British Journal of Radiology最新文献

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Oxygen concentration alters ROS yields with minor plasmid DNA damage change at Ultra High Dose Rate. 在超高剂量率下,氧浓度改变ROS产率,质粒DNA损伤变化较小。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-09-26 DOI: 10.1093/bjr/tqaf245
William Thomas, Siddharth Kulkarni, Aleksandra Ilina, Matthew Reed, Brian W Pogue
{"title":"Oxygen concentration alters ROS yields with minor plasmid DNA damage change at Ultra High Dose Rate.","authors":"William Thomas, Siddharth Kulkarni, Aleksandra Ilina, Matthew Reed, Brian W Pogue","doi":"10.1093/bjr/tqaf245","DOIUrl":"https://doi.org/10.1093/bjr/tqaf245","url":null,"abstract":"<p><strong>Objective: </strong>Ultra-high dose rate (UHDR) radiotherapy has become a large area of research due to observed normal tissue sparing without sacrificing tumor control, termed the FLASH effect. The purpose of this study was to compare reactive oxygen species (ROS) production and DNA damage across various O2 levels at UHDR and conventional dose rates (CDR) in solutions without repair enzymes and radical scavengers.</p><p><strong>Methods: </strong>Solution assays of both ROS and DNA damage assessed dose rate and oxygen dependent (0-20% O2) changes between UHDR and CDR from an IntraOp Mobetron. For ROS reporters Amplex UltraRed (H2O2), and CellROX Deep Red (non-H2O2) were quantified via intensity per unit dose. DNA damage assayed plasmid pBR322 gel electrophoresis, to differentiate both single (SSB) and double strand breaks (DSB).</p><p><strong>Results: </strong>For ROS assays, a significant reduction was noted from CDR to UHDR across all measured oxygen levels. The generation of H2O2 decreased when departing from physiologically relevant oxygen levels (1-5%), with generation 30-40% lower at UHDR. The DNA damage assay showed no trends in the SSB or DSB values with O2.</p><p><strong>Conclusion: </strong>Examination of trends between ROS and DNA damage from factors such as oxygen can help elucidate FLASH mechanisms. The H2O2 yield has maximum yield at physiological oxygenation levels (1-5%), and UHDR further diminishes yield. In DNA damage no trend was observed. It is possible that these mechanisms have underlying effects on the FLASH effect in vivo.</p><p><strong>Advances in knowledge: </strong>This study is the first to directly compare radiation chemistry differences caused by UHDR to biologically relevant DNA damage in identical solutions.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How can children benefit from total-body PET? 儿童如何从全身PET中受益?
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-09-25 DOI: 10.1093/bjr/tqaf242
Paul J H van Snick, Sasha O V Ivashchenko, Joyce van Sluis, Limme B de Langen, Georgie C van den Oever, Mostafa Roya, Andor W J M Glaudemans, Riemer H J A Slart
{"title":"How can children benefit from total-body PET?","authors":"Paul J H van Snick, Sasha O V Ivashchenko, Joyce van Sluis, Limme B de Langen, Georgie C van den Oever, Mostafa Roya, Andor W J M Glaudemans, Riemer H J A Slart","doi":"10.1093/bjr/tqaf242","DOIUrl":"https://doi.org/10.1093/bjr/tqaf242","url":null,"abstract":"<p><p>The introduction of long axial field-of-view (LAFOV) PET/CT scanners marks a major advancement in paediatric nuclear medicine. These systems provide greatly enhanced sensitivity, enabling superior image quality with reduced radiopharmaceutical doses and substantially shorter scan times. This is particularly advantageous in children, who are more radiosensitive and often struggle with prolonged procedures that may require sedation. LAFOV PET/CT allows whole-body imaging in a single bed position, reducing motion artefacts, improving patient comfort, and lessening procedural anxiety. Such benefits align with the ALARA (As Low As Reasonably Achievable) principle, critical for minimising radiation exposure in children given their increased sensitivity and longer life expectancy. Although associated with higher initial costs and increased data demands, LAFOV technology offers significant clinical advantages, including the potential for personalised imaging protocols tailored to each child's needs. This review discusses the technical attributes of LAFOV PET/CT and its expanding role in paediatric imaging, addressing both opportunities and challenges. By overcoming previous limitations related to scan duration and radiation dose, LAFOV PET/CT is poised to transform paediatric diagnostics, enabling safer, faster, and more comprehensive assessments.