British Journal of Ophthalmology最新文献

{"title":"Efficacy of lenadogene nolparvovec gene therapy versus idebenone in Leber hereditary optic neuropathy due to the m.11778G>A MT-ND4 variant: two matching adjusted indirect comparisons.","authors":"Patrick Yu-Wai-Man,Nancy J Newman,Valerio Carelli,Valerie Biousse,Adeline Pierache,François Montestruc,Magali Taiel,José-Alain Sahel","doi":"10.1136/bjo-2025-329206","DOIUrl":"https://doi.org/10.1136/bjo-2025-329206","url":null,"abstract":"BACKGROUNDLenadogene nolparvovec is an intravitreal gene therapy for patients with Leber hereditary optic neuropathy (LHON) carrying the m.11778G>A MT-ND4 variant. Idebenone, a synthetic coenzyme Q10 analogue, is the only approved treatment for LHON. To estimate the relative effects of both treatments, we performed two matching adjusted indirect comparisons (MAICs) between idebenone aggregated data from the LEROS study and expanded access programme (EAP), and lenadogene nolparvovec individual data from the REFLECT study (bilateral treatment).METHODSMatching covariates included age at disease onset, sex, baseline best-corrected visual acuity (BCVA), and time from vision loss to treatment. The outcomes of interest were clinically relevant recovery (CRR) from nadir at 24 months, time to initial CRR and change from baseline BCVA at 24 months.RESULTSFor the MAIC LEROS versus REFLECT (effective sample size (ESS): 77), a statistically higher CRR at 24 months was observed with lenadogene nolparvovec compared with idebenone (60.4% vs 35.4%; OR=2.78, 95% CI 1.53 to 5.06; p=0.001). No statistically significant difference was observed for time to initial CRR and change from baseline BCVA at 24 months. For the MAIC EAP versus REFLECT, there was a low overlap between the two populations related to a difference in the time from vision loss to treatment. In a post hoc sensitivity analysis comparing EAP to RESCUE data (ESS: 33), CRR was 39.0% for idebenone versus 69.5% for lenadogene nolparvovec (OR=3.59, 95% CI 1.42 to 9.06; p=0.011).CONCLUSIONThe two MAICs demonstrated a clinically meaningful higher visual recovery at 24 months with lenadogene nolparvovec than with idebenone in patients with LHON due to the m.11778G>A MT-ND4 variant.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"42 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147733438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epiretinal membranes: prevalence and associations in relationship to posterior vitreous detachment - the Beijing Eye Study.","authors":"Jost B Jonas,Songhomitra Panda-Jonas,Ya Xing Wang,Rahul A Jonas","doi":"10.1136/bjo-2025-328433","DOIUrl":"https://doi.org/10.1136/bjo-2025-328433","url":null,"abstract":"PURPOSETo assess prevalence and associations of epiretinal membranes (ERMs) in a general population.METHODSIn participants of the population-based Beijing Eye Study, we assessed macular volume optical coherence tomographic (OCT) scans for ERMs.RESULTSThe study included 1351 eyes (914 participants) (age: 64.7±9.8 years; range: 50-91 years). ERMs were detected in 80 eyes (5.9%; 95% CI 4.9% to 6.9%) of 60 participants (6.6%; 95% CI 5.1% to 8.1%), with ERMs without retinal surface wrinkling in 34 (2.5%) eyes, ERMs with retinal surface wrinkling and normal fovea contour in 16 (1.2%) eyes, ERMs with reduced foveal depth in 20 (1.5%) eyes, ERMs with complete foveal flattening in 6 (0.4%) eyes and ERMs with foveal elevation in 4 (0.2%) eyes. Hyper-reflective epiretinal dots (HEDs) were detected in 114 (8.4%) eyes. Higher ERM prevalence was associated (multivariable analysis) with higher stage of posterior vitreous detachment (PVD) (OR: 1.81; 95% CI 1.34 to 2.45; p<0.001), older age (OR: 1.05; 95% CI 1.01 to 1.09; p=0.002), higher prevalence of HEDs (OR: 9.18; 95% CI 4.85 to 17.4; p<0.001) and worse best corrected visual acuity (BCVA) (OR: 2.75; 95% CI 1.04 to 