British Journal of Ophthalmology最新文献_第2页

At a glance 一目了然

IF 4.1 2区医学

British Journal of Ophthalmology Pub Date : 2025-06-01 DOI: 10.1136/bjo-2025-327816

Frank Larkin

引用次数: 0

Social determinants of health as risk factors for keratoconus in the All of Us database. 全民数据库中健康的社会决定因素作为圆锥角膜的危险因素。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2025-05-30 DOI: 10.1136/bjo-2024-326229

Caleb Tan, Allan I Puran, Ahmad Santina, Fei Yu, Ken Kitayama, Victoria L Tseng, Anne L Coleman

{"title":"Social determinants of health as risk factors for keratoconus in the All of Us database.","authors":"Caleb Tan, Allan I Puran, Ahmad Santina, Fei Yu, Ken Kitayama, Victoria L Tseng, Anne L Coleman","doi":"10.1136/bjo-2024-326229","DOIUrl":"10.1136/bjo-2024-326229","url":null,"abstract":"Background/aims: Clinical risk factors for keratoconus (KCN) have previously been established. While the impact of the social determinants of health on the epidemiology and pathophysiology of KCN has been explored, further study of these associations is needed in large and diverse populations. This cross-sectional study determines how education level and income impact the prevalence of KCN in the USA using the National Institutes of Health 'All of Us' database.Methods: Exposures included the highest level of education and annual household income. Multivariable logistic regression was used to examine the odds of KCN diagnosis at different levels of education and income, adjusting for sex assigned at birth, race, ethnicity, age, atopic conditions and eyecare access.Results: The overall prevalence of KCN was 0.17% (429/255 334). In multivariable logistic regression, individuals with more than a high school education had a greater risk of having KCN than those with less than a high school equivalent (college 1-3 years: adjusted OR (aOR): 1.96; 95% CI 1.46 to 2.65; college graduate or advanced degree: aOR:2.19; 95% CI 1.61 to 3.00). There were no significant associations between income level and odds of keratoconus.Conclusion: In the study population, higher education level was associated with an increased likelihood of keratoconus, while no correlation was seen between income and KCN prevalence. After adjusting for access to eye care in a secondary analysis, there was an association between increased education level and increased prevalence of KCN. Further studies are needed to fully understand the mechanism of this finding such as increased levels of dry eye secondary to computer vision syndrome in highly educated people.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"645-651"},"PeriodicalIF":3.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optic nerve sheath enhancement on orbital MRI in giant cell arteritis. 巨细胞动脉炎的视神经鞘增强。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2025-05-30 DOI: 10.1136/bjo-2024-326608

Rebka K Ephrem, Suyash Mohan, Ryan Rebello, Rui Liang, Robert Kurtz, Jae W Song, Madhura A Tamhankar, Rennie L Rhee

{"title":"Optic nerve sheath enhancement on orbital MRI in giant cell arteritis.","authors":"Rebka K Ephrem, Suyash Mohan, Ryan Rebello, Rui Liang, Robert Kurtz, Jae W Song, Madhura A Tamhankar, Rennie L Rhee","doi":"10.1136/bjo-2024-326608","DOIUrl":"10.1136/bjo-2024-326608","url":null,"abstract":"Background: Differentiating arteritic anterior ischaemic optic neuropathy (A-AION) due to giant cell arteritis (GCA) from non-arteritic anterior ischaemic optic neuropathy (NA-AION) may pose a diagnostic challenge. Our study aimed to assess the use of standard orbital MRI in distinguishing ocular manifestations of GCA from NA-AION.Methods: This study included 25 consecutive patients (11 GCA, 14 NA-AION) who underwent contrast-enhanced orbital MRIs within 3 months of symptom onset. Two radiologists blinded to clinical data independently evaluated MRIs for the enhancement of the optic nerve sheath (ONS) and other orbital structures.Results: On orbital MRI, ONS enhancement of at least one eye was more common in patients with GCA than NA-AION (64% vs 14%, p=0.02). ONS enhancement on MRI was seen in patients with typical ophthalmologic exam findings of A-AION as well as in GCA patients with other features of ocular ischaemia (eg, retinal artery occlusion). Among patients with GCA, ONS enhancement was bilateral in six of seven cases even when visual symptoms and signs were unilateral.Conclusion: Patients with ocular GCA are more likely to have ONS enhancement on MRI compared with NA-AION. ONS enhancement was observed in (i) A-AION and other forms of ocular ischaemia, demonstrating the potential value of MRI in multiple orbital pathologies in GCA, and (ii) both the affected and unaffected eye, suggesting MRI may detect early subclinical ocular disease in GCA. These results highlight the potential value of adding orbital MRI to the diagnostic workup of ocular GCA.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"709-714"},"PeriodicalIF":3.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for visual loss after excision of orbital cavernous venous malformations: a systematic review. 眼窝海绵静脉畸形切除后视力丧失的危险因素：系统回顾。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2025-05-30 DOI: 10.1136/bjo-2024-326395

