Achim Fieß, Sandra Gißler, Alica Hartmann, Eva Mildenberger, Heike M Elflein, Omar Hahad, Norbert Pfeiffer, Stephanie D Grabitz, Alexander K Schuster
{"title":"Prevalence of strabismus, nystagmus and risk factors in children and adolescents born preterm with and without retinopathy of prematurity: results from the Gutenberg Prematurity Study Young","authors":"Achim Fieß, Sandra Gißler, Alica Hartmann, Eva Mildenberger, Heike M Elflein, Omar Hahad, Norbert Pfeiffer, Stephanie D Grabitz, Alexander K Schuster","doi":"10.1136/bjo-2025-327571","DOIUrl":"https://doi.org/10.1136/bjo-2025-327571","url":null,"abstract":"Aims This study assessed the prevalence of strabismus, nystagmus and their risk factors in children born preterm, stratified by gestational age (GA), retinopathy of prematurity (ROP) and ROP treatment. Methods This is a retrospective cohort study with a prospective follow-up in a large cohort of children born preterm and full-term aged 4–17 years. Multivariable logistic regression analyses assessed associations of strabismus and nystagmus with perinatal parameters. Participants were divided into the following groups: controls born at term (GA ≥37 weeks, group 1), children born preterm without ROP and GA 33–36 weeks (group 2), GA 29–32 weeks (group 3), GA ≤28 weeks (group 4), GA ≤32 weeks with untreated ROP (group 5) and GA ≤32 weeks with treated ROP (group 6). Results 949 children (11.21±3.92 years, 495 females) were included. Strabismus was observed in 6% of children in group 1, 10% in group 2, 12% in group 3, 23% in group 4, 20% in group 5 and 68% in group 6. Nystagmus was observed in 0.8%, 0.4%, 1.8%, 2.6%, 5.0% and 47% in the respective groups. Strabismus was associated with earlier GA (OR=1.08; p=0.01), astigmatism (OR=2.48; p=0.02) and hypermetropia (OR=2.09; p=0.04). Esotropia was associated with weeks of prematurity (OR=1.11; p=0.02), anisometropia (OR=3.09; p=0.02) and hypermetropia (OR=4.17; p<0.001). Nystagmus was associated with ROP (OR=7.49; p=0.03), anisometropia (OR=5.17; p=0.04) and myopia (OR=11.09; p<0.001). Conclusions Strabismus in children is linked to preterm birth and refractive error, while nystagmus is more prevalent in children with ROP and children with refractive errors. Data are available upon reasonable request. AF had full access to all study data and takes responsibility for the integrity of the data and the accuracy of the data analysis. Statistical analyses were performed by AF and SaG. The analysis presents clinical data of a cohort. This project constitutes a major scientific effort with high methodological standards and detailed guidelines for analysis and publication to ensure scientific analyses are on the highest level. Therefore, data are not made available for the scientific community outside the established and controlled workflows and algorithms. To meet the general idea of verification and reproducibility of scientific findings, we offer access to data at the local database upon request at any time. Interested researchers may make their requests to the coordinating principal investigator of the GPES (Achim Fieß; achim.fiess{at}unimedizin-mainz.de). More detailed contact information is available at the homepages of the University Medical Center Mainz (www.unimedizin-mainz.de).","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"39 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun Chen, Ziyi Qi, Ian Morgan, Kathryn Rose, Zhuoting Zhu, Xiaohu Ding, Jingjing Wang, Bo Zhang, Linlin Du, Jinliuxing Yang, Jianfeng Zhu, Wei Gao, Haidong Zou, Mingguang He, Xun Xu, Xiangui He
{"title":"Time outdoors prevents myopia in hyperopic children, but protection is weaker in premyopic children: a post-hoc analysis of a cluster-randomised trial","authors":"Jun Chen, Ziyi Qi, Ian Morgan, Kathryn Rose, Zhuoting Zhu, Xiaohu Ding, Jingjing Wang, Bo Zhang, Linlin Du, Jinliuxing Yang, Jianfeng Zhu, Wei Gao, Haidong Zou, Mingguang He, Xun Xu, Xiangui He","doi":"10.1136/bjo-2025-327768","DOIUrl":"https://doi.org/10.1136/bjo-2025-327768","url":null,"abstract":"Aims To investigate the effect of time outdoors on myopic shift among premyopic children. Methods Post-hoc analysis was nested in a cluster-randomised trial of the Shanghai Time Outside to Reduce Myopia (STORM) study. 