7.30; p=0.04), but not with axial length (p=0.69) or pseudophakia (p=0.98). Out of 746 eyes without PVD, 3 (0.4%) eyes had ERMs (without retinal surface wrinkling) and 9 (1.2%) eyes showed HEDs. Higher ERM stage increased with higher PVD stage (beta: 0.32; p<0.001), older age (beta: 0.11; p=0.006) and worse BCVA (beta: 0.07; p=0.04), but not with axial length (p=0.75) or pseudophakia (p=0.71).CONCLUSIONSAs measured by OCT, ERM prevalence was mainly associated with PVD and to a minor degree with older age and worse BCVA, while longer axial length, pseudophakia or ocular diseases such as age-related macular disease and glaucoma were not related to prevalence and stage of ERMs.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"21 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world early outcomes of intravitreal faricimab 6-mg and aflibercept 2-mg injection in diabetic macular oedema.","authors":"Evangelia Chalkiadaki,Yue Sing Sim,Olayinka Williams,Lucy Elder,Peter Kwesi Addison,Robin D Hamilton,Luke Nicholson,Sobha Sivaprasad,Ling Zhi Heng","doi":"10.1136/bjo-2025-328893","DOIUrl":"https://doi.org/10.1136/bjo-2025-328893","url":null,"abstract":"BACKGROUND/AIMSTo evaluate real-world, short-term anatomical and functional outcomes of faricimab versus aflibercept 2 mg in diabetic macular oedema (DMO).METHODSThis retrospective, parallel-cohort comparative study included 300 consecutive patients with DMO from Moorfields Eye Hospital. Eligible eyes were treatment-naïve and treatment-experienced not receiving therapy for ≥6 months and subsequently initiated on loading phase of faricimab or aflibercept 2mg. Follow-up was 4 months. Data were collected from the Moorfields electronic medical records system. Changes in visual acuity (VA) and central subfield thickness (CST) from baseline to the fourth injection were analysed using multiple linear regression adjusted for baseline covariates (age, gender, ethnicity, diabetes type, baseline retinopathy status, baseline VA or CST and treatment interval).RESULTSOf 300 eyes enrolled, 292 were ultimately analysed (191 aflibercept; 101 faricimab), with 246 eyes (84.2%) completing follow-up. Mean unadjusted VA gain was +3.9±10.4 letters with aflibercept and +5.2±11.8 letters with faricimab. Adjusted marginal mean VA gain was +4.2 letters for aflibercept and +4.7 letters for faricimab, with a non-significant difference of -0.5 letters (p=0.7). Baseline VA and treatment interval were significant predictors of functional response, with baseline VA exerting approximately 3.4 times the impact of treatment interval. Mean CST reduction was 87.3±106.1 µm with aflibercept and 113.1±136.7 µm with faricimab. Adjusted mean reductions were 95.4 µm and 99.8 µm, respectively (difference -4.4 µm, p=0.7). Baseline CST was the only independent predictor of anatomical response.CONCLUSIONFaricimab and aflibercept achieved comparable short-term anatomical and functional outcomes, with greater anatomical improvement associated with higher baseline CST and larger visual gains observed with lower baseline VA. Treatment interval influenced functional response, underscoring the importance of timely therapy. Baseline disease features and treatment adherence are key determinants of early outcomes, rather than drug selection.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"17 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and vascular correlates of visual field defects in branch retinal vein occlusion: a multimodal imaging study.","authors":"Kwang-Eon Choi,Eun Gyu Yoon,Hyun Woo Chung,Mihyun Choi,Seong-Woo Kim","doi":"10.1136/bjo-2025-328577","DOIUrl":"https://doi.org/10.1136/bjo-2025-328577","url":null,"abstract":"BACKGROUNDTo evaluate the association between visual field (VF) defects and retinal structural and perfusion biomarkers in eyes with branch retinal vein occlusion (BRVO), using optical