British Journal of Radiology最新文献

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Approvers, Disapprovers, and Strugglers: a Q-methodology study of rectal cancer MRI proforma use. 批准者、反对者和挣扎者:直肠癌磁共振成像形式使用的q-方法学研究。
IF 1.8 4区 医学
British Journal of Radiology Pub Date : 2025-05-01 DOI: 10.1093/bjr/tqaf035
Sarah Alderson, Chand Muthoo, Hannah Rossington, Phil Quirke, Damian Tolan
{"title":"Approvers, Disapprovers, and Strugglers: a Q-methodology study of rectal cancer MRI proforma use.","authors":"Sarah Alderson, Chand Muthoo, Hannah Rossington, Phil Quirke, Damian Tolan","doi":"10.1093/bjr/tqaf035","DOIUrl":"10.1093/bjr/tqaf035","url":null,"abstract":"<p><strong>Objectives: </strong>Rectal cancer MRI (rcMRI) allows accurate staging and informs treatment decisions in rectal cancer. There is variability in reporting completeness; however, template proforma reports can significantly increase the inclusion of key tumour descriptors. We aimed to identify socially shared viewpoints of radiologists relating to barriers to implementing proforma reporting. Measuring the subjectivity of opinions relative to other radiologists will allow identification of common patterns preventing implementation.</p><p><strong>Methods: </strong>Specialist gastrointestinal radiologists from 16 hospital trusts were invited to a Q-methodology study. Participants ranked 56 statements on barriers to using proforma reports (the Q-set) in a normal distribution (Q-grid). Factor analyses were undertaken to identify independent accounts, and additional survey data were used to support interpretation.</p><p><strong>Results: </strong>Twenty-seven radiologists participated; 11 (41%) had more than 10 years reporting rcMRIs. Three distinct accounts of radiologist attitudes to proforma-use were identified: Approvers, Disapprovers, and Struggling champions. The highest ranked barriers related to proforma format, individual radiologists' preferences and beliefs about efficacy and factors relating to wider multidisciplinary teams and health system-level implementation.</p><p><strong>Conclusions: </strong>Radiologists that disapprove of proformas are unlikely to use them unless external influences are applied, such as a requirement by treating clinicians. Increased internal and organizational support would also increase use. Targeted implementation strategies focusing on these barriers has the potential to increase uptake of similar interventions.</p><p><strong>Advances in knowledge: </strong>Specialist radiologists require a multi-level adaptive implementation strategy, tailored to proforma characteristics as well as individual and organizational barriers to increase proforma reporting for rcMRI to support accurate treatment decision making.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"701-708"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced blood vessel visualization and accelerated image acquisition using spiral magnetic resonance angiography in moyamoya disease: a comparative study with Cartesian magnetic resonance angiograhy. 螺旋MRA在烟雾病中的血管可视化和加速图像采集:与笛卡尔MRA的比较研究。
IF 1.8 4区 医学
British Journal of Radiology Pub Date : 2025-05-01 DOI: 10.1093/bjr/tqaf038
Maoxue Wang, Yongbo Yang, Yujie Yu, Chuyue Chen, Kun Wang, Mahmud Mossa-Basha, Baochen Chu, Pin Lv, Mei Yao, Wen Zhang, Xin Zhang, Zhengyang Zhu, Xiance Zhao, Lei Zhou, Bing Zhang
{"title":"Enhanced blood vessel visualization and accelerated image acquisition using spiral magnetic resonance angiography in moyamoya disease: a comparative study with Cartesian magnetic resonance angiograhy.","authors":"Maoxue Wang, Yongbo Yang, Yujie Yu, Chuyue Chen, Kun Wang, Mahmud Mossa-Basha, Baochen Chu, Pin Lv, Mei Yao, Wen Zhang, Xin Zhang, Zhengyang Zhu, Xiance Zhao, Lei Zhou, Bing Zhang","doi":"10.1093/bjr/tqaf038","DOIUrl":"10.1093/bjr/tqaf038","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the blood vessel visualization with spiral MRA (MRAspiral) and compressed SENSE accelerated Cartesian MRA (MRACS) in moyamoya disease (MMD) patients, with digital subtraction angiography (DSA) as the reference standard.