British Journal of Ophthalmology最新文献

{"title":"Sex-based differences in retinal detachment in a genotyped Stickler syndrome cohort: implications for preventive management.","authors":"Ysé Borella, Antoine Constant, Pierre-Raphaël Rothschild, Matthieu P Robert, Cyril Burin Des Roziers, Sophie Valleix, Antoine P Brezin, Dominique Bremond Gignac, Alejandra Daruich","doi":"10.1136/bjo-2025-328779","DOIUrl":"https://doi.org/10.1136/bjo-2025-328779","url":null,"abstract":"<p><strong>Aims: </strong>Stickler syndrome is a genetically inherited vitreoretinopathy that can lead to retinal detachment from early childhood. There is currently no consensus preventive treatment. We aimed at determining whether sex influences the age of onset of rhegmatogenous retinal detachment (RRD) in <i>COL2A1</i> and <i>COL11A1</i> Stickler patients.</p><p><strong>Methods: </strong>This is a retrospective study including genotyped Stickler patients from two tertiary centres with at least one RRD. We analysed differences in the age of occurrence of RRD according to sex and genetic mutation. A multivariate analysis was used to analyse risk factors for RRD including sex, presence of preventive treatment, congenital myopia or extra-ophthalmologic conditions.</p><p><strong>Results: </strong>58 patients with at least one RRD were included. In girls with <i>COL2A1</i> variants (n=30), the average age of RRD onset was later (21.3 (±14.5) years; range: 5.4-66.0), and the age distribution was broader than in boys with <i>COL2A1</i> variants (n=19, 10.07 (±5.7) years; range: 0.5-19.7; p<0.0001). Among <i>COL11A1</i> patients, there was no significant difference in age of RRD between boys and girls. Preventive treatment (360° laser or scleral buckling) was the only independent protective factor for RRD (RR=-0.49 (±0.002); p<0.001).</p><p><strong>Conclusion: </strong>In <i>COL2A1</i>-Stickler syndrome, males tend to experience RRD at an earlier age. In <i>COL11A1</i>-Stickler patients, RRD occurs earlier in life but no sex difference was found. Based on these findings, if preventive treatment is considered, it should be performed before puberty, particularly earlier in boys with COL2A1-related Stickler syndrome and in both male and female patients with COL11A1 variants.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous tumour volume improves prognostic stratification beyond AJCC stage and MLPA cytogenetic profile in uveal melanoma.","authors":"Armando Gutiérrez-Cuesta, Manuel F Bande, Paula Silva-Rodríguez, Purificación Mera, Joaquín Marticorena, María Pardo, María José Blanco-Teijeiro","doi":"10.1136/bjo-2026-329615","DOIUrl":"https://doi.org/10.1136/bjo-2026-329615","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the prognostic value of estimated tumour volume as a continuous biomarker in uveal melanoma and to compare its discriminative performance with the American Joint Committee on Cancer (AJCC) staging and multiplex ligation-dependent probe amplification (MLPA)-based genetic risk classification.</p><p><strong>Methods: </strong>This retrospective cohort study included consecutive patients with choroidal or ciliary body melanoma treated between 2016 and 2024 at a tertiary ocular oncology centre. Tumour volume (mm³) was calculated from baseline ultrasonography using an ellipsoidal (oval-base) approximation. The primary endpoint was metastasis-free survival (MFS). Survival was analysed using Kaplan-Meier methods and Cox regression. In the genetic subset, Firth-penalised Cox regression was applied. Prognostic discrimination was assessed using Harrell's concordance index (C-index) for AJCC stage, tumour volume, MLPA profile and combined models.</p><p><strong>Results: </strong>A total of 237 patients were included (mean age 65.5±13.8 years; 54.0% female). Median follow-up was 61.0 months, and 64 patients developed metastasis during follow-up. Higher tumour volume was significantly associated with worse MFS, corresponding to an approximately 10% increase in hazard per 100 mm³ (HR 1.10; 95% CI 1.05 to 1.13; p<0.001). Continuous tumour volume showed higher discrimination than AJCC staging alone (C-index 0.73 vs 0.66). The highest discrimination was observed in models combining tumour volume and MLPA profile, with limited additional gain after including AJCC stage (C-index 0.79 in the MLPA subset).