British Journal of Radiology最新文献_第5页

Investigating The Effect on Backscatter Factor When Measuring Entrance Surface Dose Using the Raysafe X2 Solid State Radiography and Fluoroscopy Detector.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-02-12 DOI: 10.1093/bjr/tqaf030

Vadim Lordinot, Chris Koller

{"title":"Investigating The Effect on Backscatter Factor When Measuring Entrance Surface Dose Using the Raysafe X2 Solid State Radiography and Fluoroscopy Detector.","authors":"Vadim Lordinot, Chris Koller","doi":"10.1093/bjr/tqaf030","DOIUrl":"https://doi.org/10.1093/bjr/tqaf030","url":null,"abstract":"Objectives: Assessment of patient dose is a critical quality assurance check towards ensuring it is kept as low as reasonably practicable. One metric used to evaluate this is Entrance Surface Dose (ESD)- the summed magnitudes of the incident radiation and Compton scatter resulting from photon interactions within tissue. ESD can be directly measured using a dosemeter that is sensitive to backscattered radiation. However, the increasing use of solid-state detectors such as the tin backed RaySafe X2 R/F detector, means that ESD cannot be directly measured. The IAEA Technical Report No.457, recommends using backscatter factors (BSF) as calculated by Petoussi-Henss et al in1998 via Monte Carlo methods when measuring ESD using such dosemeters. This research seeks to practically determine a reliable method of calculating the BSF using a PMMA patient-equivalent phantom.Methods: A comparison between the solid-state detector and an ionisation chamber capable of detecting backscatter was conducted. Special attention was given to BSF variation with both radiation field size and beam quality by varying additional copper and aluminium filtration to mimic the behaviour of patient-dose reducing techniques on modern fluoroscopy systems.Results: Results have shown significant correspondence with those of Petoussi-Henss et al using the simulated water and ICRU tissue equivalent phantoms.Conclusions: Given the results consistency, BSFs from this study have been proposed for use when measuring ESD using the RaySafe solid state detector with a PMMA patient-equivalent phantom for quality assurance purposes.Advances in knowledge: This research provides the opportunity to obtain more accurate patient dose data during quality assurance testing with modern solid-state dosemeters.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

18F-FDG PET or PET/CT in detecting high-grade transformation of chronic lymphocytic leukaemia and indolent lymphomas: A systematic review and meta-analysis. 18F-FDG PET 或 PET/CT 在检测慢性淋巴细胞白血病和轻度淋巴瘤高级别转化中的作用：系统综述和荟萃分析。

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-02-11 DOI: 10.1093/bjr/tqaf028

Osher N Y Lee, John Kuruvilla, David C Hodgson, Patrick Veit-Haibach, Ur Metser

{"title":"18F-FDG PET or PET/CT in detecting high-grade transformation of chronic lymphocytic leukaemia and indolent lymphomas: A systematic review and meta-analysis.","authors":"Osher N Y Lee, John Kuruvilla, David C Hodgson, Patrick Veit-Haibach, Ur Metser","doi":"10.1093/bjr/tqaf028","DOIUrl":"https://doi.org/10.1093/bjr/tqaf028","url":null,"abstract":"Objectives: To evaluate the diagnostic accuracy of 18F-FDG PET or PET/CT in detecting histological transformation (HT) of indolent lymphomas.Methods: A systematic search of articles up to July 2024 was performed in Embase and Medline. Eligible studies included adults with histologically proven indolent lymphoma, 18F-FDG PET or PET/CT as the index test, and sufficient data to assess diagnostic performance. Summary receiver operating characteristic curves were plotted using a bivariate model to estimate diagnostic accuracy with area under the curve (AUC).Results: Fifteen studies with 1,307 participants were included. Ten studies assessed PET ability to detect Richter's transformation, and 5 studies focussed on HT in follicular lymphoma and other subtypes. A meta-analysis of the former showed pooled sensitivity of 0.90 (95% CI, 0.84-0.93) and specificity of 0.54 (95% CI, 0.28-0.77) when using a SUVmax threshold of around 5. AUC was 0.89. Pooled sensitivity was 0.74 (95% CI, 0.54-0.87) and specificity was 0.84 (95% CI, 0.67-0.93) when using a SUVmax threshold of around 10. AUC was 0.84. For detecting HT in follicular lymphoma, thresholds were found higher than those for Richter's transformation.Conclusions: 18F-FDG PET or PET/CT demonstrates good diagnostic accuracy to detect Richter's transformation, best when employing SUVmax ≥ 5. SUVmax thresholds may be limited in discriminating follicular lymphoma from HT, and alternatives should be sought.Advances in knowledge: If biopsy is feasible, SUVmax ≥ 5 can guide biopsy in patients with clinically suspicious Richter's transformation. If biopsy is infeasible, SUVmax ≥ 10 can better identify HT and guide patient management.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The current state of imaging biomarker development and evaluation.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-02-11 DOI: 10.1093/bjr/tqaf027

