British Journal of Radiology最新文献_第2页

Percutaneous ablation of bone metastatic disease.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-03-20 DOI: 10.1093/bjr/tqaf061

Shruti Suresh, Danoob Dalili, Hakan Ilaslan

引用次数: 0

The Application Value of Ultrasound in Ovarian Hyperstimulation Syndrome and Literature Review.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-03-19 DOI: 10.1093/bjr/tqaf064

Juan-Yan Kuang, Kui Tang

{"title":"The Application Value of Ultrasound in Ovarian Hyperstimulation Syndrome and Literature Review.","authors":"Juan-Yan Kuang, Kui Tang","doi":"10.1093/bjr/tqaf064","DOIUrl":"https://doi.org/10.1093/bjr/tqaf064","url":null,"abstract":"Ovarian hyperstimulation syndrome (OHSS) is a common complication of assisted reproductive technology, caused by the excessive response of the ovaries to gonadotropins during the ovulation induction process. The clinical manifestations of OHSS include abdominal distension, abdominal pain, nausea, vomiting, etc In severe cases, it can lead to life-threatening symptoms such as ovarian rupture, ascites, and pleural effusion. Ultrasound examination, as an important auxiliary diagnostic tool, can help doctors monitor the size of the ovaries, the number and morphology of follicles, and predict and diagnose the occurrence of OHSS. In terms of treatment, ultrasound-guided puncture and fluid drainage is an effective method to alleviate the symptoms of OHSS. This article reviews the application of ultrasound technology in the prediction, diagnosis, and treatment of OHSS, aiming to provide a more accurate and effective diagnostic and treatment strategy for clinical practice. Through in-depth research, it will help doctors better understand the pathophysiology of OHSS, formulate personalized treatment plans, improve treatment outcomes, and reduce the pain and economic burden on patients.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Gaps in Magnetic Resonance Imaging for Penile Mondor's Disease: A Systematic Review.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-03-19 DOI: 10.1093/bjr/tqaf065

Yonathan William, Vera Nevyta Tarigan, Marto Sugiono, Gilbert Sterling Octavius

{"title":"Unveiling Gaps in Magnetic Resonance Imaging for Penile Mondor's Disease: A Systematic Review.","authors":"Yonathan William, Vera Nevyta Tarigan, Marto Sugiono, Gilbert Sterling Octavius","doi":"10.1093/bjr/tqaf065","DOIUrl":"https://doi.org/10.1093/bjr/tqaf065","url":null,"abstract":"Objectives: This systematic review aimed to consolidate existing MRI findings in PMD cases, establish optimal imaging indications, and explore their clinical value.Methods: The protocol for this review was registered in PROSPERO (CRD42024592190). Searches were performed in MEDLINE, Cochrane Library, PubMed, ScienceDirect, and Google Scholar on December 1, 2024. Eligible studies included those with clinically diagnosed PMD and MRI findings. Data on patient characteristics, MRI sequences, thrombus stage, and study quality were extracted and assessed using the Joanna Briggs Institute checklist for case reports.Results: From 710 records, four studies were included, encompassing four patients with PMD. The median age of the four patients is 35.5 years old (25-53), and two are from Turkey. MRI findings highlighted variable thrombus stages (one acute, two subacute, and one chronic) and heterogeneous imaging protocols. Only one study explicitly mentioned MRI indications. MRI provided detailed assessments of penile anatomy and thrombus characteristics but lacked consistency in usage, timing, and sequence protocols. No studies received a good quality rating; two were rated poor, and one was fair.Conclusion: MRI's role in PMD diagnosis is limited, with its utility primarily in complex or atypical cases. Standardized MRI indications and sequence protocols are warranted to optimize its clinical application. More extensive studies are needed to validate its diagnostic and therapeutic impact.Advances in knowledge: MRI is primarily utilized for complex cases of PMD; however, more systematic documentation of its indications could guide clinicians in determining when MRI is appropriate for PMD patients. Keywords: Penile Mondor's disease, Magnetic resonance imaging, thrombophlebitis, diagnostic imaging, systematic review.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CT-derived fractional flow reserve on therapeutic management and outcomes compared with coronary CT angiography in coronary artery disease.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-03-19 DOI: 10.1093/bjr/tqaf055