</p><p><strong>Methods: </strong>We prospectively collected MRAspiral with different acquisition windows (τ = 4, 6, 10 ms), MRACS, and DSA in MMD patients. Contrast-to-noise ratio (CNR) was measured in the M1, M2, M3, and M4 segments of the middle cerebral artery (MCA) for each MRA sequence. Vessel visualization of the distal MCA, leptomeningeal artery (LMA) collaterals, distal external carotid artery (ECA), and internal carotid artery (ICA) steno-occlusion was qualitatively analysed using three- and four-point Likert scales compared to DSA. A linear fixed-effects model was used to determine differences among the 4 sequences.</p><p><strong>Results: </strong>A total of 98 hemispheres from 55 MMD patients were included. CNR in the M2, M3, and M4 segments of the MCA was not significantly different between MRACS and MRAτ4 or MRAτ6, but it was significantly higher in MRACS than MRAτ10 (M2: P < .001, M3: P < .001, M4: P = .013). MRAspiral sequences provided better visualization of the distal MCA, LMA collaterals, and distal ECA compared to MRACS (all P < .001).</p><p><strong>Conclusions: </strong>MRAspiral offers improved vessel visualization in distal arteries with adequate image quality for patients with MMD. Compared to MRACS, MRAspiral can reduce scan time by 32.31% when the τ value is set to 6 ms, while also providing superior image quality.</p><p><strong>Advances in knowledge: </strong>Spiral MRA performs well in visualizing collateral vessels in moyamoya disease with shorter scan time.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"770-776"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quadriceps muscle injuries in athletes: a narrative review. 运动员股四头肌损伤:综述。
IF 1.8 4区 医学
British Journal of Radiology Pub Date : 2025-05-01 DOI: 10.1093/bjr/tqaf042
Sisith P Ariyaratne, Kapil Shirodkar, Rajesh Botchu, Steven L J James
{"title":"Quadriceps muscle injuries in athletes: a narrative review.","authors":"Sisith P Ariyaratne, Kapil Shirodkar, Rajesh Botchu, Steven L J James","doi":"10.1093/bjr/tqaf042","DOIUrl":"10.1093/bjr/tqaf042","url":null,"abstract":"<p><p>The quadriceps muscles are a large group of 4 muscles in the anterior compartment of the thigh, comprising the rectus femoris, vastus medialis, vastus intermedius, and vastus lateralis, which in combination act as the primary extensors of the knee joint. The rectus femoris is also responsible for hip joint flexion. Quadriceps muscle injuries are frequently encountered in sports and athletic activities and present a significant challenge in the realm of sports medicine, impacting athletes across various disciplines and levels of competition. A spectrum of sporting injuries and imaging findings can affect this muscle group, including strains and tears, avulsions, contusions, degloving injuries, and exercise-related signal abnormalities. A thorough understanding of these various pathologies and imaging features is crucial to guide appropriate diagnosis, management, and rehabilitation, as well as ensure safe and prompt return to play, minimize risk of re-injury or long-term adverse sequelae, optimize performance, and improve career longevity of these athletes. This comprehensive review article aims to review the unique anatomy of the quadriceps muscle group and integrate current knowledge of the various forms of sporting injuries affecting it, with a specific emphasis on the imaging features.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"630-639"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging and management of lymphedema in the era of precision oncology. 精准肿瘤学时代的淋巴水肿成像与管理。
IF 1.8 4区 医学
British Journal of Radiology Pub Date : 2025-05-01 DOI: 10.1093/bjr/tqaf029
Pranjal Rai, Abhishek Mahajan, Shreya Shukla, Niyati Pokar