coherence tomography (OCT) and OCT angiography (OCTA).METHODSThis retrospective cross-sectional study included 85 patients with unilateral BRVO. The eyes were classified as having either major or macular BRVO. VFs were assessed using the Humphrey 24-2 VF testing. Structural parameters were obtained from spectral-domain OCT for each parafoveal and perifoveal sublayer thickness in the superior and inferior fields. Perfusion parameters from 3×3 mm macular OCTA included vessel density (VD) in the superficial and deep capillary plexuses (DCPs), foveal avascular zone area, central non-perfusion area (NPA) and parafoveal NPA. Eyes were stratified by VF mean deviation (MD): Group 1 (significant VF defect, MD ≤-6 dB) and Group 2 (mild VF defect, MD >-6 dB). Intergroup comparisons, correlations and multivariate regression analyses were performed.RESULTSGroup 1 (n=27) had a significantly higher prevalence of major BRVO (96.3 vs 65.5%) than Group 2 (n=58). Group 1 showed thinner parafoveal ganglion cell-inner plexiform layer (GCIPL) (76.8±14.7 vs. 87.9±11.9 µm; p<0.001) and outer plexiform layer (32.5±6.6 vs. 36.1±5.5 µm; p=0.024). Hemispheric VD in the DCP was lower in Group 1 (28.9±6.2% vs. 32.7±8.1%; p=0.031). In multivariate analysis, BRVO type and parafoveal GCIPL thickness were independent predictors of significant VF loss.CONCLUSIONSVF impairment in BRVO was strongly associated with inner retinal thinning than with OCTA parameters. VF testing and structural OCT can be complemented by acuity-based assessments of BRVO.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"13 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological insights into epiretinal membranes using optical coherence tomography: the Singapore Epidemiology of Eye Diseases Study-2.","authors":"Yanyan Chen,Zhi Da Soh,Miao Li Chee,Can Can Xue,Sahil Thakur,Qingsheng Peng,Ning Cheung,Quan V Hoang,Kelvin Yc Teo,Charumathi Sabanayagam,Yih Chung Tham,Xiayin Zhang,Ching-Yu Cheng","doi":"10.1136/bjo-2025-327898","DOIUrl":"https://doi.org/10.1136/bjo-2025-327898","url":null,"abstract":"BACKGROUNDTo investigate prevalence and risk factors of epiretinal membrane (ERM), particularly those associated with ERM severity, in a multi-ethnic Asian cohort using optical coherence tomography (OCT).METHODSA total of 6762 Malays, Indians and Chinese from the Singapore Epidemiology of Eye Diseases (SEED) Study cohort underwent a comprehensive evaluation. OCT macular scans were primarily used to assess the presence of ERM. ERM was classified into three stages based on structural characteristics on OCT images and as either primary or secondary. The data acquired were analysed using various multivariable logistic regression analyses to identify the potential risk factors.RESULTSThe age-standardised prevalence of any ERM was 14.5% in Malays, 13.6% in Indians and 16.3% in Chinese. Older age (OR 1.05 (95% CI 1.04 to 1.06)), female gender (OR 1.34 (95% CI 1.13 to 1.59)), Chinese ethnicity (OR 1.23 (95% CI 1.01 to 1.50) vs Malays; OR 1.71 (95% CI 1.39 to 2.10) vs Indians) and longer axial length (OR 1.19 (95% CI 1.13 to 1.26)) were risk factors for primary ERM. Significant risk factors for primary ERM severity were older age (OR 1.04 (95% CI 1.01 to 1.07)) and cardiovascular disease (CVD) (OR 2.17 (95% CI 1.03 to 4.57)), while for severe secondary cases were Chinese ethnicity (OR 2.07 (95% CI 1.18 to 3.63) vs Malays; OR 2.49 (95% CI 1.42 to 4.38) vs Indians) and higher glycated haemoglobin (HbA1c) level (OR 1.39 (95% CI 1.15 to 1.67)).CONCLUSIONSERM was more prevalent among Chinese adults in the SEED cohort. Older age and CVD were risk factors for primary ERM severity, while Chinese ethnicity and higher HbA1c were associated with severe secondary cases.