British Journal of Radiology最新文献

{"title":"Prognostic factors of biochemical recurrence and impact of pre-treatment MRI for prostate cancer radiotherapy.","authors":"Noah Margolese, Johanna Dahan, Damien A R Olivié, Jean-Sébastien Billiard, Guila Delouya, Daniel Taussky","doi":"10.1093/bjr/tqaf122","DOIUrl":"https://doi.org/10.1093/bjr/tqaf122","url":null,"abstract":"<p><strong>Objectives: </strong>We conducted an analysis of the prognostic implications of MRI findings prior to radiotherapy in patients diagnosed with prostate cancer.</p><p><strong>Methods: </strong>Patients from our institutional database who were treated with radiotherapy between 2014-2024 were searched for diagnostic MRI. The prognostic significance of PI-RADS score, index-lesion diameter, and Cancer of the Prostate Risk Assessment (CAPRA) score on biochemical recurrence was analyzed.</p><p><strong>Results: </strong>Of the 1480 patients, 499 (33.7%) underwent a diagnostic pretreatment MRI. 49.5% were treated with low-dose brachytherapy, 29.8% with EBRT plus a high-dose rate brachytherapy boost, and 20.7% with EBRT alone. Among the patients who underwent MRI, 404 (81%) had PIRADS 4-5, including 35% with lesions ≥15 mm and 20% with lesions ≥20 mm. The median follow-up period was 44 months (IQR:23-66). Among the 78 patients who subsequently experienced biochemical recurrence, 16 underwent a diagnostic MRI prior to treatment. CAPRA score did not correlate with lesion diameter (p = 0.4). In univariate analysis, lesions ≥15 mm (p = 0.026) and ≥20 mm (p < 0.001) were significant predictors, as was CAPRA-score (p < 0.001). In multivariate analyses, lesion size ≥20 mm (hazard ratio [HR], 3.49; 95%CI:1.25-9.76, p = 0.017) but not ≥15 mm significantly predicted recurrence. Stratified by CAPRA, only in high-risk cancers (score 6-10, 21% of patients) was a lesion ≥20 mm a significant predictor (p < 0.001).</p><p><strong>Conclusions: </strong>We determined that a lesion on MRI with a diameter of ≥ 20 mm was an independent prognostic factor for biochemical recurrence, particularly in high-risk cancers. Whether the radiation dose escalation of these lesions can improve clinical outcomes must be determined.</p><p><strong>Advances in knowledge: </strong>We found that a prostate lesion on MRI with a diameter ≥20 mm was associated with poorer outcomes following radiotherapy.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of steatotic liver disease on hepatitis B related hepatocellular carcinoma: MRI manifestation and prognostic potential.","authors":"Beixuan Zheng, Yuyao Xiao, Fei Wu, Chun Yang, Ruofan Sheng, Mengsu Zeng","doi":"10.1093/bjr/tqaf121","DOIUrl":"https://doi.org/10.1093/bjr/tqaf121","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the impact of steatotic liver disease (SLD) on hepatitis B virus (HBV) related hepatocellular carcinoma (HCC) in clinical and MRI manifestations and prognostic potential.</p><p><strong>Methods: </strong>441 HBV-related HCC patients were retrospectively enrolled (mean age 55.5 years ±10.8, 366 males, 237 without and 204 with concurrent SLD). Kaplan-Meier analyses were performed to compare the overall survival (OS) and recurrence-free survival (RFS). Clinical and MRI characteristics were compared. Univariate and multivariate analyses were used to identify the different imaging features between patients with and without concurrent SLD.</p><p><strong>Results: </strong>Patients with concurrent SLD had a better OS (P = 0.047). Except for metabolism-related indicators, the level of alpha fetoprotein (Z = 7.82, P = 0.007), the grade of tumor lesion (χ2= 6.567, P = 0.035) and microvascular invasion (χ2= 6.252, P = 0.044) appeared to be lower in patients with SLD. According to the multivariate analysis, non-adjacent to porta hepatis or confluence of hepatic veins (odds ratio [OR]=1.624, P = 0.041), absent washout appearance (OR = 2.047, P = 0.001) and intact enhancing capsule (OR = 2.584, P = 0.003) were significantly different MRI manifestations between tumors with and without SLD.</p><p><strong>Conclusions: </strong>For HBV-related HCC, concurrent SLD tended to be associated with better OS. The clinical and radiological characteristics were different, which seemed to be less aggressive for those with concurrent SLD.</p><p><strong>Advances in knowledge: </strong>Concurrent SLD in HBV-related HCC patients may be associated with better overall survival, and it exhibits distinct clinical and radiological features, which seem to be less aggressive.