British Journal of Radiology最新文献

{"title":"Evaluation of Free-breathing, non-ECG triggered Magnetic Resonance T1 mapping derived from multitasking imaging at 3.0 T in patients with ischemic and non-ischemic cardiomyopathy.","authors":"Shiya Wang, Jingjing Xu, Yiying Hua, Yaqiong Wang, Hongfei Lu, Yi Sun, Jiajun Guo, Jiaqi She, Meiying Ge, Mengsu Zeng, Yinyin Chen, Hang Jin","doi":"10.1093/bjr/tqaf104","DOIUrl":"https://doi.org/10.1093/bjr/tqaf104","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the image quality of the free-breathing, non-ECG-Multitasking T1 mapping and to compare T1 values, lesion area and ROC curve with those derived from the traditional MOLLI sequence in ischemic and non-ischemic cardiomyopathy.</p><p><strong>Methods: </strong>In vitro, T1 values from CMR Multitasking and MOLLI images were compared in 4 phantoms. In vivo studies included 108 patients (38 ischemic cardiomyopathy, 70 non-ischemic cardiomyopathy) and 31 healthy volunteers. All underwent mid-ventricular short-axis CMR Multitasking（free-breathing） and MOLLI (breath-held). Image quality was scored (4-point scale). T1 values and lesion areas were compared via linear regression, Bland-Altman analysis, and ROC curves (LGE as reference).</p><p><strong>Results: </strong>Phantom T1 values showed excellent agreement (Multitasking v.s. reference: R2 = 0.99, P < 0.001). In vivo, Multitasking strongly correlated with MOLLI for native T1 in healthy subjects (R2 = 0.69), ischemic (R2 = 0.71), and nonischaemic groups (R2 = 0.81, all P < 0.001). Multitasking demonstrated superior image quality in patients with breath-holding difficulties and adverse heart rates P < 0.001). MOLLI image quality declined with breath-holding difficulties, arrhythmia, and high BMI (P < 0.05); Multitasking was less affected but still impacted by BMI (P < 0.05). Lesion areas showed no inter-sequence differences (P > 0.05). ROC analysis revealed comparable diagnostic accuracy between sequences in stable patients (P > 0.05), but superior Multitasking performance in breath-holding difficulties and arrhythmia subgroups (P < 0.05).</p><p><strong>Conclusion: </strong>Multitasking provides accurate T1 quantification and lesion delineation in cardiomyopathy, with enhanced robustness for patients with poor breath-holding or arrhythmia. BMI-related limitations warrant technical refinement.</p><p><strong>Advances in knowledge：: </strong>Free-breathing, non-ECG CMR Multitasking achieves accurate T1 mapping in ischaemic/non-ischaemic cardiomyopathy, overcoming ECG/respiratory limitation.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomography angiography of the carotid body: bridging the gap between normal and neoplastic lesions.","authors":"Sezer Nil Yılmazer Zorlu, Çağlar Uzun, Ebru Düşünceli Atman, Ruhi Erdem Ergüden, Atilla Halil Elhan","doi":"10.1093/bjr/tqaf096","DOIUrl":"https://doi.org/10.1093/bjr/tqaf096","url":null,"abstract":"<p><strong>Objective: </strong>Sympathetic nervous system hyperactivation in chronic conditions, such as hypertension and metabolic syndrome, can lead to carotid body (CB) hyperplasia, potentially mimicking small carotid body tumors (CBTs) in radiological evaluations. This study aimed to investigate computed tomography angiography (CTA) findings to differentiate CBTs from non-neoplastic CBs.</p><p><strong>Methods: </strong>Patients were categorized into CBT and non-neoplastic CB groups. Demographics (smoking status, hypertension, diabetes mellitus), shape, dimensions, volume, and density (including standard deviations) were assessed. Density ratios were calculated using CB/CBT and ipsilateral common carotid artery density. Diagnostic performance was evaluated via ROC analysis, and logistic regression identified factors associated with increased CBT risk.</p><p><strong>Results: </strong>Significant differences between the CB and CBT groups were found in gender, smoking status, and shape (p < 0.01), while age, location, hypertension, and diabetes mellitus showed no association (p > 0.05). The CBT group had significantly higher density, standard deviation, and density ratios (p < 0.001). Multivariate analysis, adjusted for age, gender, and smoking, showed that saddle shape, standard deviation ≥21.5, and density ratio ≥0.5603 predicted CBT diagnosis with 92.6% sensitivity and 99.3% specificity.