</p><p><strong>Conclusions: </strong>Continuous tumour volume provides more refined prognostic stratification in uveal melanoma and complements AJCC staging. Integrating volumetric, anatomic and molecular biomarkers improves risk assessment and may support individualised surveillance strategies.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between pre-mortem chemotherapy exposure and reduced endothelial cell density in donor corneas.","authors":"Amir Abd-Elkader, Yahav Lugassi, Guy Matzliach, Maayan Avitan, Yoav Nahum, Irit Bahar, Eitan Livny","doi":"10.1136/bjo-2026-329704","DOIUrl":"https://doi.org/10.1136/bjo-2026-329704","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate whether pre-mortem exposure to systemic chemotherapy is associated with reduced endothelial cell density (ECD) in post-mortem donor corneas.</p><p><strong>Methods: </strong>This retrospective cohort study included 912 donor corneas evaluated at a tertiary cornea bank between 2013 and 2024. Donors with a documented history of malignancy who received systemic chemotherapy, with or without head and neck radiation, within 10 years before death were compared with age-matched donors without malignancy. Endothelial parameters, including ECD, coefficient of variation and hexagonality, were assessed using ex vivo specular microscopy. Univariate analyses and multivariable linear regression models were used to identify independent predictors of ECD.</p><p><strong>Results: </strong>Mean ECD was significantly lower in donors with chemotherapy exposure compared with controls (2272±547 vs 2432±475 cells/mm²; p<0.001). Endothelial morphologic parameters did not differ between groups. Age-stratified analyses demonstrated that decreased ECD was most pronounced in donors aged 51 years and older, whereas differences in younger donors did not reach statistical significance. Head and neck radiation exposure was not associated with additional ECD reduction. In multivariable analysis, chemotherapy exposure remained an independent predictor of lower ECD (β = -108.05 cells/mm²; p<0.001) after adjusting for age, sex, systemic comorbidities and lens status.</p><p><strong>Conclusion: </strong>Pre-mortem exposure to systemic chemotherapy was independently associated with reduced ECD in donor corneas. These findings identify systemic cancer treatment as an under-recognised determinant of donor endothelial health and may have implications for donor screening and graft allocation strategies.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of visit schedule on estimated success rates in glaucoma surgical studies.","authors":"Alessandro Rabiolo, Daniela Khaliliyeh, Sang Wook Jin, Esteban Morales, Luca Rossetti, Nitin Anand, Giovanni Montesano, Francesco Oddone, Joseph Caprioli, Stefano De Cillà","doi":"10.1136/bjo-2025-329283","DOIUrl":"https://doi.org/10.1136/bjo-2025-329283","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate how different methods of managing multiple visits within predefined time windows affect intraocular pressure (IOP)-based success rates in glaucoma surgery studies.</p><p><strong>Methods: </strong>We applied literature-based high IOP failure criteria to two cohorts of 934 and 1760 eyes undergoing trabeculectomy and deep sclerectomy (DS) with median follow-up of 41.4 months and 45.4 months, respectively. Failure was defined by IOP thresholds, loss of light perception, hypotony requiring revision or additional IOP-lowering surgery. Visits were grouped into guideline-based windows and six visit-managing strategies were applied to all visits, mean, lowest, highest, median and closest IOP to the recommended time point. We calculated Kaplan-Meier success rates for each visit-managing strategy. Visual field (VF) analysis was conducted on patients in the trabeculectomy cohort with ≥4 VFs in ≥2 years post-surgery.</p><p><strong>Results: </strong>For the 21 mm Hg threshold, 5-year success was highest with the lowest IOP (trabeculectomy: 54.8%; DS: 74.5%), followed by closest IOP (trabeculectomy: 46.7%; DS: 67.6%), the median (trabeculectomy: 46.9%; DS: 69.1%) and mean IOP (trabeculectomy: 46.3%; DS: 68.6%). Success rates were lower with peak IOP (trabeculectomy: 39.3%; DS: 60.4%) and all visits IOP (trabeculectomy: 38.8%; DS: 61.0%). In the VF subset, eyes classified as failures demonstrated significantly faster mean deviation (MD) progression than those classified as successes although substantial overlap in the distribution of MD rates persisted between groups under every strategy.