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotyping Pulmonary Sarcoidosis.","authors":"Hiba Abbas, Maria Kokosi, Nishanth Sivarasan","doi":"10.1093/bjr/tqaf118","DOIUrl":"https://doi.org/10.1093/bjr/tqaf118","url":null,"abstract":"<p><p>Pulmonary sarcoidosis, although generally associated with a good prognosis, remains challenging to manage in view of its unpredictable disease behaviour and outcome. Being able to phenotype patients with sarcoidosis could potentially facilitate treatment decisions and promote research anchored to disease behaviour and outcome. Efforts to phenotype sarcoidosis using imaging date back to the early 1900s when chest x-rays were the main modality for lung parenchymal evaluation. However, despite significant advances in technology, there is currently no consensus on how we should classify this disease utilising more modern imaging techniques. In this review we provide an overview of imaging phenotypes in sarcoidosis, discuss the challenges of disease classification, evaluate associations between imaging appearance and outcome, and explore new developments in this field.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantified motility in Crohn's disease to evaluate stricture composition using cine-MRI.","authors":"K J Beek, K L van Rijn, C S de Jonge, F A E de Voogd, C J Buskens, J van der Bilt, W Bemelman, G D'Haens, A Mookhoek, E A Neefjes-Borst, K Horsthuis, J A W Tielbeek, K B Gecse, J Stoker","doi":"10.1093/bjr/tqaf120","DOIUrl":"https://doi.org/10.1093/bjr/tqaf120","url":null,"abstract":"<p><strong>Objectives: </strong>The histopathological composition of a stricture impacts clinical treatment choice. Therefore, imaging biomarkers that can distinguish a predominantly inflammatory from a chronic (ie non-inflammatory) stricture are highly relevant. The aim of our study was to determine whether it is possible to distinguish inflammatory (ie inflammatory and mixed) from chronic (ie non-inflammatory) strictures using quantified motility measured on cine-MRI in CD patients.</p><p><strong>Methods: </strong>In this prospective cross-sectional study consecutive CD patients scheduled for small bowel resection underwent 2D cine-MRI prior to surgery. Motility of small bowel strictures and pre-stricture dilatations was quantified using a validated post-processing method (GIQuant). The resection specimens were scored by two pathologists as either: predominantly inflammatory, mixed or predominantly chronic (ie non-inflammatory). For the analysis, strictures were stratified into inflammatory strictures (ie predominantly inflammatory and mixed) and chronic (ie non-inflammatory) strictures.</p><p><strong>Results: </strong>Twenty-eight patients were included with thirty strictures and fifteen pre-stricture dilatations. Pre-stricture dilatation motility was higher for chronic (ie non-inflammatory) compared to inflammatory (ie inflammatory and mixed) strictures (289.5AU [188.0-362.9] vs.113.1AU [83.6-142.4], p=0.004). Area under the curve (AUC) for chronic (ie non-inflammatory) stricture detection was 0.93 (95% CI 0.78-1.0, p=0.01). Within strictures, no difference was found between motility in different histopathology categories (p=0.6).</p><p><strong>Conclusion: </strong>Motility in the pre-stricture dilatations of chronic (ie non-inflammatory) strictures was higher compared to inflammatory (ie inflammatory and mixed) strictures. No difference in motility was observed in stricture motility among stricture subtypes. Our findings suggest that quantified motility-measured with cine-MRI-of pre-stricture dilatations could possibly distinguish chronic (ie non-inflammatory) strictures from inflammatory (ie inflammatory and mixed) strictures.</p><p><strong>Advances in knowledge: </strong>Motility measured with cine-MRI could possibly provide an imaging biomarker for the distinction between chronic (ie non-inflammatory) and inflammatory (ie inflammatory and mixed) strictures in CD.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Film measurements of kilovoltage x-ray percentage depth doses for different energies and field sizes.","authors":"Tze Yee Lim, Dershan Luo, Jamshid Moradi Kurdestany, Xin Wang, Ramesh Tailor","doi":"10.1093/bjr/tqaf107","DOIUrl":"https://doi.org/10.1093/bjr/tqaf107","url":null,"abstract":"<p><strong>Objectives: </strong>Kilovoltage x-ray therapy, which includes superficial x-rays and orthovoltage x-rays, is particularly suited for treatments near the skin surface. Radiation dose deposition at depth is typically characterized by percentage depth dose (PDD) curves. However, PDD data are difficult to obtain in kilovoltage x-ray therapy, hence clinics often rely on British Journal of Radiology Supplement 25 (BJR-25) archival data. This study measured PDD for different energies and field sizes on the Xstrahl 300 kilovoltage x-ray therapy unit for comparison with BJR-25 data.</p><p><strong>Methods: </strong>We irradiated EBT3 film in water using different energy and field size combinations, then compared the acquired PDD curves with BJR-25 data. We used 75 kVp, 125 kVp, and 250 kVp beams, for 10 × 10 cm2 open field, 4 × 4 cm2 closed-ended square applicator, and open-ended circular applicators of 1.5 cm, 2.0 cm, 2.8 cm, and 4.7 cm diameter.