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"16 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional variations in type 1 retinopathy of prematurity: GHANAROP and SUNDROP.","authors":"Sarthak V Shah,Arthur R Brant,Akwasi Ahmed,Cindy Zhao,Imoro Zeba Braimah,Geoffrey C Tabin,Darius M Moshfeghi","doi":"10.1136/bjo-2025-328512","DOIUrl":"https://doi.org/10.1136/bjo-2025-328512","url":null,"abstract":"BACKGROUND/AIMSTo compare the incidence of Zone I Stage 3 retinopathy of prematurity (ROP) without Plus disease between diverse cohorts.METHODS1164 premature infants (716 from the Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP) in the USA and 448 from GHANAROP in Ghana) underwent telemedicine ROP screening from January 2023 to March 2025. Retinal images were prospectively graded by the same expert grader using International Classification of Retinopathy of Prematurity, third edition terminology. Treatment-warranted ROP (TW-ROP) was defined as type 1 ROP or aggressive ROP. The telemedicine ROP Severity Score (tROP-SS) was quantified for each examination. Incidence of Zone I Stage 3 without Plus disease, correlation between Plus disease and TW-ROP and correlation between Stage and Plus versus tROP-SS in Zone I disease were analysed.RESULTS40% of treated eyes in GHANAROP versus 7.5% in SUNDROP (p=0.002) were Zone I Stage 3 without Plus. Treatment rates were similar between cohorts (2.2%-2.8%), although GHANAROP patients were significantly older (gestational age: 31 years, 2/7 vs 28 years, 5/7; p<0.001) and heavier (1352 g vs 1161 g; p<0.001) at birth. Correlation between Plus disease and TW-ROP was stronger in SUNDROP (Kendall's Tau 0.73 vs 0.46, both p<0.001). In Zone I disease, Stage correlated poorly with Plus in both cohorts but strongly with tROP-SS (Kendall's Tau ≥0.90, p<0.001).CONCLUSIONSZone I Stage 3 ROP without Plus is more prevalent in the Ghanaian cohort, challenging the assumed centrality of Plus disease for intervention in certain populations. Integrated scoring systems incorporating Zone, Stage and Plus may be crucial for accurate ROP classification, especially in low- and middle-income countries with zone-dominated disease.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"118 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of endophthalmitis with cataract surgery: where are we now 20 years after the ESCRS Study?","authors":"Irene C Kuo,Terrence O'Brien","doi":"10.1136/bjo-2025-328878","DOIUrl":"https://doi.org/10.1136/bjo-2025-328878","url":null,"abstract":"Acute postoperative endophthalmitis in cataract surgery, while rare, occurs despite efforts at prevention. Risk factors include host-related characteristics and technique-related aspects. The ocular surface plays a pivotal role, with external microbial flora serving as a pervasive potential source of organisms for infection. Innate natural defence mechanisms are capable of protecting against infection, despite evidence of microbial contamination, with organisms recovered from aqueous humour even in uncomplicated cataract surgeries. With acute endophthalmitis after cataract surgery, coagulase-negative Staphylococci species are the most commonly recovered organisms, followed by other Gram-positive organisms and, less frequently, Gram-negative organisms. Strategies to prevent infection aim to limit organisms entering the eye by reducing organisms on the ocular surface, preventing intraoperative intraocular bacterial contamination and preventing postoperative bacterial contamination with watertight wound closure. Secondary strategies target the eradication of organisms that (despite all precautions) might have entered the eye, including intracameral antibiotic administration. Topical ophthalmic antisepsis with administration of povidone-iodine reduces the clinical occurrence of endophthalmitis with cataract procedures. Evidence demonstrates similar low rates of postoperative endophthalmitis after cataract surgery using standardised preoperative preparation alone, with or without intracameral antibiotic administration, in routine, uncomplicated cases. Stratification of risk guides possible adjunctive intracameral antibiotic administration in addition to standardised prevention practices, with individuals at higher risk, including those undergoing same-day bilateral surgery or with complicated and combined procedures.