Ying Qian, Meng Chen, Chunhong Hu, Ximing Wang

{"title":"CT-derived fractional flow reserve on therapeutic management and outcomes compared with coronary CT angiography in coronary artery disease.","authors":"Ying Qian, Meng Chen, Chunhong Hu, Ximing Wang","doi":"10.1093/bjr/tqaf055","DOIUrl":"https://doi.org/10.1093/bjr/tqaf055","url":null,"abstract":"Purpose: To determine the value of on-site deep learning-based CT-derived fractional flow reserve (CT-FFR) for therapeutic management and adverse clinical outcomes in patients suspected of coronary artery disease (CAD) compared with computed tomography coronary angiography (CCTA) alone.Materials and methods: This single-center prospective study included consecutive patients suspected of CAD between June 2021 and September 2021 at our hospital. 461 patients were randomized into either CT-FFR+CCTA or CCTA alone group. The first endpoint was the invasive coronary angiography (ICA) efficiency, defined as the ICA with non-obstructive disease (stenosis <50%) and the ratio of revascularization to ICA (REV-to-ICA ratio) within 90 days. The second endpoint was the incidence of major adverse cardiac events (MACE) at 2 years.Results: A total of 461 patients (267 [57.9%] men; median age, 64 [55-69]) were included. At 90 days, the rate of ICA with non-obstructive disease in CT-FFR+CCTA group was lower than the CCTA group (14.7 vs. 34.0%, P = 0.047). The REV-to-ICA ratio in the CT-FFR+CCTA group was significantly higher than the CCTA group (73.5% vs. 50.9%, P = 0.036). No significant difference in ICA efficiency was found in intermediate stenosis (25-69%) between the two groups (all P > 0.05). After a median follow-up of 23 (22, 24) months, MACE were observed in 11 patients in the CT-FFR+CCTA group and 24 in the CCTA group (5.9% vs. 10.0%, P = 0.095).Conclusion: The on-site deep learning-based CT-FFR improved the efficiency of ICA utilization with the similarly low rate of MACE compared with CCTA alone.Advances in knowledge: The on-site deep learning-based CT-FFR was superior to CCTA for therapeutic management.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Standardized pancreatic MRI-T1 measurement methods: comparison between manual measurement and a semi-automated pipeline with automatic quality control.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-03-19 DOI: 10.1093/bjr/tqaf062

Alexandre Triay Bagur, Zobair Arya, Tom Waddell, Michele Pansini, Carolina Fernandes, Daniel Counter, Edward Jackson, Helena B Thomaides-Brears, Matthew D Robson, Daniel P Bulte, Rajarshi Banerjee, Paul Aljabar, Michael Brady