</p><p><strong>Results: </strong>PDD for different energies and field sizes on the Xstrahl 300 kilovoltage x-ray therapy unit agreed well with BJR-25 data. The average difference between measured and BJR-25 data was -0.3 ± 1.8%; 85.9% of the individual local differences were within ±3%, 94.8% within ±4%, and 99.5% within ±5%.</p><p><strong>Conclusions: </strong>The PDD curves presented here, together with BJR-25 data, can serve as useful comparison datasets for the commissioning of kilovoltage x-ray machines.</p><p><strong>Advances in knowledge: </strong>Our film-based measurement technique provides high spatial resolution PDD datapoints for a modern kilovoltage x-ray unit, adding to the limited published data in the kilovoltage energy range.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photon-Counting-Detector CT: Technology Overview and Radiation Dose Reduction.","authors":"Liqiang Ren, Xinhui Duan, Richard Ahn, Fernando Kay, Laleh Daftaribesheli, Wei Zhou, Jeffrey Guild, Lakshmi Ananthakrishnan","doi":"10.1093/bjr/tqaf116","DOIUrl":"https://doi.org/10.1093/bjr/tqaf116","url":null,"abstract":"<p><p>Photon-counting detector computed tomography (PCD-CT) represents a transformative advancement in CT technology, overcoming limitations of conventional energy-integrating detector (EID) based systems. It uses semiconductor materials such as cadmium telluride, cadmium zinc telluride, and silicon to directly count x-ray photons while resolving their energy levels. This energy-resolving capability ensures equal weighting of low- and high-energy photons, eliminates electronic noise, and enables material-specific imaging. The absence of physical septa in the detector-used in EIDs to prevent light photon cross-talk-results in smaller effective detector pixels in PCD-CT, enhancing detection efficiency and spatial resolution. These innovations collectively enhance diagnostic accuracy while enabling significant radiation dose reduction. This paper provides a comprehensive overview of PCD-CT technology, comparing it with EID-based systems. It highlights key advantages such as superior spatial and contrast resolution, spectral imaging, and noise reduction. Additionally, the review discusses PCD-CT's radiation dose reduction across cardiovascular, thoracic, abdominal, musculoskeletal, neuroimaging, and pediatric applications. Despite its promise, PCD-CT faces challenges, including non-ideal detector performance, increased electronic complexity, and calibration requirements to maintain accuracy. Addressing these issues will be crucial for widespread clinical adoption. As research progresses and technology improves, PCD-CT is expected to reshape clinical practice by integrating high diagnostic accuracy with improved radiation efficiency.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Amide Proton Transfer Imaging for Improved Glioma Assessment: Implications for RANO 2.0 Criteria.","authors":"Hua-Zhen Deng, Xing-Liang Liu, Wen-Jing Fan, Xue Hua, Yilinuer Yilihamu, Yongzhou Xu, Han-Wen Zhang, Xiao-Lei Liu, Fan Lin","doi":"10.1093/bjr/tqaf115","DOIUrl":"https://doi.org/10.1093/bjr/tqaf115","url":null,"abstract":"<p><strong>Objectives: </strong>The updated RANO 2.0 criteria acknowledge the limitations of conventional MRI in distinguish tumour progression (TP) from pseudoprogression (PsP) after surgery. Advanced imaging techniques, such as Amide Proton Transfer (APT) imaging, further validating its integration into the RANO 2.0 framework to enhance assessment accuracy.</p><p><strong>Methods: </strong>This study retrospectively analyzed 75 patients with high-grade gliomas who underwent MRI, including APT imaging. APT imaging was assessed for its ability to differentiate true tumor recurrence from PsP, using various regions of interest (ROIs) to analyze APT signal variations.</p><p><strong>Results: </strong>APT imaging significantly improved the diagnostic accuracy in distinguishing glioma TP from PsP when compared to conventional MRI alone. Metrics such as APTmax and APTmean demonstrated higher sensitivity and specificity compared to APTmin, validating the integration of APT imaging into the RANO 2.0 criteria by providing valuable insights into tumor metabolism and the microenvironment.</p><p><strong>Conclusions: </strong>APT imaging is a valuable addition to conventional MRI for postoperative glioma evaluation. supporting its integration into the RANO 2.0 criteria for a more accurate assessment of tumor status and potentially guiding better patient management. Further research is needed to confirm these findings and establish clinical protocols.</p><p><strong>Advances in knowledge: </strong>This study highlights the potential of APT imaging in enhancing the diagnostic accuracy for distinguishing TP from PsP, demonstrates that APT imaging, particularly when integrated with multimodal MRI (T1WI, T2WI, T2-FLAIR and contrast-enhanced T1WI), improves the sensitivity and specificity of diagnosis.