British Journal of Radiology最新文献

{"title":"Value of 2-point Dixon water-only Look-Locker T1 mapping on the assessment of liver fibrosis in chronic liver disease with hepatic steatosis.","authors":"Mayumi Higashi, Masahiro Tanabe, Ute Goerke, Hiroshi Imai, Masatoshi Yamane, Katsuyoshi Ito","doi":"10.1093/bjr/tqag044","DOIUrl":"10.1093/bjr/tqag044","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the influence of fat on the assessment of liver fibrosis in chronic liver disease using 2-point Dixon water-only Look-Locker T1 mapping by comparing the water-only derived sequence (W-Dixon) with in-phase (IP) and opposed-phase (OP)-based sequences.</p><p><strong>Methods: </strong>A 2.89-T MRI examination included 2D 2-point Dixon Look-Locker T1 mapping and proton density fat fraction (PDFF) mapping. The correlations between liver T1 values and PDFF were assessed using the Spearman correlation coefficient. T1 values on each T1 map were compared among 3 FIB-4 index range groups (FIB-4 < 1.3, 1.3-2.67, > 2.67) in patients with and without hepatic steatosis using one-way analysis of variance and the Kruskal-Wallis test.</p><p><strong>Results: </strong>A total of 204 patients with chronic liver disease were retrospectively evaluated. T1 values on IP or OP images were significantly correlated with PDFF (r = -0.373, 0.220), while no significant correlation was found between T1 values on W-Dixon images and PDFF (r = -0.071). In patients without hepatic steatosis, T1 values on each T1 map in the FIB-4 > 2.67 group were significantly higher than in the FIB-4 1.3-2.67 group (P < .01). Conversely, in patients with hepatic steatosis, only the W-Dixon sequence statistically differentiated the FIB-4 > 2.67 group from the FIB-4 1.3-2.67 group based on T1 values (P < .05).</p><p><strong>Conclusions: </strong>The assessment of liver fibrosis based on T1 values obtained by Dixon water-only T1 mapping was less influenced by the presence of fat.</p><p><strong>Advances in knowledge: </strong>Two-point Dixon water-only Look-Locker T1 mapping minimizes the confounding effect of fat, enabling proper assessment of liver fibrosis in steatotic chronic liver disease.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"973-979"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early adoption of image-guided histotripsy therapy in interventional oncology: challenges and opportunities in the United Kingdom.","authors":"Helen Hoi Lam Ng, Vinson Wai-Shun Chan, Lewis Howell, Taha Shiwani, Jim Zhong, Jacqueline Brandon, Adel Samson, James Chandler, James McLaughlan, Tze Min Wah","doi":"10.1093/bjr/tqag047","DOIUrl":"10.1093/bjr/tqag047","url":null,"abstract":"<p><p>Histotripsy represents a paradigm shift in interventional oncology (IO) as the first non-invasive, non-ionizing and non-thermal ultrasound-based ablation technology available for cancer therapy. Compared with thermal ablation techniques, the advantages of histotripsy include tissue-selective ablation near critical structures, reduced collateral injury risk, and treatment which is unaffected by the heat sink phenomenon, ensuring predictable treatment margins. Ultrasound technology can be constrained by tissue attenuation depending on the depth of the target; however, the early phase feasibility and pivotal trial results have been promising for its application in liver cancers, with emerging translational trials in renal and pancreatic cancer. In the United Kingdom, 2 well-established IO sites have participated in the pivotal #HOPE4LIVER Trial that led to approval by the US Food and Drug Administration in liver tumours therapy in 2023 and obtained Medicines and Healthcare products Regulatory Agency Unmet Clinical Need Authorisation for treatment of liver tumours in United Kingdom (April 2025) via the Innovative Devises Access Pathway. The global-first feasibility in renal cancer (CAIN trial) was also led by the United Kingdom and completed in April 2024. This review provides an overview of histotripsy and highlights the clinical challenges in early National Health Service (NHS) adoption such as the learning curve for operators and teams, regulatory processes, and synthesis of health economic evidence required for wider NHS commissioning. The review will also discuss the future directions of histotripsy, including combination immunomodulatory therapies, highlighting the need for continual national collaboration for successful integration in the NHS. Successfully integrating this technology into the NHS hinges on a unified national effort to navigate the clinical, regulatory and economic hurdles, ensuring its benefits reach patients nationwide.