{"title":"Standardized pancreatic MRI-T1 measurement methods: comparison between manual measurement and a semi-automated pipeline with automatic quality control.","authors":"Alexandre Triay Bagur, Zobair Arya, Tom Waddell, Michele Pansini, Carolina Fernandes, Daniel Counter, Edward Jackson, Helena B Thomaides-Brears, Matthew D Robson, Daniel P Bulte, Rajarshi Banerjee, Paul Aljabar, Michael Brady","doi":"10.1093/bjr/tqaf062","DOIUrl":"https://doi.org/10.1093/bjr/tqaf062","url":null,"abstract":"Objectives: Scanner-referenced T1 (srT1) is a method for measuring pancreas T1 relaxation time. The purpose of this multi-centre study is two-fold: (1) to evaluate the repeatability of manual ROI-based analysis of srT1, (2) to validate a semi-automated measurement method with an automatic quality control (QC) module to identify likely discrepancies between automated and manual measurements.Methods: Pancreatic MRI scans from a scan-rescan cohort (46 subjects) were used to evaluate the repeatability of manual analysis. 708 scans from a longitudinal multi-centre study of 466 subjects were divided into training, internal validation (IV), and external validation (EV) cohorts. A semi-automated method for measuring srT1 using machine learning is proposed and compared against manual analysis on the validation cohorts with and without automated QC.Results: Inter-operator agreement between manual ROI-based method and semi-automated method had low bias (3.8 ms or 0.5%) and limits of agreement [-36.6, 44.1] ms. There was good agreement between the two methods without automated QC (IV: 3.2 [-47.1, 53.5] ms, EV: -0.5 [-35.2, 34.2] ms). After QC, agreement on the IV set improved, was unchanged in the EV set, and the agreement in both was within inter-operator bounds (IV: -0.04 [-33.4, 33.3] ms, EV: -1.9 [-37.6, 33.7] ms). The semi-automated method improved scan-rescan agreement versus manual analysis (manual: 8.2 [-49.7, 66] ms, automated: 6.7 [-46.7, 60.1] ms).Conclusions: The semi-automated method for characterization of standardized pancreatic T1 using MRI has the potential to decrease analysis time while maintaining accuracy and improving scan-rescan agreement.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mastering CT-based radiomic research in lung cancer: a practical guide from study design to critical appraisal.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-03-18 DOI: 10.1093/bjr/tqaf051

Ashley Horne, Azadeh Abravan, Isabella Fornacon-Wood, James P B O'Connor, Gareth Price, Alan McWilliam, Corinne Faivre-Finn

{"title":"Mastering CT-based radiomic research in lung cancer: a practical guide from study design to critical appraisal.","authors":"Ashley Horne, Azadeh Abravan, Isabella Fornacon-Wood, James P B O'Connor, Gareth Price, Alan McWilliam, Corinne Faivre-Finn","doi":"10.1093/bjr/tqaf051","DOIUrl":"https://doi.org/10.1093/bjr/tqaf051","url":null,"abstract":"Radiomics is a health technology that has the potential to extract clinically meaningful biomarkers from standard of care imaging. Despite a wealth of exploratory analysis performed on scans acquired from patients with lung cancer and existing guidelines describing some of the key steps, no radiomic-based biomarker has been widely accepted. This is primarily due to limitations with methodology, data analysis and interpretation of the available studies. There is currently a lack of guidance relating to the entire radiomic workflow from study design to critical appraisal. This guide, written with early career lung cancer researchers, describes a more complete radiomic workflow. Lung cancer image analysis is the focus due to some of the unique challenges encountered such as patient movement from breathing. The guide will focus on CT imaging as these are the most common scans performed on patients with lung cancer. The aim of this article is to support the production of high-quality research that has the potential to positively impact outcome of patients with lung cancer.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting the risk grades of thymic epithelial tumors using T1 mapping and diffusion-weighted MRI.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-03-14 DOI: 10.1093/bjr/tqaf060

Jiang-Tao Lan, Chen-Xi Liu, Jie Zhang, Yu-Hui Ma, Gang Xiao, Shu-Mei Wang, Guang Yang, Guang-Bin Cui, Yu-Chuan Hu