James Pietris, Clare Quigley, Alkis James Psaltis, Geoffrey E Rose, Dinesh Selva

{"title":"Risk factors for visual loss after excision of orbital cavernous venous malformations: a systematic review.","authors":"James Pietris, Clare Quigley, Alkis James Psaltis, Geoffrey E Rose, Dinesh Selva","doi":"10.1136/bjo-2024-326395","DOIUrl":"10.1136/bjo-2024-326395","url":null,"abstract":"Background: Orbital cavernous venous malformations (OCVMs) are the most common primary orbital mass lesion and presenting symptoms are usually secondary to a mass effect. Surgical excision presents unique challenges and vision loss is a rare, but devastating, complication. This review aims to identify risk factors for vision loss with excision of OCVMs.Method: A systematic search of the databases PubMed/MEDLINE, Embase and CENTRAL was performed to May 2024, prior to data collection and risk of bias analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. 16 articles fulfilled the inclusion criteria.Results: These studies identified apical location and strong adherence to apical structures, including the optic nerve, as characteristics carrying a higher risk of postoperative vision loss. Symptoms and signs with a poor visual prognosis included preoperative visual loss, relative afferent pupillary defect, optic disc abnormality and choroidal folds. Intraoperative risk factors include prolonged vascular handling and traction on the optic nerve, as well as low intraoperative diastolic blood pressure. Central retinal artery occlusion was the most common cause of vision loss.Conclusion: There are several risk factors for poor visual outcome after excision of OCVMs. Surgical and anaesthetic teams should remain cognisant of these factors, and be willing to adapt their intraoperative management as required. Further large-scale prospective studies might aid the development of management guidelines.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"728-732"},"PeriodicalIF":3.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inferior rectus muscle detachment during strabismus surgery has a major effect on anterior segment perfusion, as shown by LSCI perfusion monitoring. 斜视手术中下直肌脱离对前段灌注有重要影响，LSCI灌注监测显示。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2025-05-30 DOI: 10.1136/bjo-2024-325916

Linn Engqvist, HannaMaria Öhnell, Ella Nygren, Aboma Merdasa, Rafi Sheikh, Ulf Dahlstrand, Malin Malmsjö

{"title":"Inferior rectus muscle detachment during strabismus surgery has a major effect on anterior segment perfusion, as shown by LSCI perfusion monitoring.","authors":"Linn Engqvist, HannaMaria Öhnell, Ella Nygren, Aboma Merdasa, Rafi Sheikh, Ulf Dahlstrand, Malin Malmsjö","doi":"10.1136/bjo-2024-325916","DOIUrl":"10.1136/bjo-2024-325916","url":null,"abstract":"Background: Anterior segment ischaemia (ASI) is a rare but feared complication associated with strabismus surgery, arising from damage of the anterior ciliary arteries that run along the extraocular rectus muscles. It has been reported that the risk of ASI following strabismus surgery increases when the vertical rectus muscles are involved. The aim of the present study was to monitor anterior segment perfusion in real time during inferior rectus muscle surgery.Methods: 17 eyes in 16 patients undergoing surgery on the inferior rectus muscle were included. Perfusion was measured in the adjacent paralimbal and iris tissue, before and after inferior rectus muscle detachment, using laser speckle contrast imaging.Results: The paralimbal vascular network was clearly visualised in the perfusion images, whereas the signals from the iris were lower. Detachment of the inferior rectus muscle resulted in a reduction in paralimbal and iris perfusion by a median of 33% (p<0.0001) and 11% (p=0.0174), respectively.Conclusion: Strabismus surgery involving the inferior rectus muscle significantly affects perfusion to the anterior segment, and to a greater extent than previously observed following surgery on horizontal rectus muscles (where the decrease was only 23% and 5%).","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"704-708"},"PeriodicalIF":3.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of macular neovascularisation characteristics for photoreceptor integrity in nAMD: a prospective observational study. 黄斑新生血管特征对光感受器完整性的预后价值：一项前瞻性观察研究。