6- to 9-year-old participants without myopia from the STORM study, who wore wristwatches to monitor time outdoors from 2017 to 2018, were included. Participants were all examined with cycloplegic refraction. Daily time outdoors was objectively monitored with the wearable smartwatch. Premyopia was defined as a cycloplegic spherical equivalent (SE) from −0.50 to +0.75 (inclusive) dioptres (D). Myopic shift was SE change from baseline to 1 year follow-up. Results Among 3194 participants (1369 premyopic; mean age 8.2±0.6 years; 49.5% boys), there were no statistical differences between premyopic and hyperopic children in time outdoors (p=0.303). Hyperopes showed reduced myopic shift with increasing outdoor time (plateau at about 120 min/day). However, premyopes exhibited a J-shaped relationship between time outdoors and myopic shift. In comparison to the subgroup with daily time outdoors <60 min, the difference in SE change in the other subgroups was not statistically significant (61–90 min/d: −0.03 (95% CI −0.10 to 0.05); 91–120 min/d: −0.03 (95% CI −0.11 to 0.05)). The reduced myopic shift was only observed with time outdoors >120 min/d, although it was still not statistically significant (>120 min/d: 0.04 (95% CI −0.05 to 0.14)). Conclusions Among premyopic children, increased time outdoors has a limited protective effect on myopic shift, suggesting longer duration of time outdoors or additional interventions to prevent or delay myopia onset in this population. Data are available upon reasonable request.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"18 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incidence and tumour location of iris melanoma in Denmark: a nationwide cohort study (1943–2021)","authors":"Kristoffer Nissen, Jane Christensen, Tine Gadegaard Hindso, Carsten Faber, Mette Bagger, Steffen Heegaard, Jens Folke Kiilgaard","doi":"10.1136/bjo-2025-327954","DOIUrl":"https://doi.org/10.1136/bjo-2025-327954","url":null,"abstract":"Background/aims Iris melanoma differs from posterior uveal melanoma in clinical behaviour and location. Situated anteriorly, it is directly exposed to ultraviolet radiation (UVR), unlike posterior melanomas shielded by the lens. However, epidemiological patterns and UVR’s role in iris melanoma development remain poorly understood. Therefore, we investigated long-term incidence trends of iris melanoma in Denmark, focusing particularly on tumour location in relation to sun exposure. Methods We conducted a nationwide retrospective cohort study of patients diagnosed with iris melanoma in Denmark from 1943 to 2021. Population-based data were obtained from national registries and institutional records, with tumours classified by anatomical location as inferior, superior or mixed. Results We included 405 patients. Disease-specific mortality was 3% (12 patients), mainly in American Joint Committee on Cancer c-subcategories with secondary glaucoma and extensive anterior chamber angle involvement. Over the study period, the age-standardised incidence increased substantially. Inferiorly located tumours constituted 58% during 1943–1962 and 84% during 2003–2021 (p<0.001), with age-standardised incidence increasing from 0.15 per 100 000 in 1943–1954 to 0.97 per 100 000 in 2010–2014. Superior melanomas demonstrated non-significant increases over time. Age-period-cohort analysis revealed effects of both age and calendar period. The age effect demonstrated a sharp increase after age 65 years for both inferior and superior tumours while the calendar period effect showed increases only for inferior iris melanomas. Conclusions Iris melanoma incidence increased significantly over the 79-year study period, primarily driven by inferior iris tumours most exposed to the sun. These findings support the hypothesis that UVR plays a pathogenic role in iris melanoma development. Data are available on reasonable request. Due to current European GDPR regulations, we are not permitted to share detailed population data publicly. However, the data may be made available on reasonable request and following the signing of a data management agreement.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"106 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariano Cozzi, Sandrine Zweifel, Konstantinos Balaskas, Christine A Curcio, Francesco Viola, Hemal Mehta, Javier Zarranz-Ventura, Kelvin Yi Chong Teo, Louise O’Toole, John Nolan, Marina Green-Gomez, Elizabeth J Johnson, Jennifer Arnold, Giovanni Staurenghi, Mark C Gillies, Daniel Barthelmes, Alessandro Invernizzi
{"title":"Minimum set of outcome measures for non-advanced age-related macular degeneration: a Delphi consensus statement by the TRACER (intermediate age-related macular degeneration) study group","authors":"Mariano Cozzi, Sandrine Zweifel, Konstantinos Balaskas, Christine A Curcio, Francesco Viola, Hemal Mehta, Javier Zarranz-Ventura, Kelvin Yi Chong Teo, Louise O’Toole, John Nolan, Marina Green-Gomez, Elizabeth J Johnson, Jennifer Arnold, Giovanni Staurenghi, Mark C Gillies, Daniel Barthelmes, Alessandro Invernizzi","doi":"10.1136/bjo-2025-327744","DOIUrl":"https://doi.org/10.1136/bjo-2025-327744","url":null,"abstract":"Background The purpose of this study was to define a minimum set of outcome measures for patients affected by non-advanced age-related macular degeneration (AMD). Methods A structured Delphi consensus process was conducted by a