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and external validation of a predictive model of nondiagnostic results in patients undergoing CT-guided percutaneous transthoracic needle lung biopsy.","authors":"Yonghao Du, Linyun Yang, Xuyin Zhang, Ting Liang, Shaonong Dang, Shanshan Liu, Rong Wang, Gang Niu","doi":"10.1093/bjr/tqaf110","DOIUrl":"https://doi.org/10.1093/bjr/tqaf110","url":null,"abstract":"<p><strong>Objectives: </strong>To develop and validate a nomogram to predict nondiagnostic results in patients undergoing CT-guided percutaneous transthoracic needle biopsy (PTNB) of the lung.</p><p><strong>Methods: </strong>A total of 954 PTNBs in the training cohort and 186 PTNBs in the external validation cohort were retrospectively included. PTNB results were categorized as diagnostic or nondiagnostic. Logistic regression was used to identify independent predictors of nondiagnostic results. C-statistic, calibration curve, and decision curve analysis were used to evaluate discrimination, calibration, and clinical usefulness, respectively.</p><p><strong>Results: </strong>Of 954 PTNBs in the training cohort, 280 (29.4%) were nondiagnostic results. The model included six independent predictors: age at biopsy, lesion size, lobulation sign, air bronchogram, the number of samples, and pre-test probability. The C-statistics for the training and external validation cohorts were 0.752 and 0.734, respectively. Two risk groups were identified with low (<40%) and high (≥40%) probabilities of nondiagnostic results. For lesions of low risk with the number of samples ≤ 2, ≤2 samples should be obtained; for lesions of low risk with the number of samples ≥3, more samples should be obtained when appropriate; for lesions of high risk with the number of samples ≥3, PTNB needs to be reconsidered.</p><p><strong>Conclusions: </strong>The nomogram showed good performance in predicting the nondiagnostic results of PTNB of the lung. Suggestions for each risk group may facilitate clinical practice.</p><p><strong>Advances in knowledge: </strong>Pretest probability was a significant factor to predict nondiagnostic results of PTNB. The number of samples of PTNB should be different for different risk groups to avoid nondiagnostic results.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Model for Predicting Omicron Prognosis Based on CT and Clinical Variables.","authors":"Hassan Tariq, Daanyal Siddiqui","doi":"10.1093/bjr/tqaf072","DOIUrl":"https://doi.org/10.1093/bjr/tqaf072","url":null,"abstract":"","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploiting the endothelial-immune axis to improve radiotherapy efficacy.","authors":"Olivier Guipaud, Claire Lago, Lucie Portier, Vincent Paget, Agnès François, Stéphane Supiot, Fabien Milliat","doi":"10.1093/bjr/tqaf114","DOIUrl":"https://doi.org/10.1093/bjr/tqaf114","url":null,"abstract":"<p><p>The immune system is essential for controlling tumours and plays a crucial role in how normal and cancer tissues respond to radiotherapy. Lining the inner surface of vessels, the endothelium acts as a barrier that normally prevents the passage of cells from the bloodstream into tissues and promotes the recruitment of immune cells during stressful, injured or infected conditions. Profound changes in endothelial function occur in response to irradiation, determining the tumour response to radiotherapy and participating in the initiation and development of adverse effects. In both normal tissues and tumours, radiation makes endothelial cells more adhesive to circulating cells, stimulates transendothelial migration and promotes immune infiltration, possibly chronic and harmful to normal tissues. Considering the active role of endothelium in immune cell recruitment, targeting endothelial cells becomes an attractive strategy to improve the therapeutic gain of radiotherapy. To this end, it is crucial to better understand how endothelial cells respond to irradiation in vivo and to determine their role in regulating immune cell recruitment. Advanced analytical technologies, such as single-cell RNA sequencing and spatial transcriptomics, now enable to uncover the molecular responses of cells in living organisms and comprehend their interactions within an organ. Here, we present the latest findings regarding the impact of radiation on the vascular endothelium and its implications for normal tissues and tumours. We also explore current research using single-cell analysis to uncover new cell types, molecular pathways, and cell-cell interactions in irradiated animal models and human patients. Additionally, we highlight how endothelial cell-mediated immune recruitment may represent a potential target for modulating the immune response.</p>","PeriodicalId":9306,"journal":{"name":"British Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}