{"title":"Imaging and management of lymphedema in the era of precision oncology.","authors":"Pranjal Rai, Abhishek Mahajan, Shreya Shukla, Niyati Pokar","doi":"10.1093/bjr/tqaf029","DOIUrl":"10.1093/bjr/tqaf029","url":null,"abstract":"<p><p>Lymphedema is a common complication of cancer treatment, leading to significant morbidity. Early and accurate diagnosis through the combined expertise of radiology and nuclear medicine is crucial for preventing lymphedema progression and improving patient outcomes. Imaging techniques such as lymphoscintigraphy, duplex ultrasound, MRI, and CT as well as newer modalities including near-infra-red lymphangiography can diagnose and assess lymphedema severity. Bioimpedance spectroscopy provides a non-invasive tool for early detection by measuring extracellular fluid changes, aiding in identifying lymphedema at its earliest stages. Pre-treatment baseline measurements and prospective surveillance models are essential for tracking limb volume changes and mobility, enhancing early intervention outcomes. Recognizing the strengths and limitations of each imaging modality allows radiologists and nuclear medicine physicians to synergistically optimize lymphedema diagnosis and management. Effective management relies on multidisciplinary collaboration and includes conservative and surgical options tailored to disease severity. Advanced imaging modalities are pivotal for planning and monitoring interventional strategies. This review explores the development and management of secondary lymphedema in oncological patients, focusing chiefly on imaging and treatment strategies. It also briefly highlights the evolving role of artificial intelligence and machine learning in enhancing imaging precision and treatment outcomes.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"619-629"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimaging Biomarkers of Post-acute Sequelae of Covid (PASC). 新冠肺炎急性后后遗症(PASC)的神经影像学生物标志物研究。
IF 1.8 4区 医学
British Journal of Radiology Pub Date : 2025-04-29 DOI: 10.1093/bjr/tqaf090
Swati Rane Levendovszky, Payal Patel, Chengcheng Zhu, Aaron M Rutman, Mahmud Mossa Basha
{"title":"Neuroimaging Biomarkers of Post-acute Sequelae of Covid (PASC).","authors":"Swati Rane Levendovszky, Payal Patel, Chengcheng Zhu, Aaron M Rutman, Mahmud Mossa Basha","doi":"10.1093/bjr/tqaf090","DOIUrl":"https://doi.org/10.1093/bjr/tqaf090","url":null,"abstract":"<p><p>COVID-19, caused by SARS-CoV-2, has led to the condition known as Long COVID or post-acute sequelae of COVID-19 (PASC), where individuals experience persistent debilitating symptoms long after the initial infection. We provide here a comprehensive review of findings in the central nervous system associated with PASC. Neuroimaging has been instrumental in identifying brain changes associated with PASC. Structural MRI studies consistently reveal gray matter volume reductions in the frontal and temporal lobes and white matter hyperintensities, particularly in the periventricular regions. Studies especially found these changes to correlate strongly with cognitive deficits. Diffusion tensor imaging has shown increased tissue damage and edema in the brain's white matter tracts, particularly in the sagittal stratum and thalamic radiation. Resting-state functional MRI studies indicate altered brain connectivity in PASC patients, especially in those with post-traumatic stress symptoms. Reduced connectivity within and between critical networks, such as the default mode network and the executive control network, has been observed. These changes correlate with cognitive impairments, such as attention and memory deficits. Dynamic functional connectivity analyses further reveal that PASC patients spend less time in states with rich inter-regional connectivity, and transitions between connectivity states were linked to post-traumatic stress disorder symptoms. Positron emission tomography scans have shown hypometabolism in the frontal and temporal lobes, particularly in regions associated with memory and executive functions. Hypometabolism in the hippocampus and thalamus is linked to symptoms like anosmia and fatigue. Despite the heterogeneity in clinical presentations and diagnostic criteria, these neuroimaging findings underscore the significant impact of COVID-19 on brain structure and function. Continued research using advanced imaging techniques is essential for a deeper understanding of PASC's neurological effects. This will aid in developing targeted interventions and improving outcomes for those affected by Long COVID and inform studies investigating downstream effects of viral infections on the brain.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High resolution-dynamic characterisation of cardiac masses -Radio-frequency spoiled 3D gradient echo sequence. 高分辨率-心脏肿块的动态特征-射频破坏三维梯度回波序列。