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"98 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147695118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic status, cardiovascular health and joint associations with incident cataract: a prospective study from UK Biobank.","authors":"Yu Peng,Yuzhou Zhang,Ka Wai Kam,Mary Ho,Cheuk Ling Yim,Sunny Chi Lik Au,Xiu Juan Zhang,Mandy Ph Ng,Patrick Ip,Alvin L Young,Chi-Pui Pang,Clement C Tham,Li Jia Chen,Jason C Yam","doi":"10.1136/bjo-2025-327738","DOIUrl":"https://doi.org/10.1136/bjo-2025-327738","url":null,"abstract":"AIMSTo investigate the interaction and combined effects of cardiovascular health (CVH) and socioeconomic status (SES) on incident cataract risk.METHODSThis prospective cohort study included 236 248 UK Biobank participants free of cataract at baseline and with complete data on SES and CVH. Incident cataract was ascertained through hospital inpatient and self-reported records. SES was derived from household income, employment and education using latent class analysis, while CVH was assessed via the Life's Essential 8 (LE8) score. Cataract risk was evaluated using multivariable Cox regression, with interaction and joint effects analyses performed to assess the interplay between SES and CVH.RESULTSThis analysis involved 236 248 participants with an average age of 55.5 years (range: 38-73); 51.6% were female and 95.6% were of white ethnicity. Over a median follow-up period of 11.7 years, 26 791 participants (11.3%) developed cataract. Compared with the high SES group, participants with low SES had a significantly higher risk of cataract (HR, 1.30; 95% CI 1.25 to 1.35). Significant additive and multiplicative interactions between SES and CVH on cataract risk were observed. Better CVH substantially mitigated the adverse association of low SES with cataract. Notably, individuals with low SES and poor CVH showed the highest cataract risk (HR, 1.74; 95% CI 1.57 to 1.93) in contrast to those with high SES and optimal CVH.CONCLUSIONSImplementing interventions aimed at enhancing both SES and CVH may prove beneficial in preventing or delaying cataract onset. Adhering to the LE8 guidelines to maintain optimal CVH has the potential to alleviate a significant portion of the excess cataract risk associated with socioeconomic disadvantage.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"22 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147695150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in incidence and survival for uveal melanoma in Norway, 1993-2021.","authors":"Nils Leitzinger,Ragnhild S Falk,Henrik Jespersen,Nils A Eide,Adele C Green,Trude E Robsahm,Marit B Veierød","doi":"10.1136/bjo-2025-327605","DOIUrl":"https://doi.org/10.1136/bjo-2025-327605","url":null,"abstract":"BACKGROUND/AIMSUnderstanding uveal melanoma incidence and survival trends is crucial for improving patient outcomes and allocating healthcare resources. We aimed to investigate the incidence and survival for uveal melanoma in Norway, 1993-2021, including information on tumour site, tumour (T) category and summary stage.METHODSThe Cancer Registry of Norway provided data on all patients diagnosed with a first primary uveal melanoma in Norway between 1 January 1993 and 31 December 2021. We calculated age-standardised incidence rates using the European standard population and estimated net survival and crude probability of death. Net survival estimates were obtained using the Pohar-Perme estimator, period