Steve Halligan, Sue Mallett

引用次数: 0

Head and neck manifestations of extramedullary plasmacytomas and their differential diagnoses: a pictorial review. 髓外浆细胞瘤的头颈部表现及其鉴别诊断：图解综述。

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-02-11 DOI: 10.1093/bjr/tqaf031

S Wilkinson, S Jawad, X Kowa

引用次数: 0

Imaging and Management of Lymphedema in the Era of Precision Oncology. 精准肿瘤学时代的淋巴水肿成像与管理。

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-02-11 DOI: 10.1093/bjr/tqaf029

Pranjal Rai, Abhishek Mahajan, Shreya Shukla, Niyati Pokar

{"title":"Imaging and Management of Lymphedema in the Era of Precision Oncology.","authors":"Pranjal Rai, Abhishek Mahajan, Shreya Shukla, Niyati Pokar","doi":"10.1093/bjr/tqaf029","DOIUrl":"https://doi.org/10.1093/bjr/tqaf029","url":null,"abstract":"Lymphedema is a common complication of cancer treatment, leading to significant morbidity. Early and accurate diagnosis through the combined expertise of radiology and nuclear medicine is crucial for preventing lymphedema progression and improving patient outcomes. Imaging techniques such as lymphoscintigraphy, duplex ultrasound, MRI, and CT as well as newer modalities including near-infrared lymphangiography can diagnose and assess lymphedema severity. Bioimpedance spectroscopy (BIS) provides a non-invasive tool for early detection by measuring extracellular fluid changes, aiding in identifying lymphedema at its earliest stages. Pretreatment baseline measurements and prospective surveillance models (PSMs) are essential for tracking limb volume changes and mobility, enhancing early intervention outcomes. Recognizing the strengths and limitations of each imaging modality allows radiologists and nuclear medicine physicians to synergistically optimize lymphedema diagnosis and management. Effective management relies on multidisciplinary collaboration and includes conservative and surgical options tailored to disease severity. Advanced imaging modalities are pivotal for planning and monitoring interventional strategies. This review explores the development and management of secondary lymphedema in oncological patients, focusing chiefly on imaging and treatment strategies. It also briefly highlights the evolving role of artificial intelligence and machine learning in enhancing imaging precision and treatment outcomes.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost-effectiveness of trans-abdominal ultrasound for gallbladder cancer surveillance in patients with gallbladder polyps less than 10 mm in the United Kingdom.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-02-05 DOI: 10.1093/bjr/tqaf024

Julia Lowin, Bernadette Sewell, Matthew Prettyjohns, Angela Farr, Kieran G Foley

{"title":"Cost-effectiveness of trans-abdominal ultrasound for gallbladder cancer surveillance in patients with gallbladder polyps less than 10 mm in the United Kingdom.","authors":"Julia Lowin, Bernadette Sewell, Matthew Prettyjohns, Angela Farr, Kieran G Foley","doi":"10.1093/bjr/tqaf024","DOIUrl":"https://doi.org/10.1093/bjr/tqaf024","url":null,"abstract":"Objective: Gallbladder polyps (GBPs) are commonly detected with trans-abdominal ultrasound (TAUS). Gallbladder cancer (GBC) is associated with GBPs but the risk of malignancy is low. International guidelines recommend ultrasound surveillance (USS) in selected cases of GBPs <10mm, with cholecystectomy advised if polyp size increases. USS (including potential surgeries) is resource intense. We evaluated the costs and potential cost-effectiveness of USS in a theoretical UK patient cohort with GBPs.Methods: A health economic model mapped expected management pathways over 2-years for 1,000 GBP patients with and without USS, stratified by initial size of GBP (<6mm and 6-9mm). We estimated USS resource and costs under alternate thresholds for surgery. Clinical data were extracted from a large-scale cohort study. TAUS and surgery costs were based on NHS tariffs. GBC costs were estimated from the literature. Outcomes included USS costs, expected numbers of GBC and incremental cost for each case of GBC avoided.Results: The 2-year additional cohort costs of USS (n=number of additional surgeries) were estimated between £213,441 (n = 50) and £750,045 (n = 253) in GBPs <6mm, and between £420,275 (n = 165) and £531,297 (n = 207) in GBPs 6-9mm, balanced against avoidance of 1.3 (<6mm) and 8.7 (6-9mm) cases of GBC. Model findings were robust to plausible changes in inputs.Conclusions: Using published data, we demonstrated that, in patients with GBPs <10mm, the costs of USS to avoid GBC outweigh potential GBC cost offsets, and would result in high rates of cholecystectomy. Additional evidence is needed to establish the formal cost-effectiveness of GBP USS in the UK.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Research Applications of FAPI Tracers: A Review.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-02-05 DOI: 10.1093/bjr/tqaf020