</p><p><strong>Conclusions: </strong>Saddle shape, along with increased density and standard deviation values, emerges as findings suggestive of a CBT diagnosis. The proposed imaging features may improve differentiation of small CBTs from non-neoplastic CBs, particularly in cases with enlarged CBs lacking typical tumor features.</p><p><strong>Advances in knowledge: </strong>Specific CTA findings, including saddle shape, increased density, and standard deviation, can effectively differentiate small CBTs from non-neoplastic CBs, offering a novel approach to improving radiological diagnostics in cases with CB hyperplasia.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproducibility of Lung Density Quantification across Photon-counting and Conventional Energy-integrating CT: A Comparative Study.","authors":"Saman Sotoudeh-Paima, Ehsan Samei, And Ehsan Abadi","doi":"10.1093/bjr/tqaf103","DOIUrl":"https://doi.org/10.1093/bjr/tqaf103","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate how photon-counting CT (PCCT) reproducibly quantifies lung density compared to conventional CT (energy-integrating CT or EICT) and assess the relevance of image quality.</p><p><strong>Methods: </strong>In this retrospective analysis of a prospective study, subjects underwent acquisitions using EICT and PCCT systems (August-December 2021) on the same day. PCCT projections were reconstructed with four kernels and two voxel sizes using 2024 reconstruction software (ReconCT, Siemens). PCCT and EICT data were compared using lung density measurements: percentage of low-attenuation areas <-950 HU (LAA-950), 15th percentile of lung density histogram (Perc15), and mean lung density (MLD). Measurement reproducibility and its relation to image quality parameters (modulation transfer function and noise) were analyzed.</p><p><strong>Results: </strong>Fifty-four subjects (mean age, 67.4 years ± 9.6, 30 female) were studied. PCCT images had the closest agreement to EICT under identical voxel size and similar kernels, yielding lower LAA-950 (-0.9%±2.7, p < 0.05), higher Perc15 (1.4HU ± 7.9, p > 0.05), and higher MLD (2.4 HU ± 10.8, p > 0.05). At higher PCCT resolution (1024 × 1024 matrix, 0.2 mm slice thickness), the smoother quantitative kernel (Qr36) improved agreement, with differences of -0.5%±3.0, -0.1HU ± 9.8, and 2.8HU ± 11.1, for LAA-950, Perc15, and MLD (p > 0.05). Image quality parameters strongly correlated with density measurements (RPerc152=85.3%).</p><p><strong>Conclusions: </strong>PCCT yields reproducible lung density measurements comparable to EICT, with optimal reproducibility dependent on optimized reconstruction parameters and explainable by image quality parameters.</p><p><strong>Advances in knowledge: </strong>Lung density reproducibility is critical for integrating PCCT into EICT-based workflows. In our study, PCCT aligned more closely with EICT using similar kernels at identical voxel sizes, or smoother kernels at smaller voxel sizes.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Parametrial Invasion Assessment in Cervical Squamous Cell Carcinoma: The Collaborative Impact of Diffusion Kurtosis Imaging & T2-Weighted Imaging, Exploring Tumor Core & 5-mm Peritumoral Tissue.","authors":"Xinyue Chen, Yushan Huang, Miya Cai, Shaoliang Tang, Ziying Wang, Sang Li, Fangmin Shen, Xiang Zheng","doi":"10.1093/bjr/tqaf100","DOIUrl":"https://doi.org/10.1093/bjr/tqaf100","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of magnetic resonance diffusion kurtosis imaging (DKI) combined with MRI T2-weighted imaging (T2WI) in assessing parametrial invasion in cervical squamous cell carcinoma.</p><p><strong>Methods: </strong>30 patients with cervical cancer underwent routine MRI and DKI scans. DKI parameters (Mean Diffusivity [MD], Mean Kurtosis [MK], Fractional Anisotropy [FA] and Kurtosis Anisotropy [KA]) were measured in the tumor parenchyma and surrounding 5 mm tissue. The integrity of the low-signal ring around the cervix on T2WI was recorded. LASSO regression identified optimal DKI parameters and ROC curves compared the diagnostic performance of each parameter and T2WI.