panel of worldwide experts in treatment outcome registries, imaging, nutrition and other AMD aspects. The experts answered anonymously to a series of surveys, each followed by a face-to-face meeting to discuss the pooled results. Supporting literature was shared among the group members by a facilitator before each round. Finally, all the results were discussed and the consensus document was created based on the level of agreement between experts. Results Six rounds were conducted until a formal consensus was achieved. Five main sections were identified: demographic characteristics, health factors, functional, imaging and clinical outcomes. A minimum set of 28 outcome measures was subsequently developed and approved by all members. Based on the priority of various items, 24 fields were designated as mandatory, while the remaining were deemed optional. Five items are required only at baseline, 12 are to be assessed annually for changes and the remaining 0 1must be collected at each clinical assessment. Conclusion This newly defined minimum set of outcome measures for non-advanced AMD could be employed in future real-world data collection registries aimed at gathering comprehensive and longitudinally extensive clinical data on a global scale. This may help to elucidate the natural progression of non-advanced AMD and its response to new therapies. Data are available upon reasonable request. The data that support the findings of this study are available from the corresponding author upon reasonable request.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"54 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative efficacy of fundus photography, optical coherence tomography and multifocal electroretinography in predicting postoperative visual acuity in highly myopic cataract patients.","authors":"Tingkun Shi,Jing Zhang,Limei Weng,Xin Zhong,Yuqiang Huang","doi":"10.1136/bjo-2025-328223","DOIUrl":"https://doi.org/10.1136/bjo-2025-328223","url":null,"abstract":"AIMSTo compare the predictive efficacy of precataract extraction fundus photography, optical coherence tomography (OCT) and multifocal electroretinogram (mfERG) in determining 3-month postcataract extraction best-corrected visual acuity (BCVA) in patients with high myopia complicated by cataracts.METHODSThis retrospective cohort study included 58 highly myopic eyes that underwent cataract surgery. Preoperative assessments included macular lesion grading from fundus photography based on the META-pathologic myopia classification; assessment of outer retinal structural integrity, specifically ellipsoid zone (EZ) status, via OCT and mfERG parameters, including P1 response density and implicit time from five concentric rings. Postoperative BCVA was recorded at 3 months. Statistical analyses included Pearson correlation, multiple linear regression and receiver operating characteristic curve analysis to evaluate the relationship and predictive power of each modality and a combined model.RESULTSThe study included 58 eyes with a mean age of 62.7±10.0 years. Preoperative BCVA, myopic maculopathy grading, EZ status and central mfERG parameters all showed strong correlations with postoperative BCVA (all p<0.001). In the multivariate linear regression model, preoperative BCVA (β=0.270, p<0.001), myopic maculopathy grading (β=0.075, p=0.029), EZ status (β=0.093, p=0.032) and central mfERG P1 amplitude density (β=-0.003, p=0.013) were all significant independent predictors of postoperative BCVA. An OCT-based model demonstrated the highest area under the curve (AUC) among single modalities (AUC=0.875). A combined mixed model incorporating all variables achieved the highest predictive accuracy (AUC=0.934).CONCLUSIONPreoperative assessments of fundus morphology, OCT-derived microstructures and retinal function are all valuable, independent predictors of visual outcomes after cataract surgery in highly myopic eyes.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"37 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chiara Olivieri, Giovanni Neri, Federico Ricardi, Francesco Gelormini, Antonio Fai, Guglielmo Parisi, Paola Marolo, Pasquale Viggiano, Francesco Boscia, Michele Reibaldi, Enrico Borrelli