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"833-846"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of apparent diffusion coefficient values to differentiate lymph nodes from testicular tissue in patients with undescended testes.","authors":"Sevgi Demiroz Tasolar, Ahmet Sigirci, Serkan Yavuz, Turan Yildiz","doi":"10.1093/bjr/tqag043","DOIUrl":"10.1093/bjr/tqag043","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the anatomical location of non-palpable undescended testes (UTs), which account for approximately 20% of all cases of UTs. Radiological imaging is essential to determine the location of such testes in the abdomen or groin. Other studies have examined the diagnostic performance of diffusion-weighted MRI (DWI) in detecting and localizing non-palpable UTs. However, no study has used apparent diffusion coefficient (ADC) values to differentiate UT tissue.</p><p><strong>Methods: </strong>This study included consecutive children referred to a pediatric surgery clinic with a prediagnosis of UT. Diffusion-weighted images were used to evaluate lymph nodes (LNs) and testicular tissue. Apparent diffusion coefficient values were measured by placing a circular region of interest at the center.</p><p><strong>Results: </strong>The study enrolled 44 boys (73 testes) who underwent pelvic MRI. Age and testicular volume were significantly positively correlated (P < .001). Testicular ADC values were higher in both inguinal and abdominal locations than in scrotal locations. However, the ADC values of LNs were significantly lower than those of testes. Our ROC analysis revealed that an ADC value < 940 10-3/mm2 could differentiate between LNs and testes (AUC = 0.826, P < .001).</p><p><strong>Conclusion: </strong>Measuring ADCs using a DWI imaging sequence is an accurate method of differentiating between testes and LNs.</p><p><strong>Advances in knowledge: </strong>This study is the first to show that ADC values from diffusion-weighted MRI can reliably differentiate non-palpable UTs from LNs. Apparent diffusion coefficient mapping appears to be a novel and accurate tool for detecting testicular localization when conventional assessment is inadequate.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"967-972"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic segmentation of clinical target volume for radiation therapy in breast-conserving patients and exploration of clinical factors influential to its performance.","authors":"Maochen Zhang, Yibin Zhang, Lu Cao, Rong Cai, Haoping Xu, Cheng Xu, Weiqi Xiong, Wei Zhang, Xinyi Wu, Jiayi Chen, Gang Cai","doi":"10.1093/bjr/tqag036","DOIUrl":"10.1093/bjr/tqag036","url":null,"abstract":"<p><strong>Objectives: </strong>To develop and validate a deep learning model for whole breast clinical target volume (CTV) contouring and evaluate clinical features affecting its performance.</p><p><strong>Methods: </strong>Five datasets with 857 patients from a single center were used. Dataset 1 (n = 300) trained and tested the model. Dataset 2 (n = 10) evaluated contouring time and dosimetric parameters. Datasets 3 (n = 20) and 4 (n = 10) were for clinical evaluation. Dataset 5 (n = 517) identified clinical factors influencing auto-contouring accuracy. Model performance was assessed using Dice Similarity Coefficient (DSC) and 95th percentile Hausdorff Distance (HD95).</p><p><strong>Results: </strong>The median DSC and HD95 for left- and right-sided models in Dataset 1 were 0.941, 1.75 mm and 0.937, 2.47 mm, respectively. In Dataset 2, both auto-contouring and auto-contouring with manual corrections were significantly faster than manual contouring (P = .005 for both), while still achieving clinically acceptable dosimetric results. In Dataset 3, two physicians rated automatic and manual contours as equivalent (P = .214, P = .075), while the other rated auto-contouring higher (P < .001). In Dataset 4, the auto-contouring model outperformed 1/5 physicians by DSC (P = .009) and 3/5 by HD95 (P = .015, P = .007, P = .017). In Dataset 5, peripheral tumor-bed and low-density breast tissue were associated with lower DSC (P < .001 for both) and higher HD95 (P < .001 for both). Cases without unfavorable factors performed better than those with (P < .001 for both).</p><p><strong>Conclusions: </strong>The proposed model demonstrated acceptable accuracy, consistency, and efficiency in breast CTV contouring. Peripheral tumor-bed and low-density breast tissue reduced auto-contouring performance.</p><p><strong>Advances in knowledge: </strong>The characteristics of challenging cases in whole breast CTV auto-contouring should be identified.