Mélanie Desaulniers, Étienne Rousseau, Kim M Pabst

引用次数: 0

Electrochemotherapy in metastatic epidural spinal cord compression: a review and technical update.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-02-04 DOI: 10.1093/bjr/tqae219

F Deschamps, L Tselikas, R L Cazzato, G Facchini, V Granata, B Bonnet, V D'Alessio, R Fusco, A Zanasi, F De Terlizzi, A Gangi, T de Baere, L M Mir

引用次数: 0

Revolutionising Osseous Biopsy: The Impact of Artificial Intelligence in the Era of Personalised Medicine.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-01-29 DOI: 10.1093/bjr/tqaf018

Amanda Isaac, Michail E Klontzas, Danoob Dalili, Asli Irmak Akdogan, Mohamed Fawzi, Giuseppe Gugliemi, Dimitrios Filippiadis

{"title":"Revolutionising Osseous Biopsy: The Impact of Artificial Intelligence in the Era of Personalised Medicine.","authors":"Amanda Isaac, Michail E Klontzas, Danoob Dalili, Asli Irmak Akdogan, Mohamed Fawzi, Giuseppe Gugliemi, Dimitrios Filippiadis","doi":"10.1093/bjr/tqaf018","DOIUrl":"https://doi.org/10.1093/bjr/tqaf018","url":null,"abstract":"In a rapidly evolving healthcare environment, artificial intelligence (AI) is transforming diagnostic techniques and personalised medicine. This is also seen in osseous biopsies. AI applications in radiomics, histopathology, predictive modelling, biopsy navigation, and interdisciplinary communication are reshaping how bone biopsies are conducted and interpreted. We provide a brief review of AI in image- guided biopsy of bone tumours (primary and secondary) and specimen handling, in the era of personalised medicine. This paper explores AI's role in enhancing diagnostic accuracy, improving safety in biopsies, and enabling more precise targeting in bone lesion biopsies, ultimately contributing to better patient outcomes in personalised medicine. We dive into various AI technologies applied to osseous biopsies, such as traditional machine learning, deep learning, radiomics, simulation and generative models. We explore their roles in tumour board meetings, communication between clinicians, radiologists, and pathologists. Additionally, we inspect ethical considerations associated with the integration of AI in bone biopsy procedures, technical limitations, and we delve into health equity, generalisability, deployment issues, and reimbursement challenges in AI-powered healthcare. Finally, we explore potential future developments and offer a list of open-source AI tools and algorithms relevant to bone biopsies, which we include to encourage further discussion and research.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Trials in Cancer Theranostics with Potential Near-Term Impact on Clinical Practice.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-01-28 DOI: 10.1093/bjr/tqaf017

Hossein Jadvar, Abtin Doroudinia, Peter S Conti, Patrick M Colletti

{"title":"Clinical Trials in Cancer Theranostics with Potential Near-Term Impact on Clinical Practice.","authors":"Hossein Jadvar, Abtin Doroudinia, Peter S Conti, Patrick M Colletti","doi":"10.1093/bjr/tqaf017","DOIUrl":"https://doi.org/10.1093/bjr/tqaf017","url":null,"abstract":"Theranostics has its roots with the first radioiodine therapy for thyroid diseases in about 80 years ago. More recently the field has experienced a remarkable renascence with the regulatory approval of paired imaging and radiopharmaceutical therapy agents in gastroenteropancreatic neuroendocrine tumors and metastatic castration-resistant prostate cancer that are now employed in routine clinical practice. The momentum is strong for identification and testing of new theranostic agents for use in various cancers and finding new clinical incications of the available agents. There are currently numerous preclinical, first-in-human studies, large-scale prospective registries, and clinical trials including randomized trials underway in cancer theranostics that target a variety of germane biological targets. The results of these investigations, if successful, will undoubtedly impact the future of cancer management which is anticipated to improve patient outcome. Multi-targeted theranostics may also provide opportunities for synergistic efficacy to tackle the inherent complexities driven by the heterogeneity of cancer. In this article, we review the currently active recruiting phase 2 and phase 3 clinical trials in cancer theranostics that are targeted to the prostate-specific membrane antigen, gastrin-releasing peptide receptor, and fibroblast activation protein, with the anticipated potential near-term (<5 years) impact on clinical practice.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0