IF 3.7 2区医学

British Journal of Ophthalmology Pub Date : 2025-05-30 DOI: 10.1136/bjo-2024-326319

Jiaxin Pu, Xuenan Zhuang, Miaoling Li, Xinlei Hao, Guiqin He, Yongyue Su, Yuhong Gan, Xiongze Zhang, Yuying Ji, Lan Mi, Yining Zhang, Ruijun Yang, Xuelin Chen, Feng Wen

{"title":"Prognostic value of macular neovascularisation characteristics for photoreceptor integrity in nAMD: a prospective observational study.","authors":"Jiaxin Pu, Xuenan Zhuang, Miaoling Li, Xinlei Hao, Guiqin He, Yongyue Su, Yuhong Gan, Xiongze Zhang, Yuying Ji, Lan Mi, Yining Zhang, Ruijun Yang, Xuelin Chen, Feng Wen","doi":"10.1136/bjo-2024-326319","DOIUrl":"10.1136/bjo-2024-326319","url":null,"abstract":"Purpose: To explore the relationship between characteristics of macular neovascularisation (MNV) and photoreceptor integrity in patients with neovascular age-related macular degeneration (nAMD).Methods: This prospective study enrolled treatment-naïve nAMD eyes and conducted a 3-month follow-up. 16 quantitative MNV features were evaluated using optical coherence tomography angiography, and the impaired areas of ellipsoid zone (EZ), external limiting membrane (ELM) and outer nuclear layer (ONL) were obtained using optical coherence tomography. Correlation and regression analyses assessed the relationships between MNV features and photoreceptor integrity.Results: 110 nAMD eyes from 110 patients (73.64% men) were included. Baseline MNV characteristics, including MNV perimeter, maxFeret, minFeret, vessel area, total vessel length, total number of junctions and endpoints, and mean E lacunarity, were positively correlated with photoreceptor damage areas (r ranging from 0.227 to 0.558, p<0.05 for all). Meanwhile, vessel density negatively correlated with photoreceptor damage (r=-0.468 for EZ, -0.394 for ELM and -0.538 for ONL, all p<0.05). After the loading phase, the EZ prognosis was independently associated with baseline MNV minFeret (Std β=0.362, p=0.011) and mean E lacunarity (Std β=0.130, p=0.041). The prognosis for ELM was independently linked to baseline MNV minFeret (Std β=0.373, p=0.014), while no significant factors were found to influence ONL prognosis (p>0.05 for all).Conclusion: A strong correlation was observed between MNV features and photoreceptor integrity, with larger and more complex vascular networks associated with greater photoreceptor damage.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"689-696"},"PeriodicalIF":3.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keratoscope-guided opening of graft-host junction to treat elevated astigmatism after deep anterior lamellar keratoplasty 角膜镜引导下移植物-宿主连接处开放治疗深前板层角膜移植术后散光加剧

IF 4.1 2区医学

British Journal of Ophthalmology Pub Date : 2025-05-28 DOI: 10.1136/bjo-2025-327208

Costanza Rossi, Andrea Lucisano, Giovanni Scalia, Sabrina Vaccaro, Giuseppe Alessio, Andrea Taloni, Maria Angela Romeo, Simone Porchia, Massimiliano Borselli, Adriano Carnevali, Vincenzo Scorcia, Giovanna Carnovale-Scalzo