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variational autoencoder-based deep learning and radiomics for predicting pathologic complete response to neoadjuvant chemoimmunotherapy in locally advanced esophageal squamous cell carcinoma. 基于变分自编码器的深度学习和放射组学预测局部晚期食管鳞状细胞癌新辅助化疗免疫治疗的病理完全反应。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-09-25 DOI: 10.1093/bjr/tqaf239
Qing Gu, Shenlun Chen, Andre Dekker, Leonard Wee, Petros Kalendralis, Meng Yan, Jin Wang, Jingping Yuan, Youhua Jiang
{"title":"Variational autoencoder-based deep learning and radiomics for predicting pathologic complete response to neoadjuvant chemoimmunotherapy in locally advanced esophageal squamous cell carcinoma.","authors":"Qing Gu, Shenlun Chen, Andre Dekker, Leonard Wee, Petros Kalendralis, Meng Yan, Jin Wang, Jingping Yuan, Youhua Jiang","doi":"10.1093/bjr/tqaf239","DOIUrl":"https://doi.org/10.1093/bjr/tqaf239","url":null,"abstract":"<p><strong>Objectives: </strong>Neoadjuvant chemoimmunotherapy (nCIT) is gradually becoming an important treatment strategy for patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC). This study aimed to predict the pathological complete response (pCR) of these patients using variational autoencoder (VAE)-based deep learning and radiomics technology.</p><p><strong>Methods: </strong>A total of 253 LA-ESCC patients who were treated with nCIT and underwent enhanced CT at our hospital between July 2019 and July 2023 were included in the training cohort. VAE-based deep learning and radiomics were utilized to construct deep learning (DL) models and deep learning radiomics (DLR) models. The models were trained and validated via 5-fold cross-validation among 253 patients. Forty patients were recruited from our institution between August 2023 and August 2024 as the test cohort.</p><p><strong>Results: </strong>The AUCs of DL and DLR model were 0.935 (95% CI: 0.786-0.992) and 0.949 (95% CI: 0.910-0.986) in the validation cohort and 0.839 (95% CI: 0.726-0.853), 0.926 (95% CI: 0.886-0.934) in the test cohort. The performance gap between Precision and Recall of the DLR model was smaller than that of DL model. The F1 scores of the DL and DLR model were 0.726 (95% confidence interval [CI]: 0.476-0.842) and 0.766 (95% CI: 0.625-0.842) in the validation cohort and 0.727 (95% CI: 0.645-0.811), 0.836 (95% CI: 0.820-0.850) in the test cohort.</p><p><strong>Conclusions: </strong>We constructed a DLR model to predict pCR in nCIT treated LA-ESCC patients, which demonstrated superior performance compared to the DL model.</p><p><strong>Advances in knowledge: </strong>We innovatively used VAE-based deep learning and radiomics to construct the DLR model for predicting pCR of LA-ESCC after nCIT.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theranostics and Molecular Imaging are taking off- current situation, requirements and how to train more physicians to fill the gap. A perspective from three different continents. 治疗学和分子影像学正在起飞的现状,需求和如何培养更多的医生来填补空白。来自三个不同大陆的视角。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-09-25 DOI: 10.1093/bjr/tqaf243
Patrick Veit-Haibach, Winnie Lam, Rebecca K S Wong, Gary J R Cook