</p><p><strong>Results: </strong>Compared to the non-parametrial infiltration group (NPI), the parametrial infiltration group (PI) had higher values of MKT, KAT and KAP (P = 0.018, 0.008, 0.042), while MDT was higher in NPI (P = 0.038). LASSO regression showed strong correlations between MKT, KAT and KAP with PI. ROC analysis revealed the AUC, sensitivity, and specificity for MKT, KAT, and KAP were 0.765, 0.706, 0.846; 0.778, 0.882, 0.615; and 0.719, 0.529, 0.923, respectively. Combining T2WI with DKI (MKT+T2WI, KAT+T2WI, KAP+T2WI) improved AUCs to 0.846, 0.828, and 0.774. MKT+KAP and KAT+KAP yielded AUCs of 0.792 and 0.787, with sensitivity of 0.706 and specificity of 0.846.</p><p><strong>Conclusion: </strong>DKI parameters (tumor MK, KA, and peritumoral KA) are valuable for assessing parametrial invasion. Combining tumor and peritumoral parameters, along with T2WI, enhances diagnostic accuracy.</p><p><strong>Advances in knowledge: </strong>This study presented an approach that combined DKI parameters with T2WI, integrating tumor and peritumoral parameter analysis to enhance the accuracy of assessing parametrial invasion.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro applications of photon-counting CT.","authors":"Akio Hiwatashi, Masahiro Nakashima, Kazuhisa Matsumoto, Takatsune Kawaguchi, Misugi Urano, Tatsuya Kawai","doi":"10.1093/bjr/tqaf082","DOIUrl":"https://doi.org/10.1093/bjr/tqaf082","url":null,"abstract":"<p><p>Photon-counting detector CT, a recent advance in CT technology, has several advantages over conventional energy-integrating detector CT. These include increased spatial resolution, reduced image noise, increased soft-tissue and iodine contrast, lower radiation dose, and inherent spectral imaging. This article comments on recent literatures in neuroradiology covering the vessels, pituitary adenoma, temporal bone, and myelography while addressing certain issues and outlining future directions.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging of Endometrial Polypoidal Lesions of the Uterus with Rad-Path correlation.","authors":"Divij Agarwal, Smita Manchanda, Ankita Aggarwal, Sandeep R Mathur","doi":"10.1093/bjr/tqaf101","DOIUrl":"https://doi.org/10.1093/bjr/tqaf101","url":null,"abstract":"<p><p>Endometrial polypoidal lesions of the uterus are very commonly encountered, and may pose a diagnostic dilemma. Ultrasound is used for initial screening, with MRI being used for further characterization. This pictorial review elucidates the imaging appearances of various types of such polyps, along with the classical histopathological appearances. Understanding the imaging features is crucial for accurate diagnosis and management, although histopathological diagnosis remains the gold standard.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FLASH-induced DNA damage reduction measured in vitro correlates with effective oxygen depletion determined in silico: further support for oxygen depletion contributing to FLASH's reduced damage burden in vitro.","authors":"Bethany Rothwell, Christian R Cooper, Donald J L Jones, Michael J Merchant, Norman F Kirkby, Karen J Kirkby, Kristoffer Petersson, Jan Schuemann, George D D Jones","doi":"10.1093/bjr/tqaf097","DOIUrl":"https://doi.org/10.1093/bjr/tqaf097","url":null,"abstract":"<p><strong>Objectives: </strong>FLASH irradiation demonstrates notable normal-tissue protective effects, including reduced damage in vitro. Radiochemical mechanisms proposed include radical-radical recombination and transient oxygen depletion (TOD), but the relative contributions remain unclear. This study compares FLASH-mediated DNA damage reduction in vitro with oxygen depletion for FLASH radiotherapy modelled in silico, to i) investigate the contribution of TOD towards the reduced damage burden in vitro, and ii) evaluate its contribution to the broader FLASH effect in vivo.