{"title":"Keratoscope-guided opening of graft-host junction to treat elevated astigmatism after deep anterior lamellar keratoplasty","authors":"Costanza Rossi, Andrea Lucisano, Giovanni Scalia, Sabrina Vaccaro, Giuseppe Alessio, Andrea Taloni, Maria Angela Romeo, Simone Porchia, Massimiliano Borselli, Adriano Carnevali, Vincenzo Scorcia, Giovanna Carnovale-Scalzo","doi":"10.1136/bjo-2025-327208","DOIUrl":"https://doi.org/10.1136/bjo-2025-327208","url":null,"abstract":"Aims To describe a simple surgical technique consisting of opening the vertical graft-host junction (GHJ) to manage high astigmatism following deep anterior lamellar keratoplasty (DALK) and to report postoperative visual and topographic outcomes. Methods This is a retrospective interventional case series. Patients affected by high astigmatism after DALK underwent progressive opening of the previous GHJ at the steep meridians, established with preoperative topography and intraoperative keratoscopic guidance. Evaluations were carried out with best corrected visual acuity (BCVA), refractive astigmatism (RA) and keratometric astigmatism (KA) measured with Casia (Tomey, Japan). Visits were conducted preoperatively (T0), 1 week (T1), 6 months (T2) and 1 year after surgery (T3). The Alpins Method was used to evaluate vectorial changes in KA between T0 and T3. Results Fifteen patients were included in the analysis. BCVA (median (IQR)) increased significantly from 0.70 (0.5–1.1) at T0 to 0.20 (0.1–0.3) logMAR at T3 (p=0.001). RA (mean±SD) at T3 was 2.28±1.59 dioptres (D). KA (mean±SD) varied significantly from 8.04±2.14 D at T0 versus 2.93±1.94 D at T1 versus 3.15±1.79 D at T2, versus 3.23±1.63 D at T3 (p<0.0001). Vectorial analysis showed that target induced astigmatism (mean±SD) was 8.04±2.14 D, while surgically induced astigmatism (mean±SD) was 7.89±4.27 D. Correction index (mean±SD) was 0.92±0.33. Conclusions High astigmatism after DALK can be safely and effectively managed by opening the GHJ down to the cleavage plane achieved with the previous surgery, providing low KA and RA, with an overall low tendency to overcorrection. Data are available upon reasonable request. For data requests contact: vscorcia@unicz.it.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"57 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic review investigating the time taken for corneal stabilisation following contact lens cessation 系统回顾调查停止佩戴隐形眼镜后角膜稳定所需的时间

IF 4.1 2区医学

British Journal of Ophthalmology Pub Date : 2025-05-26 DOI: 10.1136/bjo-2025-327121

Ali Abid, Himal Kandel, Stephanie Watson

{"title":"Systematic review investigating the time taken for corneal stabilisation following contact lens cessation","authors":"Ali Abid, Himal Kandel, Stephanie Watson","doi":"10.1136/bjo-2025-327121","DOIUrl":"https://doi.org/10.1136/bjo-2025-327121","url":null,"abstract":"Background Contact lenses (CLs), used by approximately 140 million people globally, can induce corneal warpage, altering corneal geometry. This impacts corneal imaging, influencing diagnostic assessments, follow-ups and pre-operative evaluations. This systematic review aimed to determine the optimal CL cessation period before corneal imaging. Methods A systematic literature search was conducted across multiple databases. Studies were included if they assessed corneal stabilisation post-CL cessation by using corneal imaging techniques. Quality was rated using the modified Downs and Black checklist. Results Fifteen studies met the inclusion criteria; 13 prospective observational studies, one retrospective and one observational case series. Five of these studies included a control group. Following the removal of CLs, the included studies reported stabilisation of corneal parameters as follows: for soft CLs, 2–11.6 weeks (median 2.1 weeks); for hard CLs, 1–22 weeks (median 7.6 weeks); for orthokeratology lenses, 1–2 weeks (median 1.6 weeks) and for tinted lenses, 2–3 hours. Factors influencing stabilisation included lens material, water content, wear modality, CL fit and patient age. Two studies were found to be of excellent methodological quality, 11 were assessed as good and two as fair. No studies were found to be of poor quality. Conclusion Corneal stabilisation time post-CL cessation was variable and dependent on the lens type and fit, patient age and method of determining corneal stabilisation. Personalised recommendations and standardised assessments are essential for optimising diagnostic and surgical outcomes. Further research is needed to develop comprehensive guidelines for consistent CL removal protocols. PROSPERO registration number CRD42023484401. Data sharing not applicable as no datasets generated and/or analysed for this study.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"16 1","pages":"bjo-2025-327121"},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective multicentre study on functional vision score calculation using automated perimeter 使用自动周长计算功能性视觉评分的回顾性多中心研究

IF 4.1 2区医学

British Journal of Ophthalmology Pub Date : 2025-05-24 DOI: 10.1136/bjo-2025-327122

