British Journal of Radiology最新文献

{"title":"On the Clinical Utility of Node-RADS for Axillary Evaluation in Breast Cancer.","authors":"Deniz Esin Tekcan Sanli, Ahmet Necati Sanli","doi":"10.1093/bjr/tqag102","DOIUrl":"https://doi.org/10.1093/bjr/tqag102","url":null,"abstract":"","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of contrast-associated acute kidney injury (CA-AKI) in trauma patients undergoing contrast-enhanced computed tomography using iso-osmolar contrast media.","authors":"Hyun Seung Lee, Jimi Huh, Kyungmin Lee, Jae Keun Kim, Jayoung Moon","doi":"10.1093/bjr/tqag099","DOIUrl":"https://doi.org/10.1093/bjr/tqag099","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the incidence and severity of CA-AKI, and its predictive factors in trauma patients.</p><p><strong>Materials and methods: </strong>Trauma patients from the Regional Korea Trauma Center who underwent iodixanol-enhanced CT and were monitored for 72 hours post-scan were included. Demographics, co-morbidities, and lab results were collected. CA-AKI was defined by the 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. Severity of CA-AKI was classified by the risk, injury, failure, loss of kidney function, and end-stage renal failure (RIFLE) criteria. Trauma severity was assessed by the injury severity score (ISS) category. Predictive factors of CA-AKI were evaluated by univariate and multivariate logistic regression.</p><p><strong>Results: </strong>Of 1115 patients undergoing iodixanol-enhanced CT, 799 with complete data were included. Overall CA-AKI incidence was 3.80% (30/799) and severe renal failure occurred in 2.87% (23/799). CA-AKI incidence by ISS category was 1.52% (minor), 3.95% (moderate), 42.30% (serious), and 75.0% (severe). Upon univariate analysis, significant predictive factors of CA-AKI included hypertension [odds ratio (OR) 2.87], heart disease (OR 4.06), serious ISS (OR 47.50), and severe ISS (OR 194.33). Upon multivariate analysis, significant predictive factors were ISS serious category (OR 48.20), and ISS severe category (OR 245.22).</p><p><strong>Conclusion: </strong>In trauma patients who underwent iodixanol-enhanced CT, incidence of CA-AKI was considerably low at 3.8%, with trauma severity as a significant predictive factor.</p><p><strong>Advances in knowledge: </strong>Iodixanol-enhanced CT demonstrates low CA-AKI incidence and favorable safety in trauma patients. These findings support its clinical utility in high-trauma cases where renal risk is elevated.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of transarterial chemoembolization and radiofrequency ablation plus tyrosine kinase inhibitors with or without PD-1 inhibitors for unresectable hepatocellular carcinoma.","authors":"Yue Chen, Luyao Jia, Yibo Sun, Zhenshun Wang, Yu Li, Jukun Wang, Chao Zhang, Chunjing Bian, Dongdong Lin, Tao Luo","doi":"10.1093/bjr/tqag100","DOIUrl":"https://doi.org/10.1093/bjr/tqag100","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to compare the efficacy and safety of transarterial chemoembolization combined with radiofrequency ablation (TACE-RFA) plus tyrosine kinase inhibitors (TKI) with or without programmed cell death protein-1(PD-1) inhibitors in the treatment of unresectable hepatocellular carcinoma (uHCC).</p><p><strong>Materials and methods: </strong>From January 2020 to October 2024, 87 patients with uHCC who received TACE-RFA plus TKI with or without PD-1 inhibitors in our center were retrospectively analyzed, and divided into TACE-RFA + TKI (TRK) group and TACE-RFA + TKI + PD-1 (TRKP) group. Kaplan-Meier method and log-rank test were used to analyze overall survival (OS) and progression-free survival (PFS) of the two groups. Adverse events (AEs) between the two groups were evaluated according to Common Adverse Event Evaluation Criteria (CTCAEs) Version 5.0.</p><p><strong>Results: </strong>The patients in the TRKP group had longer median OS (mOS) (24 [95% confidence interval (CI): 17.7-30.3] vs 18[95% CI: 15.1-20.9]months, p = 0.04) and median PFS (mPFS) (15[95% CI: 13.4-16.6] vs 12 [95% CI: 10.8-13.2]months, p = 0.01) than that in the TRK group. The objective response rate (ORR) (44.19% vs 36.36%, p = 0.03) and disease control rate (DCR) (86.05% vs. 70.45%, p = 0.08) in the TRKP group were better than those in the TRK group. There was no significant difference in the frequency and severity of AEs between the two groups.