</p><p><strong>Methods: </strong>An in silico model was used to identify and compare the parameter space for FLASH-induced oxygen depletion in an in-vitro setup with experimental DNA damage reduction data, previously determined using the alkaline comet assay.</p><p><strong>Results: </strong>Correlation analysis revealed a strong relationship between model-predicted oxygen depletion and experimentally-observed DNA damage reduction (Spearman's = 0.87, p = 2 x 10-6; Pearson's = 0.85, p = 4 x 10-6).</p><p><strong>Conclusions: </strong>Findings support a significant role for TOD in the FLASH-induced reduction in damage in vitro at low oxygen tensions. However, parameter spaces identified, for both oxygen depletion in silico and DNA damage reduction in vitro, suggest that TOD may only partially contribute to the wider-ranging FLASH sparing effects in vivo. Further work is required to clarify this.</p><p><strong>Advances in knowledge: </strong>Findings support TOD as a key mechanism for the reduced damage burden of FLASH in vitro. However, further work is required to demarcate the sparing effects of FLASH in vivo.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of new X-ray technology reducing patient and staff doses in interventional cardiology.","authors":"R M Sánchez-Casanueva, E Vano-Carruana, J M Fernández-Soto","doi":"10.1093/bjr/tqaf095","DOIUrl":"https://doi.org/10.1093/bjr/tqaf095","url":null,"abstract":"<p><strong>Objectives: </strong>The radiology industry has been developing advanced X-ray systems which now deliver high-quality imaging while reducing radiation exposure. In this study, we analyse the impact of the new X-ray systems on patient and occupational radiation doses, compared with the previous ones (from the same manufacturer).</p><p><strong>Methods: </strong>A dose management system (DMS) was employed to analyse large datasets from interventional cardiology procedures to assess the radiation protection improvements. Interventionists wear electronic active dosimeters wirelessly linked to the DMS to record personal occupational doses.Our analysis was conducted at four levels for the old and new X-ray systems: Patient doses, using the Kerma Area Product (KAP); Scatter radiation measured by the reference (ambient) dosimeter located on the C-arm; Occupational doses using over-apron personal electronic dosimeters, and updating local Diagnostic Reference Levels (DRLs) for the most frequent procedures.</p><p><strong>Results: </strong>This methodology enables the evaluation of the new technology's impact at different levels: patient dose values (Level 1), scatter radiation measured by the ambient dosimeters (Level 2), occupational doses for interventionists (Level 3), and updated local DRLs (Level 4).</p><p><strong>Conclusions: </strong>Based on an analysis of 5,002 interventional cardiology procedures, the new X-ray systems demonstrated a substantial reduction in radiation doses (median values): Patient doses (KAP values) decreased by 56-67%. Scatter radiation (ambient dose) decreased by 52-68%. Occupational doses: Interventionists' doses decreased by 33%. The updated local DRLs (median values) for CA and PTCA with the new X-ray systems are 17 Gy·cm2 and 50 Gy·cm2 representing reductions of 62% and 52%, respectively.</p><p><strong>Advances in knowledge: </strong>The implementation of advanced X-ray technology has significantly reduced patient and occupational radiation exposure, all without compromising diagnostic accuracy. The effects on local diagnostic reference levels and the reduction in occupational doses should be regularly assessed to ensure that appropriate optimization actions are maintained.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical photon-counting CT increases CT number precision and reduces patient size dependence compared to single- and dual-energy CT.","authors":"Jessica D Flores, Gavin Poludniowski, Adrian Szum, Georg Walther, Johan Lundberg, Patrik Nowik, Tobias Granberg","doi":"10.1093/bjr/tqaf052","DOIUrl":"10.1093/bjr/tqaf052","url":null,"abstract":"<p><strong>Objectives: </strong>To study whether photon-counting computed tomography (PCCT) can improve CT number accuracy and precision and reduce patient size dependence compared to dual-energy CT (DECT) virtual monoenergetic imaging (VMI) and single-energy CT (SECT).