</p><p><strong>Conclusions: </strong>Visit-managing strategies influence reported success rates. None of the evaluated approaches achieved a clear separation in VF progression rates, underscoring the inherent limitations of IOP-threshold-based classifications.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-arteritic anterior ischaemic optic neuropathy incidence in placebo-controlled clinical trials of liraglutide or semaglutide.","authors":"Tina Vilsbøll,Dikshit Arun Kumar,Lloyd Paul Aiello,Cecilia Rönnbäck,Michael Stellfeld,Lars Michael Larsen","doi":"10.1136/bjo-2025-328729","DOIUrl":"https://doi.org/10.1136/bjo-2025-328729","url":null,"abstract":"BACKGROUNDRisk of non-arteritic anterior ischaemic optic neuropathy (NAION) following exposure to glucagon-like peptide-1 receptor agonists (GLP-1RAs) in people with type 2 diabetes and/or obesity remains unclear. The aim of this study was to investigate NAION incidence across randomised placebo-controlled trials evaluating the GLP-1RAs liraglutide and semaglutide.METHODSPooled safety evaluation of NAION incidence from completed phase II, III and IV randomised placebo-controlled trials that evaluated the six Novo Nordisk-manufactured GLP-1RA products (active ingredients: liraglutide and semaglutide) in people with type 2 diabetes and/or overweight/obesity. Potential NAION cases were identified and categorised based on the likelihood of NAION occurrence (definite, probable, unlikely or not assessable). Definite or probable NAION cases were considered confirmed.RESULTSThis pooled analysis included 96 829 participants (GLP-1RA-treated: n=64 917; placebo-treated: n=31 912) with 205 777 participant-years of observation (PYO) (GLP-1RA-treated: 119 393 PYO; placebo-treated: 86 384 PYO). Across all trials, three confirmed NAION cases were identified in three GLP-1RA-treated participants and five confirmed cases were identified in four placebo-treated participants. In GLP-1RA-treated participants, the incidence of confirmed NAION cases was approximately three cases per 100 000 PYO, while in placebo-treated participants, the incidence was approximately six cases per 100 000 PYO. All ophthalmologist-confirmed cases reported one or more associated risk factors (eg, age >50 years, obesity, smoking, dyslipidaemia, hypertension).CONCLUSIONData from randomised placebo-controlled trials with semaglutide and liraglutide do not show an increased incidence of NAION in participants receiving GLP-1RA treatment versus those receiving placebo and, thus, do not suggest a relationship between GLP-1RA use and NAION.SUMMARYBased on data from randomised placebo-controlled trials, exposure to the glucagon-like peptide-1 receptor agonists (GLP-1RA) semaglutide and liraglutide was not associated with an increased incidence of non-arteritic anterior ischaemic optic neuropathy (NAION) relative to placebo.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"47 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROductivity Study of Presbyopia Elimination in gaRment workers (PROSPER II): a randomised trial on the productivity impact of providing near glasses to Indian garment factory workers.","authors":"Sonia Pant,Sahil Bagwe,Sangeetha Esther,Graeme MacKenzie,Lovemore Nyasha Sigwadhi,Winston D Prakash,Ving Fai Chan,Smit Gade,Simranjeet Dhir,Saumya Joshi,Sofía Calderón,Mapa Prabhath Piyasena,Mike Clarke,Lynne Lohfeld,Michael Cooke,Ella R Gudwin,Achyuta Adhvaryu,Anant Nyshadham,Nathan Congdon","doi":"10.1136/bjo-2025-328563","DOIUrl":"https://doi.org/10.1136/bjo-2025-328563","url":null,"abstract":"BACKGROUNDCorrection for presbyopia, the world's most common cause of vision impairment, significantly improves productivity in agriculture and crafts. However, effects on productivity in manufacturing remain unstudied.METHODSPROSPER II was an individually randomised, investigator-masked, controlled trial conducted in Karnataka, India. Eligible garment factory workers aged ≥35 years with presbyopia (better-eye near