</p><p><strong>Conclusions: </strong>The treatment of TACE-RFA+TKI+PD-1 inhibitors is effective and safe for uHCC.</p><p><strong>Advances in knowledge: </strong>This study advances knowledge by showing that the TACE-RFA+TKI+PD-1 (TRKP) regimen is more effective than TACE-RFA+TKI (TRK) in improving median overall survival, median progression-free survival and objective response rate for unresectable hepatocellular carcinoma (uHCC) with controllable adverse events, and identifies TRKP as an independent favorable prognostic factor, while AFP ≥ 400 ng/mL and BCLC stage C as adverse prognostic factors for uHCC.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organ Dose Modulation: a useful tool for dose reduction in clinical practice?","authors":"Nienke Wentink, Margo van Gent, Chris Borns","doi":"10.1093/bjr/tqag098","DOIUrl":"https://doi.org/10.1093/bjr/tqag098","url":null,"abstract":"<p><strong>Purpose: </strong>To quantify the reduction in effective dose achieved through organ dose modulation (ODM) on a General Electric Revolution Apex CT scanner, while preserving image quality.</p><p><strong>Methods: </strong>First, the noise index (NI) corresponding to comparable image quality-defined by signal-to-noise ratio (SNR)-was determined using a PMMA cylindrical phantom (CTDI phantom), both with and without ODM. Scan protocols for the thorax, abdomen, and head were evaluated. Next, radiation dose was measured at every 10° scan angle using a 10 cm ionization chamber for each protocol, with and without ODM. Finally, effective dose was estimated using the angle-dependent dose measurements in Monte Carlo simulation software (PCXMC), for tube voltages of 80, 100, and 120 kVp.</p><p><strong>Results: </strong>Effective dose was reduced by 12-14 ± 1% for thorax, 12-13 ± 1% for abdomen. when using ODM. No significant change in effective dose was found for CT head. Notably, radiosensitive organs such as the breasts and eye lenses received 19-21 ± 1% and 25 ± 7% (upper-bound estimate) less dose, respectively.</p><p><strong>Conclusions: </strong>This study demonstrates that ODM could significantly reduce both effective and organ-specific radiation doses without compromising image quality, especially when applied to the whole scan field.</p><p><strong>Advances in knowledge: </strong>This study demonstrates with dose measurements with 10° angular accuracy that for this specific implementation of ODM, it should be applied to the whole scan field for both dose reduction and consistent image quality. This finding is contradictory to the vendor's recommendation to apply ODM only to an area with a specific radiosensitive organ, such as the breasts.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonographic Stratification of Adhesive Capsulitis Using CHL:SGHL Ratio - A Paradigm Shift Towards Clinico-Radiological Concordance.","authors":"Ajay Fullara, Skand Sinha, Upinderjeet Singh, Nishith Kumar, Alfa Shamim Saifi, Dharmendra Kumar Singh","doi":"10.1093/bjr/tqag101","DOIUrl":"https://doi.org/10.1093/bjr/tqag101","url":null,"abstract":"<p><strong>Objectives: </strong>To stratify adhesive capsulitis (AC) into clinically discernible grades using CHL thickness and a novel CHL/SGHL thickness ratio.</p><p><strong>Materials and methods: </strong>This prospective observational study was carried out at a tertiary care university teaching hospital over a period of 18 months. 75 patients enrolled in the study underwent assessment of passive external rotation with a goniometer and graded as, Severe 0-15°, Moderate 15-30° & Mild 30-45° passive external rotation, followed by ultrasonography of the affected shoulder on S-3000 Acuson (Siemens) by the linear high frequency transducer.