{"title":"Predicting the risk grades of thymic epithelial tumors using T1 mapping and diffusion-weighted MRI.","authors":"Jiang-Tao Lan, Chen-Xi Liu, Jie Zhang, Yu-Hui Ma, Gang Xiao, Shu-Mei Wang, Guang Yang, Guang-Bin Cui, Yu-Chuan Hu","doi":"10.1093/bjr/tqaf060","DOIUrl":"https://doi.org/10.1093/bjr/tqaf060","url":null,"abstract":"Objective: To explore the value of native T1 and apparent diffusion coefficients (ADC) for predicting subtypes and stages of thymic epithelial tumors (TETs).Methods: Sixty-seven patients with TETs confirmed by pathological analysis were retrospectively enrolled. The mean native T1 (T1mean), global native T1 (ADCtotal), relative minimum ADC (ADCmin), and global ADC (ADCtotal) values of the tumor were measured and compared for differences among low-risk thymoma (LRT), high-risk thymoma (HRT), and thymic carcinoma (TC). The differentiating efficacy was determined using receiver operating characteristic curve analysis.Results: The native T1 values in thymoma or early stage were significantly higher than those in TC (P < 0.05/3) or advanced stage of TETs (P < 0.01). The ADC values in LRT or early stage were significantly higher than those in TC (P < 0.05/3) or advanced stage of TETs (P < 0.001). For differentiating the thymoma or HRT from TC, a combination of native T1 and ADC achieved the highest efficacy with an AUC of 0.891 and 0.851, respectively. For determining the TET stage, ADCmin achieved a relatively high diagnostic efficacy with an AUC of 0.933, and a combination of native T1 and ADC obtained an AUC of 0.876.Conclusion: The combination of native T1 and ADC values could be helpful in clinical practice regarding evaluating TETs before treatment.Advances in knowledge: The combination of T1 mapping and DWI can improve diagnostic accuracy and help guide clinical practice in providing the best individual treatment for TET patients.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Splenial Angle on Axial T1 and FLAIR MRI Images and Idiopathic Normal Pressure Hydrocephalus.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-03-14 DOI: 10.1093/bjr/tqaf058

Samantha Lee, Robert Chen, Sumeet Kumar, Weiling Lee, Huihua Li, Louis C S Tan, Eng King Tan, Nicole C H Keong, Ling Ling Chan

{"title":"Splenial Angle on Axial T1 and FLAIR MRI Images and Idiopathic Normal Pressure Hydrocephalus.","authors":"Samantha Lee, Robert Chen, Sumeet Kumar, Weiling Lee, Huihua Li, Louis C S Tan, Eng King Tan, Nicole C H Keong, Ling Ling Chan","doi":"10.1093/bjr/tqaf058","DOIUrl":"https://doi.org/10.1093/bjr/tqaf058","url":null,"abstract":"Objectives: The splenial angle (SA), measured on axial DTI colour fractional anisotropy MRI, outperformed the callosal angle (CA) in predicting idiopathic normal pressure hydrocephalus (NPH) patients from those with Alzheimer's dementia, Parkinson's disease (PD) and healthy controls (HC). We investigated its reliability and classification performance on more commonly acquired T1 MPRAGE and FLAIR images.Methods: SA was measured on axial MPRAGE and FLAIR images in 57 subjects (19 NPH, PD and HC each) by two raters, and compared across groups. Receiver operating characteristics (ROC) analysis was used to assess its classification performance differentiating NPH from non-NPH groups, in comparison to the CA.Results: Inter-rater reliability for SA were excellent (intraclass correlation coefficients ≥0.91). SA was effective in differentiating NPH from non-NPH patients on MPRAGE and FLAIR images (p < 0.001). Its ROC curves showed excellent performance classifying NPH from HC (AUC 1) and PD (AUC >0.93) groups, and were highly comparable to those for CA (1; 0.947). Angles wider than 60° and narrower than 45° robustly (100%) excluded and predicted NPH from HC, respectively. The narrower 45° cutoff yielded better sensitivity (84.2-89.5%) in differentiating NPH from PD patients.Conclusions: The SA on MPRAGE/FLAIR images showed excellent inter-rater reliability and classification performance predicting NPH from non-NPH groups, rivalling those of the CA.Advances in knowledge: The SA on MPRAGE and FLAIR images is reproducible and shows excellent diagnostic performance differentiating NPH from non-NPH groups, with potential to replace the CA in NPH screening given its accessibility on routine axial neuroimaging.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric cerebrovascular syndromes: imaging clues to a diagnosis.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-03-13 DOI: 10.1093/bjr/tqaf057