{"title":"Comparative diagnostic performance of six imaging modalities for detecting macular atrophy in neovascular age-related macular degeneration","authors":"Chiara Olivieri, Giovanni Neri, Federico Ricardi, Francesco Gelormini, Antonio Fai, Guglielmo Parisi, Paola Marolo, Pasquale Viggiano, Francesco Boscia, Michele Reibaldi, Enrico Borrelli","doi":"10.1136/bjo-2025-328225","DOIUrl":"https://doi.org/10.1136/bjo-2025-328225","url":null,"abstract":"Purpose To evaluate the diagnostic accuracy of six imaging modalities—colour fundus photography (CFP), multicolour imaging (MC), blue autofluorescence (BAF), green autofluorescence (GAF), near-infrared reflectance (NIR) and structural optical coherence tomography (OCT)—for detecting macular atrophy (MA) in patients with previously treated neovascular age-related macular degeneration (AMD). Methods This retrospective cohort study included 113 eyes from patients treated with anti-vascular endothelial growth factor for at least 1 year. All eyes underwent six imaging modalities during the same visit. MA was identified by a senior retinal specialist using multimodal criteria and served as the diagnostic reference (ie, gold standard). Sensitivity and specificity of each imaging modality were calculated relative to this reference. Two masked graders independently assessed images using modality-specific definitions of MA. Discrepancies were resolved by consensus. Sensitivity, specificity, positive predictive value, negative predictive value and inter-reader agreement were calculated for each modality. Results MA was present in 46.9% of eyes based on multimodal imaging. Structural OCT detected MA in 43.4% of cases, followed by GAF (36.3%), BAF and NIR (35.4% each), MC (33.6%) and CFP (30.1%). Structural OCT demonstrated the highest diagnostic accuracy, with 92.4% sensitivity and 96.7% specificity. Other modalities showed moderate sensitivity (64.1–77.4%) and specificity (75.0–88.3%). Inter-reader agreement was moderate for BAF (κ=0.46) and lower for the remaining modalities, lowest for CFP (κ=0.18). Conclusions Structural OCT offers the highest accuracy and reliability for detecting MA in neovascular AMD, supporting its use in both clinical practice and research. Other modalities may supplement OCT when needed, but CFP alone is limited. Data are available upon reasonable request. Data are available upon reasonable request to the corresponding author.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"20 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Augmented medial rectus recession versus botulinum toxin therapy for acute acquired comitant esotropia: analysis of outcomes and recurrence predictors","authors":"Yueping Li, Tengyue Zhang, Juan Ding, Rui Hao, Liping Chen, Fang Xie, Ping Zhu, Wei Zhang","doi":"10.1136/bjo-2025-328201","DOIUrl":"https://doi.org/10.1136/bjo-2025-328201","url":null,"abstract":"Objective To compare the motor and sensory outcomes and quality of life (QOL) of augmented medial rectus recession (aMRc) and botulinum toxin A (BTXA) therapy in acute acquired comitant esotropia (AACE) treatment and to investigate the predictors of recurrence. Methods We conducted a prospective, non-randomised clinical trial that enrolled 63 AACE patients with a disease course of 6 months to 2 years and deviation angles of 15 to 60 prism diopters. The patients were assigned to BTXA (n=31) and aMRc group (n=32). We compared and analysed the deviation angles, fusion amplitudes (FA) of convergence and divergence, stereopsis, and scores of QOL and diplopia between the two groups before treatment and at 2, 4, 6 and 12 months post-treatment. Results Both groups exhibited significant improvements in motor and sensory outcomes. The aMRc group showed more stable and satisfactory deviation than the BTXA group at 6 and 12 months post-treatment, with a significant increase in divergent FA. The aMRc group achieved a higher success rate (93.75%) than the BTXA group (64.52%) 1 year post-treatment. QOL improved significantly in both groups after treatment, except for reading function in the BTXA group. Compared with the BTXA group, the aMRc group showed greater improvements in self-perception, general function, and diplopia scores (p<0.05). Survival analysis revealed a significant difference between the two groups (p=0.0046). Treatment method and convergent FA at near before treatment were identified as recurrence predictors (p=0.023 and 0.025). Conclusions Augmented MRc treatment was superior to BTXA injection in AACE patients with courses >6 months during 1-year observation, particularly in maintaining alignment, eliminating diplopia and improving divergent FA and QOL. Trial registration number ChiCTR2300068735. Data are available upon reasonable request.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"63 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"At a glance","authors":"Daniel F P Larkin","doi":"10.1136/bjo-2025-328552","DOIUrl":"https://doi.org/10.1136/bjo-2025-328552","url":null,"abstract":"There has been a marked change in the prevalence and distribution of refraction between the parents and children. These changes have occurred in parallel with markedly increased educational commitments and decreased time outdoors for children. This international consensus study, involving 35 experts, represents the first global collaborative effort to standardise a corneal and ocular surface disease dataset for use in clinical practice and electronic health records. Keratoscope-guided graft-host junction opening effectively treats high astigmatism after deep anterior lamellar keratoplasty. It improves visual acuity by reducing keratometric astigmatism, with vectorial analysis confirming accurate on-axis correction. This offers a reliable alternative to standard techniques. Eyes with lens thickness≥5 mm …","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"24 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaekyoung Lee,Young Kook Kim,Ki Ho Park,Jin Wook Jeoung
