) were included: 14 patients (27 eyes) in the AMT suture group and 9 patients (18 eyes) in the AMT glue group. There was no difference between the two groups in BCVA at the most recent visit (p=0.5112) or development of a SOC (p=1.000). The glue method was shorter in duration than the suture method (p<0.001). Random effects model additionally indicated that there was no difference in BCVA at most recent follow-up between patients who had received glued versus sutured AMT (p=0.1460).Conclusions: Our glued technique for AMT is as effective as our sutured technique in stabilising the ocular surface and mitigating chronic ocular complications in SJS/TEN. The glued technique is also shorter in duration and performed more expediently than the sutured technique.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140136517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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