</p><p><strong>Methods: </strong>Clinical PCCT, DECT, and SECT scanners were used to image a multi-energy quality assurance phantom and tissue-equivalent inserts with/without an outer nested annulus, representing 2 object sizes (18 and 33 cm). CT numbers were converted to linear attenuation coefficients (LAC) and regions of interest applied. Theoretical monoenergetic LAC were calculated from known elemental compositions as a ground truth. Percent differences in mean LAC between phantom sizes, between mean and theoretical LAC, and its coefficient of variation (COV) were calculated.</p><p><strong>Results: </strong>Mean LAC percent differences between small and larger phantoms were highest in DECT (within -3% to 9%) and SECT (within 1%-5%), particularly at higher calcium and iodine concentrations, while being relatively constant in PCCT over material concentrations and VMI energies (within ±2%). The COV in mean LAC was consistently lower (about 2-5 times) in PCCT relative to DECT and SECT for calcium in the large phantom. With consideration of the theoretical uncertainties of 2%, both PCCT and DECT showed comparable agreement to theoretical LAC.</p><p><strong>Conclusions: </strong>PCCT VMI produces CT numbers with less dependence on patient size and increased precision in large object sizes than DECT VMI and SECT.</p><p><strong>Advances in knowledge: </strong>Clinical PCCT provides less variable CT numbers than DECT and SECT with less sensitivity to the imaged object size.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"721-733"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of colorectal cancer liver metastases with gadoxetate-enhanced MRI at multiple time points is associated with disease-free survival following hepatectomy.","authors":"Joshua Shur, Leila Kafaei, Angela Riddell, Ian Chau, Ricky Bhogal, Long Jiao, Dow-Mu Koh","doi":"10.1093/bjr/tqaf040","DOIUrl":"10.1093/bjr/tqaf040","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate signal intensity of colorectal cancer liver metastases (CRLM) at hepatobiliary phase (HBP) gadoxetate-enhanced MRI at 2 time points pre- (TP1) and post- chemotherapy (TP2) and association with disease-free survival (DFS) in patients undergoing curative liver resection.</p><p><strong>Methods: </strong>Retrospective study was conducted. Single largest tumours were outlined and HBP T1 signal intensity was measured and normalized to skeletal muscle at TP1 and TP2. Enhancement thresholds were defined and risk groups at each TP and Kaplan-Meier survival curves were compared using the log-rank test. Univariate and multivariate association of enhancement and 8 clinical features with risk of recurrence were calculated using Cox proportional hazards.</p><p><strong>Results: </strong>82 patients (48 male, mean age 59 years) underwent 135 imaging studies, 58 at TP1, 77 at TP2, and 53 patients at TP1 + 2. Of 82 patients, 58 recurred with a median time to recurrence of 11.7 months. Enhancement of ≥135 and ≥15 at TP1 and TP2, respectively, were predictive of reduced risk of recurrence (P < .05), although not when corrected for multiple testing (P = .33 and .20, respectively). Enhancement was not associated with recurrence in multivariate model including 8 clinical features (P > .05). Change in enhancement between TP was not associated with risk of recurrence; however, tumours that consistently exhibited low enhancement were 9 times more likely to recur.</p><p><strong>Conclusions: </strong>Increased CRLM enhancement in the HBP following gadoxetic acid at 2 TPs is associated with improved DFS in patients undergoing liver resection. This initial observation warrants further investigation of serial enhancement measurements as prognostic biomarkers.</p><p><strong>Advances in knowledge: </strong>Dual-time point signal assessment may be informative for clinical outcomes in CRLM undergoing resection.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"744-751"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}