vision N6.3 or worse (Snellen 6/12), correctable to N4 (Snellen 6/7.5)) and not owning glasses were randomised (1:1) to intervention (immediate delivery of glasses suited to working distance) or control (identical glasses delivered at endline). The primary outcome was work productivity, defined as the hourly number of items completed, normalised to a factory target rate, over 12 weeks. Secondary outcomes included glasses wear adherence, visual function, and ROI.RESULTSAmong 4990 potentially eligible workers, 3648 (73.1%) underwent eye examinations, and 682 (18.7%, mean age 41.0 years, 99.0% female) were enrolled and randomised (intervention: n=344, 50.4%; control: n=338, 49.6%). All participants completed 12-week observation. In panel regression models for the pre-specified primary analysis, intervention group assignment (difference=0.0325, 95% CI 0.006 to 0.060, p=0.017) was significantly associated with greater productivity. Compared with workers in the highest skill grade (A), those in the lowest grade (C) had significantly lower productivity (difference=-0.049, 95% CI -0.087 to -0.011, p=0.011). Glasses increased productivity in the intervention group relative to controls by 5.70% (95% CI 1.04% to 10.4%).CONCLUSIONSFree near glasses confer a significant productivity benefit in this factory setting, and are substantially less costly than other successful interventions such as management training.TRIAL REGISTRATION NUMBERNCT04629820.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"5 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associations of intraretinal hyperreflective foci in age-related macular degeneration: the Beijing Eye Study.","authors":"Jost B Jonas,Songhomitra Panda-Jonas,Zhe Pan,Jie Xu,Rahul A Jonas,Ya Xing Wang","doi":"10.1136/bjo-2025-328004","DOIUrl":"https://doi.org/10.1136/bjo-2025-328004","url":null,"abstract":"BACKGROUNDTo assess prevalence and associations of intraretinal hyperreflective foci (HRFs) in a general population.METHODSParticipants of the population-based Beijing Eye Study underwent optical coherence tomography and macula photography.RESULTSThe study cohort included 1641 eyes (mean age: 62.8±9.1 years; range: 50-93 years). Prevalence of any HRF or HRFs located only above the ellipsoid zone (EZ) increased from 33/590 (5.6%; 95% CI 4.0 to 7.0) and 22/590 (3.7%; 95% CI 2.2 to 5.2), respectively, in normal eyes to 371/725 (51.2%; 95% CI 47.7 to 54.7) and 246/725 (33.9%; 95% CI 30.4 to 37.4), respectively, in eyes with early age-related macular degeneration (AMD), to 283/314 (90.1%; 95% CI 87.1 to 93.1) and 260/314 (82.8%; 95% CI 78.8 to 86.8), respectively, in eyes with intermediate AMD, and to 12/12 (100%) and 12/12 (100%), respectively, in late AMD. HRFs above the EZ were spatially associated with EZ defects in 298/540 (55.2%) eyes and external limiting membrane (ELM) defects in 203/540 (37.6%) eyes. 52 (96%) of 54 eyes with macular hyperpigmentations showed HRFs above the EZ, and 52 (9.6%) of 540 eyes with HRFs above the EZ had corresponding macular hyperpigmentations. Higher HRF prevalence was associated (multivariable analysis) with higher AMD stage (OR: 1.75; 95% CI 1.36 to 2.26; p<0.001), and higher prevalences of EZ defects (OR: 36.6; 95% CI 8.56 to 157; p<0.001), reticular pseudodrusen (OR: 1.91; 95% CI 1.29 to 2.82; p<0.001), retinal pigment epithelium (RPE) elevations (OR: 34.5; 95% CI 10.4 to 111; p<0.001) and interdigitation zone thinnings (OR: 4.22; 95% CI 1.90 to 9.35; p<0.001).CONCLUSIONSThe HRF prevalence was relatively high in early AMD and increased to late AMD. HRF location and shape suggested intraretinally migrated RPE cells as their equivalent. The majority of HRFs were not associated with an ophthalmoscopically detected macular hyperpigmentation. HRFs can also be found in locations with a localised interdigitation zone thinning with spatially corresponding EZ defects and ELM defects.