</p><p><strong>Results: </strong>40/75 patients had mild to moderate AC and 35/75 patients had severe AC. The median CHL thickness in the patients who were clinically diagnosed with AC was 2.3mm, while the CHL thickness ranged from 2.2- 3.6mm. We sub stratified AC into a severe and non-severe subgroup (mild/moderate AC). The median CHL thickness was 2.5mm in the severe AC subgroup & 2.3mm in non-severe subgroup. Statistical significance demonstrated between the 2 groups via CHL/SGHL Thickness Ratio (p = <0.001). Using ROC's CHL Thickness (mm) ≥2.3, predicted severe adhesive capsulitis with a 77% sensitivity and 48% specificity while CHL/SGHL Thickness Ratio >1, predicted severe adhesive capsulitis with 89% sensitivity and 98% specificity demonstrating excellent diagnostic performance & statistical significance (p = <0.001).</p><p><strong>Conclusion: </strong>Our study successfully demonstrated the US changes at the rotator interval and their correlation with the clinical severity of adhesive capsulitis (Clinico-Radiological concordance). CHL/SGHL thickness ratio correlates diagnostically and predicts the severity of AC with higher accuracy than CHL thickness alone. This simple and elegant parameter can aid in clinical management of patients with varying degrees of adhesive capsulitis essentially converting the pandora of conservative and interventional management decisions into a binary scenario for non-severe subgroup and severe subgroup, respectively.</p><p><strong>Advances in knowledge: </strong>Isolated CHL thickness to quantify adhesive capsulitis into various clinical grades may prove fallacious depending on the clinical stage (Pre-freeze/Frozen/Thaw) of presentation. The novel CHL:SGHL thickness ratio has emerged as a standalone and powerful marker with statistically significant diagnostic accuracy to stratify adhesive capsulitis radiologically into a severe group, requiring interventional management & a non-severe subgroup, often managed conservatively.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sound approach to stay on the ball-a review of scrotal pathologies on ultrasound imaging.","authors":"Jeffrey Lam Shin Cheung, Mousumi Bhaduri","doi":"10.1093/bjr/tqag063","DOIUrl":"10.1093/bjr/tqag063","url":null,"abstract":"<p><p>Scrotal ultrasound imaging findings range from benign anatomical variants to surgical emergencies. Scrotal assessments can be daunting for clinicians who are unfamiliar with the typical anatomy and expected imaging characteristics of common pathologies. This pictorial review highlights key anatomical considerations and essential tips for scrotal ultrasound imaging. A practical approach to scrotal pathologies is discussed and supplemented with a plethora of ultrasound imaging examples. Particular emphasis is placed on describing the clinical presentation, imaging findings, and recommended management for: infectious/inflammatory conditions, vascular anomalies, sequelae of trauma, cystic lesions, and common testicular neoplasms.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"847-858"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary fibrosis and its rehabilitation after radiation therapy for breast cancer.","authors":"Serzhan Nazarbek, Dilyara Kaidarova, Yevgeniy Ishkinin, Saniya Ossikbayeva, Tatyana Goncharova","doi":"10.1093/bjr/tqag003","DOIUrl":"10.1093/bjr/tqag003","url":null,"abstract":"<p><strong>Objectives: </strong>Postoperative radiotherapy (RT) for breast cancer (BC) improves survival by preventing local recurrence but can lead to radiation-induced pulmonary fibrosis (RIPF). RIPF typically appears within 6-12 months post-RT and may progress over 2 years. This study assessed RIPF development in BC patients undergoing hypofractionated RT and evaluated the effects of rehabilitation interventions.</p><p><strong>Methods: </strong>A total of 209 BC patients were observed: 106 in the study group received rehabilitation, while 103 in the control group followed the standard protocol. Rehabilitation included medications (Aquadetrim, Adenorin, Contimax, Magnesium B6) and topical sodium nucleonate spray. All patients received an average dose of 42.56 Gy over 16 sessions.</p><p><strong>Results: </strong>RIPF developed in 90.3% of patients, with an average onset at 8.7 months post-RT. Rehabilitation delayed RIPF onset-by 8.9 months in the control group vs. 9.8 months in the rehabilitation group-showing a 9.9% improvement (P = .034). Body mass index (BMI) was a significant factor: patients with BMI >25 developed RIPF earlier (7.5 months) than those with BMI <25 (11.3 months, P = .005). Age and cancer side had no significant effect, though right-sided BC showed slightly earlier onset. Grade 2 skin reactions were linked to higher fibrosis incidence, though not statistically significant.