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"942-950"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distal radioulnar joint stability and ulnar styloid bone marrow oedema: the added value of MRI in triangular fibrocartilage complex injuries.","authors":"Liu Huli, Tang Wen, Xie Qianyun, Zhang Chenchen, Yang Ying","doi":"10.1093/bjr/tqaf300","DOIUrl":"10.1093/bjr/tqaf300","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the diagnostic value of MRI combined with distal radioulnar joint (DRUJ) stability characteristics and ulnar styloid bone marrow oedema (BMO) in differentiating peripheral vs. central triangular fibrocartilage complex (TFCC) injuries, and to establish a multiparametric MRI diagnostic model to optimize preoperative classification accuracy.</p><p><strong>Methods: </strong>A retrospective analysis of 76 patients with arthroscopically confirmed TFCC injuries (55 peripheral tears, 21 central tears) was conducted. Preoperative MRI evaluated DRUJ stability and BMO. Chi-square tests analysed intergroup differences, binary logistic regression identified predictors, diagnostic efficacy metrics were calculated, and MRI-based classification, DRUJ stability, BMO, and combined models were compared using arthroscopy as the gold standard.</p><p><strong>Results: </strong>The peripheral tear group exhibited significantly higher BMO positivity (82.9% vs. 11.1%) and DRUJ instability rates (70.9% vs. 9.5%) compared to the central tear group (both P < .001). Logistic regression identified BMO positivity (OR = 0.140, 95% CI: 0.044-0.444) and DRUJ instability (OR = 0.103, 95% CI: 0.013-0.428) as independent predictors of peripheral tears (P = .001). The combined model (MRI + DRUJ + BMO) demonstrated superior diagnostic performance (AUC = 0.898, 95% CI: 0.818-0.978; sensitivity = 76.2%, specificity = 94.6%) compared to MRI alone (AUC = 0.810) or DRUJ + BMO models (AUC = 0.822).</p><p><strong>Conclusions: </strong>The combined model integrating anatomic stability improves diagnostic specificity, providing critical guidance for preoperative stratification, surgical planning, and personalized treatment.</p><p><strong>Advances in knowledge: </strong>BMO and DRUJ stability hold potential as supplementary MRI imaging biomarkers for TFCC injuries classification.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"872-877"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balloon-occluded retrograde transvenous obliteration for duodenal varices: a retrospective observational study.","authors":"Masanori Ozaki, Atsushi Jogo, Akira Yamamoto, Toshio Kaminou, Eisaku Terayama, Shohei Harada, Kazuki Matsushita, Kazuo Asano, Ken Kageyama, Mariko Nakano, Kazuki Murai, Yukio Miki","doi":"10.1093/bjr/tqag046","DOIUrl":"10.1093/bjr/tqag046","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the efficacy of balloon-occluded retrograde transvenous obliteration (BRTO) for duodenal varices.</p><p><strong>Methods: </strong>Twenty-two consecutive cases of BRTO for duodenal varices between January 2001 and September 2020 were retrospectively reviewed. Preoperative patient characteristics, anatomical features of duodenal varices, treatment outcomes and technical aspects of BRTO, long-term results (bleeding-free survival and recurrence-free survival), overall survival, and complications were evaluated.</p><p><strong>Results: </strong>Technical success was achieved in 77.3% (17/22) of cases. The technical success rate was 87.5% (14/16) in prophylactic cases, and 50.0% (3/6) in emergency cases. Clinical success was achieved in all 17 technically successful cases. After 6, 12, and 24 months of successful BRTO, bleeding-free survival remained 100% at all time points, recurrence-free survival was 100%, 92.3%, and 83.1% and overall survival was 86.7%, 86.7%, and 78.0%, respectively. Overall survival was significantly lower in ruptured cases than in non-ruptured cases (P = .0002). Within 3 months of BRTO, ascites worsened in 29.4% (5/17) of patients, and other gastrointestinal varices worsened in 25.0% (4/16) of patients. Post-BRTO portal vein thrombosis was detected within 1 week in 5.9% (1/17) cases.</p><p><strong>Conclusion: </strong>BRTO appears to be a safe and effective primary prophylactic treatment option for duodenal varices.</p><p><strong>Advances in knowledge: </strong>This study provides evidence of the efficacy of balloon-occluded retrograde transvenous obliteration (BRTO) in treating duodenal varices. Since duodenal variceal rupture has the possibility of worsening patient prognosis, prophylactic BRTO might be performed to prevent rupture.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"989-998"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced setup and positioning accuracy in nasopharyngeal carcinoma radiotherapy: a customized cushion/mask/bite-block immobilization approach.","authors":"Yanxin Zhang, Yichen Hou, Yang Liu, Fukui Huan, Bao Wan, Gengqiang Zhu, Ke Zhou, Kun Zhang, Songsong Geng, Junlin Yi, Runye Wu","doi":"10.1093/bjr/tqaf317","DOIUrl":"10.1093/bjr/tqaf317","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether a customized cushion/mask/bite-block (CMB) immobilization strategy was superior to the standard head and neck immobilization system in terms of enhancing setup and positioning accuracy across diverse anatomical planes during IMRT for nasopharyngeal carcinoma (NPC).