{"title":"Theranostics and Molecular Imaging are taking off- current situation, requirements and how to train more physicians to fill the gap. A perspective from three different continents.","authors":"Patrick Veit-Haibach, Winnie Lam, Rebecca K S Wong, Gary J R Cook","doi":"10.1093/bjr/tqaf243","DOIUrl":"https://doi.org/10.1093/bjr/tqaf243","url":null,"abstract":"<p><p>The field of radiopharmaceuticals and therapies is currently rapidly increasing. However, there is no consensus about how to address the expected shortage of qualified personnel to deliver such therapies. This commentary gives an overview over the current situation in different exemplary jurisdictions and also tries to show possible paths forward and how to prepare the upcoming physician's generation for these radiopharmaceutical therapies.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparities in Imaging and Management of Multiple Sclerosis: A Review. 多发性硬化症影像学和治疗的差异:综述。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-09-20 DOI: 10.1093/bjr/tqaf233
Alvin Tran, George F Grant, Olutola P Akande, Gelareh Sadigh
{"title":"Disparities in Imaging and Management of Multiple Sclerosis: A Review.","authors":"Alvin Tran, George F Grant, Olutola P Akande, Gelareh Sadigh","doi":"10.1093/bjr/tqaf233","DOIUrl":"https://doi.org/10.1093/bjr/tqaf233","url":null,"abstract":"<p><p>Despite advancements in multiple sclerosis (MS) imaging and treatment, there are sex-specific differences and disparities across sociodemographic factors (e.g., race, ethnicity, socioeconomic status, health literacy, and geography) that can result in disparate clinical presentation, diagnosis, management, and outcomes. These social determinants of health often intersect, limiting access to MRI or disease-modifying therapies. Financial and geographic barriers can delay diagnosis and treatment, particularly in rural or underserved areas. Patients with low health literacy may have difficulty navigating care, while provider-related factors, like implicit biases and varying practices in low-resource settings, contribute to unequal imaging and treatment utilization. Radiologists are uniquely positioned to help reduce these inequities. By collaborating with clinical teams, standardizing imaging protocols, and expanding access through extended service hours and patient navigation programs, radiology practices can address many barriers. Subspecialized neuroradiology expertise, delivered through teleradiology, can help mitigate diagnostic disparities in underserved regions. Radiologists can support health equity by engaging in community outreach to improve health literacy and by working to increase workforce diversity. This review examines the intersection of clinical and radiologic disparities in MS, identifies key barriers to imaging access and utilization, and highlights how radiology can promote equitable MS care to improve outcomes across all populations.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-request chest X-ray services-reducing barriers to diagnosis of lung cancer. 自我要求胸部x光服务-减少诊断肺癌的障碍。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-09-18 DOI: 10.1093/bjr/tqaf232
Joanna L Start, Stephen Bradley, Matthew E J Callister, Willy Choon Kon Yune, Tom Daniels, Matthew Evison, Seamus Grundy, Rehan Naseer, Ben Noble, Charlotte A Porter, Bobby S K Bhartia
{"title":"Self-request chest X-ray services-reducing barriers to diagnosis of lung cancer.","authors":"Joanna L Start, Stephen Bradley, Matthew E J Callister, Willy Choon Kon Yune, Tom Daniels, Matthew Evison, Seamus Grundy, Rehan Naseer, Ben Noble, Charlotte A Porter, Bobby S K Bhartia","doi":"10.1093/bjr/tqaf232","DOIUrl":"https://doi.org/10.1093/bjr/tqaf232","url":null,"abstract":"<p><p>Despite the welcome introduction of the NHS Lung Cancer Screening Programme, most diagnoses of lung cancer will continue to be made via symptomatic and emergency presentations. Multiple patient related factors act as a barrier to symptomatic presentation and eventual diagnosis including perceptions of personal risk and a view that the often-non-specific symptoms may be unworthy of medical attention in an ever-busy NHS. Self-request chest x-ray services rolled out in Leeds and Greater Manchester aim to reduce these barriers to diagnosis in order to achieve earlier diagnosis of lung cancer and improve outcomes. The services