</p><p><strong>Conclusions: </strong>Rehabilitation may delay RIPF onset, and BMI appears to be a strong predictor of its development. Future research should explore additional risk factors for RIPF in BC patients post-RT.</p><p><strong>Advances in knowledge: </strong>This study is among the first to show that targeted rehabilitation protocols may effectively delay RIPF onset after hypofractionated RT in BC patients.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"886-897"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of endometrial pathologies with infertility and malignant potential in pre- and postmenopausal women-a systematic review.","authors":"Zobia Saleem","doi":"10.1093/bjr/tqag031","DOIUrl":"10.1093/bjr/tqag031","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this systematic review is to investigate and synthesize the existing literature on the association of endometrial pathologies with infertility and malignant potential in premenopausal and postmenopausal women, with a specific emphasis on evaluating the diagnostic utility of transvaginal ultrasound.</p><p><strong>Methods: </strong>Google Scholar and PubMed were searched systematically, in addition to manual searches, to compile the literature review. We came across 50 papers; only 35 made it past the initial screening. Twenty-four items were left out because they were either non-English references, needed copyright clearance, or required a subscription. The final review had a total of 15 papers. Only original research papers and systematic reviews that sonographically examined the endometrial pathologies and papers that mentioned infertility risk and malignant potential of these diseases in pre- and postmenopausal women were included.</p><p><strong>Results: </strong>The results underscore the complex interplay between endometrial pathologies, infertility, and malignant potential, providing valuable insights for clinicians and researchers in the field.</p><p><strong>Conclusions: </strong>Postmenopausal women are at increased risk of malignant potential as compared to premenopausal women. The malignant potential of endometrial hyperplasia is exceptionally high, while it is lower in the case of endometrial polyps and submucosal uterine leiomyomas. Some endometrial lesions, such as endometrial polyps, submucosal uterine leiomyomas and endometritis, are reportedly strongly associated with infertility.</p><p><strong>Advances in knowledge: </strong>This review adds clarity to how different endometrial pathologies relate to infertility and cancer risk, and it underscores the value of transvaginal ultrasound in assessing these conditions across various reproductive stages.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"859-865"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of [68Ga]Ga-FAPI PET/CT-derived parameters in thyroid nodules with emphasis on indeterminate cytology.","authors":"Merve Okuyan, Umut Elboga, Mehmet Bastemir, Gokturk Maralcan, Seckin Bilgic, Ertan Sahin, Mehmet Sokucu","doi":"10.1093/bjr/tqag042","DOIUrl":"10.1093/bjr/tqag042","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the diagnostic performance of [68Ga]Ga-FAPI PET/CT-derived metabolic parameters in thyroid nodules and their association with cytological risk stratification, with particular emphasis on indeterminate nodules.</p><p><strong>Methods: </strong>Forty patients with 53 thyroid nodules who underwent [68Ga]Ga-FAPI PET/CT were prospectively analysed. Maximum standardized uptake value (SUVmax) and tumour-to-background ratio (TBR) were calculated for each nodule. Ultrasound-based malignancy classification (USG-BM) and Bethesda cytology categories were recorded. Comparisons between benign and malignant nodules were performed in the overall cohort (Bethesda I-VI) and within the Bethesda III-IV subgroup. Multivariable logistic regression was used to identify independent predictors of malignancy. Diagnostic performance was assessed using receiver operating characteristic analysis.