IF 1.8 4区 医学
British Journal of Radiology Pub Date : 2025-04-28 DOI: 10.1093/bjr/tqaf093
Elif Peker, Sena Ünal, Ruhi Erdem Ergüden, Nil Sezer Yılmazer Zorlu, Sena Bozer Uludağ
{"title":"High resolution-dynamic characterisation of cardiac masses -Radio-frequency spoiled 3D gradient echo sequence.","authors":"Elif Peker, Sena Ünal, Ruhi Erdem Ergüden, Nil Sezer Yılmazer Zorlu, Sena Bozer Uludağ","doi":"10.1093/bjr/tqaf093","DOIUrl":"https://doi.org/10.1093/bjr/tqaf093","url":null,"abstract":"<p><strong>Introduction: </strong>Volumetric interpolated breath-hold examination (VIBE) sequence is a radio-frequency-spoiled gradient echo sequence that is mostly used in the evaluation of soft tissues, allows dynamic high-resolution images to be taken in 30 seconds of breath holding time in MRI, and is used to create 3-dimensional images. In this study, we aimed to determine the detectability of cardiac masses and thrombi and their differentiation from the blood pool with the T1 VIBE imaging method.</p><p><strong>Material and methods: </strong>Precontrast, early and late post-contrast VIBE images were evaluated. Lesion contours were drawn with a free-hand ROI in the phase in which the lesion better depicted. All ROIs were placed in the phase where the lesion appeared best and then copied to other phases.SNR was calculated as SI/SD of background intensity, CNR was calculated as SNR thrombus-SNR myocardium and SNR thrombus-SNR blood pool. SNR and CNR values of thrombus, blood pool and myocardium measured at maps and contrast-enhanced images were compared with each other.</p><p><strong>Conclusion: </strong>There are many sequences used routinely to detect cardiac masses and thrombi. Many of these techniques require long acquisiton time. With the VIBE sequence, precontrast, arterial and venous images of the lesion can be obtained quickly. Although the SNR and CNR values obtained with VIBE images are lower than those with routine post-contrast images, our study can be considered as a preliminary study for future studies to evaluate dynamic images.</p><p><strong>Advances in knowledge: </strong>For our knowledge this is the first paper written on the visual assessment of cardiac masses on VIBE images.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and Efficacy of Aneurysms Treated with Endovascular Devices (SEATED). 血管内装置治疗动脉瘤的安全性和有效性。
IF 1.8 4区 医学
British Journal of Radiology Pub Date : 2025-04-26 DOI: 10.1093/bjr/tqaf094
Ahmed R Bassiouny, Anand Sastry, Alex Mortimer, Jeremy Lynch, Hemant Sonwalkar, Aaron Bleakley, Ahmed Iqbal, Ana Paula Narata, Tufail Patankar, Islim Fathallah, Naga Kandasamy, Parthiban Balasundaram, Sara Sciacca, Juveria Siddiqui, Thomas C Booth
{"title":"Safety and Efficacy of Aneurysms Treated with Endovascular Devices (SEATED).","authors":"Ahmed R Bassiouny, Anand Sastry, Alex Mortimer, Jeremy Lynch, Hemant Sonwalkar, Aaron Bleakley, Ahmed Iqbal, Ana Paula Narata, Tufail Patankar, Islim Fathallah, Naga Kandasamy, Parthiban Balasundaram, Sara Sciacca, Juveria Siddiqui, Thomas C Booth","doi":"10.1093/bjr/tqaf094","DOIUrl":"https://doi.org/10.1093/bjr/tqaf094","url":null,"abstract":"<p><strong>Objectives: </strong>To create a nationwide consortium to gather all the data related to advanced devices used for aneurysm treatment and conduct pragmatic real-world studies despite the variations amongst all centres. The strength of this study will be in pooling data of the less commonly used recent devices where there is less evidence. The study will be prospective and retrospective where the initial recruitment figure is expected to be around 5000 patients.