Zuha Hasan, Adam A Dmytriw, Susan Blaser, Prakash Muthusami

{"title":"Pediatric cerebrovascular syndromes: imaging clues to a diagnosis.","authors":"Zuha Hasan, Adam A Dmytriw, Susan Blaser, Prakash Muthusami","doi":"10.1093/bjr/tqaf057","DOIUrl":"https://doi.org/10.1093/bjr/tqaf057","url":null,"abstract":"CNS vascular syndromes are being increasingly recognized and diagnosed in the pediatric population. Their rarity and complexity makes diagnosis challenging. These syndromes can present in a number of different ways clinically and radiologically. A systematic method of image interpretation often reveals a pattern, allowing the diagnosis to be narrowed or further testing to be directed. Although the CNS vascular appearance itself is rarely specific, additional information gleaned from imaging other systems aids in pattern recognition. We retrospectively reviewed pediatric cases of CNS vasculopathy with a confirmed diagnosis of a syndromic disorder. We recorded the predominant CNS vascular appearance in each case, and assessed imaging clues from multiple systems, including brain, orbits, skull, spine, long bones, viscera and skin. Several of these syndromes also had systemic vascular involvement, which allowed further categorization. Some imaging patterns allowed a specific diagnosis to be made. In other cases, the constellations of imaging appearances helped distinguish between clinically similar phenotypes. The imaging pattern within each pediatric CNS vascular syndrome is fairly consistent, and awareness of these syndromes and expected imaging patterns allow the radiologist to suggest further imaging or targeted genetic testing.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation-induced lymphocyte apoptosis and chromosomic aberrations for prediction of toxicities in patients undergoing radical radiotherapy for breast or prostate cancers.

IF 1.8 4区医学

British Journal of Radiology Pub Date : 2025-03-13 DOI: 10.1093/bjr/tqaf056

David Azria, Joanne S Haviland, Muriel Brengues, Clare Griffin, Jayne Moquet, Stephen Barnard, David P Dearnaley, Annie Gao, Lone Gothard, Kai Rothkamm, John R Yarnold

{"title":"Radiation-induced lymphocyte apoptosis and chromosomic aberrations for prediction of toxicities in patients undergoing radical radiotherapy for breast or prostate cancers.","authors":"David Azria, Joanne S Haviland, Muriel Brengues, Clare Griffin, Jayne Moquet, Stephen Barnard, David P Dearnaley, Annie Gao, Lone Gothard, Kai Rothkamm, John R Yarnold","doi":"10.1093/bjr/tqaf056","DOIUrl":"https://doi.org/10.1093/bjr/tqaf056","url":null,"abstract":"Objectives: Radiation-induced lymphocyte apoptosis (RILA) and chromosomal damage assays (CDA) assays are proposed predictors of radiotherapy (RT) adverse events (RTAE). This study evaluated RILA and CDA in patients undergoing different RT dose regimens for early breast (FAST trial) or prostate (CHHiP trial) cancer.Methods: Consecutive patients were recruited from each trial. Fresh heparinised blood samples were analyzed for RILA and CDA. The primary endpoint was time to first change in photographic breast appearance (FAST) or time to first grade ≥2 RTOG bladder or bowel toxicity (CHHiP). The secondary endpoint in FAST was breast fibrosis.Results: The dataset included 103 FAST and 297 CHHiP trial patients. No significant association of RILA with the primary endpoint was observed in the FAST trial. However, the risk of grade ≥2 breast fibrosis was lower in patients with RILA ≥24% compared to those with RILA ≤16% (p = 0.012). In the CHHiP trial, no significant associations were found between CDA after prostate radiotherapy outcomes. However, higher levels of micronuclei per cell were associated with a lower risk of grade ≥2 RTOG pelvic toxicities. The relative risk of developing grade ≥2 RTAE decreased for patients with RILA ≥ 24% but was not statistically significant.Conclusions: No association was found between RILA and photographic breast appearance. High RILA values were statistically associated with a lower risk of grade ≥2 breast fibrosis. In the CHHiP trial, most assays showed no association with pelvic toxicities.Advances in knowledge: RILA is confirmed as a potential predictor of breast fibrosis regarding fraction sizes.","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0