</p><p><strong>Methods: </strong>This study analysed CBCT images of 22 patients undergoing IMRT for NPC, assessing setup errors at distinct anatomical levels (sphenoid, C1, C4, C7, mandible) and calculating corresponding CTV-PTV margin expansions. Intra-fractional positional uncertainties were also evaluated. Differences in setup errors, required PTV margins and intra-fractional positional accuracy were compared between the 2 groups.</p><p><strong>Results: </strong>The CMB group showed significant improvement in inter-fractional setup error within the ROI for PTV compared to the standard headrest group. Compared with the standard headrest group, the CMB group significantly reduced systematic and random errors, especially in the X (left-right) and Y (superior-inferior) directions. The respective systematic and random errors (mm) were as follows: X (0.73 ± 0.98 vs. 1.16 ± 0.99), Y (1.12 ± 0.86 vs. 1.70 ± 0.96), and Z (0.86 ± 1.12 vs. 0.85 ± 1.14). Furthermore, the CMB group significantly improved the positional repeatability of various local ROIs (sphenoid, C1, C4, C7, and mandible). Additionally, the CMB group had reduced CTV-PTV margin expansions in the 3 directions.</p><p><strong>Conclusion: </strong>Compared to the standard headrest group, the CMB immobilization protocol significantly improved setup and positioning accuracy for IMRT in NPC patients, reducing the need for PTV margin expansion across various anatomical levels. This novel immobilization approach was deemed effective, simple, and robust during IMRT for NPC.</p><p><strong>Advances in knowledge: </strong>This study provides valuable clinical insights into improving setup and positioning accuracy at various anatomical levels during IMRT for NPC.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"878-885"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI response to neoadjuvant chemotherapy and prognostic implications in breast cancer patients.","authors":"Soraia Quaranta Damião, Eduarda Ferreira Rodrigues da Cunha, Monique Celeste Tavares, Solange Moraes Sanches, Cynthia Aparecida Bueno de Toledo Osorio, Marina De Brot, Fabiana Baroni Makdissi, Almir Galvão Vieira Bitencourt","doi":"10.1093/bjr/tqag023","DOIUrl":"10.1093/bjr/tqag023","url":null,"abstract":"<p><strong>Objective: </strong>To correlate response evaluation after neoadjuvant chemotherapy (NAC), assessed by MRI and pathology, with disease-free survival (DFS) in breast cancer patients, according to immunophenotype.</p><p><strong>Methods: </strong>Single-centre, IRB-approved retrospective cohort study included consecutive breast cancer patients who underwent NAC and preoperative breast MRI. Pathologic response was evaluated using the residual cancer burden (RCB) system, with pathological complete response (pCR) defined as the absence of invasive carcinoma. Radiological complete response (rCR) was defined as the absence of abnormal enhancement on MRI. The Kaplan-Meier method estimated DFS and Cox regression analysis calculated hazard ratios (HRs).</p><p><strong>Results: </strong>Five hundred seventy-one patients were included (mean age 46 years, range 26-90). The most common immunophenotype was luminal (42.3%), followed by triple-negative (TNBC, 31.5%) and HER2 overexpressed (26.3%). Radiological and pathological responses were concordant in 71.5%. Overall, 35.2% achieved rCR and 37.5% achieved pCR. Disease-free survival curves did not differ significantly according to radiologic-pathologic response combinations in the luminal or HER2 groups (LogRank P = .505 and P = .257). In the TNBC group, patients without pCR or rCR had significantly worse DFS compared to those achieving either response (LogRank P = .001). Cox regression revealed that TNBC patients with both non-rCR and non-pCR had a markedly higher risk of recurrence or death (HR 7.728; 95% CI 2.696-22.149; P < .001).</p><p><strong>Conclusions: </strong>Integrating MRI and pathological response assessments after NAC may enhance risk stratification and prognostication, especially in triple-negative breast cancer.</p><p><strong>Advances in knowledge: </strong>Patients with both non-rCR and non-pCR have significantly worse DFS, underscoring the prognostic value of combining imaging and pathological findings, particularly in TNBC.