have been accessed over 14 000 times. Lung cancer is a leading cause of health inequality, and these services effectively target populations with high levels of deprivation who are at the greatest risk of lung cancer and yet face the greatest barriers to diagnosis. Self-request services empower patients to take ownership of their health. Supported by organisations representing those affected by lung cancer, the initiative is a step towards restoring access to healthcare. This commentary discusses the rationale for the self-request chest x-ray service and describes the service model, addressing areas of potential concern and controversy.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy outcomes in childhood cancer survivors according to uterine radiation dose and other factors. 子宫辐射剂量和其他因素对儿童期癌症幸存者妊娠结局的影响。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-09-18 DOI: 10.1093/bjr/tqaf130
Christophe Legrand, Boris Schwartz, Stéphanie Bolle, Francois Doz, Vassilis Tsatsaris, Sabine Sarnacki, Brice Fresneau, Claire Alapetite, Sylvie Helfre, Anne Laprie, Pierre-Yves Bondiau, Monia Zidane, Rodrigue Allodji, Nadia Haddy, Neige Journy, Marjorie Boussac, Cécile Thomas-Teinturier, Ibrahima Diallo, Cristina Veres, Vincent Souchard, Giao Vu-Bezin, Florent De Vathaire, Charlotte Demoor-Goldschmidt
{"title":"Pregnancy outcomes in childhood cancer survivors according to uterine radiation dose and other factors.","authors":"Christophe Legrand, Boris Schwartz, Stéphanie Bolle, Francois Doz, Vassilis Tsatsaris, Sabine Sarnacki, Brice Fresneau, Claire Alapetite, Sylvie Helfre, Anne Laprie, Pierre-Yves Bondiau, Monia Zidane, Rodrigue Allodji, Nadia Haddy, Neige Journy, Marjorie Boussac, Cécile Thomas-Teinturier, Ibrahima Diallo, Cristina Veres, Vincent Souchard, Giao Vu-Bezin, Florent De Vathaire, Charlotte Demoor-Goldschmidt","doi":"10.1093/bjr/tqaf130","DOIUrl":"https://doi.org/10.1093/bjr/tqaf130","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to describe pregnancy and maternal outcomes according to radiation doses received to the uterus during photon beam therapy in the French Childhood Cancer Survivor Study (FCCSS) cohort.</p><p><strong>Methods: </strong>Of the 7670 5-years survivors, 1159 women treated by radiotherapy and with no hysterectomy, followed between 2006-2018 were included. Uterus dose were reconstructed within phantoms modelling patient's anatomy in treatment position. A statistical analysis was performed including demographic information, treatment variables and co-factors.</p><p><strong>Results: </strong>Among 1,159 women, 297(25.6%) had at least one pregnancy, of whom 105/297(35.3%) had a uterine dose of Dmedian>1Gy. The proportion of ectopic pregnancy, spontaneous and medical abortions was 20.3%(101/498) and increased to 39% if Dmedian_uterus>20Gy, versus 12% reported in the French's general population. When medical pregnancy terminations were excluded significant associations with an increase in risks were found for women who were older than 40 at the time of pregnancy and Dmedian_uterus>20Gy. Two women whose entire uterus received over 40 Gy had one pregnancy, resulting in a live birth. One woman passed away due to haemorrhage during delivery, treated at age 16 with D80%uterus=35Gy. No other delivery-related deaths were reported.</p><p><strong>Conclusion: </strong>Assessing the dose to the uterus for pelvic irradiation treatments is necessary and volume receiving 20 Gy should be minimised. Even if pregnancy is feasible after really high dose received on the uterus (Dmean>40Gy), a close obstetrical monitoring is recommended and home delivery should be contraindicated due to the risk of vital hemorrhage.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Ultrasound-based Nomogram Using Contrast-enhanced and Conventional Ultrasound Features to Improve Preoperative Diagnosis of Parathyroid Adenomas versus Cervical Lymph Nodes. 一种新的基于超声造影增强和常规超声特征的Nomogram超声造影改善甲状旁腺瘤与颈淋巴结的术前诊断。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-09-17 DOI: 10.1093/bjr/tqaf230