</p><p><strong>Methods: </strong>To assess how endovascular techniques vary among different UK centres we illustrate the results of initial surveys that were sent to those centres across the UK using a single device, the pipeline embolization device with vantage technology (PEDV).</p><p><strong>Results: </strong>Although the centres were using the same device, the antiplatelet protocol varied from one centre to another as well as follow-up protocols according to the local experience, patient clinical status or even according to the adjuncts uses (e.g., adjunct coiling).</p><p><strong>Conclusions: </strong>The illustrated results show that although the centres were using the same device, the antiplatelet protocol varied from one centre to another. Also, follow-up protocols vary from one centre to another according to the local experience, patient clinical status or even according to the adjuncts used (e.g. adjunct coiling). This exemplar serves to illustrate that a nationwide consortium can pool and analyse data of any recent endovascular device.</p><p><strong>Advances in knowledge: </strong>Obtaining nationwide data regarding safety, efficacy as well as risk factors for aneurysm recurrence when using recent devices. This study will add valuable data regarding the less commonly used recent devices where there is less evidence..</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Photon Counting Detector Computed Tomography in Pediatric Imaging: A Review of current literature and future directions". 儿童影像中的光子计数检测器计算机断层扫描:当前文献综述和未来方向。
IF 1.8 4区 医学
British Journal of Radiology Pub Date : 2025-04-25 DOI: 10.1093/bjr/tqaf088
Kelly K Horst, Lifeng Yu, Henry Larson, Marilyn J Siegel
{"title":"\"Photon Counting Detector Computed Tomography in Pediatric Imaging: A Review of current literature and future directions\".","authors":"Kelly K Horst, Lifeng Yu, Henry Larson, Marilyn J Siegel","doi":"10.1093/bjr/tqaf088","DOIUrl":"https://doi.org/10.1093/bjr/tqaf088","url":null,"abstract":"<p><p>The benefits of photon counting detector (PCD) computed tomography (CT) include improved spatial resolution, increased radiation dose efficiency, and the elimination of electronic noise. Unlike traditional energy-integrating-detector (EID) CT systems, photon counting detectors have inherent spectral capabilities, which support \"always-on\" dual energy and multi-energy imaging acquisition. PCD-CT directly converts X-ray photons into electrical signals and captures their individual energy levels. Current commercially available PCD-CT scanners, all from one manufacturer, include two models that incorporate dual-source geometry. This innovation is particularly advantageous for pediatric imaging by enabling rapid scans that reduce motion artifact and therefore the need for sedation and can now be combined in the current model with multi-energy imaging or ultra-high-resolution acquisition. This review article explores how the technical benefits of PCD CT improve the diagnostic quality of images and opens the field of pediatric radiology up to future opportunities for research and new applications.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MRI-based radiomics nomogram to predict complete response to definitive chemoradiation in patients with anal cancer. 基于mri的放射组学图预测肛门癌患者对最终放化疗的完全反应。
IF 1.8 4区 医学
British Journal of Radiology Pub Date : 2025-04-18 DOI: 10.1093/bjr/tqaf087
Hugo C Temperley, Fariba Tohidinezhad, Niall J O'Sullivan, Benjamin M Mac Curtain, Brian J Mehigan, Colm Kerr, John O Larkin, Peter Beddy, Paul H McCormick, David Gallagher, Alison Corr, Colm Bergin, Charles Gillham, Michael E Kelly