{"title":"Preperimetric glaucoma: conversion to primary open-angle glaucoma in a 10-year follow-up.","authors":"Jaekyoung Lee,Young Kook Kim,Ki Ho Park,Jin Wook Jeoung","doi":"10.1136/bjo-2024-327048","DOIUrl":"https://doi.org/10.1136/bjo-2024-327048","url":null,"abstract":"BACKGROUND/AIMSTo investigate the clinical course of preperimetric open-angle glaucoma (PPG) over follow-up period exceeding 10 years and to identify factors associated with conversion to primary open-angle glaucoma (POAG).METHODSA total of 124 eyes from 124 PPG patients, followed for more than 10 years, were included. Progression was defined as either structural or functional deterioration. Cox proportional hazard modelling was employed to identify factors for progression. Kaplan-Meier survival analysis was used to compare cumulative progression probability in PPG patients with or without optic disc haemorrhage (DH).RESULTSAmong the PPG subjects included, 44 eyes (35.5%) converted to POAG, with a mean deviation change of -0.39±0.64 dB/year over a mean follow-up of 12.2±4.2 years. The mean time to conversion was 5.3±2.2 years. Within the conversion group, 30 eyes (68.2%) exhibited functional progression, 23 eyes (52.3%) showed structural progression and nine eyes (20.5%) demonstrated both. Factors significantly associated with glaucoma progression were migraine/headache (HR=2.19, p=0.012), reduction of intraocular pressure (IOP; HR=0.75, p=0.009), and disc haemorrhage (DH; HR=3.78, p<0.001). Notably, patients with DH exhibited higher cumulative probability of progression compared with those without DH (p=0.017).CONCLUSIONSThis study of PPG with more than 10 years of follow-up demonstrates a substantial proportion (35.5%) converting to POAG, highlighting the need for long-term monitoring in these patients. PPG with insufficient IOP reduction and DH was associated with significantly higher cumulative probability of progression, emphasising its prognostic significance in PPG patients.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"42 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk factors for macular complications in large solitary peripheral retinal capillary haemangiomas: a multimodal imaging study.","authors":"Xiaonan Zhuang,FengJuan Gao,Jie Hong,Rui Jiang,Yi Xuan,Yao Zhou,Xiaofeng Ye,Min Wang,Qing Chang,Gezhi Xu,Xin Huang,Wei Liu","doi":"10.1136/bjo-2025-328147","DOIUrl":"https://doi.org/10.1136/bjo-2025-328147","url":null,"abstract":"PURPOSETo characterise the clinical and multimodal imaging features of large solitary peripheral retinal capillary haemangiomas (RCHs) and identify risk factors for distinct macular complications.METHODSIn this cross-sectional study, eyes with a large (>1.5 mm) solitary peripheral RCH were included and stratified into three groups according to macular status: RCH with macular sparing (RCH-MS), with macular exudation (RCH-ME) and with macular traction (RCH-MT). Demographic, clinical and multimodal imaging data were collected and compared. Univariable and multivariable regression analyses were performed to assess risk factors.RESULTSAmong 69 eyes, 16 were classified as RCH-MS, 33 as RCH-ME and 20 as RCH-MT. Compared with RCH-MS, RCH-ME and RCH-MT exhibited significantly worse visual acuity. Multivariable analysis revealed that RCH-MT was associated with greater tumour-to-foveola distance (OR 1.347, 95% CI 1.024 to 1.771) and higher prevalence of fibrovascular proliferation overlying the RCH (OR 14.371, 95% CI 1.622 to 127.301). Feeding artery dilation was significantly associated with RCH-ME (OR 17.392, 95% CI 2.121 to 142.627) and worse visual acuity (β=0.374, 95% CI 0.023 to 0.724). Feeding artery beading was inversely associated with RCH-ME (OR 0.057, 95% CI 0.006 to 0.552) and correlated with better visual outcome (β=-0.472, 95% CI -0.894 to -0.051).CONCLUSIONSThe macular status of large solitary peripheral RCHs is influenced by tumour location, fibrovascular proliferation and feeding artery characteristics. These findings highlight the predictive value of multimodal imaging for macular involvement and visual outcomes and provide insights into the mechanisms underlying RCH-associated macular exudation and traction.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"57 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}