Yan Xu, Zhongkun Zuo, Qinghai Peng, Rongsen Zhang, Kui Tang, Chengcheng Niu
{"title":"A Novel Ultrasound-based Nomogram Using Contrast-enhanced and Conventional Ultrasound Features to Improve Preoperative Diagnosis of Parathyroid Adenomas versus Cervical Lymph Nodes.","authors":"Yan Xu, Zhongkun Zuo, Qinghai Peng, Rongsen Zhang, Kui Tang, Chengcheng Niu","doi":"10.1093/bjr/tqaf230","DOIUrl":"https://doi.org/10.1093/bjr/tqaf230","url":null,"abstract":"<p><strong>Introduction: </strong>Precise preoperative localization of parathyroid gland lesion is essential for guiding surgery in primary hyperparathyroidism (PHPT). The aim of our study was to investigate the contrast-enhanced ultrasound (CEUS) characteristics of parathyroid gland adenoma (PGA) and to evaluate whether PGA can be differentiated from central cervical lymph nodes (CCLN).</p><p><strong>Methods: </strong>Fifty-four consecutive patients with PHPT were retrospectively enrolled and underwent preoperative imaging with high-resolution ultrasound (US) and CEUS, and underwent subsequent parathyroidectomy. One hundred and seventy-four lymph nodes of papillary thyroid carcinomas (PTC) patients were examined by high-resolution US and CEUS, and underwent unilateral, subtotal, or total thyroidectomy with central neck dissection were enrolled. By incorporating US and CEUS characteristics, a predictive model presented as a nomogram was developed, and their performance and utility were evaluated by plotting receiver operating characteristic (ROC) curves, calibration curves and decision curve analysis (DCA).</p><p><strong>Results: </strong>Three US characteristics and two CEUS characteristics were independent characteristics related to PGA for their differentiation from CCLN, and were obtained for machine learning model construction. The area under the receiver characteristic curve (AUC) of the US+CEUS model was 0.915, was higher than the other US model (0.874) and CEUS model (0.791).</p><p><strong>Conclusion: </strong>It is recommended that CEUS techniques be used to enhance the diagnostic utility of US in cases of suspected parathyroid lesions.</p><p><strong>Advances in knowledge: </strong>This is the first study to use a combination of US+CEUS to build a nomogram to distinguish between PGA and CCLN, filling a gap in the existing literatures.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound radiomics-based dynamic nomogram to predict histologic grade in soft tissue sarcoma: a multi-center cohort study. 基于超声放射组学的动态图预测软组织肉瘤的组织学分级:一项多中心队列研究。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-09-17 DOI: 10.1093/bjr/tqaf227
Mengjie Wu, Boyang Zhou, Ao Li, Hailing Zha, Xinyue Wang, Hongjin Hua, Tiantian Zhang, Shuping Wei, Wei Zhang, Huixiong Xu
{"title":"Ultrasound radiomics-based dynamic nomogram to predict histologic grade in soft tissue sarcoma: a multi-center cohort study.","authors":"Mengjie Wu, Boyang Zhou, Ao Li, Hailing Zha, Xinyue Wang, Hongjin Hua, Tiantian Zhang, Shuping Wei, Wei Zhang, Huixiong Xu","doi":"10.1093/bjr/tqaf227","DOIUrl":"https://doi.org/10.1093/bjr/tqaf227","url":null,"abstract":"<p><strong>Objectives: </strong>To predict histologic grade of soft tissue sarcoma (STS) with preoperative ultrasound images, aiding in the selection of personalized treatment plans and improving long-term prognosis.</p><p><strong>Methods: </strong>In total, 238 patients with histologically proven STS were retrospectively enrolled from April 2016 to December 2023 and divided into the training and internal validation cohorts. 70 patients were prospectively enrolled from three centers between January 2024 and December 2024 as the external validation cohort. Radiomics features were extracted from preoperative grayscale ultrasound images. The dynamic nomogram (DynNom) was developed by using multivariable logistic regression analysis. Predictive performance was evaluated with the receiving operating characteristic curve, calibration curve, Hosmer-Lemeshow test, decision curve analysis (DCA), and clinical impact curve (CIC).