Mieko Tsuruoka, Yoshimune Hiratsuka, Kenji Inoue, Miki Murakami, Kazuma Oku, Hiroyuki Kondo, Mayumi Sainohira, Taiji Sakamoto, Akira Murakami

{"title":"Retrospective multicentre study on functional vision score calculation using automated perimeter","authors":"Mieko Tsuruoka, Yoshimune Hiratsuka, Kenji Inoue, Miki Murakami, Kazuma Oku, Hiroyuki Kondo, Mayumi Sainohira, Taiji Sakamoto, Akira Murakami","doi":"10.1136/bjo-2025-327122","DOIUrl":"https://doi.org/10.1136/bjo-2025-327122","url":null,"abstract":"Background/aims This study aimed to develop a predictive equation for Functional Field Score (FFS), a component of the Functional Vision Score (FVS) derived from binocular Esterman test results via automated perimetry (AP) and to evaluate agreement with Goldmann perimetry (GP)-based FFS. Methods This retrospective multicentre study included 240 patients (mean age: 61±17.5 years) who underwent both GP and AP testing at four Japanese institutions from January 2019 to October 2023. Binocular Esterman visual field testing was conducted using the Humphrey Field Analyser. After conducting a correlation analysis using Pearson’s correlation coefficient, we derived a predictive equation for GP-based FFS from AP-based FFS using linear regression analysis. Bland-Altman analysis assessed agreement between predicted AP-FFS and GP-FFS. Results A strong correlation was observed between FFS based on GP and the number of points seen in the binocular Esterman test (r=0.77; 95% CI 0.71 to 0.81). The predictive equation for FFS was: FFS=(the number of points seen)×0.41+37.0. Agreement between predicted and GP-based FFS was high, with a mean difference of 0.12 (95% CI −21.63 to 21.88). Conclusions AP-based FFS provides a reliable alternative to GP-based FVS, enabling effective assessment of visual impairment in environments lacking GP accessibility. This approach may enhance the practical evaluation of functional vision, particularly in clinical or research settings where AP is more widely available. No data are available.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"46 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tocilizumab effectiveness in paediatric non-infectious uveitis: data from the International AIDA Network Registries on ocular inflammatory disorders 托珠单抗在儿童非感染性葡萄膜炎中的有效性：来自国际AIDA网络注册的眼部炎症性疾病数据

IF 4.1 2区医学

British Journal of Ophthalmology Pub Date : 2025-05-24 DOI: 10.1136/bjo-2025-327410

Jurgen Sota, Luciana Breda, Maria Pia Paroli, Soad Hashad, Alejandra de-la-Torre, Silvana Guerriero, Abdurrahman Tufan, Juanita Cardona-López, María José Altamar-García, Saverio La Bella, Antonio Vitale, Edoardo Biancalana, Emanuela Del Giudice, Francesca Minoia, Sulaiman Al-Mayouf, Bruno Frediani, Luca Cantarini, Claudia Fabiani

{"title":"Tocilizumab effectiveness in paediatric non-infectious uveitis: data from the International AIDA Network Registries on ocular inflammatory disorders","authors":"Jurgen Sota, Luciana Breda, Maria Pia Paroli, Soad Hashad, Alejandra de-la-Torre, Silvana Guerriero, Abdurrahman Tufan, Juanita Cardona-López, María José Altamar-García, Saverio La Bella, Antonio Vitale, Edoardo Biancalana, Emanuela Del Giudice, Francesca Minoia, Sulaiman Al-Mayouf, Bruno Frediani, Luca Cantarini, Claudia Fabiani","doi":"10.1136/bjo-2025-327410","DOIUrl":"https://doi.org/10.1136/bjo-2025-327410","url":null,"abstract":"To describe tocilizumab (TCZ) effectiveness in 15 children with refractory non-infectious uveitis. Reported outcomes are the number of relapses before and after treatment, steroid-sparing effect and drug retention rate. Macular oedema, fluorangiographic findings and ocular complications are also reported. The mean number of ocular relapses significantly decreased from 314 per 100 eyes/year to 106 per 100 eyes/year (p=0.016). A significant steroid-sparing effect was detected (p=0.037). TCZ drug survival was 77.4% at 6 months, followed by 61.9% at 12, 24 and 36 months of follow-up. Macular oedema and retinal vasculitis resolved in all affected eyes. Data are available upon reasonable request. The data underlying this article will be shared upon reasonable request to the corresponding author.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"34 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0