</p><p><strong>Results: </strong>In the overall cohort, SUVmax and TBR were significantly higher in malignant nodules than in benign nodules (P < .01). In multivariable analysis, TBR showed a stronger independent association with malignancy, whereas USG-BM was not independently predictive. Within the Bethesda III-IV subgroup, SUVmax and TBR did not differ significantly in univariable analyses; however, TBR demonstrated a borderline independent association with malignancy in multivariable analysis (P = .058). Maximum standardized uptake value and TBR values were significantly higher in Bethesda V-VI nodules compared with Bethesda III-IV nodules (both P < .001). Receiver operating characteristic (ROC) analysis demonstrated good discriminative performance for both parameters, with TBR yielding a higher area under the curve and high negative predictive values.</p><p><strong>Conclusion: </strong>[68Ga]Ga-FAPI PET/CT-derived metabolic parameters, particularly TBR, show promising diagnostic performance for thyroid nodule characterization. High negative predictive values suggest a potential complementary role for excluding malignancy, especially in indeterminate nodules. Further multicentre studies are warranted.</p><p><strong>Advances in knowledge: </strong>[68Ga]Ga-FAPI PET/CT-derived metabolic parameters were higher in malignant thyroid nodules compared with benign lesions. These findings suggest that FAPI PET/CT may provide complementary functional information in nodules with indeterminate cytology.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"959-966"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiparametric MRI for preoperative identification of aggressive type endometrial carcinoma in FIGO 2023: Integrating intratumoral and peritumoral parameters from multi-b-value diffusion-weighted imaging and dynamic contrast-enhanced MRI.","authors":"Jieying Zhang, Qi Zhang, Shuang Chen, Yuying Sun, Luyuan Li, Yan Song, Lizhi Xie, Xiaoduo Yu, Yan Chen","doi":"10.1093/bjr/tqag032","DOIUrl":"10.1093/bjr/tqag032","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate a multiparametric MRI protocol encompassing intravoxel incoherent motion diffusion-weighted imaging, diffusion kurtosis imaging, and dynamic contrast-enhanced MRI for discriminating aggressive (AEC) from non-aggressive type endometrial carcinoma (NAEC) according to the FIGO 2023 staging system.</p><p><strong>Methods: </strong>This study involved retrospective analyses of a prospective dataset. A total of 112 consecutive patients (77 NAEC and 35 AEC) underwent multiparametric MRI. Intratumoral and peritumoral quantitative MRI parameters were calculated. A multivariate logistic regression model comprising clinical data, conventional MRI features, and quantitative MRI metrics was constructed. Model performance was evaluated using receiver operating characteristic analysis, calibration curves, and bootstrap resampling (n = 1000).</p><p><strong>Results: </strong>Aggressive type endometrial carcinoma demonstrated significantly lower perfusion fraction (f) and mean diffusivity (MD), but higher pseudo diffusion coefficient (D*) and peritumoral D* (D*_peri) compared to NAEC (all P < .05). Multivariate analysis identified f, peritumoral mean kurtosis (MK_peri), and peritumoral maximum slope of increase (MaxSlope_peri) as independent predictors of AEC (AUC = 0.791, 95% CI, 0.692-0.891). Integration of menopause status, tumour location and extension beyond the corpus, and quantitative MRI parameters yielded a combined model with a stratified bootstrap AUC of 0.830 (95% CI, 0.800-0.846), particularly for FIGO 2023 stage I-II patients (AUC = 0.832, 95% CI, 0.742-0.922). Significant differences in D*, D*_peri, f, and MD were observed among NAEC with and without squamous differentiation, and AEC groups.</p><p><strong>Conclusions: </strong>Multiparametric MRI, incorporating advanced quantitative sequences and conventional MRI features, could effectively predict AEC before surgery.</p><p><strong>Advances in knowledge: </strong>The study bridges advanced imaging with the updated FIGO 2023 staging system, potentially offering a non-invasive assessment tool for endometrial carcinoma management.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"931-941"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}