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"40 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cone structure and retinal sensitivity assessment in patients with red-green colour vision deficiency using multimodal imaging.","authors":"Jia Liang,Zhenhua Zou,Lu Chen,Xiangqing Hei,Yingying Diao,Lujia Feng,Yijing Zhuang,Wangting Li,Huiyan Zheng,Pan Xiao,Qiang Lin,Changfeng Pan,Jie Zhang,Wei Chi,Dong Fang,Shaochong Zhang","doi":"10.1136/bjo-2025-329412","DOIUrl":"https://doi.org/10.1136/bjo-2025-329412","url":null,"abstract":"BACKGROUND/AIMSTo evaluate cone morphology, retinal sublayer thicknesses and vessel density (VD) and their associations with retinal sensitivity (RS) in red-green colour vision deficiency (CVD).METHODS36 patients with red-green CVD and 38 age-matched controls were enrolled. Diagnosis was confirmed by pseudoisochromatic plates and the Farnsworth-Munsell 100-hue test. All participants underwent adaptive optics scanning laser ophthalmoscopy (AO-SLO), optical coherence tomography (OCT), OCT-angiography and microperimetry.RESULTSPatients with red-green CVD exhibited significantly decreased cone density and regularity, increased cone dispersion and spacing at 3° eccentricity, and thinner myoid and ellipsoid zone (MEZ) and outer segment (OS) (all p<0.01). VDs, blue-yellow error score and axial length did not differ between groups. Patients with CVD had higher red-green error scores and lower RS (p<0.05). Temporal cone density was correlated with RS only in CVD (r=0.410, p=0.011). Mean cone density correlated with favourable cone parameters and MEZ thickness (r=-0.827 to 0.862, p<0.005) and predicted higher RS (r=0.463, p<0.001).CONCLUSIONRed-green CVD features reduced cone density, disorganised arrangement and MEZ and OS thinning, which are closely linked to RS. Cone structural integrity has clinical value for managing visual impairments in CVD.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"140 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keeping a PROMise: embedding patient voices in ophthalmic outcomes.","authors":"David P Crabb","doi":"10.1136/bjo-2025-328622","DOIUrl":"10.1136/bjo-2025-328622","url":null,"abstract":"","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"480-482"},"PeriodicalIF":3.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological characteristics of secondary enucleation after iodide-125 plaque radiotherapy in Chinese patients with uveal melanoma.","authors":"Haihan Zhang,Heng Wang,Yueming Liu,Jingting Luo,Shiyi Yin,Xiaolin Xu,Wenbin Wei","doi":"10.1136/bjo-2024-327082","DOIUrl":"https://doi.org/10.1136/bjo-2024-327082","url":null,"abstract":"PURPOSETo explore the histopathological characteristics in eyes with uveal melanoma (UM) that had secondary enucleation after iodine-125 plaque radiotherapy (PRT).METHODSThis study included 243 patients with unilateral UM treated at Beijing Tongren Hospital from 2007 to 2020. Of these, 119 initially received PRT, followed by enucleation 2 months-9 years later. We retrospectively examined the histopathological features of enucleated ocular tissues to investigate microscopic differences based on treatment methods and reasons for secondary enucleation.RESULTSCompared with 124 primary enucleations, eyes after PRT were more likely to show tumour diffuse distribution; had more tumour cell necrosis and more inflammation. In addition, eyes after PRT had a higher frequency of sclera invasion, optic nerve invasion by the tumour and neovascularisation of the iris. Histopathologically, 55 eyes (46%) were removed due to local control failure. Compared with eyes enucleated because of severe radiotherapy complications, eyes enucleated for local control failure had tumours invading the optic disc and ciliary body more frequently, pathological mitosis and the proportion of tumour diffuse distribution were higher. Eyes with radiotherapy complications had more tumour tissue necrosis and more neovascularisation of the iris.CONCLUSIONSBy observing the pathological features, we regrouped the patients who underwent secondary enucleation after PRT. These differences in histopathology may represent tissue effects of radiotherapy radiation or features related to tumour progression and growth. Tumour insensitivity and progression after PRT clearly increased the risk of metastasis-related death. Some pathological microscopic features may be important prognostic indicators of patients with UM.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"38 1","pages":"592-600"},"PeriodicalIF":4.1,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147733387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}