approach and cohort approach.RESULTSAltogether, 1497 patients (49.6% men) were diagnosed with a primary uveal melanoma in 1993-2021. The age-standardised incidence rate increased from 6.8 (95% CI 5.7 to 7.9) per million person-years in 1993-1997 to 9.8 (95% CI 8.8 to 11.0) per million person-years in 2017-2021, with an overall rate of 9.0 (95% CI 8.6 to 9.5). This increase was primarily driven by localised, T1 and T2 choroidal melanomas. Ten-year net survival for patients with uveal melanoma remained relatively stable between 57.2% (95% CI 36.2% to 73.5%) in 1993-1997 and 65.5% (95% CI 53.8% to 74.9%) in 2017-2021. Over the same periods, there was a notable net survival improvement in patients with choroidal melanoma from 53.4% (95% CI 27.9% to 73.4%) to 74.8% (95% CI 59.8% to 84.9%).CONCLUSIONThe increased uveal melanoma incidence in Norway was mainly due to localised choroidal tumours. Improved detection of choroidal tumours is likely to have contributed to both the increased incidence and long-term net survival, highlighting the potential benefits of early detection strategies.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"8 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147695159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world effect of vitrectomy combined with intravitreal conbercept for treatment of vitreous haemorrhage in proliferative diabetic retinopathy (QILIN I): a prospective cohort study.","authors":"Yuanyuan Liu,Jinglin Huang,Mingxin Ao,Yanming Huang,Xiang Ma,Quanhong Han,Dawei Sun,Jie Zhong,Qinghua Qiu,Hui Peng,Zhijun Wang,Junjie Ye,Zhizhong Ma,Yuhua Hao,Yuntao Hu,Qing Chang,Hai Lu,Xiaorong Li,Jianhong Liang,Suyan Li,Jianqiao Li,Xiaobing Yu,Liu Yang,Chunchao Bi,Bo Li,Fan Zhang,Ronghan Wu,Xuemin Jin,Guohong Zhou,Mengyu Liao,Yi Lei,Han Han,Hua Yan","doi":"10.1136/bjo-2025-329066","DOIUrl":"https://doi.org/10.1136/bjo-2025-329066","url":null,"abstract":"AIMSTo evaluate the efficacy of intravitreal conbercept (IVC) combined with pars-plana vitrectomy (PPV) for severe, non-clearing vitreous haemorrhage (VH) caused by proliferative diabetic retinopathy (PDR) in real-world practice.METHODSThis prospective, observational, multicentre, cohort study enrolled 523 patients with VH due to PDR at 26 hospitals from August 2022 to June 2024. Patients were treated with preoperative IVC (3-7 days prior to PPV), intraoperative IVC (at completion of PPV) and PPV alone as control. The primary outcome was the incidence of early (7-30 days) postoperative VH (POVH). Secondary outcomes included late POVH (30-180 days), postoperative best-corrected visual acuity (BCVA) and distribution of POVH severity.RESULTSOf 425 participants (425 eyes) finally enrolled, 406 completed 30-day-visit, and 341 completed 180-day-visit. The incidence of early POVH was 24.0% (36 of 150) in preoperative IVC versus 23.2% (33 of 142) intraoperative IVC compared with 37.6% (50 of 133) in control (p=0.0160, 0.0122). The incidence of late POVH was 11.9% (16 of 134) in preoperative IVC versus 17.5% (20 of 114) intraoperative IVC versus 17.8% (19 of 107) in control (p=0.4109, 0.4661). The early POVH was less severe in preoperative and intraoperative IVC cohorts compared with control (p=0.0067, 0.0304), while the severity of late POVH was comparable (p=0.4860, 0.8353). Mean postoperative BCVA was all improved but showed no significant intergroup differences (p>0.05).CONCLUSIONSThis study, with the largest participants to date, demonstrates that IVC administered preoperatively or intraoperatively effectively reduces early POVH incidence, rather than late POVH. Preoperative IVC may be preferable for patients with more severe baseline disease characteristics.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"21 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147685077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}