{"title":"MRI-based radiomics nomogram to predict complete response to definitive chemoradiation in patients with anal cancer.","authors":"Hugo C Temperley, Fariba Tohidinezhad, Niall J O'Sullivan, Benjamin M Mac Curtain, Brian J Mehigan, Colm Kerr, John O Larkin, Peter Beddy, Paul H McCormick, David Gallagher, Alison Corr, Colm Bergin, Charles Gillham, Michael E Kelly","doi":"10.1093/bjr/tqaf087","DOIUrl":"https://doi.org/10.1093/bjr/tqaf087","url":null,"abstract":"<p><strong>Introduction: </strong>Treatment response to definitive chemoradiation(dCRT) in patients with anal cancer varies significantly, with a subset experiencing persistent or progressive disease despite therapy. Radiomics extracts quantitative features from medical images, with the potential to develop predictive tools to assess treatment response. We aim to develop and validate an MRI-based radiomics nomogram to predict response to dCRT in patients with anal cancer.</p><p><strong>Methods: </strong>A single-institutional retrospective analysis of 45 patients with anal cancer treated with dCRT was performed. Radiomic features were extracted from pre-treatment T2-weighted MRI scans and predictive models were constructed. Clinical and radiomic features were analysed to develop the nomogram. Internal validation with 1000 bootstrap samples was performed to calculate optimism-corrected performance measures.</p><p><strong>Results: </strong>30/45(66.7%) achieved a complete treatment response. Male gender was found to be an independent predictor of incomplete response to dCRT (OR4.763,95%CI : 1.170-19.384,*P = 0.029). Two radiomic signatures emerged as strong predictors of treatment response to dCRT. The combined model outperformed the clinical and radiomic models. The combined model showed the highest predictive accuracy, achieving an apparent AUC : 0.87(0.75-0.99) and an optimism-corrected AUC: 0.85, mean absolute error : 0.029, PPV(0.68)and NPV(0.92), indicating excellent discriminative performance. It demonstrated a positive net benefit in decision analysis. The optimism-corrected calibration curves demonstrate that the radiomic and combined model provide well-calibrated predictions.</p><p><strong>Conclusion: </strong>This MRI-based radiomics nomogram offers a promising approach to predict response to dCRT in patients with anal cancer.</p><p><strong>Advances in knowledge: </strong>This study is the first to integrate radiomics and clinical features into a validated predictive model for anal cancer.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual-Energy Computed Tomography Systems: Technical Aspects and Selected Clinical Applications. 双能量计算机断层扫描系统:技术方面和选定的临床应用。
IF 1.8 4区 医学
British Journal of Radiology Pub Date : 2025-04-18 DOI: 10.1093/bjr/tqaf086
Daniel Parrott, Paul Smereka, Bari Dane
{"title":"Dual-Energy Computed Tomography Systems: Technical Aspects and Selected Clinical Applications.","authors":"Daniel Parrott, Paul Smereka, Bari Dane","doi":"10.1093/bjr/tqaf086","DOIUrl":"https://doi.org/10.1093/bjr/tqaf086","url":null,"abstract":"<p><p>Dual-energy computed tomography (DECT) has been available for clinical use since 2006. Since its clinical debut, multiple different dual energy systems have been developed including sequential acquisition, rapid-switching, dual-source, and twin-beam, in addition to spectral imaging techniques such as dual-layer and photon counting CT. While the specifics of these techniques vary, the underlying principles remain the same; by acquiring at least two data sets, material specific information in each image voxel can be determined. Most commonly used to evaluate for the presence or absence of iodine, DECT has found clinical applications in the assessment of gastrointestinal bleeding, bone marrow edema, the characterization of renal stones, and the accurate evaluation of vascular stenosis, among other uses. This review aims to familiarize the radiologist with the theoretical basis underlying DECT, describe the different types of DECT including the relative strengths and weaknesses of each, and highlight specific clinical applications for which DECT may be valuable.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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