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"913-920"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI-based analysis of organ at risk stability during prolonged voluntary deep inspiration breath-hold in prone and supine breast cancer radiotherapy.","authors":"Vincent Huybrechts, Vincent Vakaet, Renée De Noyette, Bruno Speleers, Michael Stouthandel, Hans Van Hulle, Sophie Pommé, Frederik Vanhoutte, Wilfried De Neve, Françoise Kayser, Pascal Pellegrin, Marc Coppens, Werner De Gersem, Liv Veldeman","doi":"10.1093/bjr/tqag018","DOIUrl":"10.1093/bjr/tqag018","url":null,"abstract":"<p><strong>Objectives: </strong>Deep inspiration breath-hold (DIBH) is commonly used in breast cancer radiotherapy to reduce radiation exposure to the heart and lungs. Recent techniques incorporating oxygen supplementation and hyperventilation have enabled DIBHs exceeding 2.5 minutes. However, data on internal organ stability during prolonged breath-holds (L-DIBH) remain limited.</p><p><strong>Methods: </strong>In this prospective observational physiological study, 10 healthy female volunteers performed 2 L-DIBHs (2 minutes 8 seconds each) in both prone and supine positions, following a validated hyperventilation and oxygenation protocol. Serial 3D MRI scans were acquired every 16 seconds during each L-DIBH to assess positional stability of the heart, lungs, and left-sided breast. Cumulative distance-volume histograms (cDiVHs) were used to evaluate spatial relationships between organs and quantify internal displacement over time.</p><p><strong>Results: </strong>A total of 319 high-quality 3D MRI series were analysed. cDiVHs demonstrated consistent organ positions across timepoints and sessions. While left breast position remained stable throughout all L-DIBHs, minor but statistically significant heart displacement was observed during each L-DIBH increasing over time, more pronounced in the prone position than supine.</p><p><strong>Conclusions: </strong>L-DIBHs of 2 minutes and 8 seconds are achievable and demonstrate stability in left breast positioning, with minimal movement of adjacent internal organs. Small but progressive shifts of the portion of the heart nearest the breast were detected, particularly in prone positioning.</p><p><strong>Advances in knowledge: </strong>To account for these minimal displacements during L-DIBH, asymmetrical safety margins around the heart of 3 mm in prone and 2 mm in supine positions may be appropriate.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"898-905"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological review of the level of statistical support declared in radiological research articles.","authors":"Amisha Pradhan, Tom Parry, Sue Mallett, Steve Halligan","doi":"10.1093/bjr/tqag026","DOIUrl":"10.1093/bjr/tqag026","url":null,"abstract":"<p><strong>Objectives: </strong>We assessed if there was disparity between qualified statisticians and other researchers regarding the level of statistical assistance deemed necessary to support radiological research.</p><p><strong>Methods: </strong>We categorized 50 consecutive, eligible original research articles published in an indexed imaging journal (European Radiology) in 2024, according to authors' statements regarding statistical support, declared in the \"Statistics and Biometry\" section. Two reviewers extracted data related to study design, statistical methods, and analysis. Two medical statisticians categorized each study as presenting \"complex\" statistical methods or not and then compared this with authors' own assessment of statistical complexity, stated in the published article. We performed descriptive analyses.</p><p><strong>Results: </strong>Most studies were observational (49, 98%) and retrospective (38, 76%). 35 (70%) studies were diagnostic, 7 (14%) prognostic, and 6 (12%) mixed. Malignancy was the most frequent topic (29 studies, 58%), and MRI the most frequent modality (35 studies, 70%). We deemed most studies (33, 66%) presented complex statistical methods. Of these, 13 studies (26% overall) declared that \"no complex statistical methods were necessary for this paper.\" However, 10 of these employed hypothesis testing, frequently using multiple methods; 9 employed agreement and/or reliability analyses; all presented accuracy measures; 11 (85%) presented a regression model.</p><p><strong>Conclusions: </strong>We found that approximately one quarter of original research articles published in our sample stated that \"no complex statistical methods were necessary,\" but then presented complex analyses.</p><p><strong>Advances in knowledge: </strong>Some radiological researchers may underestimate the complexities of statistical analysis and requirement for specialist statistical support, which risks inappropriate analyses and misleading results.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":"921-930"},"PeriodicalIF":3.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}