</p><p><strong>Results: </strong>The DynNom based on clinical-US characteristics (metastasis status, echogenicity, fascia layer, and vascularity) and radiomics features yielded an optimal AUC of 0.915 (95% CI, 0.873-0.947), 0.87 (95% CI, 0.79-0.93), and 0.90 (95% CI, 0.80-0.96) for predicting the STS histologic grade in the training, internal and external validation cohorts, respectively. The DynNom outperformed the conventional model and radiomics model (P < 0.05). Calibration curves and Hosmer-Lemeshow tests indicated its satisfactory calibration ability. DCA confirmed that the DynNom outperformed other models in overall net benefit, meanwhile CIC suggested that the DynNom had great clinical applicability in predicting histologic grade.</p><p><strong>Conclusions: </strong>The dynamic nomogram is a practical tool that could predict the histologic grade of STS, which might help clinicians to screen histologic high-grade STSs as neoadjuvant treatment candidates.</p><p><strong>Advances in knowledge: </strong>The dynamic nomogram had the potential to accurately predict histologic grade in STS patients before surgery. High-risk patients defined by the dynamic nomogram were potential candidates for preoperative radiotherapy and neoadjuvant chemotherapy.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound Imaging/Guidance for Insertional Achilles Tendinopathy. 插入性跟腱病的超声成像/指导。
IF 3.4 4区 医学
British Journal of Radiology Pub Date : 2025-09-16 DOI: 10.1093/bjr/tqaf231
Vincenzo Ricci, Toru Omodani, Ke-Vin Chang, Costantino Ricci, Ondřej Naňka, Antonio Corvino, Massimo Caulo, Andrea Delli Pizzi, Vito Cantisani, Giorgio Tamborrini, Giulio Cocco, Levent Özçakar
{"title":"Ultrasound Imaging/Guidance for Insertional Achilles Tendinopathy.","authors":"Vincenzo Ricci, Toru Omodani, Ke-Vin Chang, Costantino Ricci, Ondřej Naňka, Antonio Corvino, Massimo Caulo, Andrea Delli Pizzi, Vito Cantisani, Giorgio Tamborrini, Giulio Cocco, Levent Özçakar","doi":"10.1093/bjr/tqaf231","DOIUrl":"https://doi.org/10.1093/bjr/tqaf231","url":null,"abstract":"<p><strong>Objectives: </strong>This observational study aimed to define a standardized sonographic approach for evaluating the elementary lesions of the tendon-bone junction (TBJ) in insertional Achilles tendinopathy (IAT).</p><p><strong>Methods: </strong>Using high-frequency transducers, we matched the histological microarchitecture and the anatomical features of the TBJ of the Achilles tendon in patients with a clinical diagnosis of IAT. Color/power Doppler assessments have been performed as well.</p><p><strong>Results: </strong>Fifty eight patients, with a mean age of 54 years (54.50 ± 11.72) and a gender distribution of 32 males (55.17%) and 26 females (44.83%), were enrolled in this observational study. Five elementary lesions of IAT were sonographically defined: bone spur, calcified longitudinal fissuration, intra-tendinous bony formation, tendon-bone disjunction, and fibrocartilage hyperemia. Moreover, specific sonographic signs have been identified to differentiate bony spurs in the growing phase and end-stage.</p><p><strong>Conclusions: </strong>Using high-frequency B-mode and high-sensitive Doppler imaging, detailed sonographic assessment of the TBJ can be performed in IAT patients. The aforementioned five elementary lesions can be considered as a standardized approach for prompt examination of this complex/anatomical region.</p><p><strong>Advances in knowledge: </strong>Recent advances in ultrasound equipment allow for accurate assessment of the TBJ of the AT. The present observational study defined five elementary sonographic lesions of the IAT as bone spur, calcified longitudinal fissuration, intra-tendinous bony formation, tendon-bone disjunction, and fibrocartilage hyperemia. Pertinent ultrasound-guided procedures targeting the TBJ are also discussed.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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